Collated Gene Ontology terms

Biological process: small GTPase binding(2022, 2025) signaling adaptor activity(2019, 2025) actin binding(2025) GTPase inhibitor activity(2003)

Molecular function: regulation of Rho protein signal transduction2011, 2025 regulation of cell shape2006, 2025 phagocytosis2025 regulation of signal transduction2008, 2025 actin filament organization2025 small GTPase-mediated signal transduction2006 signal transduction2003 regulation of actin filament polymerization2022 negative regulation of JNK cascade2006 midbrain-hindbrain boundary morphogenesis2013

Cellular component: plasma membrane2003, 2008, 2017, 2025 cytoskeleton2025 phagocytic cup2025 cell junction2025 nucleus2025 cytoplasm2022 cell cortex2006

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1K9D9_ANOCA
Ensembl»
0.0
CDC42SE2 CDC42 small effector 2 Anolis carolinensis
TI:28377 None
   
H9GUV0_ANOCA
Ensembl»
0.0
CRIB domain-containing protein Anolis carolinensis
TI:28377 None
   
Q7PTP8_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP003263 AGAP003263-PA Anopheles gambiae
TI:7165 None
 
Q7Q2V6_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP001081 AGAP001081-PA Anopheles gambiae
TI:7165 None
 
A0A3Q1NGJ3_BOVIN
Ensembl»
0.0
CDC42 small effector protein 1 Bos taurus
TI:9913 None
   
C42S1_BOVIN
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Bos taurus
TI:9913 None
 
C42S2_BOVIN
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Bos taurus
TI:9913 None
 
A0A9J7MJS5_BRAFL
euHCVdb»
0.0
LOC118411509 CDC42 small effector protein 2-like Branchiostoma floridae
TI:7739 None
   
A8WJV2_CAEBR
WormBase»
0.0
CBG24041 CBG_24041 Protein CBG24041 Caenorhabditis briggsae
TI:6238 None
 
Q19275_CAEEL
WormBase»
0.0
CELE_F09F7.5 F09F7.5 CRIB domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3N9L7_CANLF
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Canis lupus
TI:9612 None
   
H2XYC4_CIOIN
Ensembl»
0.0
CRIB domain-containing protein Ciona intestinalis
TI:7719 None
 
C42S1_DANRE
ZFIN»
0.8
cdc42se1 CDC42 small effector protein 1 Danio rerio
TI:7955 None
 
C42S2_DANRE
ZFIN»
0.5
cdc42se2 CDC42 small effector protein 2 Danio rerio
TI:7955 None
 
E9GG67_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_50104 Wiskott-Aldrich syndrome protein Daphnia pulex
TI:6669 None
 
E9H8T3_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_326794 CRIB domain-containing protein Daphnia pulex
TI:6669 None
 
E9I207_DAPPU
neXtProt»
0.0
DAPPUDRAFT_204885 CRIB domain-containing protein Daphnia pulex
TI:6669 None
 
C42ES_DROME
FlyBase»
1.5
Spec2 CDC42 small effector protein homolog (Dspec) Drosophila melanogaster
TI:7227 None
 
A0A9L0SIK0_HORSE
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Equus caballus
TI:9796 None
   
F6TCM7_HORSE
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Equus caballus
TI:9796 None
   
A0A8V0Y2B6_CHICK
Ensembl»
0.0
CDC42SE2 CDC42 small effector 2 Gallus gallus
TI:9031 None
   
A0A8V0Z1B4_CHICK
Ensembl»
0.0
LOC100859848 CRIB domain-containing protein Gallus gallus
TI:9031 None
   
A0A8V1AL84_CHICK
Ensembl»
0.0
CDC42SE1 CDC42 small effector 1 Gallus gallus
TI:9031 None
   
C42S1_CHICK
CTD»
0.0
CDC42SE1 CDC42 small effector protein 1 Gallus gallus
TI:9031 None
 
G3QYT6_GORGO
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Gorilla gorilla
TI:9593 None
 
G3R8P0_GORGO
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Gorilla gorilla
TI:9593 None
 
C42S1_HUMAN
Ensembl»
1.8
CDC42SE1 CDC42 small effector protein 1 (CDC42-binding protein
SCIP1) (Small effector of CDC42 protein 1)		 Homo sapiens
TI:9606 None
 
C42S2_HUMAN
Ensembl»
1.6
CDC42SE2 CDC42 small effector protein 2
(Small effector of CDC42 protein 2)		 Homo sapiens
TI:9606 None
 
B7PV65_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW007778 CRIB domain-containing protein Ixodes scapularis
TI:6945 None
 
W5MNR8_LEPOC
Ensembl»
0.0
CDC42 small effector 2 Lepisosteus oculatus
TI:7918 None
 
W5N657_LEPOC
Ensembl»
0.0
CDC42 small effector protein 2-like Lepisosteus oculatus
TI:7918 None
 
W5NAX1_LEPOC
Ensembl»
0.0
WASP actin nucleation promoting factor b Lepisosteus oculatus
TI:7918 None
 
F6T0R1_MACMU
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Macaca mulatta
TI:9544 None
 
G7MTX9_MACMU
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Macaca mulatta
TI:9544 None
 
F6ZHW3_MONDO
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Monodelphis domestica
TI:13616 None
   
F7GKB5_MONDO
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Monodelphis domestica
TI:13616 None
   
A9V3F9_MONBE
euHCVdb»
0.0
MONBRDRAFT_33166 CRIB domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9V6R1_MONBE
euHCVdb»
0.0
MONBRDRAFT_38251 Non-specific serine/threonine protein kinase Monosiga brevicollis
TI:81824 None
 
C42S1_MOUSE
Ensembl»
1.5
Cdc42se1 CDC42 small effector protein 1 Mus musculus
TI:10090 None
 
C42S2_MOUSE
Ensembl»
1.5
Cdc42se2 CDC42 small effector protein 2 Mus musculus
TI:10090 None
 
A7REW2_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g176973 CRIB domain-containing protein Nematostella vectensis
TI:45351 None
 
A0A6I8P8D6_ORNAN
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HU11_ORYLA
Ensembl»
0.0
cdc42se1 CRIB domain-containing protein Oryzias latipes
TI:8090 None
   
H2M876_ORYLA
Ensembl»
0.0
CDC42SE2 CDC42 small effector 2 Oryzias latipes
TI:8090 None
   
H2QZW3_PANTR
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Pan troglodytes
TI:9598 None
 
H2R2H3_PANTR
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Pan troglodytes
TI:9598 None
 
C42S1_RAT
RGD»
0.0
Cdc42se1 CDC42 small effector protein 1 Rattus norvegicus
TI:10116 None
 
C42S2_RAT
RGD»
1.5
Cdc42se2 CDC42 small effector protein 2 Rattus norvegicus
TI:10116 None
 
A0A7M7MZS2_STRPU
EnsemblMetazoa»
0.0
CRIB domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A287AEN9_PIG
Ensembl»
0.0
CDC42SE2 CDC42 small effector protein 2 Sus scrofa
TI:9823 None
   
A0A4X1W2X3_PIG
Ensembl»
0.0
CDC42SE1 CDC42 small effector protein 1 Sus scrofa
TI:9823 None
   
D6WRY1_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_09513 CDC42 small effector
protein homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
B3RU45_TRIAD
CTD»
0.0
TRIADDRAFT_55151 CRIB domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8HPI8_XENLA
Xenbase»
0.0
cdc42se2l.S CDC42 small effector protein 2-A isoform X1 Xenopus laevis
TI:8355 None
   
A0A1L8HYP9_XENLA
Xenbase»
0.0
cdc42se2l.L CDC42 small effector protein 2 Xenopus laevis
TI:8355 None
   
A0A8J1JJ12_XENTR
Xenbase»
0.0
cdc42se2l CDC42 small effector protein 2-A isoform X1 Xenopus tropicalis
TI:8364 None
   
A0ABD8CTG8_XENLA
euHCVdb»
0.0
cdc42se2.L CDC42 small effector protein 2-B Xenopus laevis
TI:8355 None
   
A0ABE4L2E8_XENLA
euHCVdb»
0.0
cdc42se1.L CDC42 small effector protein 1-B Xenopus laevis
TI:8355 None
   
C42S1_XENTR
Xenbase»
0.0
cdc42se1 CDC42 small effector protein 1 Xenopus tropicalis
TI:8364 None
 
C4S1A_XENLA
Xenbase»
0.0
cdc42se1-a CDC42 small effector protein 1-A Xenopus laevis
TI:8355 None
 
C4S1B_XENLA
Xenbase»
0.0
cdc42se1-b CDC42 small effector protein 1-B Xenopus laevis
TI:8355 None
 
C4S2A_XENLA
Xenbase»
0.0
cdc42se2-a CDC42 small effector protein 2-A Xenopus laevis
TI:8355 None
 
C4S2A_XENTR
Ensembl»
0.0
cdc42se2-A CDC42 small effector protein 2-A Xenopus tropicalis
TI:8364 None
 
C4S2B_XENLA
Xenbase»
0.0
cdc42se2-b CDC42 small effector protein 2-B Xenopus laevis
TI:8355 None
 
C4S2B_XENTR
Xenbase»
0.0
cdc42se2-B CDC42 small effector protein 2-B Xenopus tropicalis
TI:8364 None
 
C4S2C_XENLA
Xenbase»
0.0
cdc42se2-c CDC42 small effector protein 2-C Xenopus laevis
TI:8355 None