GO evidence weights

EXP: experimental evidence used in manual assertion
HDA: high throughput direct assay evidence used in manual assertion
HEP: high throughput expression pattern evidence used in manual assertion
HGI: high throughput genetic interaction phenotypic evidence used in manual assertion
HMP: high throughput mutant phenotypic evidence used in manual assertion
HTP: high throughput evidence used in manual assertion
IBA: biological aspect of ancestor evidence used in manual assertion
IBD: biological aspect of descendant evidence used in manual assertion
IC: curator inference used in manual assertion
IDA: direct assay evidence used in manual assertion
IEA: evidence used in automatic assertion
IEP: expression pattern evidence used in manual assertion
IGC: genomic context evidence used in manual assertion
IGI: genetic interaction evidence used in manual assertion
IMP: mutant phenotype evidence used in manual assertion
IMR: phylogenetic determination of loss of key residues evidence used in manual assertion
IPI: physical interaction evidence used in manual assertion
IRD: rapid divergence from ancestral sequence evidence used in manual assertion
ISA: sequence alignment evidence used in manual assertion
ISM: match to sequence model evidence used in manual assertion
ISO: sequence orthology evidence used in manual assertion
ISS: sequence similarity evidence used in manual assertion
NAS: author statement without traceable support used in manual assertion
ND: no evidence data found used in manual assertion
RCA: automatically integrated combinatorial evidence used in manual assertion
TAS: author statement supported by traceable reference used in manual assertion

GO domain weights

C: Cellular component
P: Biological process
F: Molecular function

Calulate custom knownness

Use the following button to (re)calculate custom knownness values for each protein cluster in the Unknome database using the GO evidence and domain weights presented on this page. These clustom values may be used to filter the clusters etc., but are local to your internet session. The standard knownness, calculated using the default weights, will still be avaiable for comparison.