Biological process: small GTPase binding^{(2011, 2022, 2024)} signaling adaptor activity^{(2019, 2024)} actin binding⁽²⁰²⁴⁾ protein kinase binding⁽²⁰²⁴⁾ phospholipase binding⁽²⁰²⁴⁾ identical protein binding⁽²⁰²⁴⁾ actin monomer binding⁽²⁰²⁴⁾ SH3 domain binding⁽²⁰²⁴⁾ GTPase inhibitor activity⁽²⁰⁰³⁾ Arp2/3 complex binding⁽²⁰²⁴⁾

Molecular function: regulation of Rho protein signal transduction^{2011, 2024} regulation of cell shape^{2006, 2024} phagocytosis²⁰²⁴ regulation of signal transduction^{2008, 2024} actin filament organization²⁰²⁴ small GTPase mediated signal transduction²⁰⁰⁶ signal transduction²⁰⁰³ regulation of stress fiber assembly²⁰²⁴ regulation of lamellipodium assembly²⁰²⁴ regulation of actin polymerization or depolymerization²⁰²⁴
± 18 regulation of actin filament polymerization²⁰²² regulation of T cell antigen processing and presentation²⁰²⁴ positive regulation of transcription by RNA polymerase II²⁰²⁴ positive regulation of double-strand break repair via homologous recombination²⁰²⁴ negative regulation of stress fiber assembly²⁰²⁴ negative regulation of cell motility²⁰²⁴ negative regulation of JNK cascade²⁰⁰⁶ mitotic cytokinesis²⁰²⁴ mitotic actomyosin contractile ring assembly²⁰²⁴ midbrain-hindbrain boundary morphogenesis²⁰¹³ immune response²⁰²⁴ establishment or maintenance of cell polarity²⁰²⁴ endocytosis²⁰²⁴ actin filament polymerization²⁰²⁴ actin filament branching²⁰²⁴ actin cortical patch assembly²⁰²⁴ Cdc42 protein signal transduction²⁰²⁴ Arp2/3 complex-mediated actin nucleation²⁰²⁴

Cellular component: plasma membrane^{2003, 2008, 2017, 2024} cytoskeleton²⁰²⁴ cytoplasm^{2022, 2024} cell junction^{2023, 2024} nucleus²⁰²⁴ phagocytic cup²⁰²⁴ cell projection²⁰²⁴ cell cortex^{2006, 2011} site of double-strand break²⁰²⁴ medial cortex²⁰²⁴
± 4 mating projection tip²⁰²⁴ cytosol²⁰²⁴ actin filament²⁰²⁴ actin cortical patch²⁰²⁴