Collated Gene Ontology terms

Biological process: methylthioribulose 1-phosphate dehydratase activity(2010, 2013, 2016, 2017, 2024) zinc ion binding(2016, 2022, 2024) metal ion binding(2024) lyase activity(2024) identical protein binding(2024) catalytic activity(2024) magnesium ion binding(2024) hydrolase activity(2024) acireductone synthase activity(2024) 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity(2024)
2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity2024

Molecular function: L-methionine salvage from methylthioadenosine2013, 2017, 2024 methionine biosynthetic process2024 L-methionine salvage from S-adenosylmethionine2024 apoptotic process2005, 2024 negative regulation of apoptotic process2013, 2016, 2024 regulation of ERK1 and ERK2 cascade2013, 2024 pyroptosis2016, 2024 protein homotetramerization2016, 2024 monosaccharide metabolic process2024 translation2021

Cellular component: cytoplasm2016, 2018, 2020, 2024 cytosol2009, 2010, 2011, 2013 membrane2024 nucleus2009, 2024 cytoskeleton2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 8/39 
Archea: 0/8 
Bacteria: 5/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A061E327_THECC
EnsemblPlants»
0.0
TCM_046722 Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]		 Theobroma cacao
TI:3641 None
 
A0A1L8GIP2_XENLA
Xenbase»
0.0
apip.L Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Xenopus laevis
TI:8355 None
   
A0A1U8IIY4_GOSHI
Ensembl»
0.0
LOC107897216 Probable bifunctional methylthioribulose-1-phosphate
dehydratase/enolase-phosphatase E1 isoform X1		 Gossypium hirsutum
TI:3635 None
   
A0A1U8KTC0_GOSHI
Ensembl»
0.0
LOC107919256 Probable bifunctional
methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1		 Gossypium hirsutum
TI:3635 None
   
A0A1U8NRV0_GOSHI
Ensembl»
0.0
LOC107951147 Probable bifunctional
methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1		 Gossypium hirsutum
TI:3635 None
   
A0A251URB8_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr05g0153011 Putative class II
aldolase/adducin N-terminal, Methylthioribulose-1-phosphate dehydratase		 Helianthus annuus
TI:4232 None
 
A0A251VNF7_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr01g0015321 HanXRQr2_Chr01g0023261 Methylthioribulose-1-phosphate dehydratase, class II aldolase/adducin domain
superfamily (Putative class II aldolase/adducin, Methylthioribulose-1-phosphate dehydratase)		 Helianthus annuus
TI:4232 None
 
A0A2A6CUL3_PRIPA
EnsemblMetazoa»
0.0
WBGene00092541 Aldolase_II domain-containing protein Pristionchus pacificus
TI:54126 None
 
A0A2K3E5R9_CHLRE
EnsemblPlants»
0.0
CHLRE_01g016528v5 Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6XT43_MARPO
EnsemblPlants»
0.0
MARPO_0003s0138 Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]		 Marchantia polymorpha
TI:3197 None
 
A0A3N7H8Z5_POPTR
EnsemblPlants»
0.0
POPTR_011G118066 Class II aldolase/adducin
N-terminal domain-containing protein		 Populus trichocarpa
TI:3694 None
 
A0A3Q2LAZ8_HORSE
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Equus caballus
TI:9796 None
   
A0A5F8GU04_MONDO
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Monodelphis domestica
TI:13616 None
   
A0A5G2R267_PIG
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Sus scrofa
TI:9823 None
   
A0A7M7TH15_STRPU
EnsemblMetazoa»
0.0
Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SYB5_ANOCA
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Anolis carolinensis
TI:28377 None
   
A0A8I3PE93_CANLF
Ensembl»
0.0
APIP Class II aldolase/adducin
N-terminal domain-containing protein		 Canis lupus
TI:9612 None
   
A0A8J0V8V4_XENLA
Xenbase»
0.0
apip.S Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Xenopus laevis
TI:8355 None
   
A0A9J7KXV3_BRAFL
CTD»
0.0
LOC118413307 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Branchiostoma floridae
TI:7739 None
   
A0A9J7KZM7_BRAFL
CTD»
0.0
LOC118413308 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Branchiostoma floridae
TI:7739 None
   
A0A9K3E535_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr14g0620661 Methylthioribulose-1-phosphate dehydratase, class
II aldolase/adducin domain superfamily		 Helianthus annuus
TI:4232 None
 
A0A9K3EB18_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr14g0653291 Methylthioribulose-1-phosphate dehydratase, class
II aldolase/adducin domain superfamily		 Helianthus annuus
TI:4232 None
 
A0A9K3J2Q4_HELAN
EnsemblPlants»
0.0
HanXRQr2_Chr05g0224231 Methylthioribulose-1-phosphate dehydratase, class
II aldolase/adducin domain superfamily		 Helianthus annuus
TI:4232 None
 
A8WRQ1_CAEBR
WormBase»
0.0
CBG01970 CBG_01970 Protein CBG01970 Caenorhabditis briggsae
TI:6238 None 		 
 
B6K229_SCHJY
EnsemblFungi»
0.0
SJAG_02293 5'-methylthioribulose-1-phosphate dehydratase Schizosaccharomyces japonicus
TI:4897 None
 
B7PIM8_IXOSC
EnsemblMetazoa»
0.0
8029502 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Ixodes scapularis
TI:6945 None
 
B8C6J0_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_270286 Class II aldolase/adducin
N-terminal domain-containing protein		 Thalassiosira pseudonana
TI:35128 None
 
D3ZUI1_RAT
RGD»
5.5
Apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Rattus norvegicus
TI:10116 None
   
D6WY90_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_02174 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Tribolium castaneum
TI:7070 None
 
D8QZT1_SELML
EnsemblPlants»
0.0
SELMODRAFT_266773 Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]		 Selaginella moellendorffii
TI:88036 None
 
D8QZV1_SELML
EnsemblPlants»
0.0
SELMODRAFT_405839 Class II aldolase/adducin
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8QZV9_SELML
EnsemblPlants»
0.0
SELMODRAFT_405846 Class II aldolase/adducin
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8TC30_SELML
EnsemblPlants»
0.0
SELMODRAFT_431271 Class II aldolase/adducin
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8TC38_SELML
EnsemblPlants»
0.0
SELMODRAFT_431278 Class II aldolase/adducin
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8TC57_SELML
EnsemblPlants»
0.0
SELMODRAFT_187281 Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [Includes: Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109); Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)]		 Selaginella moellendorffii
TI:88036 None
 
E3KUM5_PUCGT
EnsemblFungi»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Puccinia graminis
TI:5297 None
 
F0ZL55_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_33571 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Dictyostelium purpureum
TI:5786 None
 
F4NZV9_BATDJ
EnsemblBacteria»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Batrachochytrium dendrobatidis
TI:109871 None
 
F6PQB9_ORNAN
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Ornithorhynchus anatinus
TI:9258 None
   
F6UIW1_CIOIN
Ensembl»
0.0
Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Ciona intestinalis
TI:7719 None
 
F7HS49_MACMU
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Macaca mulatta
TI:9544 None
 
G3RWT9_GORGO
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Gorilla gorilla
TI:9593 None
 
H2L5W1_ORYLA
Ensembl»
0.0
apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Oryzias latipes
TI:8090 None
   
H2Q3E7_PANTR
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Pan troglodytes
TI:9598 None
 
K7LV33_SOYBN
EnsemblPlants»
0.0
GLYMA_12G153200 Class II aldolase/adducin
N-terminal domain-containing protein		 Glycine max
TI:3847 None
 
M3VYQ9_FELCA
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Felis catus
TI:9685 None
 
MTNB_ANOGA
EnsemblMetazoa»
0.0
AGAP000470 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Anopheles gambiae
TI:7165 None
 
MTNB_ASHGO
EnsemblFungi»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Ashbya gossypii
TI:33169 None
 
MTNB_ASPFU
EnsemblFungi»
0.0
mde1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Aspergillus fumigatus
TI:746128 None
 
MTNB_BACCR
EnsemblBacteria»
0.0
mtnB Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Bacillus cereus
TI:1396 None
 
MTNB_BACSU
EnsemblBacteria»
0.0
mtnB Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Bacillus subtilis
TI:1423 None
 
MTNB_BOVIN
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein)		 Bos taurus
TI:9913 None
 
MTNB_CAEEL
WormBase»
2.0
ZC373.5 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Caenorhabditis elegans
TI:6239 None
 
MTNB_CANAL
EnsemblFungi»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Candida albicans
TI:5476 None
 
MTNB_CHICK
Ensembl»
2.5
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Gallus gallus
TI:9031 None
 
MTNB_CRYNJ
EnsemblFungi»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Cryptococcus neoformans
TI:5207 None
 
MTNB_DANRE
ZFIN»
2.5
apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Danio rerio
TI:7955 None
 
MTNB_DICDI
dictyBase»
2.0
DDB_G0284915 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Dictyostelium discoideum
TI:44689 None
 
MTNB_DROME
FlyBase»
2.0
CG11134 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Drosophila melanogaster
TI:7227 None
 
MTNB_EMENI
EnsemblFungi»
0.0
mde1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Emericella nidulans
TI:162425 None
 
MTNB_HUMAN
Ensembl»
7.1
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein) (hAPIP)		 Homo sapiens
TI:9606 None
 
MTNB_LEIMA
EnsemblProtists»
0.0
LmjF28.1840 LmjF_28_1840 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Leishmania major
TI:5664 None
 
MTNB_LEPIN
EnsemblBacteria»
0.0
mtnB Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Leptospira interrogans
TI:173 None
 
MTNB_MONBE
EnsemblProtists»
0.0
29994 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Monosiga brevicollis
TI:81824 None
 
MTNB_MOUSE
Ensembl»
5.4
Apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC
4.2.1.109) (APAF1-interacting protein) (Monocyte/macrophage protein 19)		 Mus musculus
TI:10090 None
 
MTNB_NEMVE
EnsemblMetazoa»
0.0
v1g197093 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Nematostella vectensis
TI:45351 None
 
MTNB_NEUCR
EnsemblFungi»
0.0
mde-1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Neurospora crassa
TI:5141 None
 
MTNB_PSEAE
EnsemblBacteria»
0.0
mtnB Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Pseudomonas aeruginosa
TI:287 None
 
MTNB_SCHJY
EnsemblFungi»
0.0
mde1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Schizosaccharomyces japonicus
TI:4897 None
 
MTNB_SCHPO
PomBase»
1.0
mde1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Schizosaccharomyces pombe
TI:4896 None
 
MTNB_SCLS1
EnsemblFungi»
0.0
mde1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Sclerotinia sclerotiorum
TI:5180 None
 
MTNB_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_64275 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Trichoplax adhaerens
TI:10228 None
 
MTNB_XANCP
EnsemblBacteria»
0.0
mtnB Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Xanthomonas campestris
TI:339 None
 
MTNB_XENLA
Xenbase»
0.0
apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Xenopus laevis
TI:8355 None
 
MTNB_XENTR
Xenbase»
0.0
apip Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Xenopus tropicalis
TI:8364 None
 
MTNB_YARLI
EnsemblFungi»
0.0
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Yarrowia lipolytica
TI:4952 None
 
MTNB_YEAST
SGD»
3.2
MDE1 Methylthioribulose-1-phosphate dehydratase (MTRu-1-P
dehydratase) (EC 4.2.1.109)		 Saccharomyces cerevisiae
TI:4932 None
 
T1FYI7_HELRO
EnsemblMetazoa»
0.0
20213885 Probable methylthioribulose-1-phosphate dehydratase
(MTRu-1-P dehydratase) (EC 4.2.1.109)		 Helobdella robusta
TI:6412 None
 
W5LZG7_LEPOC
Ensembl»
0.0
APIP Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)
(EC 4.2.1.109) (APAF1-interacting protein homolog)		 Lepisosteus oculatus
TI:7918 None
 
YFY6_SCHPO
PomBase»
1.0
SPAC9.06c Methylthioribulose-1-phosphate
dehydratase-like protein		 Schizosaccharomyces pombe
TI:4896 None