Collated Gene Ontology terms

Biological process: hydrolase activity(2008, 2025) carboxylesterase activity(2025) carboxylic ester hydrolase activity(2025) phosphatidylcholine lysophospholipase activity(2020, 2021, 2025) hydrolase activity, acting on ester bonds(2020, 2025) serine hydrolase activity(2016, 2021) nucleic acid binding(2025) methyltransferase activity(2025)

Molecular function: secondary metabolite biosynthetic process2012, 2020, 2025 secondary metabolic process2012, 2022 response to retinoic acid2008, 2025 apoptotic process2020, 2025 methylation2025 asperfuranone biosynthetic process2012

Cellular component: cytoplasm2008, 2018, 2024, 2025 nucleus2008, 2009, 2017, 2018, 2025 cytosol2009, 2024, 2025 nucleoplasm2024, 2025 peroxisome2022 mitochondrion2024 cell tip2009 cell division site2009

Phylogenetic distribution

Chordates: 13/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 3/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
OVCA2_MOUSE
Ensembl»
2.0
Ovca2 Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase
domain-containing protein) (Ovarian cancer-associated gene 2 protein homolog)		 Mus musculus
TI:10090 None
 
OVCA2_HUMAN
Ensembl»
2.7
OVCA2 Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase
domain-containing protein) (Ovarian cancer-associated gene 2 protein)		 Homo sapiens
TI:9606 None
 
FSH1_YEAST
SGD»
2.9
FSH1 Family of serine hydrolases 1 (EC 3.1.-.-) Saccharomyces cerevisiae
TI:4932 None
 
A0A8V1ANK8_CHICK
Ensembl»
0.5
Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Gallus gallus
TI:9031 None
   
F7GI08_MONDO
Ensembl»
0.0
OVCA2 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Monodelphis domestica
TI:13616 None
   
G3R1S1_GORGO
Ensembl»
0.0
OVCA2 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Gorilla gorilla
TI:9593 None
 
YF36_SCHPO
PomBase»
1.0
SPAC22A12.06c Uncharacterized hydrolase
C22A12.06c (EC 3.1.-.-)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A1L8H4T1_XENLA
Xenbase»
0.0
ovca2.S Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Xenopus laevis
TI:8355 None
   
A0A8J0UDZ1_XENLA
CTD»
0.0
ovca2.L Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Xenopus laevis
TI:8355 None
   
A0ABK0LFP2_RAT
Ensembl»
1.0
Ovca2 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Rattus norvegicus
TI:10116 None
   
A2FNB1_TRIV3
TubercuList»
0.0
TVAG_427290 Serine hydrolase domain-containing protein Trichomonas vaginalis
TI:5722 None
 
AFOC_EMENI
EnsemblFungi»
0.0
afoC Probable esterase afoC (EC
3.1.2.-) (Asperfuranone biosynthesis protein B)		 Emericella nidulans
TI:162425 None
 
DBAE_EMENI
EnsemblFungi»
0.0
dbaE Esterase dbaE (EC 3.1.2.-) (Derivative
of benzaldehyde biosynthesis cluster protein E)		 Emericella nidulans
TI:162425 None
 
FSH2_YEAST
SGD»
0.5
FSH2 Family of serine hydrolases 2 (EC 3.1.-.-) Saccharomyces cerevisiae
TI:4932 None
 
OVCA2_BOVIN
CTD»
0.0
OVCA2 Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase
domain-containing protein) (Ovarian cancer-associated gene 2 protein homolog)		 Bos taurus
TI:9913 None
 
OVCA2_DANRE
ZFIN»
1.0
ovca2 Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase
domain-containing protein) (Ovarian cancer-associated gene 2 protein homolog)		 Danio rerio
TI:7955 None
 
OVCA2_XENTR
euHCVdb»
0.0
ovca2 Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase
domain-containing protein) (Ovarian cancer-associated gene 2 protein homolog)		 Xenopus tropicalis
TI:8364 None
 
Q5ADX4_CANAL
CGD»
0.0
CAALFM_C307700WA orf19.14009 Serine hydrolase Candida albicans
TI:5476 None
 
Q5BBP9_EMENI
TubercuList»
0.0
ANIA_02031 Serine hydrolase domain-containing protein Emericella nidulans
TI:162425 None
 
Q75C41_EREGS
euHCVdb»
0.0
AGOS_ACR076C ACR076Cp Eremothecium gossypii
TI:33169 None
 
A7EKE2_SCLS1
TubercuList»
0.0
SS1G_05789 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
F6QJ19_HORSE
Ensembl»
0.0
OVCA2 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Equus caballus
TI:9796 None
   
FSH3_YEAST
SGD»
0.5
FSH3 Family of serine hydrolases 3 (EC 3.1.-.-) Saccharomyces cerevisiae
TI:4932 None
 
H2LDW9_ORYLA
Ensembl»
0.0
OVCA2 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Oryzias latipes
TI:8090 None
   
LOVG_DROME
FlyBase»
1.5
CG5412 Esterase CG5412 (EC 3.1.2.-) Drosophila melanogaster
TI:7227 None
 
Q5BG01_EMENI
TubercuList»
0.0
ANIA_00529 Serine hydrolase domain-containing protein Emericella nidulans
TI:162425 None
 
A0A9J7MA56_BRAFL
euHCVdb»
0.0
LOC118429138 Esterase OVCA2 (EC 3.1.1.1)
(OVCA2 serine hydrolase domain-containing protein)		 Branchiostoma floridae
TI:7739 None
   
A7E524_SCLS1
TubercuList»
0.0
SS1G_00396 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7E9L9_SCLS1
TubercuList»
0.0
SS1G_01999 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7EHB8_SCLS1
TubercuList»
0.0
SS1G_04710 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7EVV3_SCLS1
TubercuList»
0.0
SS1G_09462 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7F7Q9_SCLS1
TubercuList»
0.0
SS1G_13639 Serine hydrolase domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
ALNB_EMENI
EnsemblFungi»
0.0
alnB Esterase alnB (EC 3.1.2.-)
(Asperlin biosynthesis cluster protein B)		 Emericella nidulans
TI:162425 None
 
C8V9Z4_EMENI
TubercuList»
0.0
ANIA_11117 DUF341 family oxidoreductase,
putative (AFU_orthologue AFUA_3G01420)		 Emericella nidulans
TI:162425 None
 
C8VC20_EMENI
TubercuList»
0.0
ANIA_10993 EF-hand calcium-binding domain
protein, putative (AFU_orthologue AFUA_2G01310)		 Emericella nidulans
TI:162425 None
 
C8VL88_EMENI
TubercuList»
0.0
ANIA_11156 Serine hydrolase domain-containing protein Emericella nidulans
TI:162425 None
 
INPF_EMENI
EnsemblFungi»
0.0
inpF Esterase inpF (EC 3.1.2.-) (Fellutamide B biosynthesis
cluster protein F) (Inp cluster protein F)		 Emericella nidulans
TI:162425 None
 
Q4WB35_ASPFU
TubercuList»
0.0
AFUA_8G00910 Serine hydrolase domain-containing protein Aspergillus fumigatus
TI:746128 None
 
Q4WDP5_ASPFU
TubercuList»
0.0
AFUA_5G00200 Serine hydrolase domain-containing protein Aspergillus fumigatus
TI:746128 None
 
Q4WFQ2_ASPFU
TubercuList»
0.0
AFUA_3G01420 DUF341 family oxidoreductase, putative Aspergillus fumigatus
TI:746128 None
 
Q4WIM6_ASPFU
TubercuList»
0.0
AFUA_2G01310 EF-hand calcium-binding domain protein, putative Aspergillus fumigatus
TI:746128 None
 
Q4WIM7_ASPFU
TubercuList»
0.0
AFUA_2G01300 Serine hydrolase domain-containing protein Aspergillus fumigatus
TI:746128 None
 
Q4WR32_ASPFU
TubercuList»
0.0
AFUA_1G17720 Oxidoreductase, putative Aspergillus fumigatus
TI:746128 None
 
Q4WWP7_ASPFU
TubercuList»
0.0
AFUA_3G06620 Dihydrofolate reductase Aspergillus fumigatus
TI:746128 None
 
Q5ARC1_EMENI
TubercuList»
0.0
ANIA_09159 Serine hydrolase domain-containing protein Emericella nidulans
TI:162425 None
 
Q5AY41_EMENI
TubercuList»
0.0
ANIA_06789 Serine hydrolase domain-containing protein Emericella nidulans
TI:162425 None
 
Q5B3V4_EMENI
TubercuList»
0.0
ANIA_04776 Dihydrofolate reductase
(AFU_orthologue AFUA_3G06620)		 Emericella nidulans
TI:162425 None
 
Q7RX12_NEUCR
TubercuList»
0.0
NCU05012 Serine hydrolase domain-containing protein Neurospora crassa
TI:5141 None
 
Q7S2E5_NEUCR
TubercuList»
0.0
NCU06012 Serine hydrolase domain-containing protein Neurospora crassa
TI:5141 None
 
Q7S3L0_NEUCR
TubercuList»
0.0
NCU08233 Serine hydrolase domain-containing protein Neurospora crassa
TI:5141 None
 
Q7S865_NEUCR
TubercuList»
0.0
NCU08691 EF-hand calcium-binding
domain-containing protein		 Neurospora crassa
TI:5141 None
 
Q7SGJ0_NEUCR
TubercuList»
0.0
NCU08094 Dihydrofolate reductase Neurospora crassa
TI:5141 None
 
A0A139WJ81_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_30670 UPF0483 protein CG5412-like Protein Tribolium castaneum
TI:7070 None
 
A0A1D8PNX1_CANAL
CGD»
0.0
CAALFM_C504350CA orf19.11403 Serine hydrolase Candida albicans
TI:5476 None
 
A0A2A6B5U7_PRIPA
EnsemblMetazoa»
0.0
WBGene00092440 FSH1 domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A2K3D7P5_CHLRE
euHCVdb»
0.0
CHLRE_11g467682v5 Serine hydrolase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DZP1_CHLRE
neXtProt»
0.0
CHLRE_03g201439v5 Serine hydrolase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3E0Y3_CHLRE
neXtProt»
0.0
CHLRE_02g085600v5 Serine hydrolase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WZA5_MARPO
euHCVdb»
0.0
MARPO_0046s0001 Serine hydrolase domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A644F0J1_GIAIC
TubercuList»
0.0
GL50803_0014828 Alpha/beta hydrolase Giardia intestinalis
TI:5741 None
 
A0A7M7T131_STRPU
EnsemblMetazoa»
0.0
Serine hydrolase domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0D1W9_PARTE
euHCVdb»
0.0
GSPATT00012561001 Serine hydrolase domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0D1X0_PARTE
neXtProt»
0.0
GSPATT00012562001 Serine hydrolase domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0D5Q5_PARTE
euHCVdb»
0.0
GSPATT00013802001 Serine hydrolase domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0DEB8_PARTE
neXtProt»
0.0
GSPATT00016211001 Serine hydrolase domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0EA70_PARTE
euHCVdb»
0.0
GSPATT00024919001 Serine hydrolase domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A7SDP4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g210684 Serine hydrolase domain-containing protein Nematostella vectensis
TI:45351 None
 
B3RJ41_TRIAD
CTD»
0.0
TRIADDRAFT_52561 Serine hydrolase domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B6K2W1_SCHJY
TubercuList»
0.0
fsh2 Serine hydrolase Schizosaccharomyces japonicus
TI:4897 None
 
B8BYE8_THAPS
neXtProt»
0.0
THAPSDRAFT_261864 Serine hydrolase domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B8CBP0_THAPS
neXtProt»
0.0
THAPSDRAFT_24702 Serine hydrolase domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
E3L512_PUCGT
TubercuList»
0.0
PGTG_17691 Serine hydrolase domain-containing protein Puccinia graminis
TI:5297 None
 
E9FVY6_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_220828 Serine hydrolase domain-containing protein Daphnia pulex
TI:6669 None
 
F0ZPI1_DICPU
TubercuList»
0.0
DICPUDRAFT_98320 Serine hydrolase domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F4NZ31_BATDJ
neXtProt»
0.0
BATDEDRAFT_23456 Serine hydrolase domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
H3GEI5_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GGX6_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GMP9_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GQU3_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GQU4_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GQU7_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GQU8_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3H609_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3HC90_PHYRM
EnsemblProtists»
0.0
Serine hydrolase domain-containing protein Phytophthora ramorum
TI:164328 None
 
LOVG_ANOGA
EnsemblMetazoa»
0.0
AGAP003155 Esterase AGAP003155 (EC 3.1.2.-) Anopheles gambiae
TI:7165 None
 
LOVG_CAEBR
WormBase»
0.0
CBG03338 Esterase CBG03338 (EC 3.1.2.-) Caenorhabditis briggsae
TI:6238 None
 
LOVG_CAEEL
WormBase»
0.5
C25G4.2 Esterase C25G4.2 (EC 3.1.2.-) Caenorhabditis elegans
TI:6239 None
 
Q55D01_DICDI
dictyBase»
0.5
DDB_G0270972 DUF341 family protein Dictyostelium discoideum
TI:44689 None
 
Q5KJH3_CRYD1
TubercuList»
0.0
CNC06550 Expressed protein Cryptococcus deneoformans
TI:40410 None
 
Q5KJH4_CRYD1
TubercuList»
0.0
CNC06540 Serine hydrolase domain-containing protein Cryptococcus deneoformans
TI:40410 None
 
Q6C8U4_YARLI
TubercuList»
0.0
YALI0_D16940g YALI0D16940p Yarrowia lipolytica
TI:4952 None
 
Q756B1_EREGS
euHCVdb»
0.0
AGOS_AER356C AER356Cp Eremothecium gossypii
TI:33169 None
 
A0A7U2F3Y2_PHANO
TubercuList»
0.0
JI435_152720 Serine hydrolase domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2FGC7_PHANO
TubercuList»
0.0
JI435_112740 Serine hydrolase domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2FH95_PHANO
TubercuList»
0.0
JI435_128980 Serine hydrolase domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2HTH9_PHANO
TubercuList»
0.0
JI435_007470 Serine hydrolase domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2I6H0_PHANO
TubercuList»
0.0
JI435_110630 Serine hydrolase domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A9K3IJX3_HELAN
euHCVdb»
0.0
HanXRQr2_Chr07g0290851 Serine hydrolase FSH, alpha/Beta hydrolase Helianthus annuus
TI:4232 None
 
B7Q352_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020303 Serine hydrolase domain-containing protein Ixodes scapularis
TI:6945 None