Collated Gene Ontology terms

Biological process: transcription coregulator activity(2007, 2025) zinc ion binding(2025) metal ion binding(2025) RNA binding(2025)

Molecular function: regulation of DNA-templated transcription2025 DNA-templated transcription2025 stem cell population maintenance2012 positive regulation of transcription initiation by RNA polymerase II2024, 2025 positive regulation of transcription elongation by RNA polymerase II2024, 2025 RNA polymerase II preinitiation complex assembly2024, 2025 regulation of transcription by RNA polymerase II2020 positive regulation of DNA-templated transcription2024 follicle cell of egg chamber development2015

Cellular component: core mediator complex2024, 2025 nucleus2018, 2024, 2025 nucleoplasm2010, 2013, 2024, 2025 cytoplasm2025 mediator complex2009, 2021 membrane2014

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
MED15_ANOGA
EnsemblMetazoa»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Anopheles gambiae
TI:7165 None
 
A0AAA9SHM7_BOVIN
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Bos taurus
TI:9913 None
   
A0A9J7LZK8_BRAFL
euHCVdb»
0.0
LOC118426117 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Branchiostoma floridae
TI:7739 None
   
A0A8I3PQB3_CANLF
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Canis lupus
TI:9612 None
   
A0A2K3CRB3_CHLRE
euHCVdb»
0.0
CHLRE_17g734805v5 F-box domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3CY50_CHLRE
euHCVdb»
0.0
CHLRE_14g623403v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3D0T3_CHLRE
euHCVdb»
0.0
CHLRE_13g585600v5 Potassium channel tetramerisation-type
BTB domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3D455_CHLRE
euHCVdb»
0.0
CHLRE_12g521800v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3D5S9_CHLRE
neXtProt»
0.0
CHLRE_12g556550v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3D8P9_CHLRE
euHCVdb»
0.0
CHLRE_11g480551v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3DFD2_CHLRE
euHCVdb»
0.0
CHLRE_09g407120v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3DZ79_CHLRE
euHCVdb»
0.0
CHLRE_03g203100v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3E2L2_CHLRE
euHCVdb»
0.0
CHLRE_02g105250v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3E3D5_CHLRE
euHCVdb»
0.0
CHLRE_02g117100v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2K3E8C1_CHLRE
euHCVdb»
0.0
CHLRE_01g055350v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
   
F6SWM7_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
   
MED15_DANRE
ZFIN»
0.0
med15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Danio rerio
TI:7955 None
 
E9H9W0_DAPPU
neXtProt»
0.0
DAPPUDRAFT_60117 Uncharacterized protein Daphnia pulex
TI:6669 None 		 
 
E9I517_DAPPU
neXtProt»
0.0
DAPPUDRAFT_341016 ARC105/Med15 mediator subunit
central domain-containing protein		 Daphnia pulex
TI:6669 None 		 
 
Q557F5_DICDI
dictyBase»
0.0
DDB_G0273391 DDB_G0273593 DDE Tnp4 domain-containing protein Dictyostelium discoideum
TI:44689 None
   
MED15_DROME
FlyBase»
2.4
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15) (dARC105)		 Drosophila melanogaster
TI:7227 None
 
F6Z710_HORSE
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Equus caballus
TI:9796 None
   
A0ABI8A623_FELCA
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Felis catus
TI:9685 None
   
A0A8V1AD23_CHICK
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Gallus gallus
TI:9031 None
   
G3S027_GORGO
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Gorilla gorilla
TI:9593 None
 
T1EZM1_HELRO
EnsemblMetazoa»
0.0
20202021 Uncharacterized protein Helobdella robusta
TI:6412 None
   
T1F2J8_HELRO
EnsemblMetazoa»
0.0
20203048 Sema domain-containing protein Helobdella robusta
TI:6412 None
 
T1FIY4_HELRO
EnsemblMetazoa»
0.0
20208783 PID domain-containing protein Helobdella robusta
TI:6412 None
 
T1FNI9_HELRO
EnsemblMetazoa»
0.0
20210386 Uncharacterized protein Helobdella robusta
TI:6412 None
 
MED15_HUMAN
Ensembl»
1.8
MED15 Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex
subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)		 Homo sapiens
TI:9606 None
 
B7Q503_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW010764 Positive cofactor 2, subunit of a
RNA polymerase II multiprotein coactivator, putative		 Ixodes scapularis
TI:6945 None 		 
 
W5MHF7_LEPOC
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Lepisosteus oculatus
TI:7918 None
 
F6QGI0_MACMU
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Macaca mulatta
TI:9544 None
   
A0A5F8HK71_MONDO
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Monodelphis domestica
TI:13616 None
   
MED15_MOUSE
Ensembl»
2.6
Med15 Mediator of RNA polymerase II transcription subunit 15 (Mediator complex
subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (mPcqap)		 Mus musculus
TI:10090 None
 
A7S2Y6_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g102638 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A0A6I8PL92_ORNAN
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Ornithorhynchus anatinus
TI:9258 None
   
F6PL34_ORNAN
Ensembl»
0.0
Uncharacterized protein Ornithorhynchus anatinus
TI:9258 None 		     
K7E9T9_ORNAN
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HED2_ORYLA
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Oryzias latipes
TI:8090 None
   
A0A3B3IH37_ORYLA
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Oryzias latipes
TI:8090 None
   
H2QZT1_PANTR
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Pan troglodytes
TI:9598 None
 
A0BBQ9_PARTE
euHCVdb»
0.0
GSPATT00000411001 PHD-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CJM8_PARTE
euHCVdb»
0.0
GSPATT00000707001 PHD-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0E6D9_PARTE
euHCVdb»
0.0
GSPATT00003721001 PHD-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
Q6BG97_PARTE
euHCVdb»
0.0
PTMB.125 PHD-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
Q8I515_PLAF7
TubercuList»
0.0
PF3D7_1241400 RNA-binding protein, putative Plasmodium falciparum
TI:5833 None
 
Q8I5J4_PLAF7
TubercuList»
0.0
PF3D7_1221900 Uncharacterized protein Plasmodium falciparum
TI:5833 None
   
Q8IIV9_PLAF7
TubercuList»
0.0
PF3D7_1104300 Uncharacterized protein Plasmodium falciparum
TI:5833 None
 
Q8IJD3_PLAF7
TubercuList»
0.0
PF3D7_1027000 Uncharacterized protein Plasmodium falciparum
TI:5833 None
   
A0ABK0LFT4_RAT
RGD»
0.5
Med15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Rattus norvegicus
TI:10116 None
   
A0A7M7N7H2_STRPU
EnsemblMetazoa»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7P6P6_STRPU
EnsemblMetazoa»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7P809_STRPU
EnsemblMetazoa»
0.0
Mediator complex subunit 15 Strongylocentrotus purpuratus
TI:7668 None
   
A0A287AKD0_PIG
Ensembl»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Sus scrofa
TI:9823 None
   
D6WKC9_TRICA
euHCVdb»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Tribolium castaneum
TI:7070 None
 
B3S4L1_TRIAD
CTD»
0.0
MED15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Trichoplax adhaerens
TI:10228 None
 
A0A1L8I0E1_XENLA
Xenbase»
0.0
med15.L Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Xenopus laevis
TI:8355 None
   
A0A8J0QZN9_XENTR
Xenbase»
0.0
med15 Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Xenopus tropicalis
TI:8364 None
   
A0A8J0U1Y6_XENLA
Xenbase»
0.0
med15.S Mediator of RNA polymerase II transcription
subunit 15 (Mediator complex subunit 15)		 Xenopus laevis
TI:8355 None
   
MED15_XENLA
Xenbase»
0.0
med15 Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited
cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15)		 Xenopus laevis
TI:8355 None