Collated Gene Ontology terms

Biological process: sepiapterin reductase activity(2003, 2005, 2009, 2010, 2017, 2024) oxidoreductase activity(2024) protein homodimerization activity(2009) benzil reductase [(S)-benzoin-forming] activity(2024) aldo-keto reductase (NADP) activity(2006) NADP binding(2006)

Molecular function: tetrahydrobiopterin biosynthetic process2005, 2006, 2007, 2017, 2024 nitric oxide biosynthetic process2006, 2024 voluntary musculoskeletal movement2008 tetrahydrobiopterin metabolic process2008 serotonin metabolic process2008 response to oxidative stress2015, 2024 regulation of multicellular organism growth2008 pteridine-containing compound biosynthetic process2006, 2024 pteridine metabolic process2008 norepinephrine metabolic process2008
dopamine metabolic process2008 cell morphogenesis involved in neuron differentiation2008 L-phenylalanine metabolic process2008 response to Gram-negative bacterium2020 positive regulation of cell population proliferation2007

Cellular component: cytoplasm2024 cytosol2013, 2023, 2024 nucleoplasm2023, 2024 mitochondrion2009, 2024 extracellular exosome2014

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 2/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1L8HSS2_XENLA
Xenbase»
0.0
spr.L Sepiapterin reductase isoform X1 Xenopus laevis
TI:8355 None
   
A0A2I2UR05_FELCA
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Felis catus
TI:9685 None
 
A0A2K3DB28_CHLRE
EnsemblPlants»
0.0
CHLRE_10g449600v5 Sepiapterin reductase Chlamydomonas reinhardtii
TI:3055 None
 
A0A3B3IAZ2_ORYLA
Ensembl»
0.0
spr Sepiapterin reductase (EC 1.1.1.153) Oryzias latipes
TI:8090 None
   
A0A3Q1N453_BOVIN
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Bos taurus
TI:9913 None
   
A0A480ZCU6_PIG
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Sus scrofa
TI:9823 None
 
A0A5F8GMM8_MONDO
Ensembl»
0.0
LOC100010091 Sepiapterin reductase (EC 1.1.1.153) Monodelphis domestica
TI:13616 None
   
A0A6I8NTR7_ORNAN
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RA92_STRPU
EnsemblMetazoa»
0.0
Sepiapterin reductase (EC 1.1.1.153) Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RDY8_STRPU
EnsemblMetazoa»
0.0
Sepiapterin reductase (EC 1.1.1.153) Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RHJ4_STRPU
EnsemblMetazoa»
0.0
Sepiapterin reductase (EC 1.1.1.153) Strongylocentrotus purpuratus
TI:7668 None
   
A0A803K5T0_XENTR
Ensembl»
0.0
spr Sepiapterin reductase (EC 1.1.1.153) Xenopus tropicalis
TI:8364 None
   
A0A8I3S3P1_CANLF
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Canis lupus
TI:9612 None
   
A0A8V0ZD26_CHICK
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Gallus gallus
TI:9031 None
   
A0A9J7L2T4_BRAFL
CTD»
0.0
LOC118414398 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
   
A0A9J7MLL4_BRAFL
CTD»
0.0
LOC118412662 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
   
A0A9J7N6X0_BRAFL
CTD»
0.0
LOC118427753 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
   
A7RQ68_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g161481 Sepiapterin reductase (EC 1.1.1.153) Nematostella vectensis
TI:45351 None
 
A9UQI4_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_22416 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
B3DJY2_DANRE
ZFIN»
1.0
LOC795445 Sepiapterin reductase (EC 1.1.1.153) Danio rerio
TI:7955 None
 
B3S2B2_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_58441 Sepiapterin reductase Trichoplax adhaerens
TI:10228 None
 
B7PCL0_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW002953 Sepiapterin reductase (EC 1.1.1.153) Ixodes scapularis
TI:6945 None
 
B7Q704_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011426 Short-chain dehydrogenase,
putative (EC 1.1.1.153)		 Ixodes scapularis
TI:6945 None
 
B7QGH5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW012651 Dehydrogenase, putative (EC 1.1.1.153) Ixodes scapularis
TI:6945 None
 
B7QMY1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW015341 Short-chain dehydrogenase,
putative (EC 1.1.1.153)		 Ixodes scapularis
TI:6945 None
 
B8BVR3_THAPS
EnsemblProtists»
0.0
SPR1 Sepiapterin reductase (EC 1.1.1.153) Thalassiosira pseudonana
TI:35128 None
 
B8C1A6_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_40218 Short-chain dehydrogenase Thalassiosira pseudonana
TI:35128 None
 
BZRD_BACSU
EnsemblBacteria»
0.0
yueD Benzil reductase ((S)-benzoin
forming) (EC 1.1.1.320)		 Bacillus subtilis
TI:1423 None
 
C3XPE4_BRAFL
CTD»
0.0
LOC118430567 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
 
C3XQX1_BRAFL
CTD»
0.0
LOC118423522 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
 
C3Z9Z6_BRAFL
CTD»
0.0
LOC118409801 Sepiapterin reductase (EC 1.1.1.153) Branchiostoma floridae
TI:7739 None
 
D3ZT59_RAT
RGD»
1.0
Spr-ps1 Sepiapterin reductase (EC 1.1.1.153) Rattus norvegicus
TI:10116 None
   
D6WWG1_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_06384 Sepiapterin reductase (EC 1.1.1.153) Tribolium castaneum
TI:7070 None
 
E9HAJ7_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_309138 Sepiapterin reductase (EC 1.1.1.153) Daphnia pulex
TI:6669 None
 
F0ZZ19_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_157402 Sepiapterin reductase (EC 1.1.1.153) Dictyostelium purpureum
TI:5786 None
 
F1QWX4_DANRE
ZFIN»
1.0
fj86h06 Sepiapterin reductase (EC 1.1.1.153) Danio rerio
TI:7955 None
 
F4NSN2_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_84986 Sepiapterin reductase Batrachochytrium dendrobatidis
TI:109871 None
 
F6QRU4_CIOIN
Ensembl»
0.0
Sepiapterin reductase Ciona intestinalis
TI:7719 None
 
F6WU12_CIOIN
Ensembl»
0.0
Sepiapterin reductase (EC 1.1.1.153) Ciona intestinalis
TI:7719 None
 
F6YUE9_MACMU
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Macaca mulatta
TI:9544 None
   
F7BPB8_HORSE
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Equus caballus
TI:9796 None
   
F7FSW2_MONDO
Ensembl»
0.0
LOC100010137 Sepiapterin reductase (EC 1.1.1.153) Monodelphis domestica
TI:13616 None
   
G3QSC9_GORGO
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Gorilla gorilla
TI:9593 None
 
H3H918_PHYRM
EnsemblProtists»
0.0
Sepiapterin reductase (EC 1.1.1.153) Phytophthora ramorum
TI:164328 None
 
H3H9V2_PHYRM
EnsemblProtists»
0.0
Sepiapterin reductase Phytophthora ramorum
TI:164328 None
 
H9G4I3_ANOCA
Ensembl»
0.0
Sepiapterin reductase (EC 1.1.1.153) Anolis carolinensis
TI:28377 None
   
K7B3E1_PANTR
Ensembl»
0.0
SPR Sepiapterin reductase (EC 1.1.1.153) Pan troglodytes
TI:9598 None
 
O76752_DROME
FlyBase»
1.8
Sptr Sepiapterin reductase (EC 1.1.1.153) Drosophila melanogaster
TI:7227 None
 
Q7PJ32_ANOGA
EnsemblMetazoa»
0.0
1277951 Sepiapterin reductase (EC 1.1.1.153) Anopheles gambiae
TI:7165 None
 
Q81AL5_BACCR
EnsemblBacteria»
0.0
BC_3548 Benzil reductase (EC 1.-.-.-) Bacillus cereus
TI:1396 None
 
Q9W3F1_DROME
FlyBase»
1.0
144701_at RE21057p Drosophila melanogaster
TI:7227 None
 
SPRE_BOVIN
CTD»
0.0
SPR Sepiapterin reductase (SPR) (EC 1.1.1.153) Bos taurus
TI:9913 None
 
SPRE_DICDI
dictyBase»
5.2
sprA Sepiapterin reductase (SPR) (SR) (EC 1.1.1.153) Dictyostelium discoideum
TI:44689 None
 
SPRE_HUMAN
Ensembl»
5.9
SPR Sepiapterin reductase (SPR) (EC 1.1.1.153) Homo sapiens
TI:9606 None
 
SPRE_MOUSE
AG»
8.5
Spr Sepiapterin reductase (SPR) (EC 1.1.1.153) Mus musculus
TI:10090 None
 
SPRE_RAT
RGD»
10.7
Spr Sepiapterin reductase (SPR) (EC 1.1.1.153) Rattus norvegicus
TI:10116 None
 
SPRE_XENLA
AG»
0.0
spr Sepiapterin reductase (SPR) (EC 1.1.1.153) Xenopus laevis
TI:8355 None
 
SPRE_XENTR
CTD»
0.0
spr Sepiapterin reductase (SPR) (EC 1.1.1.153) Xenopus tropicalis
TI:8364 None
 
T1G7K9_HELRO
EnsemblMetazoa»
0.0
20217056 Sepiapterin reductase (EC 1.1.1.153) Helobdella robusta
TI:6412 None
 
W5LZ44_LEPOC
Ensembl»
0.0
Sepiapterin reductase (EC 1.1.1.153) Lepisosteus oculatus
TI:7918 None