Collated Gene Ontology terms

Biological process: riboflavin reductase (NADPH) activity(2010, 2018, 2022, 2023, 2025) biliverdin reductase [NAD(P)H] activity(2003, 2010, 2018, 2022, 2023, 2025) peptidyl-cysteine S-nitrosylase activity(2023, 2025) catalytic activity(2025) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(2022, 2025) oxidoreductase activity(2025) transferase activity(2025) FMN reductase (NADPH) activity(2025) FMN reductase (NADH) activity(2025)

Molecular function: negative regulation of insulin receptor signaling pathway2023, 2025 megakaryocyte differentiation2023, 2025 heme catabolic process2010, 2023, 2025 reactive oxygen species biosynthetic process2025 membrane lipid catabolic process2025 homeostasis of number of cells2025 hemopoiesis2025 erythrocyte differentiation2025 cellular response to stress2025 cell fate specification2025
bone marrow development2025 animal organ morphogenesis2025 sterigmatocystin biosynthetic process2024 mating2025 insulin receptor signaling pathway2025

Cellular component: cytosol2010, 2013, 2025 cytoplasm2023, 2025 terminal bouton2016, 2022, 2025 membrane2025 plasma membrane2025 nucleoplasm2025 extracellular exosome2013

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 7/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 10/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
BLVRB_MOUSE
Ensembl»
16.6
Blvrb Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (Biliverdin-IX beta-reductase)
(EC 1.3.1.-) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-)		 Mus musculus
TI:10090 None
 
A0A8I5ZUN1_RAT
RGD»
7.5
Blvrb Flavin reductase (NADPH) (EC 1.5.1.30) (Biliverdin reductase B)
(Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (S-nitroso-CoA-assisted nitrosyltransferase)		 Rattus norvegicus
TI:10116 None
   
BLVRB_HUMAN
Ensembl»
7.5
BLVRB Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase)
(Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-)		 Homo sapiens
TI:9606 None
 
BLVRB_BOVIN
Ensembl»
0.0
BLVRB Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (Biliverdin-IX beta-reductase) (EC 1.3.1.-)
(Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-)		 Bos taurus
TI:9913 None
 
G3R9B2_GORGO
Ensembl»
0.0
BLVRB Flavin reductase (NADPH) (EC 1.5.1.30) (Biliverdin reductase B)
(Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (S-nitroso-CoA-assisted nitrosyltransferase)		 Gorilla gorilla
TI:9593 None
 
G7NLH4_MACMU
Ensembl»
0.0
BLVRB Flavin reductase (NADPH) (EC 1.5.1.30) (Biliverdin reductase B)
(Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (S-nitroso-CoA-assisted nitrosyltransferase)		 Macaca mulatta
TI:9544 None
 
H2QGC7_PANTR
Ensembl»
0.0
BLVRB Flavin reductase (NADPH) (EC 1.5.1.30) (Biliverdin reductase B)
(Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (S-nitroso-CoA-assisted nitrosyltransferase)		 Pan troglodytes
TI:9598 None
 
I3LQH7_PIG
Ensembl»
0.0
BLVRB Flavin reductase (NADPH) (EC 1.5.1.30) (Biliverdin reductase B)
(Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (S-nitroso-CoA-assisted nitrosyltransferase)		 Sus scrofa
TI:9823 None
 
A0A803SU05_ANOCA
Ensembl»
0.0
BLVRB Biliverdin reductase B Anolis carolinensis
TI:28377 None
   
A0A8I3MIS0_CANLF
Ensembl»
0.0
BLVRB Biliverdin reductase B Canis lupus
TI:9612 None
   
F7D2D9_HORSE
Ensembl»
0.0
BLVRB Biliverdin reductase B Equus caballus
TI:9796 None
   
F7EVI4_MONDO
Ensembl»
0.0
BLVRB Biliverdin reductase B Monodelphis domestica
TI:13616 None
   
Q9VH72_DROME
FlyBase»
2.8
BVR TA01656p1 (Uncharacterized protein, isoform A) (Uncharacterized
protein, isoform B (EC 1.3.1.24, EC 1.5.1.30))		 Drosophila melanogaster
TI:7227 None
 
Q6GQF4_XENLA
Xenbase»
0.0
blvrb.L Biliverdin reductase B
L homeolog (MGC80107 protein)		 Xenopus laevis
TI:8355 None
 
B7PJY6_IXOSC
EnsemblMetazoa»
0.0
8030073 Flavonol reductase/cinnamoyl-CoA reductase,
putative (EC 1.5.1.30)		 Ixodes scapularis
TI:6945 None
 
STCO_EMENI
EnsemblFungi»
0.0
stcO Averufin oxidase stcO (EC 1.-.-.-)
(Sterigmatocystin biosynthesis cluster protein O)		 Emericella nidulans
TI:162425 None
 
A0A6I8PLQ3_ORNAN
Ensembl»
0.0
BLVRB NAD(P)-binding domain-containing protein Ornithorhynchus anatinus
TI:9258 None
   
A0A8I6A3K7_RAT
RGD»
1.0
ENSRNOG00000064875 NAD(P)-binding domain-containing protein Rattus norvegicus
TI:10116 None
   
A0A8J1IPN3_XENTR
Xenbase»
0.0
LOC116406791 LOW QUALITY PROTEIN: flavin reductase (NADPH) Xenopus tropicalis
TI:8364 None
   
D6WR30_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_09981 Flavin reductase (NADPH)-like Protein Tribolium castaneum
TI:7070 None
 
E9G6Z2_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_230602 NAD(P)-binding domain-containing protein Daphnia pulex
TI:6669 None
 
F6WNP9_CIOIN
Ensembl»
0.0
NAD(P)-binding domain-containing protein Ciona intestinalis
TI:7719 None
 
Q7PXB6_ANOGA
EnsemblMetazoa»
0.0
1281857 AGAP001321-PA Anopheles gambiae
TI:7165 None
 
W5NBC4_LEPOC
Ensembl»
0.0
Biliverdin reductase B Lepisosteus oculatus
TI:7918 None
 
A0A8M1N0W6_DANRE
ZFIN»
0.0
blvrb Flavin reductase (NADPH) (EC 1.3.1.24) Danio rerio
TI:7955 None
   
A2EA58_TRIV3
TubercuList»
0.0
TVAG_484150 NAD(P)-binding domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2EJQ2_TRIV3
TubercuList»
0.0
TVAG_342900 Isoflavone reductase, putative Trichomonas vaginalis
TI:5722 None
 
A7E952_SCLS1
TubercuList»
0.0
SS1G_01832 NAD(P)-binding domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7ETA8_SCLS1
TubercuList»
0.0
SS1G_08563 NAD(P)-binding domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
Q5K9Z2_CRYD1
TubercuList»
0.0
CNK00190 NAD(P)-binding domain-containing protein Cryptococcus deneoformans
TI:40410 None
 
Q7SA22_NEUCR
TubercuList»
0.0
NCU07341 NAD(P)-binding domain-containing protein Neurospora crassa
TI:5141 None
 
A0A6I8SEW4_XENTR
Xenbase»
0.0
blvrb Biliverdin reductase B (Flavin
reductase (NADPH) isoform X1)		 Xenopus tropicalis
TI:8364 None
   
A0ABI8AMX9_FELCA
Ensembl»
0.0
BLVRB NAD(P)-binding domain-containing protein Felis catus
TI:9685 None
   
A5HYH9_CLOBH
euHCVdb»
0.0
CBO0286 NAD(P)-binding domain-containing protein Clostridium botulinum
TI:1491 None
 
C8VDD4_EMENI
TubercuList»
0.0
ANIA_10896 NAD(P)-binding domain-containing protein Emericella nidulans
TI:162425 None
 
F4PF00_BATDJ
euHCVdb»
0.0
BATDEDRAFT_92947 NAD(P)-binding domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
Q4WT01_ASPFU
TubercuList»
0.0
AFUA_1G11040 NAD(P)-binding domain-containing protein Aspergillus fumigatus
TI:746128 None
 
Q815S8_BACCR
neXtProt»
0.0
BC_5054 NAD-dependent dehydrogenase Bacillus cereus
TI:1396 None
 
Q81EE0_BACCR
euHCVdb»
0.0
BC_2042 NAD-dependent dehydrogenase Bacillus cereus
TI:1396 None
 
Q89I04_BRADU
EnsemblBacteria»
0.0
bll5835 Bll5835 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89Z24_BACTN
EnsemblBacteria»
0.0
BT_4553 NAD-dependent epimerase/dehydratase Bacteroides thetaiotaomicron
TI:818 None
 
Q8DNX9_STRR6
euHCVdb»
0.0
spr1468 NAD(P)-binding domain-containing protein Streptococcus pneumoniae
TI:1313 None
 
Q8EIR7_SHEON
euHCVdb»
0.0
SO_0768 NAD dependent
epimerase/dehydratase family protein		 Shewanella oneidensis
TI:70863 None
 
Q8Y8U8_LISMO
EnsemblBacteria»
0.0
lmo0794 Lmo0794 protein Listeria monocytogenes
TI:1639 None
 
Q9I5I8_PSEAE
PharmGKB»
0.0
PA0741 NAD(P)-binding domain-containing protein Pseudomonas aeruginosa
TI:287 None
 
Q9KKP8_VIBCH
EnsemblBacteria»
0.0
VC_A1054 NAD(P)-binding domain-containing protein Vibrio cholerae
TI:666 None
 
YHEG_BACSU
EnsemblBacteria»
0.0
yheG Uncharacterized protein YheG Bacillus subtilis
TI:1423 None
 
YWNB_BACSU
EnsemblBacteria»
0.0
ywnB Uncharacterized protein YwnB Bacillus subtilis
TI:1423 None
 
A0A7U2EXX9_PHANO
TubercuList»
0.0
JI435_079840 NAD(P)-binding domain-containing protein Phaeosphaeria nodorum
TI:13684 None 		 
 
A0A7U2F3J3_PHANO
TubercuList»
0.0
JI435_041440 NAD(P)-binding domain-containing protein Phaeosphaeria nodorum
TI:13684 None 		 
 
A0A7U2FAM0_PHANO
TubercuList»
0.0
JI435_144660 NAD(P)-binding domain-containing protein Phaeosphaeria nodorum
TI:13684 None 		 
 
A2G6A3_TRIV3
TubercuList»
0.0
TVAG_169470 Oxidoreductase, putative Trichomonas vaginalis
TI:5722 None