Collated Gene Ontology terms

Biological process: nucleoside diphosphate kinase activity(2025) microtubule binding(2015, 2022, 2025) 3'-5'-DNA exonuclease activity(2025) hydrolase activity(2025) transferase activity(2025) metal ion binding(2025) kinase activity(2025)

Molecular function: UTP biosynthetic process2025 GTP biosynthetic process2025 CTP biosynthetic process2025 cilium assembly2015, 2022, 2025 DNA catabolic process2025 spermatogenesis2025 flagellated sperm motility2015, 2022 cell differentiation2025 cellular response to reactive oxygen species2015 spermatid development2005
cell redox homeostasis2022

Cellular component: axoneme2020, 2022, 2025 sperm principal piece2015, 2020, 2022, 2025 cytoplasm2020, 2025 nucleus2020, 2025 cytosol2011, 2024, 2025 sperm midpiece2020, 2025 sperm flagellum2025 sperm cytoplasmic droplet2015, 2025 outer dynein arm2015, 2025 dynein axonemal particle2021, 2025
sperm fibrous sheath2015 ruffle2025 nuclear speck2025 mitochondrion2023 lamellipodium2025 cytoskeleton2025 cilium2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1S4H9Y2_ANOGA
EnsemblMetazoa»
0.0
Thioredoxin domain-containing protein 3 Anopheles gambiae
TI:7165 None 		 
 
A0A5F8G8L3_MONDO
Ensembl»
0.0
Thioredoxin domain-containing protein Monodelphis domestica
TI:13616 None 		     
A0A6I8MXE5_ORNAN
Ensembl»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7N220_STRPU
EnsemblMetazoa»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SUG1_STRPU
EnsemblMetazoa»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SVM5_ANOCA
Ensembl»
0.0
Thioredoxin domain-containing protein Anolis carolinensis
TI:28377 None 		     
A0A8V0ZXR7_CHICK
Ensembl»
0.0
Thioredoxin domain-containing protein Gallus gallus
TI:9031 None 		     
F7FMF8_ORNAN
Ensembl»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Ornithorhynchus anatinus
TI:9258 None
   
W5M771_LEPOC
Ensembl»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Lepisosteus oculatus
TI:7918 None 		 
 
W5MTQ7_LEPOC
Ensembl»
0.0
NME/NM23 family member 9 Lepisosteus oculatus
TI:7918 None
 
W5N0B4_LEPOC
Ensembl»
0.0
Nucleoside diphosphate
kinase-like domain-containing protein		 Lepisosteus oculatus
TI:7918 None
 
T1FXJ1_HELRO
EnsemblMetazoa»
0.0
20213539 Thioredoxin domain-containing protein Helobdella robusta
TI:6412 None 		 
 
A0A139WH38_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_33152 Thioredoxin domain-containing protein Tribolium castaneum
TI:7070 None
 
F4P4A3_BATDJ
euHCVdb»
0.0
BATDEDRAFT_35212 Nucleoside diphosphate kinase Batrachochytrium dendrobatidis
TI:109871 None
 
A8J594_CHLRE
euHCVdb»
0.0
CHLRE_12g528850v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A8JDC5_CHLRE
euHCVdb»
0.0
CHLRE_17g714250v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
TXND3_CIOIN
Ensembl»
0.0
CiIC3 Thioredoxin domain-containing protein 3
homolog (Dynein intermediate chain 3)		 Ciona intestinalis
TI:7719 None
 
E9G4E0_DAPPU
neXtProt»
0.0
DAPPUDRAFT_237790 Thioredoxin domain-containing protein Daphnia pulex
TI:6669 None 		 
 
M9PHK6_DROME
FlyBase»
0.0
Dmel\CG14221 Uncharacterized protein, isoform C Drosophila melanogaster
TI:7227 None 		 
 
Q9VYR5_DROME
FlyBase»
0.0
Dmel\CG18130 FI06001p Drosophila melanogaster
TI:7227 None 		 
 
A8BLA6_GIAIC
TubercuList»
0.0
GL50803_0014135 Nucleoside diphosphate kinase Giardia intestinalis
TI:5741 None
 
A8BXI4_GIAIC
TubercuList»
0.0
GL50803_0015460 Dynein-like protein Giardia intestinalis
TI:5741 None 		 
 
A0A1Y1IDC9_KLENI
neXtProt»
0.0
KFL_003070150 Thioredoxin domain-containing protein Klebsormidium nitens
TI:105231 None 		 
 
A0A9J7HQM9_BRAFL
euHCVdb»
0.0
LOC118407607 nucleoside-diphosphate kinase (EC 2.7.4.6) Branchiostoma floridae
TI:7739 None
   
A9V116_MONBE
neXtProt»
0.0
MONBRDRAFT_32671 Nucleoside diphosphate
kinase-like domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
A7S268_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g101462 Nucleoside diphosphate
kinase-like domain-containing protein		 Nematostella vectensis
TI:45351 None
 
A0A1D5PUV4_CHICK
Ensembl»
0.0
NME8 NME/NM23 family member 8 Gallus gallus
TI:9031 None
   
A0A2J8PZ64_PANTR
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Pan troglodytes
TI:9598 None
 
A0A8I3PJ76_CANLF
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Canis lupus
TI:9612 None
   
A0AAA9TK73_BOVIN
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Bos taurus
TI:9913 None
   
A0ABI7XD53_FELCA
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein Felis catus
TI:9685 None 		     
F1SAE4_PIG
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Sus scrofa
TI:9823 None
   
F6QHM5_MACMU
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Macaca mulatta
TI:9544 None
   
F7A1E6_HORSE
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Equus caballus
TI:9796 None
   
G3QWW2_GORGO
Ensembl»
0.0
NME8 Thioredoxin domain-containing protein 3 (3'-5' exonuclease
NME8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2)		 Gorilla gorilla
TI:9593 None
 
NDK8_HUMAN
Ensembl»
4.7
NME8 Protein NME8 (NM23-H8) (NME/NM23 family member 8) (Nucleoside diphosphate kinase 8) (NDK8) (Protein kinase NME8)
(EC 2.7.-.-) (Putative 3'-5'-DNA exonuclease NDK8) (EC 3.1.11.-) (Spermatid-specific thioredoxin-2) (Sptrx-2) (Thioredoxin domain-containing protein 3)		 Homo sapiens
TI:9606 None
 
A0A2I2YW59_GORGO
Ensembl»
0.0
NME9 NME/NM23 family member 9 Gorilla gorilla
TI:9593 None
 
A0A2I3SG45_PANTR
Ensembl»
0.0
NME9 NME/NM23 family member 9 Pan troglodytes
TI:9598 None
 
A0A3Q2H9C0_HORSE
Ensembl»
0.0
NME9 NME/NM23 family member 9 Equus caballus
TI:9796 None
   
A0A8I3PRC2_CANLF
Ensembl»
0.0
NME9 NME/NM23 family member 9 Canis lupus
TI:9612 None
   
A0A8W4F8Y8_PIG
Ensembl»
0.0
NME9 NME/NM23 family member 9 Sus scrofa
TI:9823 None
   
A0ABI7Y4N6_FELCA
Ensembl»
0.0
NME9 Nucleoside diphosphate
kinase-like domain-containing protein		 Felis catus
TI:9685 None
   
F6TSD9_MACMU
Ensembl»
0.0
NME9 NME/NM23 family member 9 Macaca mulatta
TI:9544 None
   
F7EXL8_ORNAN
Ensembl»
0.0
NME9 NME/NM23 family member 9 Ornithorhynchus anatinus
TI:9258 None
   
F7FRS4_MONDO
Ensembl»
0.0
NME9 NME/NM23 family member 9 Monodelphis domestica
TI:13616 None
   
Q148E9_BOVIN
Ensembl»
0.0
NME9 NME/NM23 family member 9
(Thioredoxin domain containing 6)		 Bos taurus
TI:9913 None
 
TXND6_HUMAN
Ensembl»
0.0
NME9 Thioredoxin domain-containing protein 6
(Thioredoxin-like protein 2) (Txl-2)		 Homo sapiens
TI:9606 None
 
NDK8_MOUSE
Ensembl»
6.1
Nme8 Protein NME8 (NME/NM23 family member 8) (Nucleoside diphosphate kinase 8) (NDK8) (Protein kinase NME8)
(EC 2.7.-.-) (Putative 3'-5'-DNA exonuclease NDK8) (EC 3.1.11.-) (Spermatid-specific thioredoxin-2) (Sptrx-2) (Thioredoxin domain-containing protein 3)		 Mus musculus
TI:10090 None
 
NDK8_RAT
RGD»
6.1
Nme8 Protein NME8 (NME/NM23 family member 8) (Nucleoside diphosphate kinase 8) (NDK8) (Protein kinase NME8)
(EC 2.7.-.-) (Putative 3'-5'-DNA exonuclease NDK8) (EC 3.1.11.-) (Spermatid-specific thioredoxin-2) (Sptrx-2) (Thioredoxin domain-containing protein 3)		 Rattus norvegicus
TI:10116 None
 
TXND6_MOUSE
Ensembl»
0.0
Nme9 Thioredoxin domain-containing protein 6
(Thioredoxin-like protein 2) (Txl-2)		 Mus musculus
TI:10090 None
 
B3RRV0_TRIAD
CTD»
0.0
TRIADDRAFT_22954 Thioredoxin domain-containing protein Trichoplax adhaerens
TI:10228 None 		 
 
B3RIU9_TRIAD
CTD»
0.0
TRIADDRAFT_51377 Nucleoside diphosphate
kinase-like domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
A0A8M9Q4G2_DANRE
ZFIN»
0.0
nme9 Thioredoxin domain-containing protein
6 isoform X1		 Danio rerio
TI:7955 None
   
H2MPF9_ORYLA
Ensembl»
0.0
nme9 Nucleoside diphosphate kinase B Oryzias latipes
TI:8090 None
   
TXND6_XENLA
Xenbase»
0.0
nme9 Thioredoxin domain-containing protein 6
(Thioredoxin-like protein 2) (Txl-2)		 Xenopus laevis
TI:8355 None
 
Q8IKL4_PLAF7
TubercuList»
0.0
tlp1 Thioredoxin-like protein Plasmodium falciparum
TI:5833 None