Collated Gene Ontology terms

Biological process: structural molecule activity(2025) molecular adaptor activity(2025) protein homodimerization activity(2022, 2025) cysteine desulfurase activity(2014, 2025) iron-sulfur cluster binding(2011) transferase activity(2025)

Molecular function: iron-sulfur cluster assembly2013, 2025 [2Fe-2S] cluster assembly2018, 2022, 2025 [4Fe-4S] cluster assembly2022 tRNA thio-modification2011

Cellular component: mitochondrion2009, 2011, 2013, 2018, 2022, 2023, 2024, 2025 L-cysteine desulfurase complex2014, 2024, 2025 nucleus2009, 2023, 2025 mitochondrial [2Fe-2S] assembly complex2022, 2024, 2025 nuclear body2025 mitochondrial matrix2005, 2013, 2024, 2025 cytoplasm2017 kinetoplast2025 cytosol2009

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
LYRM4_MOUSE
Ensembl»
4.4
Lyrm4 LYR motif-containing protein 4 Mus musculus
TI:10090 None
 
LYRM4_HUMAN
Ensembl»
5.3
LYRM4 LYR motif-containing protein 4 Homo sapiens
TI:9606 None
 
LYRM4_BOVIN
Ensembl»
0.0
LYRM4 LYR motif-containing protein 4 Bos taurus
TI:9913 None
 
ISD11_YEAST
SGD»
4.8
ISD11 Protein ISD11 (Iron-sulfur protein
biogenesis, desulfurase-interacting protein 11)		 Saccharomyces cerevisiae
TI:4932 None
 
A0A287AUJ0_PIG
Ensembl»
0.0
LYRM4 LYR motif containing 4 Sus scrofa
TI:9823 None
   
A0A8I3S0X2_CANLF
Ensembl»
0.0
LYRM4 LYR motif containing 4 Canis lupus
TI:9612 None
   
ISD11_SCHPO
PomBase»
2.0
isd11 Protein isd11 Schizosaccharomyces pombe
TI:4896 None
 
LYRM4_DROME
FlyBase»
2.3
bcn92 LYR motif-containing protein
4 homolog (Protein bcn92)		 Drosophila melanogaster
TI:7227 None
 
Q389E2_TRYB2
TubercuList»
0.0
Tb10.389.1785 Iron-sulfur cluster assembly protein Trypanosoma brucei
TI:5691 None
 
A0A1D8PMF5_CANAL
CGD»
0.0
CAALFM_C405820WA orf19.1267.1 Complex 1 LYR protein domain-containing protein Candida albicans
TI:5476 None
 
Q4Q452_LEIMA
TubercuList»
0.0
LMJF_33_1355 Complex 1 LYR protein domain-containing protein Leishmania major
TI:5664 None
 
Q6C9C7_YARLI
TubercuList»
0.0
YALI0_D12254g YALI0D12254p Yarrowia lipolytica
TI:4952 None
 
ISD11_PLAF7
EnsemblProtists»
0.0
Isd11 Protein Isd11 (PfIsd11) Plasmodium falciparum
TI:5833 None
 
LYRM4_XENLA
Xenbase»
0.0
lyrm4 LYR motif-containing protein 4 Xenopus laevis
TI:8355 None
 
A0A8J0T6R1_XENLA
Xenbase»
0.0
lyrm4.S LYR motif-containing protein 4 Xenopus laevis
TI:8355 None
   
LYRM4_DANRE
ZFIN»
1.0
lyrm4 LYR motif-containing protein 4 Danio rerio
TI:7955 None
 
LYRM4_DICDI
dictyBase»
1.0
lyrm4 LYR motif-containing protein 4 Dictyostelium discoideum
TI:44689 None
 
A0A139WG63_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_31181 Protein bcn92-like Protein Tribolium castaneum
TI:7070 None
 
A0A2A6BUI9_PRIPA
EnsemblMetazoa»
0.0
WBGene00097905 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6C8A9_PRIPA
EnsemblMetazoa»
0.0
WBGene00273264 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6CRV7_PRIPA
EnsemblMetazoa»
0.0
WBGene00103681 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6CRZ8_PRIPA
EnsemblMetazoa»
0.0
WBGene00276059 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2I2Z0B2_GORGO
Ensembl»
0.0
LYRM4 LYR motif containing 4 Gorilla gorilla
TI:9593 None
 
A0A2I3SE95_PANTR
Ensembl»
0.0
LYRM4 LYR motif containing 4 Pan troglodytes
TI:9598 None
 
A0A2R8F5A8_CAEEL
WormBase»
1.0
CELE_F53G2.12 F53G2.12 Complex 1 LYR protein domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A2R8Q8D7_DANRE
ZFIN»
1.0
LOC103909737 LYR motif-containing
protein 4 (Si:ch211-152c8.4)		 Danio rerio
TI:7955 None
 
A0A3B3IJ86_ORYLA
Ensembl»
0.0
LYRM4 LYR motif containing 4 Oryzias latipes
TI:8090 None
   
A0A5F8G883_MONDO
Ensembl»
0.0
LYRM4 LYR motif containing 4 Monodelphis domestica
TI:13616 None
   
A0A6I8NNX6_ORNAN
Ensembl»
0.0
LYRM4 LYR motif containing 4 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8Q5L5_XENTR
Xenbase»
0.0
lyrm4 LYR motif containing 4
(LYR motif-containing protein 4)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7GGW5_STRPU
EnsemblMetazoa»
0.0
Complex 1 LYR protein domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SZ02_ANOCA
Ensembl»
0.0
Complex 1 LYR protein domain-containing protein Anolis carolinensis
TI:28377 None
   
A0A8V0YBJ8_CHICK
Ensembl»
1.0
LYRM4 LYR motif containing 4 Gallus gallus
TI:9031 None
   
A0A9J7LBM4_BRAFL
neXtProt»
0.0
LOC118417994 LYR motif-containing protein 4-like Branchiostoma floridae
TI:7739 None
   
A0C079_PARTE
euHCVdb»
0.0
GSPATT00006049001 Complex 1 LYR protein domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0D9L7_PARTE
euHCVdb»
0.0
GSPATT00014664001 Complex 1 LYR protein domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0NDE4_ANOGA
EnsemblMetazoa»
0.0
4576796 AGAP004196-PA Anopheles gambiae
TI:7165 None
 
A7EG73_SCLS1
TubercuList»
0.0
SS1G_04314 Complex 1 LYR protein domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7S3W0_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g206387 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
B3S7F9_TRIAD
CTD»
0.0
TRIADDRAFT_30723 Complex 1 LYR protein domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B6JWW9_SCHJY
TubercuList»
0.0
isd11 Iron sulfur cluster assembly protein Isd11 Schizosaccharomyces japonicus
TI:4897 None
 
B7QAJ3_IXOSC
EnsemblMetazoa»
0.0
8038340 LYR motif-containing protein, putative Ixodes scapularis
TI:6945 None
 
C8VAQ6_EMENI
TubercuList»
0.0
ANIA_10584 Iron-sulfur cluster biosynthesis protein
Isd11, putative (AFU_orthologue AFUA_3G06492)		 Emericella nidulans
TI:162425 None
 
D3ZYM7_RAT
RGD»
1.0
Lyrm4 LYR motif containing 4 Rattus norvegicus
TI:10116 None
   
E9FZ49_DAPPU
neXtProt»
0.0
DAPPUDRAFT_306461 Complex 1 LYR protein domain-containing protein Daphnia pulex
TI:6669 None
 
F1A1V4_DICPU
TubercuList»
0.0
DICPUDRAFT_42342 Complex 1 LYR protein domain-containing protein Dictyostelium purpureum
TI:5786 None
 
H9GLP7_ANOCA
Ensembl»
0.0
Complex 1 LYR protein domain-containing protein Anolis carolinensis
TI:28377 None
   
Q4WWN5_ASPFU
TubercuList»
0.0
AFUA_3G06492 Iron-sulfur cluster biosynthesis
protein Isd11, putative		 Aspergillus fumigatus
TI:746128 None
 
Q5KJ23_CRYD1
TubercuList»
0.0
CND00920 Mitochondrion protein, putative Cryptococcus deneoformans
TI:40410 None
 
Q75AN5_EREGS
euHCVdb»
0.0
AGOS_ADL113C ADL113Cp Eremothecium gossypii
TI:33169 None
 
Q7SFM5_NEUCR
TubercuList»
0.0
NCU02007 Iron-sulfur cluster biosynthesis protein Isd11 Neurospora crassa
TI:5141 None
 
T1G2B9_HELRO
EnsemblMetazoa»
0.0
20215217 Complex 1 LYR protein domain-containing protein Helobdella robusta
TI:6412 None
 
W5N120_LEPOC
Ensembl»
0.0
LYR motif containing 4 Lepisosteus oculatus
TI:7918 None
 
A0A7U2EPM4_PHANO
TubercuList»
0.0
JI435_001850 Complex 1 LYR protein domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A803TQC3_ANOCA
Ensembl»
0.0
Complex 1 LYR protein domain-containing protein Anolis carolinensis
TI:28377 None
   
A0A9L0RWD7_HORSE
Ensembl»
0.0
Complex 1 LYR protein domain-containing protein Equus caballus
TI:9796 None
   
A0ABI7XZ97_FELCA
Ensembl»
0.0
LYRM4 Complex 1 LYR protein domain-containing protein Felis catus
TI:9685 None
   
A0ABI7Y5I3_FELCA
Ensembl»
0.0
LYRM4 Complex 1 LYR protein domain-containing protein Felis catus
TI:9685 None
   
E3L8B6_PUCGT
TubercuList»
0.0
PGTG_18570 Uncharacterized protein Puccinia graminis
TI:5297 None