Standard knownness: 2.4; Custom knownness: None; Num. species: 34; Orthology database: Panther19.0; Protein members: 56
Molecular function: negative regulation of actin filament depolymerization2013, 2021, 2024 animal organ morphogenesis2024 neuron differentiation2024 system development2024 motor neuron axon guidance2017 branching involved in blood vessel morphogenesis2006 blood vessel morphogenesis2006 axon guidance2006 G protein-coupled receptor signaling pathway2024
                   Cellular component:
                   
                     cytoskeleton2024
                   
                     cytoplasm2013, 2021, 2024
                   
                     plasma membrane2013, 2023, 2024
                   
                     lamellipodium2013, 2024
                   
                     cortical actin cytoskeleton2013, 2024
                   
                     nucleoplasm2023, 2024
                   
                     nuclear body2023, 2024
                   
                     cytosol2023, 2024
                   
                     cell periphery2024
                   
                     membrane2024
                   
                   
                      
                      
                      
                        
                          cell projection2024
                        
                      
                    
                    
| Chordates: | 21/21 |  | 
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 1/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 | 
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| UniProt ID Organism DB» | Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y34F_DROME FlyBase» | 
 | 
 | CG43867 | Uncharacterized protein CG43867 | Drosophila melanogaster TI:7227 None |  |  |  | |||||
| B7P3I2_IXOSC EnsemblMetazoa» | 
 | 
 | IscW_ISCW000929 | PlekhH1, putative (EC 2.4.1.173) (PlekhH1, putative (Fragment)) | Ixodes scapularis TI:6945 None |  |  |  | |||||
| G3RA52_GORGO Ensembl» | 
 | 
 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Gorilla gorilla TI:9593 None |  |  |  | ||||||
| PKHH2_MOUSE Ensembl» | 
 | 
 | Plekhh2 | Pleckstrin homology domain-containing family H member 2 | Mus musculus TI:10090 None |  |  |  | |||||
| PKHH1_MOUSE Ensembl» | 
 | 
 | Plekhh1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | Mus musculus TI:10090 None |  |  |  | |||||
| PKHH1_HUMAN Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | Homo sapiens TI:9606 None |  |  |  | |||||
| PKHH2_HUMAN Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology domain-containing family H member 2 | Homo sapiens TI:9606 None |  |  |  | |||||
| I3LFD9_PIG Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology domain-containing family H member 2 (Pleckstrin homology, MyTH4 and FERM domain containing H2) | Sus scrofa TI:9823 None |  |  |  | |||||
| G5ED24_CAEEL WormBase» | 
 | 
 | max-1 | MAX-1A (PH domain-containing protein) | Caenorhabditis elegans TI:6239 None |  |  |  | |||||
| T1ENW0_HELRO EnsemblMetazoa» | 
 | 
 | 20198260 | FERM domain-containing protein | Helobdella robusta TI:6412 None |  |  |  | |||||
| A0A139WJC1_TRICA EnsemblMetazoa» | 
 | 
 | AUGUSTUS-3.0.2_08185 | Uncharacterized protein CG43867-like Protein | Tribolium castaneum TI:7070 None |  |  |  | |||||
| A0A1S4GDI2_ANOGA EnsemblMetazoa» | 
 | 
 | Plekhh1 | Anopheles gambiae TI:7165 None |  |  |  | ||||||
| A0A2A6CS72_PRIPA EnsemblMetazoa» | 
 | 
 | WBGene00203219 | Max-1 | Pristionchus pacificus TI:54126 None |  |  |  | |||||
| A0A2I2YBJ3_GORGO Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Gorilla gorilla TI:9593 None |  |  |  | |||||
| A7RZW1_NEMVE EnsemblMetazoa» | 
 | 
 | NEMVEDRAFT_v1g99085 | Uncharacterized protein | Nematostella vectensis TI:45351 None |  |  |  | |||||
| A7T3D1_NEMVE EnsemblMetazoa» | 
 | 
 | NEMVEDRAFT_v1g221761 | MyTH4 domain-containing protein | Nematostella vectensis TI:45351 None |  |  |  | |||||
| A7T3D2_NEMVE EnsemblMetazoa» | 
 | 
 | NEMVEDRAFT_v1g221763 | Uncharacterized protein | Nematostella vectensis TI:45351 None |  |  | ||||||
| A8X936_CAEBR WormBase» | 
 | 
 | max-1.2 | Protein CBR-MAX-1 | Caenorhabditis briggsae TI:6238 None |  |  |  | |||||
| A8X938_CAEBR WormBase» | 
 | 
 | max-1.1 | Protein CBG09439 | Caenorhabditis briggsae TI:6238 None |  |  |  | |||||
| A9VBE1_MONBE EnsemblProtists» | 
 | 
 | MONBRDRAFT_34394 | PH domain-containing protein | Monosiga brevicollis TI:81824 None |  |  |  | |||||
| B3SDC8_TRIAD EnsemblMetazoa» | 
 | 
 | TRIADDRAFT_33842 | MyTH4 domain-containing protein | Trichoplax adhaerens TI:10228 None |  |  |  | |||||
| E9G354_DAPPU EnsemblMetazoa» | 
 | 
 | DAPPUDRAFT_308469 | PH domain-containing protein | Daphnia pulex TI:6669 None |  |  |  | |||||
| H2QHT8_PANTR Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Pan troglodytes TI:9598 None |  |  |  | |||||
| H2R9A1_PANTR Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Pan troglodytes TI:9598 None |  |  |  | |||||
| H2Y1W2_CIOIN Ensembl» | 
 | 
 | Uncharacterized protein | Ciona intestinalis TI:7719 None |  |  |  | ||||||
| M3WIW4_FELCA Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Felis catus TI:9685 None |  |  |  | |||||
| M3WK16_FELCA Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Felis catus TI:9685 None |  |  |  | |||||
| PKHH1_DANRE ZFIN» | 
 | 
 | plekhh1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) (Protein max-1 homolog) | Danio rerio TI:7955 None |  |  |  | |||||
| W5N9C0_LEPOC Ensembl» | 
 | 
 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Lepisosteus oculatus TI:7918 None |  |  |  | ||||||
| W5NI31_LEPOC Ensembl» | 
 | 
 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Lepisosteus oculatus TI:7918 None |  |  |  | ||||||
| A0A1L8G199_XENLA Xenbase» | 
 | 
 | plekhh2.S | Pleckstrin homology domain-containing family H member 2 isoform X1 | Xenopus laevis TI:8355 None |  |  | ||||||
| A0A7M7T5N6_STRPU EnsemblMetazoa» | 
 | 
 | Pleckstrin homology domain-containing family H member 2 | Strongylocentrotus purpuratus TI:7668 None |  |  | |||||||
| A0A8I3MK66_CANLF Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Canis lupus TI:9612 None |  |  | ||||||
| A0A8I3PKY1_CANLF Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Canis lupus TI:9612 None |  |  | ||||||
| A0A8J1KM77_XENLA Xenbase» | 
 | 
 | LOC121393598 | Pleckstrin homology domain-containing family H member 2-like | Xenopus laevis TI:8355 None |  |  | ||||||
| A0A8J1KM90_XENLA Xenbase» | 
 | 
 | plekhh2.L | Pleckstrin homology domain-containing family H member 2 | Xenopus laevis TI:8355 None |  |  | ||||||
| A0A8M9QFR0_DANRE CTD» | 
 | 
 | plekhh2 | Pleckstrin homology domain-containing family H member 2 | Danio rerio TI:7955 None |  |  | ||||||
| A0A8V0ZCE8_CHICK Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Gallus gallus TI:9031 None |  |  | ||||||
| A0A8V0ZK98_CHICK Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Gallus gallus TI:9031 None |  |  | ||||||
| A0A9J7LCN9_BRAFL CTD» | 
 | 
 | LOC118418046 | Pleckstrin homology domain-containing family H member 1-like isoform X1 | Branchiostoma floridae TI:7739 None |  |  | ||||||
| D3ZNS6_RAT RGD» | 
 | 
 | Plekhh2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Rattus norvegicus TI:10116 None |  |  | ||||||
| D4AA54_RAT RGD» | 
 | 
 | Plekhh1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Rattus norvegicus TI:10116 None |  |  | ||||||
| E1BF01_BOVIN Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Bos taurus TI:9913 None |  |  | ||||||
| F1MH50_BOVIN Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Bos taurus TI:9913 None |  |  | ||||||
| F1SA37_PIG Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Sus scrofa TI:9823 None |  |  | ||||||
| F6SWM6_HORSE Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Equus caballus TI:9796 None |  |  | ||||||
| F6URG8_MACMU Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Macaca mulatta TI:9544 None |  |  | ||||||
| F6VU91_HORSE Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Equus caballus TI:9796 None |  |  | ||||||
| F6Y5I6_MONDO Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Monodelphis domestica TI:13616 None |  |  | ||||||
| F6ZRY3_MACMU Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Macaca mulatta TI:9544 None |  |  | ||||||
| F7CHP0_XENTR Xenbase» | 
 | 
 | plekhh2 | Pleckstrin homology domain-containing family H member 2 (Pleckstrin homology, MyTH4 and FERM domain-containing H2) | Xenopus tropicalis TI:8364 None |  |  | ||||||
| F7FLH1_MONDO Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Monodelphis domestica TI:13616 None |  |  | ||||||
| H2L7N6_ORYLA Ensembl» | 
 | 
 | plekhh2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Oryzias latipes TI:8090 None |  |  | ||||||
| H2LXB5_ORYLA Ensembl» | 
 | 
 | plekhh1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Oryzias latipes TI:8090 None |  |  | ||||||
| H9GAG7_ANOCA Ensembl» | 
 | 
 | PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | Anolis carolinensis TI:28377 None |  |  | ||||||
| H9GLZ3_ANOCA Ensembl» | 
 | 
 | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2 | Anolis carolinensis TI:28377 None |  |  | ||||||