Collated Gene Ontology terms

Biological process: actin binding(2013, 2021, 2025) nucleotide binding(2025) G protein-coupled receptor activity(2025) G protein-coupled peptide receptor activity(2025) ATP binding(2025)

Molecular function: negative regulation of actin filament depolymerization2013, 2021, 2025 animal organ morphogenesis2025 neuron differentiation2025 system development2025 motor neuron axon guidance2017, 2025 signal transduction2025 branching involved in blood vessel morphogenesis2006 blood vessel morphogenesis2006 G protein-coupled receptor signaling pathway2025

Cellular component: cytoskeleton2025 cytoplasm2010, 2013, 2021, 2025 plasma membrane2013, 2025 lamellipodium2013, 2025 cortical actin cytoskeleton2013, 2025 cell periphery2025 nucleoplasm2025 nuclear body2025 membrane2025 cytosol2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
Y34F_DROME
FlyBase»
0.0
CG43867 Uncharacterized protein CG43867 Drosophila melanogaster
TI:7227 None
 
A0A1S4KKL1_IXOSC
EnsemblMetazoa»
0.0
PlekhH1, putative Ixodes scapularis
TI:6945 None
 
G3RA52_GORGO
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Gorilla gorilla
TI:9593 None
 
PKHH2_MOUSE
Ensembl»
2.6
Plekhh2 Pleckstrin homology domain-containing
family H member 2		 Mus musculus
TI:10090 None
 
PKHH1_MOUSE
Ensembl»
0.0
Plekhh1 Pleckstrin homology domain-containing family H member
1 (PH domain-containing family H member 1)		 Mus musculus
TI:10090 None
 
PKHH1_HUMAN
Ensembl»
0.0
PLEKHH1 Pleckstrin homology domain-containing family H member
1 (PH domain-containing family H member 1)		 Homo sapiens
TI:9606 None
 
PKHH2_HUMAN
Ensembl»
2.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Homo sapiens
TI:9606 None
 
I3LFD9_PIG
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Sus scrofa
TI:9823 None
 
G5ED24_CAEEL
WormBase»
0.8
max-1 MAX-1A (PH domain-containing protein) Caenorhabditis elegans
TI:6239 None
 
T1ENW0_HELRO
EnsemblMetazoa»
0.0
20198260 FERM domain-containing protein Helobdella robusta
TI:6412 None
 
A0A139WJC1_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_08185 Uncharacterized protein CG43867-like Protein Tribolium castaneum
TI:7070 None
 
A0A1S4GDI2_ANOGA
EnsemblMetazoa»
0.0
Plekhh1 Anopheles gambiae
TI:7165 None
 
A0A2I2YBJ3_GORGO
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Gorilla gorilla
TI:9593 None
 
A7RZW1_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g99085 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A7T3D1_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g221761 MyTH4 domain-containing protein Nematostella vectensis
TI:45351 None
 
A7T3D2_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g221763 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A8X936_CAEBR
WormBase»
0.0
max-1.2 Protein CBR-MAX-1 Caenorhabditis briggsae
TI:6238 None
 
A8X938_CAEBR
WormBase»
0.0
max-1.1 Protein CBG09439 Caenorhabditis briggsae
TI:6238 None
 
A9VBE1_MONBE
euHCVdb»
0.0
MONBRDRAFT_34394 PH domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3SDC8_TRIAD
CTD»
0.0
TRIADDRAFT_33842 MyTH4 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
E9G354_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_308469 PH domain-containing protein Daphnia pulex
TI:6669 None
 
H2QHT8_PANTR
Ensembl»
0.0
PLEKHH2 Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Pan troglodytes
TI:9598 None
 
H2R9A1_PANTR
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Pan troglodytes
TI:9598 None
 
H2Y1W2_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
PKHH1_DANRE
ZFIN»
1.6
plekhh1 Pleckstrin homology domain-containing family H member 1 (PH
domain-containing family H member 1) (Protein max-1 homolog)		 Danio rerio
TI:7955 None
 
W5N9C0_LEPOC
Ensembl»
0.0
Pleckstrin homology domain containing, family
H (with MyTH4 domain) member 1		 Lepisosteus oculatus
TI:7918 None
 
W5NI31_LEPOC
Ensembl»
0.0
Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Lepisosteus oculatus
TI:7918 None
 
A0A1L8G199_XENLA
Xenbase»
0.0
plekhh2.S Pleckstrin homology domain-containing family
H member 2 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A2A6CS72_PRIPA
EnsemblMetazoa»
0.0
WBGene00203219 Max-1 Pristionchus pacificus
TI:54126 None
   
A0A5F7ZSM5_MACMU
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Macaca mulatta
TI:9544 None
   
A0A7M7T5N6_STRPU
EnsemblMetazoa»
0.0
Pleckstrin homology domain-containing
family H member 2		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3MK66_CANLF
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Canis lupus
TI:9612 None
   
A0A8I3PKY1_CANLF
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Canis lupus
TI:9612 None
   
A0A8J1KM77_XENLA
CTD»
0.0
LOC121393598 Pleckstrin homology domain-containing
family H member 2-like		 Xenopus laevis
TI:8355 None
   
A0A8J1KM90_XENLA
CTD»
0.0
plekhh2.L Pleckstrin homology domain-containing
family H member 2		 Xenopus laevis
TI:8355 None
   
A0A8M1QLE4_DANRE
ZFIN»
0.0
plekhh2 Pleckstrin homology domain-containing
family H member 2		 Danio rerio
TI:7955 None 		     
A0A8V0ZCE8_CHICK
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Gallus gallus
TI:9031 None
   
A0A8V0ZK98_CHICK
Ensembl»
1.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Gallus gallus
TI:9031 None
   
A0A9J7LCN9_BRAFL
neXtProt»
0.0
LOC118418046 Pleckstrin homology domain-containing family
H member 1-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
A0ABI7XP42_FELCA
Ensembl»
0.0
PLEKHH2 Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Felis catus
TI:9685 None
   
A0ABI7YNC7_FELCA
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Felis catus
TI:9685 None
   
D3ZNS6_RAT
RGD»
2.0
Plekhh2 Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Rattus norvegicus
TI:10116 None
   
D4AA54_RAT
RGD»
0.0
Plekhh1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Rattus norvegicus
TI:10116 None
   
E1BF01_BOVIN
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Bos taurus
TI:9913 None
   
F1MH50_BOVIN
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Bos taurus
TI:9913 None
   
F1SA37_PIG
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Sus scrofa
TI:9823 None
   
F6SWM6_HORSE
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Equus caballus
TI:9796 None
   
F6VU91_HORSE
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Equus caballus
TI:9796 None
   
F6Y5I6_MONDO
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Monodelphis domestica
TI:13616 None
   
F6ZRY3_MACMU
Ensembl»
0.0
PLEKHH2 Pleckstrin homology domain-containing
family H member 2		 Macaca mulatta
TI:9544 None
   
F7CHP0_XENTR
Xenbase»
0.0
plekhh2 Pleckstrin homology domain-containing family H member 2
(Pleckstrin homology, MyTH4 and FERM domain-containing H2)		 Xenopus tropicalis
TI:8364 None
   
F7FLH1_MONDO
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Monodelphis domestica
TI:13616 None
   
H2L7N6_ORYLA
Ensembl»
0.0
PLEKHH2 Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Oryzias latipes
TI:8090 None
   
H2LXB5_ORYLA
Ensembl»
0.0
PLEKHH1 Pleckstrin homology domain containing, family
H (with MyTH4 domain) member 1		 Oryzias latipes
TI:8090 None
   
H9GAG7_ANOCA
Ensembl»
0.0
PLEKHH1 Pleckstrin homology, MyTH4 and
FERM domain containing H1		 Anolis carolinensis
TI:28377 None
   
H9GLZ3_ANOCA
Ensembl»
0.0
PLEKHH2 Pleckstrin homology, MyTH4 and
FERM domain containing H2		 Anolis carolinensis
TI:28377 None