Standard knownness: 2.4; Custom knownness: None; Num. species: 34; Orthology database: Panther19.0; Protein members: 56
Molecular function: negative regulation of actin filament depolymerization2013, 2021, 2024 animal organ morphogenesis2024 neuron differentiation2024 system development2024 motor neuron axon guidance2017 branching involved in blood vessel morphogenesis2006 blood vessel morphogenesis2006 axon guidance2006 G protein-coupled receptor signaling pathway2024
                   Cellular component:
                   
                     cytoskeleton2024
                   
                     cytoplasm2013, 2021, 2024
                   
                     plasma membrane2013, 2023, 2024
                   
                     lamellipodium2013, 2024
                   
                     cortical actin cytoskeleton2013, 2024
                   
                     nucleoplasm2023, 2024
                   
                     nuclear body2023, 2024
                   
                     cytosol2023, 2024
                   
                     cell periphery2024
                   
                     membrane2024
                   
                   
                      
                      
                      
                        
                          cell projection2024
                        
                      
                    
                    
| Chordates: | 21/21 | ![]()  | 
                   
                 
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 1/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 | 
Click here to switch to the previous version of the database.
| UniProt ID Organism DB»  | 
	    
        
          
            Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 
        A0A139WJC1_TRICA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        AUGUSTUS-3.0.2_08185 | Uncharacterized protein CG43867-like Protein | 
        Tribolium castaneum TI:7070 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A1L8G199_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        plekhh2.S | Pleckstrin homology domain-containing family H member 2 isoform X1  | 
        
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A1S4GDI2_ANOGA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        Plekhh1 | 
        Anopheles gambiae TI:7165 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A2A6CS72_PRIPA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        WBGene00203219 | Max-1 | 
        Pristionchus pacificus TI:54126 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A2I2YBJ3_GORGO Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Gorilla gorilla TI:9593 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A7M7T5N6_STRPU EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        Pleckstrin homology domain-containing family H member 2  | 
        
        Strongylocentrotus purpuratus TI:7668 None  | 
        
          
           | 
        
          
           | 
        |||||||
| 
        A0A8I3MK66_CANLF Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Canis lupus TI:9612 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8I3PKY1_CANLF Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Canis lupus TI:9612 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8J1KM77_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        LOC121393598 | Pleckstrin homology domain-containing family H member 2-like  | 
        
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8J1KM90_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        plekhh2.L | Pleckstrin homology domain-containing family H member 2  | 
        
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8M9QFR0_DANRE CTD»  | 
        
          
  | 
        
          
  | 
        plekhh2 | Pleckstrin homology domain-containing family H member 2  | 
        
        Danio rerio TI:7955 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8V0ZCE8_CHICK Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Gallus gallus TI:9031 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8V0ZK98_CHICK Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Gallus gallus TI:9031 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A9J7LCN9_BRAFL CTD»  | 
        
          
  | 
        
          
  | 
        LOC118418046 | Pleckstrin homology domain-containing family H member 1-like isoform X1  | 
        
        Branchiostoma floridae TI:7739 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A7RZW1_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g99085 | Uncharacterized protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A7T3D1_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g221761 | MyTH4 domain-containing protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A7T3D2_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g221763 | Uncharacterized protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A8X936_CAEBR WormBase»  | 
        
          
  | 
        
          
  | 
        max-1.2 | Protein CBR-MAX-1 | 
        Caenorhabditis briggsae TI:6238 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A8X938_CAEBR WormBase»  | 
        
          
  | 
        
          
  | 
        max-1.1 | Protein CBG09439 | 
        Caenorhabditis briggsae TI:6238 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A9VBE1_MONBE EnsemblProtists»  | 
        
          
  | 
        
          
  | 
        MONBRDRAFT_34394 | PH domain-containing protein | 
        Monosiga brevicollis TI:81824 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        B3SDC8_TRIAD EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        TRIADDRAFT_33842 | MyTH4 domain-containing protein | 
        Trichoplax adhaerens TI:10228 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        B7P3I2_IXOSC EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        IscW_ISCW000929 | PlekhH1, putative (EC 2.4.1.173) (PlekhH1, putative (Fragment))  | 
        
        Ixodes scapularis TI:6945 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        D3ZNS6_RAT RGD»  | 
        
          
  | 
        
          
  | 
        Plekhh2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Rattus norvegicus TI:10116 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        D4AA54_RAT RGD»  | 
        
          
  | 
        
          
  | 
        Plekhh1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Rattus norvegicus TI:10116 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        E1BF01_BOVIN Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Bos taurus TI:9913 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        E9G354_DAPPU EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        DAPPUDRAFT_308469 | PH domain-containing protein | 
        Daphnia pulex TI:6669 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        F1MH50_BOVIN Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Bos taurus TI:9913 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F1SA37_PIG Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Sus scrofa TI:9823 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6SWM6_HORSE Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Equus caballus TI:9796 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6URG8_MACMU Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Macaca mulatta TI:9544 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6VU91_HORSE Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Equus caballus TI:9796 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6Y5I6_MONDO Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Monodelphis domestica TI:13616 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6ZRY3_MACMU Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Macaca mulatta TI:9544 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F7CHP0_XENTR Xenbase»  | 
        
          
  | 
        
          
  | 
        plekhh2 | Pleckstrin homology domain-containing family H member 2 (Pleckstrin homology, MyTH4 and FERM domain-containing H2)  | 
        
        Xenopus tropicalis TI:8364 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F7FLH1_MONDO Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Monodelphis domestica TI:13616 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        G3RA52_GORGO Ensembl»  | 
        
          
  | 
        
          
  | 
        Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Gorilla gorilla TI:9593 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        G5ED24_CAEEL WormBase»  | 
        
          
  | 
        
          
  | 
        max-1 | MAX-1A (PH domain-containing protein) | 
        Caenorhabditis elegans TI:6239 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        H2L7N6_ORYLA Ensembl»  | 
        
          
  | 
        
          
  | 
        plekhh2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Oryzias latipes TI:8090 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H2LXB5_ORYLA Ensembl»  | 
        
          
  | 
        
          
  | 
        plekhh1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Oryzias latipes TI:8090 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H2QHT8_PANTR Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Pan troglodytes TI:9598 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        H2R9A1_PANTR Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Pan troglodytes TI:9598 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        H2Y1W2_CIOIN Ensembl»  | 
        
          
  | 
        
          
  | 
        Uncharacterized protein | 
        Ciona intestinalis TI:7719 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H9GAG7_ANOCA Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Anolis carolinensis TI:28377 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H9GLZ3_ANOCA Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Anolis carolinensis TI:28377 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        I3LFD9_PIG Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology domain-containing family H member 2 (Pleckstrin homology, MyTH4 and FERM domain containing H2)  | 
        
        Sus scrofa TI:9823 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        M3WIW4_FELCA Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Felis catus TI:9685 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        M3WK16_FELCA Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Felis catus TI:9685 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        PKHH1_DANRE ZFIN»  | 
        
          
  | 
        
          
  | 
        plekhh1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) (Protein max-1 homolog)  | 
        
        Danio rerio TI:7955 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        PKHH1_HUMAN Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1)  | 
        
        Homo sapiens TI:9606 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        PKHH1_MOUSE Ensembl»  | 
        
          
  | 
        
          
  | 
        Plekhh1 | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1)  | 
        
        Mus musculus TI:10090 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        PKHH2_HUMAN Ensembl»  | 
        
          
  | 
        
          
  | 
        PLEKHH2 | Pleckstrin homology domain-containing family H member 2  | 
        
        Homo sapiens TI:9606 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        PKHH2_MOUSE Ensembl»  | 
        
          
  | 
        
          
  | 
        Plekhh2 | Pleckstrin homology domain-containing family H member 2  | 
        
        Mus musculus TI:10090 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        T1ENW0_HELRO EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        20198260 | FERM domain-containing protein | 
        Helobdella robusta TI:6412 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        W5N9C0_LEPOC Ensembl»  | 
        
          
  | 
        
          
  | 
        Pleckstrin homology, MyTH4 and FERM domain containing H1  | 
        
        Lepisosteus oculatus TI:7918 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        W5NI31_LEPOC Ensembl»  | 
        
          
  | 
        
          
  | 
        Pleckstrin homology, MyTH4 and FERM domain containing H2  | 
        
        Lepisosteus oculatus TI:7918 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        Y34F_DROME FlyBase»  | 
        
          
  | 
        
          
  | 
        CG43867 | Uncharacterized protein CG43867 | 
        Drosophila melanogaster TI:7227 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||