Collated Gene Ontology terms

Biological process: SH3 domain binding(2025) protein-macromolecule adaptor activity(2025) ubiquitin-like ligase-substrate adaptor activity(2022, 2025) protein-RNA adaptor activity(2022, 2025) glutathione transferase activity(2022)

Molecular function: cytoskeleton organization2022, 2025 proteasome-mediated ubiquitin-dependent protein catabolic process2022, 2025 positive regulation of cytoplasmic translational initiation2022, 2025 positive regulation of actin filament bundle assembly2025

Cellular component: cytosol2022, 2025 nucleus2005, 2025 ruffle membrane2022, 2025 plasma membrane2025 nucleoplasm2024, 2025 cytoplasm2005, 2025 extracellular exosome2013, 2014 nuclear membrane2025 nuclear body2025 extracellular space2013

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 7/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
SH3L2_HUMAN
Ensembl»
0.5
SH3BGRL2 SH3 domain-binding glutamic acid-rich-like protein
2 (Fovea-associated SH3 domain-binding protein)		 Homo sapiens
TI:9606 None
 
SH3BG_HUMAN
Ensembl»
0.5
SH3BGR SH3 domain-binding glutamic acid-rich protein
(SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)		 Homo sapiens
TI:9606 None
 
SH3L1_MOUSE
Ensembl»
4.0
Sh3bgrl Adapter Sh3bgrl (SH3 domain-binding
glutamic acid-rich-like protein 1)		 Mus musculus
TI:10090 None
 
G2HEW4_PANTR
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Pan troglodytes
TI:9598 None
 
SH3L1_HUMAN
Ensembl»
5.2
SH3BGRL Adapter SH3BGRL (SH3 domain-binding
glutamic acid-rich-like protein 1)		 Homo sapiens
TI:9606 None
 
G3SIZ4_GORGO
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Gorilla gorilla
TI:9593 None
 
SH3L3_HUMAN
Ensembl»
2.1
SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding
protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1)		 Homo sapiens
TI:9606 None
 
SH3L2_XENTR
Xenbase»
0.0
sh3bgrl2 SH3 domain-binding glutamic
acid-rich-like protein 2		 Xenopus tropicalis
TI:8364 None
 
G3QQN5_GORGO
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Gorilla gorilla
TI:9593 None
 
G3RR85_GORGO
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Gorilla gorilla
TI:9593 None
 
G7NS79_MACMU
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Macaca mulatta
TI:9544 None
 
H2RAI3_PANTR
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein
(SH3 domain binding glutamic acid-rich protein)		 Pan troglodytes
TI:9598 None
 
Q7T2A8_DANRE
ZFIN»
2.0
sh3bgrl SH3 domain-binding
glutamic acid-rich-like protein		 Danio rerio
TI:7955 None
 
SH3BG_DROME
FlyBase»
0.0
Sh3beta SH3 domain-binding glutamic acid-rich
protein homolog (SH3BGR protein)		 Drosophila melanogaster
TI:7227 None
 
SH3L2_MOUSE
Ensembl»
0.5
Sh3bgrl2 SH3 domain-binding glutamic
acid-rich-like protein 2		 Mus musculus
TI:10090 None
 
B7PZP2_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020127 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
H9G0H1_MACMU
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Macaca mulatta
TI:9544 None
 
Q7ZUC9_DANRE
ZFIN»
0.5
sh3bgrl3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Danio rerio
TI:7955 None
 
SH3L1_BOVIN
Ensembl»
0.0
SH3BGRL Adapter SH3BGRL (SH3 domain-binding
glutamic acid-rich-like protein 1)		 Bos taurus
TI:9913 None
 
SH3L3_MOUSE
Ensembl»
1.5
Sh3bgrl3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Mus musculus
TI:10090 None
 
SH3L3_RAT
RGD»
1.5
Sh3bgrl3 SH3 domain-binding glutamic acid-rich-like protein
3 (TNF inhibitory protein B1) (TIP-B1)		 Rattus norvegicus
TI:10116 None
 
T1ENP3_HELRO
EnsemblMetazoa»
0.0
20198193 SH3 domain-binding
glutamic acid-rich-like protein		 Helobdella robusta
TI:6412 None
 
T1FFG8_HELRO
EnsemblMetazoa»
0.0
20207567 SH3 domain-binding
glutamic acid-rich-like protein		 Helobdella robusta
TI:6412 None
 
W5NCX8_LEPOC
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Lepisosteus oculatus
TI:7918 None
 
A0A139WH43_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_33138 SH3 domain-binding glutamic
acid-rich protein homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
A0A286ZWS0_PIG
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding
glutamic acid-rich-like protein		 Sus scrofa
TI:9823 None
 
A0A2I3RQG3_PANTR
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Pan troglodytes
TI:9598 None
 
A0A2I3TIY5_PANTR
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Pan troglodytes
TI:9598 None
 
A0A803KGY7_XENTR
Xenbase»
0.0
sh3bgrl3 SH3 domain-binding
glutamic acid-rich-like protein		 Xenopus tropicalis
TI:8364 None
 
A7ER20_SCLS1
TubercuList»
0.0
SS1G_07773 Glutaredoxin domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A7URF6_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP007362 AGAP007362-PA Anopheles gambiae
TI:7165 None
 
A8X7A0_CAEBR
WormBase»
0.0
CBG08740 CBG_08740 Protein CBG08740 Caenorhabditis briggsae
TI:6238 None
 
A9V030_MONBE
euHCVdb»
0.0
MONBRDRAFT_37176 SH3 domain-binding
glutamic acid-rich-like protein		 Monosiga brevicollis
TI:81824 None 		 
 
D6WJV4_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_14808 SH3 domain-binding glutamic
acid-rich protein homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
E9GEL1_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_210791 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZTC3_DICPU
TubercuList»
0.0
DICPUDRAFT_49338 Uncharacterized protein Dictyostelium purpureum
TI:5786 None 		 
 
F4P116_BATDJ
neXtProt»
0.0
BATDEDRAFT_24491 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
G3QEA5_GORGO
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Gorilla gorilla
TI:9593 None
 
H2XK87_CIOIN
Ensembl»
0.0
Glutaredoxin domain-containing protein Ciona intestinalis
TI:7719 None
 
H2XRF2_CIOIN
Ensembl»
0.0
LOC100184789 SH3 domain-binding glutamic
acid-rich-like protein 2		 Ciona intestinalis
TI:7719 None
 
H2XWK0_CIOIN
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Ciona intestinalis
TI:7719 None
 
K8ES47_CAEEL
WormBase»
0.0
CELE_Y105E8A.1 Y105E8A.1 Glutaredoxin domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Q4X000_ASPFU
TubercuList»
0.0
AFUA_2G15180 Uncharacterized protein Aspergillus fumigatus
TI:746128 None
 
Q54XE7_DICDI
dictyBase»
0.0
DDB_G0279011 Thioredoxin domain-containing protein Dictyostelium discoideum
TI:44689 None 		 
 
Q58E92_XENLA
Xenbase»
0.0
sh3bgrl.L SH3 domain-binding
glutamic acid-rich-like protein		 Xenopus laevis
TI:8355 None
 
Q5AVU3_EMENI
TubercuList»
0.0
ANIA_07587 Glutaredoxin domain-containing protein Emericella nidulans
TI:162425 None
 
Q5KLQ3_CRYD1
TubercuList»
0.0
CNB04460 Uncharacterized protein Cryptococcus deneoformans
TI:40410 None
 
Q6GPW0_XENLA
Xenbase»
0.0
sh3bgr.L MGC82574 protein (SH3 domain
binding glutamate-rich protein L homeolog)		 Xenopus laevis
TI:8355 None
 
Q6NTS6_XENLA
Xenbase»
0.0
sh3bgrl3.S SH3 domain-binding
glutamic acid-rich-like protein		 Xenopus laevis
TI:8355 None
 
Q6PBF9_XENTR
Xenbase»
0.0
sh3bgr SH3 domain binding glutamate-rich protein
(SH3 domain-binding glutamic acid-rich protein)		 Xenopus tropicalis
TI:8364 None
 
Q7SGP1_NEUCR
TubercuList»
0.0
NCU08374 Uncharacterized protein Neurospora crassa
TI:5141 None
 
SH3BG_MOUSE
Ensembl»
0.5
Sh3bgr SH3 domain-binding glutamic
acid-rich protein (SH3BGR protein)		 Mus musculus
TI:10090 None
 
SH3L2_BOVIN
CTD»
0.0
SH3BGRL2 SH3 domain-binding glutamic
acid-rich-like protein 2		 Bos taurus
TI:9913 None
 
SH3L2_DANRE
ZFIN»
0.5
sh3bgrl2 SH3 domain-binding glutamic
acid-rich-like protein 2		 Danio rerio
TI:7955 None
 
SH3L3_BOVIN
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Bos taurus
TI:9913 None
 
SH3LA_XENLA
Xenbase»
0.0
sh3bgrl2-a SH3 domain-binding glutamic
acid-rich-like protein 2-A		 Xenopus laevis
TI:8355 None
 
SH3LB_XENLA
Xenbase»
0.0
sh3bgrl2-b SH3 domain-binding glutamic
acid-rich-like protein 2-B		 Xenopus laevis
TI:8355 None
 
W5M087_LEPOC
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Lepisosteus oculatus
TI:7918 None
 
W5M8S7_LEPOC
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Lepisosteus oculatus
TI:7918 None
 
W5NHB2_LEPOC
Ensembl»
0.0
SH3 domain-binding glutamic
acid-rich-like protein 3		 Lepisosteus oculatus
TI:7918 None
 
W5NHB4_LEPOC
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Lepisosteus oculatus
TI:7918 None
 
A0A1L8F379_XENLA
Xenbase»
0.0
sh3bgrl.S SH3 domain-binding
glutamic acid-rich-like protein		 Xenopus laevis
TI:8355 None
   
A0A287AEJ4_PIG
Ensembl»
0.0
Uncharacterized protein Sus scrofa
TI:9823 None 		     
A0A2A6BDE3_PRIPA
EnsemblMetazoa»
0.0
WBGene00278043 Glutaredoxin domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A3B3H6V3_ORYLA
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Oryzias latipes
TI:8090 None
   
A0A3B3HS99_ORYLA
Ensembl»
0.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Oryzias latipes
TI:8090 None
   
A0A3B3HVQ6_ORYLA
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Oryzias latipes
TI:8090 None
   
A0A3B3HXV6_ORYLA
Ensembl»
0.0
zgc:153284 Uncharacterized protein Oryzias latipes
TI:8090 None
   
A0A3Q2L515_HORSE
Ensembl»
0.0
SH3 domain-binding glutamic
acid-rich-like protein 1		 Equus caballus
TI:9796 None
   
A0A5F5PGG8_HORSE
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Equus caballus
TI:9796 None
   
A0A5F5Q3T2_HORSE
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Equus caballus
TI:9796 None
   
A0A5F8GBN2_MONDO
Ensembl»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Monodelphis domestica
TI:13616 None
   
A0A5F8H1T8_MONDO
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Monodelphis domestica
TI:13616 None
   
A0A6I8NIT8_ORNAN
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NQ46_ORNAN
Ensembl»
0.0
SH3 domain binding glutamate rich protein like 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PCV3_ORNAN
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding
glutamic acid-rich-like protein		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7PIL4_STRPU
EnsemblMetazoa»
0.0
SH3 domain-binding glutamic
acid-rich-like protein 3		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7TGL2_STRPU
EnsemblMetazoa»
0.0
SH3 domain-binding
glutamic acid-rich-like protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803JV87_XENTR
Xenbase»
0.0
sh3bgrl SH3 domain-binding
glutamic acid-rich-like protein		 Xenopus tropicalis
TI:8364 None
   
A0A8I3NAS3_CANLF
Ensembl»
0.0
SH3BGRL2 SH3 domain binding glutamate rich protein like 2 Canis lupus
TI:9612 None
   
A0A8I3NJI4_CANLF
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding
glutamic acid-rich-like protein		 Canis lupus
TI:9612 None
   
A0A8I3PBA6_CANLF
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Canis lupus
TI:9612 None
   
A0A8I3PGB1_CANLF
Ensembl»
0.0
LOC100684236 Uncharacterized protein Canis lupus
TI:9612 None
   
A0A8I3Q991_CANLF
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Canis lupus
TI:9612 None
   
A0A8I6GHH3_RAT
RGD»
4.0
Sh3bgrl SH3 domain-binding glutamic
acid-rich-like protein 1		 Rattus norvegicus
TI:10116 None
   
A0A8J0UBD1_XENLA
CTD»
0.0
sh3bgr.S SH3 domain-binding glutamic
acid-rich-like protein isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J0UD26_XENLA
Xenbase»
0.0
sh3bgrl3.L SH3 domain-binding glutamic
acid-rich-like protein 3		 Xenopus laevis
TI:8355 None
   
A0A8M1P0S2_DANRE
ZFIN»
0.5
zgc:153284 Uncharacterized protein LOC751696 isoform 1 Danio rerio
TI:7955 None
   
A0A8M2BH31_DANRE
ZFIN»
0.5
sh3bgr SH3 domain-binding glutamic
acid-rich protein isoform X1		 Danio rerio
TI:7955 None
   
A0A8V0XFH0_CHICK
Ensembl»
0.5
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Gallus gallus
TI:9031 None
   
A0A8V0YLT6_CHICK
Ensembl»
0.5
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Gallus gallus
TI:9031 None
   
A0A8V0YSJ7_CHICK
Ensembl»
0.5
SH3BGR SH3 domain binding glutamate rich protein Gallus gallus
TI:9031 None
   
A0A8V0Z2K4_CHICK
Ensembl»
2.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Gallus gallus
TI:9031 None
   
A0A8W4FER1_PIG
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Sus scrofa
TI:9823 None
   
A0A9J7LQW3_BRAFL
neXtProt»
0.0
LOC118423122 SH3 domain-binding glutamic acid-rich-like
protein 2 isoform X1		 Branchiostoma floridae
TI:7739 None
   
A0A9L0RK65_HORSE
Ensembl»
0.0
LOC100630699 SH3 domain-binding
glutamic acid-rich-like protein		 Equus caballus
TI:9796 None
   
A0A9L0SX28_HORSE
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Equus caballus
TI:9796 None
   
A0AAA9TVI1_BOVIN
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Bos taurus
TI:9913 None 		     
A0ABI0NRA9_BOVIN
Ensembl»
0.0
SH3BGRL2 SH3 domain binding glutamate rich protein like 2 Bos taurus
TI:9913 None
   
A0ABI7VRT6_FELCA
Ensembl»
0.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Felis catus
TI:9685 None
   
A0ABI7VRT7_FELCA
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding
glutamic acid-rich-like protein		 Felis catus
TI:9685 None 		     
A0ABI7Y875_FELCA
Ensembl»
0.0
SH3BGRL2 SH3 domain binding glutamate rich protein like 2 Felis catus
TI:9685 None
   
A0ABI8A6U7_FELCA
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Felis catus
TI:9685 None 		     
A0ABI8AGN3_FELCA
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Felis catus
TI:9685 None
   
A0ABK0LV52_RAT
RGD»
0.0
Sh3bgrl2 SH3 domain binding glutamate-rich protein like 2 Rattus norvegicus
TI:10116 None
   
D4AAC3_RAT
RGD»
0.5
Sh3bgr SH3 domain binding glutamate-rich protein Rattus norvegicus
TI:10116 None
   
F1S1R4_PIG
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Sus scrofa
TI:9823 None
   
F6RMM1_HORSE
Ensembl»
0.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Equus caballus
TI:9796 None
   
F6U6M6_MONDO
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding
glutamic acid-rich-like protein		 Monodelphis domestica
TI:13616 None
   
F6X6Y2_MONDO
Ensembl»
0.0
SH3BGRL SH3 domain-binding
glutamic acid-rich-like protein		 Monodelphis domestica
TI:13616 None
   
F7FLU2_ORNAN
Ensembl»
0.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Ornithorhynchus anatinus
TI:9258 None
   
G1KE21_ANOCA
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Anolis carolinensis
TI:28377 None
   
G1KTW0_ANOCA
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Anolis carolinensis
TI:28377 None
   
H2MCB5_ORYLA
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate-rich protein Oryzias latipes
TI:8090 None
   
H9GLD8_ANOCA
Ensembl»
0.0
SH3BGRL SH3 domain-binding glutamic
acid-rich-like protein 1		 Anolis carolinensis
TI:28377 None
   
H9GPN4_ANOCA
Ensembl»
0.0
SH3BGRL3 SH3 domain-binding glutamic
acid-rich-like protein 3		 Anolis carolinensis
TI:28377 None
   
I3LEV7_PIG
Ensembl»
0.0
SH3BGR SH3 domain binding glutamate rich protein Sus scrofa
TI:9823 None
   
K7E2N2_MONDO
Ensembl»
0.0
SH3BGRL2 SH3 domain-binding
glutamic acid-rich-like protein		 Monodelphis domestica
TI:13616 None