Collated Gene Ontology terms

Biological process: oxidoreductase activity(2024) flavin adenine dinucleotide binding(2011, 2014, 2017, 2024) electron-transferring-flavoprotein dehydrogenase activity(2017) rubredoxin-NAD+ reductase activity(2014, 2024) protein disulfide isomerase activity(2024) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(2014, 2024) NADP binding(2024) CoA-disulfide reductase activity(2024) NADH dehydrogenase (ubiquinone) activity(2024) rubredoxin-NADP+ reductase activity(2011)
mercury (II) reductase activity2024 ferredoxin-NAD+ reductase activity2024 NADPH:sulfur oxidoreductase activity2024 L-amino-acid oxidase activity2024

Molecular function: cellular response to oxidative stress2017, 2024 respiratory electron transport chain2024 proton transmembrane transport2024 nitric oxide catabolic process2014 cellular response to nitric oxide2014 alkane catabolic process2024

Cellular component: cytoplasm2018, 2022, 2024 sarcomere2017, 2024 nucleus2017, 2018, 2024 extracellular region2024 membrane2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 7/8 
Bacteria: 18/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
H2Q5K8_PANTR
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Pan troglodytes
TI:9598 None
 
PYRD1_HUMAN
Ensembl»
0.8
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Homo sapiens
TI:9606 None
 
NORW_ECOLI
EnsemblBacteria»
4.0
norW Nitric oxide reductase FlRd-NAD(+) reductase (EC
1.18.1.-) (Flavorubredoxin reductase) (FlRd-reductase) (FlavoRb reductase)		 Escherichia coli
TI:562 None
 
B7QKK4_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW014336 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein, putative (EC 1.16.1.1,
EC 1.18.1.3) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein, putative (Fragment))		 Ixodes scapularis
TI:6945 None
 
PYRD1_DROME
FlyBase»
0.0
Pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Drosophila melanogaster
TI:7227 None
 
PYRD1_MOUSE
Ensembl»
0.5
Pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Mus musculus
TI:10090 None
 
CDR_STAA8
EnsemblBacteria»
0.0
cdr Coenzyme A disulfide reductase
(CoA-disulfide reductase) (CoADR) (EC 1.8.1.14)		 Staphylococcus aureus
TI:1280 None
 
NAOX_MYCGE
EnsemblBacteria»
0.0
nox NADH oxidase (NOXase) (EC 1.6.3.4) Mycoplasma genitalium
TI:2097 None
 
Q9HP48_HALSA
EnsemblBacteria»
0.0
noxA Flavin-dependent pyridine
nucleotideoxidoreductase (NADH oxidase)		 Halobacterium salinarum
TI:2242 None
 
T1FX41_HELRO
EnsemblMetazoa»
0.0
20213389 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Helobdella robusta
TI:6412 None
 
A0A2I2Z7N4_GORGO
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Gorilla gorilla
TI:9593 None
 
A0A2K3DXV8_CHLRE
EnsemblPlants»
0.0
CHLRE_03g182550v5 FAD/NAD(P)-binding domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A644EYY1_GIAIC
EnsemblProtists»
0.0
GL50803_0033769 NADH oxidase Giardia intestinalis
TI:5741 None
 
A5I1G8_CLOBH
Ensembl»
0.0
CBO1333 Oxidoreductase, NAD/FAD binding subunit Clostridium botulinum
TI:1491 None
 
A7RHE0_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g81327 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Nematostella vectensis
TI:45351 None
 
A7T583_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g222496 FAD/NAD(P)-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
A8WNA0_CAEBR
WormBase»
0.0
CBG00695 CBG_00695 Protein CBG00695 Caenorhabditis briggsae
TI:6238 None 		 
 
A8WNA2_CAEBR
WormBase»
0.0
CBG00693 CBG_00693 Protein CBG00693 Caenorhabditis briggsae
TI:6238 None
 
A9WAH8_CHLAA
EnsemblBacteria»
0.0
Caur_3584 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Chloroflexus aurantiacus
TI:1108 None
 
B1L687_KORCO
EnsemblBacteria»
0.0
Kcr_1220 NADH oxidase Korarchaeum cryptofilum
TI:498846 None
 
B1WAU8_XENTR
Xenbase»
0.0
pyroxd1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Xenopus tropicalis
TI:8364 None
 
B3RS58_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_22271 FAD/NAD(P)-binding domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B8DYU4_DICTD
EnsemblBacteria»
0.0
Dtur_0145 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Dictyoglomus turgidum
TI:513050 None
 
B8E1J3_DICTD
EnsemblBacteria»
0.0
Dtur_0189 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Dictyoglomus turgidum
TI:513050 None
 
C4LS93_ENTH1
EnsemblProtists»
0.0
EHI_153000 Pyridine nucleotide-disulfide
oxidoreductase family protein		 Entamoeba histolytica
TI:5759 None
 
D6WL78_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_14309 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Tribolium castaneum
TI:7070 None
 
E9G1T4_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_44178 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Daphnia pulex
TI:6669 None
 
F0ZNL1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_88309 FAD/NAD(P)-binding domain-containing protein Dictyostelium purpureum
TI:5786 None
 
H2XK75_CIOIN
Ensembl»
0.0
Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Ciona intestinalis
TI:7719 None
 
M3WHX3_FELCA
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Felis catus
TI:9685 None
 
NAOX_METJA
EnsemblBacteria»
0.0
MJ0649 NADH oxidase (NOXase) (EC 1.6.3.4) Methanocaldococcus jannaschii
TI:2190 None
 
NAOX_STRR6
EnsemblBacteria»
0.0
nox NADH oxidase (NOXase) (EC 1.6.3.4) Streptococcus pneumoniae
TI:1313 None
 
NORW_SALTY
EnsemblBacteria»
0.0
norW Nitric oxide reductase FlRd-NAD(+) reductase (EC
1.18.1.-) (Flavorubredoxin reductase) (FlRd-reductase) (FlavoRb reductase)		 Salmonella typhimurium
TI:28901 None
 
NSR_THEKO
EnsemblBacteria»
0.0
TK1299 NAD(P)H sulfur oxidoreductase (CoA-dependent) (NSR) (EC
1.8.1.18) (NAD(P)H oxidase (H2O-forming)) (NOX) (EC 1.6.3.2)		 Thermococcus kodakarensis
TI:311400 None
 
O67007_AQUAE
EnsemblBacteria»
0.0
nox NADH oxidase Aquifex aeolicus
TI:63363 None
 
O69869_STRCO
EnsemblBacteria»
0.0
SCO6039 Flavoprotein oxidoreductase Streptomyces coelicolor
TI:1902 None
 
PYRD1_BOVIN
CTD»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Bos taurus
TI:9913 None
 
PYRD1_DANRE
ZFIN»
0.0
pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Danio rerio
TI:7955 None
 
PYRD1_DICDI
dictyBase»
0.0
pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Dictyostelium discoideum
TI:44689 None
 
PYRD1_RAT
RGD»
1.0
Pyroxd1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.8.1.-)		 Rattus norvegicus
TI:10116 None
 
Q18213_CAEEL
WormBase»
0.0
C26D10.3 CELE_C26D10.3 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Caenorhabditis elegans
TI:6239 None
 
Q5JFZ8_THEKO
EnsemblBacteria»
0.0
TK0304 NADH oxidase Thermococcus kodakarensis
TI:311400 None
 
Q5JHY2_THEKO
EnsemblBacteria»
0.0
TK0828 NAD(P)H:rubredoxin oxidoreductase Thermococcus kodakarensis
TI:311400 None
 
Q5JJB9_THEKO
EnsemblBacteria»
0.0
TK1481 NADH:polysulfide oxidoreductase Thermococcus kodakarensis
TI:311400 None
 
Q74BE6_GEOSL
EnsemblBacteria»
0.0
GSU2095 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74DS8_GEOSL
EnsemblBacteria»
0.0
GSU1237 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74EQ3_GEOSL
EnsemblBacteria»
0.0
GSU0909 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74EW6_GEOSL
EnsemblBacteria»
0.0
GSU0843 Rubredoxin reductase Geobacter sulfurreducens
TI:35554 None
 
Q74F15_GEOSL
EnsemblBacteria»
0.0
GSU0794 FAD-dependent pyridine nucleotide-disulfide oxidoreductase
family protein, rhodanese homology domain-containing		 Geobacter sulfurreducens
TI:35554 None
 
Q7Q3T9_ANOGA
EnsemblMetazoa»
0.0
1277910 AGAP008042-PA Anopheles gambiae
TI:7165 None
 
Q81GF7_BACCR
EnsemblBacteria»
0.0
BC_1246 NADH dehydrogenase (EC 1.6.99.3) Bacillus cereus
TI:1396 None
 
Q83EN9_COXBU
EnsemblBacteria»
0.0
CBU_0276 Rubredoxin-NAD(+) reductase (EC 1.18.1.1) Coxiella burnetii
TI:777 None
 
Q89RG4_BRADU
EnsemblBacteria»
0.0
blr2808 Blr2808 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q8R649_FUSNN
EnsemblBacteria»
0.0
FN1088 NADH oxidase (EC 1.6.-.-) Fusobacterium nucleatum
TI:851 None
 
Q8TH86_METAC
EnsemblBacteria»
0.0
ndh NADH dehydrogenase Methanosarcina acetivorans
TI:2214 None
 
Q8ZVB1_PYRAE
EnsemblBacteria»
0.0
PAE2371 NADH oxidase (Nox) Pyrobaculum aerophilum
TI:13773 None
 
Q97WE3_SACS2
EnsemblBacteria»
0.0
SSO2283 NADH oxidase Saccharolobus solfataricus
TI:2287 None
 
Q9L2D3_STRCO
EnsemblBacteria»
0.0
nirB Nitrite reductase NirB Streptomyces coelicolor
TI:1902 None
 
Q9RVN5_DEIRA
EnsemblBacteria»
0.0
DR_0992 NADH oxidase Deinococcus radiodurans
TI:1299 None
 
Q9WYL1_THEMA
EnsemblBacteria»
0.0
TM_0379 NADH oxidase Thermotoga maritima
TI:2336 None
 
Q9WYM6_THEMA
EnsemblBacteria»
0.0
TM_0395 NADH oxidase, putative Thermotoga maritima
TI:2336 None
 
Q9WZL3_THEMA
EnsemblBacteria»
0.0
TM_0754 Oxidoreductase Thermotoga maritima
TI:2336 None
 
RURE_PSEAE
EnsemblBacteria»
0.0
alkT Rubredoxin-NAD(+) reductase (RdxR) (EC 1.18.1.1) Pseudomonas aeruginosa
TI:287 None
 
W5NE84_LEPOC
Ensembl»
0.0
Pyridine nucleotide-disulphide
oxidoreductase domain 1		 Lepisosteus oculatus
TI:7918 None
 
A0A1L8GVW1_XENLA
Xenbase»
0.0
pyroxd1.L Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Xenopus laevis
TI:8355 None
   
A0A3B3HFM0_ORYLA
Ensembl»
0.0
pyroxd1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Oryzias latipes
TI:8090 None
   
A0A452DKI2_BOVIN
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Bos taurus
TI:9913 None
   
A0A7M7PHF1_STRPU
EnsemblMetazoa»
0.0
FAD/NAD(P)-binding domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3P0R6_CANLF
Ensembl»
0.0
PYROXD1 Uncharacterized protein Canis lupus
TI:9612 None
   
A0A8V0YNN2_CHICK
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Gallus gallus
TI:9031 None
   
A0A9J7NCT1_BRAFL
CTD»
0.0
LOC118431408 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
F1SQZ8_PIG
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Sus scrofa
TI:9823 None
   
F6WM02_HORSE
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Equus caballus
TI:9796 None
   
F6ZXZ9_MONDO
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Monodelphis domestica
TI:13616 None
   
F7G3D3_MACMU
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Macaca mulatta
TI:9544 None
   
G1KR18_ANOCA
Ensembl»
0.0
PYROXD1 L-amino-acid oxidase (EC 1.4.3.2) Anolis carolinensis
TI:28377 None
   
K7EEF4_ORNAN
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulphide
oxidoreductase domain 1		 Ornithorhynchus anatinus
TI:9258 None