Collated Gene Ontology terms

Biological process: phospholipase A2 activity(2003, 2004, 2019, 2025) calcium ion binding(2025) metal ion binding(2025) hydrolase activity(2025) serine-type peptidase activity(2025) peptidase activity(2025) serine-type endopeptidase activity(2025) cysteine-type peptidase activity(2025) cysteine-type endopeptidase activity(2025)

Molecular function: lipid catabolic process2004, 2025 phospholipid metabolic process2025 arachidonate secretion2025 triglyceride homeostasis2013, 2019, 2025 cholesterol homeostasis2013, 2019, 2025 lipid metabolic process2025 proteolysis2025 low-density lipoprotein particle remodeling2020 immune system process2025 protein processing2025
complement activation2025 apoptotic process2025

Cellular component: extracellular region2003, 2011, 2025 cytoplasm2025 membrane2025 endoplasmic reticulum2011 Golgi apparatus2011

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803SS01_ANOCA
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Anolis carolinensis
TI:28377 None
   
A0A803TGE4_ANOCA
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Anolis carolinensis
TI:28377 None
   
Q7QHA9_ANOGA
EnsemblMetazoa»
0.0
1270816 AGAP011108-PA Anopheles gambiae
TI:7165 None
 
A0AAA9TSQ4_BOVIN
Ensembl»
0.0
CASP6 Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Bos taurus
TI:9913 None
   
E1BFK0_BOVIN
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Bos taurus
TI:9913 None
   
A0A9J7KWD4_BRAFL
euHCVdb»
0.0
LOC118412599 Group XIIA secretory phospholipase A2-like Branchiostoma floridae
TI:7739 None
   
A0A8I3Q2H7_CANLF
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Canis lupus
TI:9612 None
   
A0A8I3RSZ9_CANLF
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Canis lupus
TI:9612 None
   
A0ACD6B6F5_DANRE
ZFIN»
0.0
pla2g12b Group XIIB secretory phospholipase
A2-like protein isoform X1		 Danio rerio
TI:7955 None 		     
A3KNJ5_DANRE
ZFIN»
0.5
pla2g12a Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Danio rerio
TI:7955 None
 
E9G470_DAPPU
euHCVdb»
0.0
PLA2G12B Phospholipase-like protein A2,
group (EC 3.1.1.4)		 Daphnia pulex
TI:6669 None
 
E9G471_DAPPU
neXtProt»
0.0
PLA2G12A Phospholipase-like protein A2,
group (EC 3.1.1.4)		 Daphnia pulex
TI:6669 None
 
E9GMY7_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_225232 Uncharacterized protein Daphnia pulex
TI:6669 None
 
Q9VUV6_DROME
FlyBase»
0.6
GXIVsPLA2 GXIVsPLA2, isoform A (GXIVsPLA2, isoform D
(EC 3.1.1.4)) (Group XIV secreted phospholipase A2)		 Drosophila melanogaster
TI:7227 None
 
A0A9L0T504_HORSE
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Equus caballus
TI:9796 None
   
A0ABI7YKS0_FELCA
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Felis catus
TI:9685 None
   
A0A8V0XHP6_CHICK
Ensembl»
0.5
PLA2G12A Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Gallus gallus
TI:9031 None
   
A0A8V0ZJ65_CHICK
Ensembl»
1.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Gallus gallus
TI:9031 None
   
A0A2I2ZUU7_GORGO
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase A2
(EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Gorilla gorilla
TI:9593 None
 
G3RAI5_GORGO
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Gorilla gorilla
TI:9593 None
 
A0A2R8Y3M9_HUMAN
Ensembl»
0.0
Group XIIA secretory phospholipase A2
(EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Homo sapiens
TI:9606 None
 
PG12A_HUMAN
Ensembl»
1.1
PLA2G12A Group XIIA secretory phospholipase A2 (GXII
sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Homo sapiens
TI:9606 None
 
PG12B_HUMAN
Ensembl»
1.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein (Group XIII
secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)		 Homo sapiens
TI:9606 None
 
B7P1D1_IXOSC
EnsemblMetazoa»
0.0
8053294 Secreted salivary gland
peptide, putative (EC 3.1.1.4)		 Ixodes scapularis
TI:6945 None
 
B7P603_IXOSC
EnsemblMetazoa»
0.0
8025135 Salivary phospholipase A2, putative Ixodes scapularis
TI:6945 None
 
W5MPV7_LEPOC
Ensembl»
0.0
Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Lepisosteus oculatus
TI:7918 None
 
W5N370_LEPOC
Ensembl»
0.0
Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Lepisosteus oculatus
TI:7918 None
 
F6U7T4_MACMU
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Macaca mulatta
TI:9544 None
   
F7HTT9_MACMU
Ensembl»
0.0
CFI Group XIIA secretory phospholipase A2
(EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Macaca mulatta
TI:9544 None
   
F6WX38_MONDO
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Monodelphis domestica
TI:13616 None
   
F6YC85_MONDO
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Monodelphis domestica
TI:13616 None
   
PG12A_MOUSE
Ensembl»
2.3
Pla2g12a Group XIIA secretory phospholipase A2 (GXII
sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Mus musculus
TI:10090 None
 
PG12B_MOUSE
AG»
3.4
Pla2g12b Group XIIB secretory phospholipase A2-like protein (Group XIII
secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)		 Mus musculus
TI:10090 None
 
A7STQ9_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g131395 Group XIIA secretory phospholipase A2 Nematostella vectensis
TI:45351 None
 
A0A6I8P722_ORNAN
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8P744_ORNAN
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3H3R7_ORYLA
Ensembl»
0.0
PLA2G12B Phospholipase A2, group XIIB Oryzias latipes
TI:8090 None
   
A0A3B3I4C5_ORYLA
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Oryzias latipes
TI:8090 None
   
H2Q229_PANTR
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Pan troglodytes
TI:9598 None
 
K7BN83_PANTR
Ensembl»
0.0
PLA2G12A Group XIIA secretory phospholipase A2
(EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Pan troglodytes
TI:9598 None
 
H3GN10_PHYRM
EnsemblProtists»
0.0
Phospholipase A2 Phytophthora ramorum
TI:164328 None
 
B0K018_RAT
RGD»
1.0
Pla2g12a Group XIIA secretory phospholipase A2
(EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Rattus norvegicus
TI:10116 None
 
M0RCI5_RAT
RGD»
2.5
Pla2g12b Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Rattus norvegicus
TI:10116 None
   
A0A7M7LLI4_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
F1S132_PIG
Ensembl»
0.0
CASP6 Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Sus scrofa
TI:9823 None
   
F1SU77_PIG
Ensembl»
0.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Sus scrofa
TI:9823 None
   
B8BX83_THAPS
euHCVdb»
0.0
THAPSDRAFT_3244 Phospholipase A2 Thalassiosira pseudonana
TI:35128 None
 
D6WWD0_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_06362 Group XIIA secretory
phospholipase A2-like Protein		 Tribolium castaneum
TI:7070 None
 
B3RKT8_TRIAD
CTD»
0.0
TRIADDRAFT_51761 Phospholipase A2 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8FF19_XENLA
Xenbase»
0.0
pla2g12b.S Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Xenopus laevis
TI:8355 None
   
A0A1L8FJV5_XENLA
Xenbase»
0.0
pla2g12b.L Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Xenopus laevis
TI:8355 None
   
A0A8J0STL3_XENTR
Xenbase»
0.0
pla2g12b Group XIIB secretory phospholipase A2-like protein
(Group XIII secretory phospholipase A2-like protein) (sPLA2-GXIIB)		 Xenopus tropicalis
TI:8364 None
   
Q28GM9_XENTR
Xenbase»
0.0
pla2g12a Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Xenopus tropicalis
TI:8364 None
 
Q6GQC0_XENLA
Xenbase»
0.0
pla2g12a.S Group XIIA secretory phospholipase
A2 (Phosphatidylcholine 2-acylhydrolase 12A)		 Xenopus laevis
TI:8355 None