Collated Gene Ontology terms

Biological process: metal ion binding(2024) lyase activity(2024) 6-pyruvoyltetrahydropterin synthase activity(2003, 2005, 2007, 2008, 2016, 2024) 6-carboxy-5,6,7,8-tetrahydropterin synthase activity(2009, 2017, 2024) identical protein binding(2014, 2019, 2024) zinc ion binding(2011)

Molecular function: tetrahydrobiopterin biosynthetic process2003, 2005, 2007, 2008, 2016, 2024 queuosine biosynthetic process2017, 2024 response to oxidative stress2015, 2024 folic acid biosynthetic process2005, 2024 response to Gram-negative bacterium2020 pteridine biosynthetic process2006 central nervous system development2003 amino acid metabolic process2003

Cellular component: mitochondrion2009, 2010, 2017, 2024 cytoplasm2010, 2024 membrane2024 cytosol2013

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 6/8 
Bacteria: 27/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
PTPS_HUMAN
Ensembl»
4.4
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Homo sapiens
TI:9606 None
 
QUED_ECOLI
EnsemblBacteria»
3.7
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Escherichia coli
TI:562 None
 
PTPS_RAT
RGD»
3.2
Pts 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Rattus norvegicus
TI:10116 None
 
PTPS_DICDI
dictyBase»
2.9
ptsA 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Dictyostelium discoideum
TI:44689 None
 
PTPS_CAEEL
WormBase»
2.4
ptps-1 Putative 6-pyruvoyl tetrahydrobiopterin synthase
(PTP synthase) (PTPS) (EC 4.2.3.12)		 Caenorhabditis elegans
TI:6239 None
 
PTPS_MOUSE
Ensembl»
2.4
Pts 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Mus musculus
TI:10090 None
 
PTPS_DROME
FlyBase»
1.6
pr 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS)
(EC 4.2.3.12) (Protein purple) (Sepiapterin synthase A)		 Drosophila melanogaster
TI:7227 None
 
A0A1L8GD72_XENLA
Xenbase»
0.0
pts.S 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Xenopus laevis
TI:8355 None
   
A0A1W3JGZ9_CIOIN
Ensembl»
0.0
LOC100183853 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Ciona intestinalis
TI:7719 None
 
A0A2I2UEC0_FELCA
Ensembl»
0.0
6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Felis catus
TI:9685 None
 
A0A2I2YV86_GORGO
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Gorilla gorilla
TI:9593 None
 
A0A3N4B9V9_YERPE
EnsemblBacteria»
0.0
ygcM 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Yersinia pestis
TI:632 None
 
A0A3Q1LM71_BOVIN
Ensembl»
0.0
6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Bos taurus
TI:9913 None
   
A0A3Q1MA59_BOVIN
Ensembl»
0.0
6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Bos taurus
TI:9913 None
   
A0A454XXG2_PRIPA
EnsemblMetazoa»
0.0
WBGene00099579 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Pristionchus pacificus
TI:54126 None
 
A0A5F8GKA0_MONDO
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Monodelphis domestica
TI:13616 None
   
A0A6I8P7P8_ORNAN
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RGQ8_STRPU
EnsemblMetazoa»
0.0
6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803JKE4_XENTR
Ensembl»
0.0
pts 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Xenopus tropicalis
TI:8364 None
   
A0A803SN59_ANOCA
Ensembl»
0.0
6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Anolis carolinensis
TI:28377 None
   
A0A803T9Q1_ANOCA
Ensembl»
0.0
6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Anolis carolinensis
TI:28377 None
   
A0A8J0V0D6_XENLA
CTD»
0.0
pts.L 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Xenopus laevis
TI:8355 None
   
A0A8V1A5P5_CHICK
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Gallus gallus
TI:9031 None
   
A0A8W4FDH0_PIG
Ensembl»
0.0
6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Sus scrofa
TI:9823 None
   
A5I019_CLOBH
Ensembl»
0.0
CBO0827 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Clostridium botulinum
TI:1491 None
 
A5I229_CLOBH
Ensembl»
0.0
CBO1554 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Clostridium botulinum
TI:1491 None
 
A5PKS5_DANRE
ZFIN»
0.0
ptps 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Danio rerio
TI:7955 None
 
A7S0L6_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g242015 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Nematostella vectensis
TI:45351 None
 
A7SAN5_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g111107 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Nematostella vectensis
TI:45351 None
 
A8Y1U6_CAEBR
WormBase»
0.0
ptps-1 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Caenorhabditis briggsae
TI:6238 None
 
A9A4R1_NITMS
EnsemblBacteria»
0.0
Nmar_1469 6-pyruvoyl tetrahydropterin synthase Nitrosopumilus maritimus
TI:338192 None
 
A9UXK1_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_16767 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Monosiga brevicollis
TI:81824 None
 
A9WC20_CHLAA
EnsemblBacteria»
0.0
Caur_0159 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Chloroflexus aurantiacus
TI:1108 None
 
A9WIW9_CHLAA
EnsemblBacteria»
0.0
Caur_2640 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Chloroflexus aurantiacus
TI:1108 None
 
B3RSD0_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_63103 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Trichoplax adhaerens
TI:10228 None
 
B5YJJ7_THEYD
EnsemblBacteria»
0.0
THEYE_A0569 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Thermodesulfovibrio yellowstonii
TI:28262 None
 
B8C0F3_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_4834 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Thalassiosira pseudonana
TI:35128 None
 
B8DZG9_DICTD
EnsemblBacteria»
0.0
Dtur_0614 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Dictyoglomus turgidum
TI:513050 None
 
B9TK85_RICCO
EnsemblBacteria»
0.0
RCOM_2048230 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Ricinus communis
TI:3988 None
 
C3ZBP8_BRAFL
CTD»
0.0
LOC118418052 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Branchiostoma floridae
TI:7739 None
 
C6KTB6_PLAF7
EnsemblProtists»
0.0
PF3D7_0628000 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Plasmodium falciparum
TI:5833 None
 
D2A5P8_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15575 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Tribolium castaneum
TI:7070 None
 
E9FSQ0_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_230142 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Daphnia pulex
TI:6669 None
 
F0ZJL9_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_151723 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Dictyostelium purpureum
TI:5786 None
 
F1MX94_BOVIN
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Bos taurus
TI:9913 None
   
F1SM93_PIG
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Sus scrofa
TI:9823 None
   
F4PDC7_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_28226 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Batrachochytrium dendrobatidis
TI:109871 None
 
F6VDI5_HORSE
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Equus caballus
TI:9796 None
   
F7DZN4_MACMU
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Macaca mulatta
TI:9544 None
   
H2MD33_ORYLA
Ensembl»
0.0
pts 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Oryzias latipes
TI:8090 None
   
H2R4Y8_PANTR
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Pan troglodytes
TI:9598 None
 
H3GQV0_PHYRM
EnsemblProtists»
0.0
6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Phytophthora ramorum
TI:164328 None
 
M3XBA1_FELCA
Ensembl»
0.0
PTS 6-pyruvoyl tetrahydrobiopterin synthase (PTP
synthase) (PTPS) (EC 4.2.3.12)		 Felis catus
TI:9685 None
 
O67020_AQUAE
EnsemblBacteria»
0.0
aq_853 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Aquifex aeolicus
TI:63363 None
 
O86696_STRCO
EnsemblBacteria»
0.0
SCO6650 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Streptomyces coelicolor
TI:1902 None
 
Q2G1X5_STAA8
EnsemblBacteria»
0.0
SAOUHSC_00720 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Staphylococcus aureus
TI:1280 None
 
Q5JE65_THEKO
EnsemblBacteria»
0.0
TK1119 6-pyruvoyl-tetrahydropterin synthase Thermococcus kodakarensis
TI:311400 None
 
Q5JF52_THEKO
EnsemblBacteria»
0.0
TK0563 6-pyruvoyl-tetrahydropterin
synthase-related protein		 Thermococcus kodakarensis
TI:311400 None
 
Q74CF4_GEOSL
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Geobacter sulfurreducens
TI:35554 None
 
Q7CPW5_SALTY
EnsemblBacteria»
0.0
ptpS 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Salmonella typhimurium
TI:28901 None
 
Q7NFE7_GLOVI
EnsemblBacteria»
0.0
glr3579 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Gloeobacter violaceus
TI:33072 None
 
Q7Q899_ANOGA
EnsemblMetazoa»
0.0
1275581 6-pyruvoyltetrahydropterin synthase
(EC 4.2.3.12)		 Anopheles gambiae
TI:7165 None
 
Q7UGM2_RHOBA
EnsemblBacteria»
0.0
RB5135 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Rhodopirellula baltica
TI:265606 None
 
Q7UMI8_RHOBA
EnsemblBacteria»
0.0
RB8806 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Rhodopirellula baltica
TI:265606 None
 
Q81G68_BACCR
EnsemblBacteria»
0.0
BC_1342 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Bacillus cereus
TI:1396 None
 
Q83AK2_COXBU
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (EC 4.1.2.50)
(Queuosine biosynthesis protein QueD)		 Coxiella burnetii
TI:777 None
 
Q89SC1_BRADU
EnsemblBacteria»
0.0
bll2482 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89ZC4_BACTN
EnsemblBacteria»
0.0
BT_4453 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Bacteroides thetaiotaomicron
TI:818 None
 
Q8F2M2_LEPIN
EnsemblBacteria»
0.0
LA_2749 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Leptospira interrogans
TI:173 None
 
Q8F965_LEPIN
EnsemblBacteria»
0.0
LA_0332 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Leptospira interrogans
TI:173 None
 
Q8PCW2_XANCP
EnsemblBacteria»
0.0
ptps 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Xanthomonas campestris
TI:339 None
 
Q8TIF6_METAC
EnsemblBacteria»
0.0
MA_4196 6-pyruvoyltetrahydropterin synthase Methanosarcina acetivorans
TI:2214 None
 
Q8TS49_METAC
EnsemblBacteria»
0.0
ptpS 6-pyruvoyltetrahydropterin synthase Methanosarcina acetivorans
TI:2214 None
 
Q97W30_SACS2
EnsemblBacteria»
0.0
SSO2412 6-pyruvoyl tetrahydrobiopterin synthase Saccharolobus solfataricus
TI:2287 None
 
Q9HHN6_HALSA
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.1.2.50) (Vng6306c)		 Halobacterium salinarum
TI:2242 None
 
Q9HQS7_HALSA
EnsemblBacteria»
0.0
VNG_1024C PtpS family protein Halobacterium salinarum
TI:2242 None
 
Q9I0H2_PSEAE
EnsemblBacteria»
0.0
PA2666 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Pseudomonas aeruginosa
TI:287 None
 
Q9K0Q7_NEIMB
EnsemblBacteria»
0.0
NMB0527 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Neisseria meningitidis
TI:487 None
 
Q9KSF7_VIBCH
EnsemblBacteria»
0.0
VC_1299 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Vibrio cholerae
TI:666 None
 
Q9WXP5_THEMA
EnsemblBacteria»
0.0
TM_0038 6-carboxy-5,6,7,8-tetrahydropterin synthase
(EC 4.-.-.-)		 Thermotoga maritima
TI:2336 None
 
QUED_AQUAE
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Aquifex aeolicus
TI:63363 None
 
QUED_BACSU
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Bacillus subtilis
TI:1423 None
 
QUED_HAEIN
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Haemophilus influenzae
TI:727 None
 
QUED_HELPY
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Helicobacter pylori
TI:210 None
 
QUED_METJA
EnsemblBacteria»
0.0
queD Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase)
(EC 4.1.2.50) (Archaeosine biosynthesis protein QueD)		 Methanocaldococcus jannaschii
TI:2190 None
 
QUED_SYNY3
EnsemblBacteria»
0.0
queD 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC
4.1.2.50) (Queuosine biosynthesis protein QueD)		 Synechocystis sp.
TI:1148 None
 
T1G0Y7_HELRO
EnsemblMetazoa»
0.0
20214735 6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Helobdella robusta
TI:6412 None
 
W5N1Q0_LEPOC
Ensembl»
0.0
6-pyruvoyl tetrahydrobiopterin
synthase (EC 4.2.3.12)		 Lepisosteus oculatus
TI:7918 None