Collated Gene Ontology terms

Biological process: cobalamin binding(2007, 2009, 2011, 2017, 2020, 2022, 2025) cargo receptor ligand activity(2021, 2022, 2023, 2025) molecular carrier activity(2022, 2025) metal ion binding(2025) vitamin binding(2005) molecular sequestering activity(2022)

Molecular function: cobalamin transport2005, 2009, 2017, 2021, 2022, 2023, 2025 cobalt ion transport2025 monoatomic ion transport2025 cellular response to xenobiotic stimulus2008

Cellular component: extracellular space2003, 2007, 2009, 2014, 2017, 2018, 2022, 2025 extracellular region2013, 2021, 2025 microvillus2009, 2025 endosome2009, 2025 apical plasma membrane2009, 2025 external side of plasma membrane2021, 2025 lysosomal lumen2021 tertiary granule lumen2016 specific granule lumen2016 plasma membrane2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
IF_MOUSE
Ensembl»
5.7
Cblif Cobalamin binding intrinsic factor (Gastric
intrinsic factor) (Intrinsic factor) (IF) (INF)		 Mus musculus
TI:10090 None
 
TCO2_MOUSE
Ensembl»
6.7
Tcn2 Transcobalamin-2 (TC-2) (Transcobalamin
II) (TC II) (TCII)		 Mus musculus
TI:10090 None
 
TCO2_HUMAN
Ensembl»
4.3
TCN2 Transcobalamin-2 (TC-2) (Transcobalamin
II) (TC II) (TCII)		 Homo sapiens
TI:9606 None
 
IF_HUMAN
Ensembl»
4.3
CBLIF Cobalamin binding intrinsic factor (Gastric
intrinsic factor) (Intrinsic factor) (IF) (INF)		 Homo sapiens
TI:9606 None
 
TCO2_RAT
RGD»
5.2
Tcn2 Transcobalamin-2 (TC-2) (Transcobalamin
II) (TC II) (TCII)		 Rattus norvegicus
TI:10116 None
 
IF_RAT
RGD»
4.7
Cblif Cobalamin binding intrinsic factor (Gastric
intrinsic factor) (Intrinsic factor) (IF) (INF)		 Rattus norvegicus
TI:10116 None
 
TCO1_HUMAN
Ensembl»
3.5
TCN1 Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein
R) (Transcobalamin I) (TC I) (TCI)		 Homo sapiens
TI:9606 None
 
A0A5F8AEH5_MACMU
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Macaca mulatta
TI:9544 None
   
A0A6I8P7M7_ORNAN
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Ornithorhynchus anatinus
TI:9258 None
   
A0A803TGQ6_ANOCA
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Anolis carolinensis
TI:28377 None
   
A0A8D1ENZ1_PIG
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Sus scrofa
TI:9823 None
   
A0A8I3PAV5_CANLF
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Canis lupus
TI:9612 None
   
E1BCN2_BOVIN
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Bos taurus
TI:9913 None
   
F1RPE4_PIG
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Sus scrofa
TI:9823 None
 
F6QKL7_MONDO
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Monodelphis domestica
TI:13616 None
   
F6TLY2_HORSE
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Equus caballus
TI:9796 None
   
F7FXU9_MONDO
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Monodelphis domestica
TI:13616 None
   
F7G1U8_MACMU
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Macaca mulatta
TI:9544 None
   
G1KJI5_ANOCA
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Anolis carolinensis
TI:28377 None
   
G3QD18_GORGO
Ensembl»
0.0
Transcobalamin-2 (Transcobalamin II) Gorilla gorilla
TI:9593 None
 
G3QYP7_GORGO
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Gorilla gorilla
TI:9593 None
 
H2Q3R7_PANTR
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Pan troglodytes
TI:9598 None
 
H2QLH6_PANTR
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Pan troglodytes
TI:9598 None
 
IF_CANLF
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor (Gastric intrinsic factor)
(Intrinsic factor) (IF) (INF) (Pancreatic intrinsic factor)		 Canis lupus
TI:9612 None
 
TCO2_BOVIN
CTD»
0.0
TCN2 Transcobalamin-2 (TC-2) (Transcobalamin
II) (TC II) (TCII)		 Bos taurus
TI:9913 None
 
A0A1L8HQW2_XENLA
CTD»
0.0
tcn2.S Transcobalamin-2 (Transcobalamin II) Xenopus laevis
TI:8355 None
   
A0A1L8I1B1_XENLA
CTD»
0.0
tcn2.L Transcobalamin-2 (Transcobalamin II) Xenopus laevis
TI:8355 None
   
A0A8V0X783_CHICK
Ensembl»
1.0
TCN2 Transcobalamin-2 (Transcobalamin II) Gallus gallus
TI:9031 None
   
A0A9L0TR27_HORSE
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Equus caballus
TI:9796 None
   
A9ULJ2_XENTR
Xenbase»
0.0
tcn2 Transcobalamin-2 (Transcobalamin II) Xenopus tropicalis
TI:8364 None
 
F2Z4S3_DANRE
ZFIN»
2.6
tcn2 Transcobalamin II (Transcobalamin-2 precursor) Danio rerio
TI:7955 None
 
F7AW49_ORNAN
Ensembl»
0.0
Transcobalamin-2 (Transcobalamin II) Ornithorhynchus anatinus
TI:9258 None
   
A0A1L8FKQ5_XENLA
CTD»
0.0
LOC108695811 Cobalamin binding intrinsic factor Xenopus laevis
TI:8355 None
   
TCO1_PIG
euHCVdb»
0.0
TCN1 Transcobalamin-1 (TC-1) (Cobalophilin) (Haptocorrin) (Protein
R) (Transcobalamin I) (TC I) (TCI)		 Sus scrofa
TI:9823 None
 
A0A287A0W9_PIG
Ensembl»
0.0
TCN1 Transcobalamin-1 Sus scrofa
TI:9823 None
 
A0A803JXJ1_XENTR
Xenbase»
0.0
cblif Cobalamin binding intrinsic factor Xenopus tropicalis
TI:8364 None
   
A0A803TCF3_ANOCA
Ensembl»
0.0
TCN1 Transcobalamin 1 Anolis carolinensis
TI:28377 None
   
A0A8I3P9U6_CANLF
Ensembl»
0.0
LOC119878488 Transcobalamin 1 Canis lupus
TI:9612 None
   
A0A8V1A3I6_CHICK
Ensembl»
1.0
CBLIF DUF4430 domain-containing protein Gallus gallus
TI:9031 None
   
A0A9J7LXX7_BRAFL
euHCVdb»
0.0
LOC118426191 Cobalamin binding intrinsic
factor-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
E1BCU6_BOVIN
Ensembl»
0.0
TCN1 Transcobalamin 1 Bos taurus
TI:9913 None
   
F6UPX6_CIOIN
Ensembl»
0.0
LOC100185885 Transcobalamin-2-like Ciona intestinalis
TI:7719 None
 
F6Z770_MACMU
Ensembl»
0.0
TCN1 Transcobalamin 1 Macaca mulatta
TI:9544 None
   
G3SJL1_GORGO
Ensembl»
0.0
TCN1 Transcobalamin 1 Gorilla gorilla
TI:9593 None
 
H2LQC9_ORYLA
Ensembl»
0.0
tcn2 Transcobalamin II Oryzias latipes
TI:8090 None
   
H2Q3R8_PANTR
Ensembl»
0.0
TCN1 Transcobalamin 1 Pan troglodytes
TI:9598 None
 
W5MMY0_LEPOC
Ensembl»
0.0
Transcobalamin II Lepisosteus oculatus
TI:7918 None
 
A0A1S4GMN7_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A7M7P8Q9_STRPU
EnsemblMetazoa»
0.0
DUF4430 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7P9B8_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SU17_STRPU
EnsemblMetazoa»
0.0
DUF4430 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0ABI7ZV98_FELCA
Ensembl»
0.0
TCN2 Transcobalamin-2 (Transcobalamin II) Felis catus
TI:9685 None
   
B7QBB5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW013188 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
D2A5I5_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_15544 Uncharacterized protein CG3556-like Protein Tribolium castaneum
TI:7070 None
 
E9FZT1_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_347705 Cobalamin-binding-like protein Daphnia pulex
TI:6669 None
 
E9G922_DAPPU
neXtProt»
0.0
DAPPUDRAFT_315204 Uncharacterized protein Daphnia pulex
TI:6669 None
 
Y3556_DROME
FlyBase»
1.0
CG3556 Uncharacterized protein CG3556 Drosophila melanogaster
TI:7227 None
 
A0ABI8AQE6_FELCA
Ensembl»
0.0
CBLIF Cobalamin binding intrinsic factor Felis catus
TI:9685 None
   
A0ABI8AQE8_FELCA
Ensembl»
0.0
TCN1 Transcobalamin-like C-terminal
domain-containing protein		 Felis catus
TI:9685 None
   
F6T7K7_HORSE
Ensembl»
0.0
TCN1 Transcobalamin 1 Equus caballus
TI:9796 None
   
F6U678_ORNAN
Ensembl»
0.0
TCN1 Transcobalamin-like C-terminal
domain-containing protein		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7LSR1_STRPU
EnsemblMetazoa»
0.0
DUF4430 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A7RWL1_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g241193 Transcobalamin-like C-terminal
domain-containing protein		 Nematostella vectensis
TI:45351 None
 
B3RPE9_TRIAD
CTD»
0.0
TRIADDRAFT_53510 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
B3RPF0_TRIAD
CTD»
0.0
TRIADDRAFT_53511 DUF4430 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
H2L6F8_ORYLA
Ensembl»
0.0
LOC101156171 Transcobalamin-like C-terminal
domain-containing protein		 Oryzias latipes
TI:8090 None
   
A2BFS9_DANRE
ZFIN»
1.6
tcnbb Transcobalamin beta b Danio rerio
TI:7955 None
 
A2BFT0_DANRE
ZFIN»
0.8
tcnba Similar to Transcobalamin-1 (Transcobalamin I)
(TCI) (TC I) (Transcobalamin beta a)		 Danio rerio
TI:7955 None
 
A0A7M7P783_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7PD82_STRPU
EnsemblMetazoa»
0.0
Egg coat matrix protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A9J7L3S8_BRAFL
euHCVdb»
0.0
LOC118415303 Uncharacterized protein LOC118415303 Branchiostoma floridae
TI:7739 None 		     
A0A9J7LZA0_BRAFL
neXtProt»
0.0
LOC118426291 Uncharacterized protein LOC118426291 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MBG0_BRAFL
euHCVdb»
0.0
LOC118430648 Uncharacterized protein LOC118430648 Branchiostoma floridae
TI:7739 None 		     
A0A9J7N965_BRAFL
euHCVdb»
0.0
LOC118428470 Uncharacterized protein LOC118428470 isoform X1 Branchiostoma floridae
TI:7739 None 		     
A9WJY0_CHLAA
EnsemblBacteria»
0.0
Caur_1201 LPXTG-motif cell wall anchor domain protein Chloroflexus aurantiacus
TI:1108 None 		 
 
H2MKN4_ORYLA
Ensembl»
0.0
Uncharacterized protein Oryzias latipes
TI:8090 None 		     
W5M890_LEPOC
Ensembl»
0.0
Gastric intrinsic factor-like Lepisosteus oculatus
TI:7918 None 		 
 
W5M8C3_LEPOC
Ensembl»
0.0
Transcobalamin-2-like Lepisosteus oculatus
TI:7918 None