Collated Gene Ontology terms

Biological process: RNA polymerase II cis-regulatory region sequence-specific DNA binding(2014, 2016, 2017, 2024, 2025) DNA-binding transcription factor activity, RNA polymerase II-specific(2004, 2005, 2014, 2017, 2019, 2020, 2023, 2025) DNA binding(2003, 2005, 2025) protein dimerization activity(2017, 2025) DNA-binding transcription factor activity(2001, 2003, 2004, 2009, 2020, 2023, 2025) DNA-binding transcription activator activity, RNA polymerase II-specific(2014, 2016, 2020, 2022, 2025) sequence-specific double-stranded DNA binding(2020, 2025) E-box binding(2017, 2023, 2025) transcription cis-regulatory region binding(2009, 2025) chromatin binding(2005, 2025)
DNA-binding transcription repressor activity, RNA polymerase II-specific2014, 2020, 2025 protein heterodimerization activity2009, 2025 enzyme binding2020, 2025 sequence-specific DNA binding2010, 2016, 2018 RNA polymerase II-specific DNA-binding transcription factor binding2021

Molecular function: DNA-templated transcription2004, 2017, 2025 regulation of transcription by RNA polymerase II2011, 2017, 2019, 2024, 2025 regulation of DNA-templated transcription2001, 2005, 2006, 2017, 2025 positive regulation of transcription by RNA polymerase II2009, 2013, 2014, 2016, 2018, 2020, 2023, 2025 positive regulation of DNA-templated transcription2001, 2003, 2016, 2019, 2020, 2025 lysosome organization2013, 2016, 2021, 2023, 2025 humoral immune response2009, 2025 melanocyte differentiation2001, 2004, 2008, 2017, 2020, 2025 positive regulation of autophagy2013, 2020, 2025 negative regulation of transcription by RNA polymerase II2014, 2020, 2025
regulation of osteoclast differentiation2004, 2025 positive regulation of cell adhesion2013, 2025 positive regulation of gene expression2014, 2021, 2025 regulation of RNA biosynthetic process2011, 2025 protein-containing complex assembly2011, 2025 positive regulation of DNA-templated transcription initiation2014, 2025 negative regulation of cell migration2018, 2025 cellular response to starvation2016, 2020, 2025 cellular response to amino acid starvation2020, 2025 antibacterial innate immune response2022, 2023, 2025 regulation of lysosome organization2022, 2024, 2025 lysosome localization2019, 2025 defense response to Gram-negative bacterium2014, 2016, 2025 embryonic placenta development2009, 2025 pigmentation2006, 2008, 2015, 2017 immune system process2025 adaptive immune response2025 positive regulation of brown fat cell differentiation2020 negative regulation of cold-induced thermogenesis2018 defense response to Gram-positive bacterium2014, 2016, 2017, 2025 osteoclast differentiation2008, 2022 determination of adult lifespan2014, 2016, 2025 regulation of gene expression2008 regulation of cell population proliferation2003 regulation of autophagy2013, 2025 positive regulation of macroautophagy2021, 2025 positive regulation of cell size2025 negative regulation of apoptotic process2008 cellular response to toxic substance2021, 2025 cellular response to heat2009 cell fate commitment2005 cell differentiation2005 camera-type eye development2005 bone remodeling2008 autophagy2025 Wnt signaling pathway2003 response to ethanol2022 positive regulation of xenophagy2021 positive regulation of plasma membrane repair2021 positive regulation of melanocyte differentiation2021 positive regulation of autophagosome maturation2016 peroxisome fission2024 mitochondria-nucleus signaling pathway2024 lipid catabolic process2016 imaginal disc morphogenesis2025 compound eye morphogenesis2006 closure of optic fissure2021 circadian rhythm2016 cellular response to zinc ion starvation2022 cellular response to tumor cell2024 cellular response to oleic acid2013 autophagy of mitochondrion2013

Cellular component: nucleus2001, 2003, 2009, 2011, 2013, 2019, 2020, 2021, 2023, 2024, 2025 cytoplasm2009, 2013, 2019, 2020, 2022, 2023, 2025 lysosomal membrane2020, 2023, 2025 nucleoplasm2004, 2024, 2025 cytosol2020, 2023, 2024, 2025 protein-containing complex2011, 2025 transcription regulator complex2005, 2025 chromatin2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 3/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 10.0 20.0 30.0 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
HLH30_CAEEL
WormBase»
13.2
hlh-30 Helix-loop-helix protein 30 Caenorhabditis elegans
TI:6239 None
 
A0ACD6B819_DANRE
ZFIN»
0.0
tfeb Transcription factor EB isoform X1 Danio rerio
TI:7955 None 		     
F1Q885_DANRE
ZFIN»
4.4
mitfb Melanocyte-inducing transcription factor b
(Microphthalmia-associated transcription factor b)		 Danio rerio
TI:7955 None
 
F1R1N1_DANRE
ZFIN»
1.5
tfe3b Transcription factor E3b isoform X1
(Transcription factor-binding to IGHM enhancer 3b)		 Danio rerio
TI:7955 None
 
Q561Z2_DANRE
ZFIN»
3.1
tfe3a Tfe3a protein (Transcription factor E3a) (Transcription
factor binding to IGHM enhancer 3a)		 Danio rerio
TI:7955 None
 
Q9PWC2_DANRE
ZFIN»
10.0
mitfa Melanocyte inducing transcription factor a isoform 1 (Melanocyte-inducing
transcription factor a) (Microphthalmia-associated transcription factor a) (Microphthalmia-related protein)		 Danio rerio
TI:7955 None
 
C3KGP2_DROME
FlyBase»
10.3
Mitf MIP04163p (Mitf, isoform C) Drosophila melanogaster
TI:7227 None
 
A0A3Q2U6P0_CHICK
Ensembl»
2.0
MITF Melanocyte inducing transcription factor Gallus gallus
TI:9031 None
   
A0A8V0X7F5_CHICK
Ensembl»
1.5
TFEC Transcription factor EC Gallus gallus
TI:9031 None
   
A0A8V1AD97_CHICK
Ensembl»
2.5
TFEB Transcription factor EB Gallus gallus
TI:9031 None
   
TFEC_CHICK
CTD»
1.5
TFEC Transcription factor EC (TFE-C) Gallus gallus
TI:9031 None
 
MITF_HUMAN
Ensembl»
16.9
MITF Microphthalmia-associated transcription factor (Class E
basic helix-loop-helix protein 32) (bHLHe32)		 Homo sapiens
TI:9606 None
 
TFE3_HUMAN
Ensembl»
11.7
TFE3 Transcription factor E3 (Class E
basic helix-loop-helix protein 33) (bHLHe33)		 Homo sapiens
TI:9606 None
 
TFEB_HUMAN
Ensembl»
17.2
TFEB Transcription factor EB (Class E
basic helix-loop-helix protein 35) (bHLHe35)		 Homo sapiens
TI:9606 None
 
TFEC_HUMAN
Ensembl»
6.1
TFEC Transcription factor EC (TFE-C) (Class E basic
helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L)		 Homo sapiens
TI:9606 None
 
MITF_MOUSE
Ensembl»
33.2
Mitf Microphthalmia-associated transcription factor Mus musculus
TI:10090 None
 
TFE3_MOUSE
Ensembl»
16.1
Tfe3 Transcription factor E3 (mTFE3) Mus musculus
TI:10090 None
 
TFEB_MOUSE
Ensembl»
21.1
Tfeb Transcription factor EB Mus musculus
TI:10090 None
 
TFEC_MOUSE
Ensembl»
4.8
Tfec Transcription factor EC (TFE-C) (mTFEC) Mus musculus
TI:10090 None
 
A0A8I6ATP3_RAT
RGD»
10.0
Tfeb Transcription factor EB Rattus norvegicus
TI:10116 None
   
D3ZAW6_RAT
RGD»
9.0
Tfe3 Transcription factor binding to IGHM enhancer 3 Rattus norvegicus
TI:10116 None
   
MITF_RAT
RGD»
23.0
Mitf Microphthalmia-associated transcription factor Rattus norvegicus
TI:10116 None
 
TFEC_RAT
RGD»
7.2
Tfec Transcription factor EC (TFE-C) (rTFEC) Rattus norvegicus
TI:10116 None
 
RTG3_YEAST
SGD»
10.0
RTG3 Retrograde regulation protein 3 Saccharomyces cerevisiae
TI:4932 None