Collated Gene Ontology terms

Biological process: RNA polymerase II cis-regulatory region sequence-specific DNA binding(2014, 2016, 2017, 2024, 2025) DNA-binding transcription factor activity, RNA polymerase II-specific(2004, 2005, 2014, 2017, 2019, 2020, 2023, 2025) DNA binding(2003, 2005, 2025) protein dimerization activity(2017, 2025) DNA-binding transcription factor activity(2001, 2003, 2004, 2009, 2020, 2023, 2025) DNA-binding transcription activator activity, RNA polymerase II-specific(2014, 2016, 2020, 2022, 2025) sequence-specific double-stranded DNA binding(2020, 2025) E-box binding(2017, 2023, 2025) transcription cis-regulatory region binding(2009, 2025) chromatin binding(2005, 2025)
DNA-binding transcription repressor activity, RNA polymerase II-specific2014, 2020, 2025 protein heterodimerization activity2009, 2025 enzyme binding2020, 2025 sequence-specific DNA binding2010, 2016, 2018 RNA polymerase II-specific DNA-binding transcription factor binding2021

Molecular function: DNA-templated transcription2004, 2017, 2025 regulation of transcription by RNA polymerase II2011, 2017, 2019, 2024, 2025 regulation of DNA-templated transcription2001, 2005, 2006, 2017, 2025 positive regulation of transcription by RNA polymerase II2009, 2013, 2014, 2016, 2018, 2020, 2023, 2025 positive regulation of DNA-templated transcription2001, 2003, 2016, 2019, 2020, 2025 lysosome organization2013, 2016, 2021, 2023, 2025 humoral immune response2009, 2025 melanocyte differentiation2001, 2004, 2008, 2017, 2020, 2025 positive regulation of autophagy2013, 2020, 2025 negative regulation of transcription by RNA polymerase II2014, 2020, 2025
regulation of osteoclast differentiation2004, 2025 positive regulation of cell adhesion2013, 2025 positive regulation of gene expression2014, 2021, 2025 regulation of RNA biosynthetic process2011, 2025 protein-containing complex assembly2011, 2025 positive regulation of DNA-templated transcription initiation2014, 2025 negative regulation of cell migration2018, 2025 cellular response to starvation2016, 2020, 2025 cellular response to amino acid starvation2020, 2025 antibacterial innate immune response2022, 2023, 2025 regulation of lysosome organization2022, 2024, 2025 lysosome localization2019, 2025 defense response to Gram-negative bacterium2014, 2016, 2025 embryonic placenta development2009, 2025 pigmentation2006, 2008, 2015, 2017 immune system process2025 adaptive immune response2025 positive regulation of brown fat cell differentiation2020 negative regulation of cold-induced thermogenesis2018 defense response to Gram-positive bacterium2014, 2016, 2017, 2025 osteoclast differentiation2008, 2022 determination of adult lifespan2014, 2016, 2025 regulation of gene expression2008 regulation of cell population proliferation2003 regulation of autophagy2013, 2025 positive regulation of macroautophagy2021, 2025 positive regulation of cell size2025 negative regulation of apoptotic process2008 cellular response to toxic substance2021, 2025 cellular response to heat2009 cell fate commitment2005 cell differentiation2005 camera-type eye development2005 bone remodeling2008 autophagy2025 Wnt signaling pathway2003 response to ethanol2022 positive regulation of xenophagy2021 positive regulation of plasma membrane repair2021 positive regulation of melanocyte differentiation2021 positive regulation of autophagosome maturation2016 peroxisome fission2024 mitochondria-nucleus signaling pathway2024 lipid catabolic process2016 imaginal disc morphogenesis2025 compound eye morphogenesis2006 closure of optic fissure2021 circadian rhythm2016 cellular response to zinc ion starvation2022 cellular response to tumor cell2024 cellular response to oleic acid2013 autophagy of mitochondrion2013

Cellular component: nucleus2001, 2003, 2009, 2011, 2013, 2019, 2020, 2021, 2023, 2024, 2025 cytoplasm2009, 2013, 2019, 2020, 2022, 2023, 2025 lysosomal membrane2020, 2023, 2025 nucleoplasm2004, 2024, 2025 cytosol2020, 2023, 2024, 2025 protein-containing complex2011, 2025 transcription regulator complex2005, 2025 chromatin2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 3/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 10.0 20.0 30.0 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A139WP70_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_14225 Transcription factor E3-like Protein Tribolium castaneum
TI:7070 None
 
A0A1D5QF51_MACMU
Ensembl»
0.0
TFE3 Transcription factor E3 (Transcription factor
binding to IGHM enhancer 3)		 Macaca mulatta
TI:9544 None
 
A0A1D5QUV2_MACMU
Ensembl»
0.0
TFEC Transcription factor EC Macaca mulatta
TI:9544 None
   
A0A1L8F5F4_XENLA
Xenbase»
0.0
tfe3.L Transcription factor E3 Xenopus laevis
TI:8355 None
   
A0A287BAS8_PIG
Ensembl»
0.0
TFEC Transcription factor EC Sus scrofa
TI:9823 None
   
A0A2A6BYJ1_PRIPA
EnsemblMetazoa»
0.0
WBGene00202776 Hlh-30 Pristionchus pacificus
TI:54126 None
   
A0A2I2Y530_GORGO
Ensembl»
0.0
TFEC Transcription factor EC Gorilla gorilla
TI:9593 None
 
A0A2I2YS93_GORGO
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Gorilla gorilla
TI:9593 None
 
A0A2I2YXN7_GORGO
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Gorilla gorilla
TI:9593 None
 
A0A2I3RWW4_PANTR
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Pan troglodytes
TI:9598 None
 
A0A3B3HNN5_ORYLA
Ensembl»
0.0
MITF Melanocyte inducing transcription factor b Oryzias latipes
TI:8090 None
   
A0A3B3I0H0_ORYLA
Ensembl»
0.0
TFEC Transcription factor EC Oryzias latipes
TI:8090 None
   
A0A3B3ILR6_ORYLA
Ensembl»
0.0
tfe3a BHLH domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3Q1LFW9_BOVIN
Ensembl»
0.0
TFEC Transcription factor EC Bos taurus
TI:9913 None
   
A0A3Q2U6P0_CHICK
Ensembl»
2.0
MITF Melanocyte inducing transcription factor Gallus gallus
TI:9031 None
   
A0A5F5PRV7_HORSE
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Equus caballus
TI:9796 None
   
A0A5F8GMJ1_MONDO
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Monodelphis domestica
TI:13616 None
   
A0A6I8MYD3_ORNAN
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8N1N4_ORNAN
Ensembl»
0.0
TFEC Transcription factor EC Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RDY6_STRPU
EnsemblMetazoa»
0.0
BHLH domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803J330_XENTR
Xenbase»
0.0
tfe3 Transcription factor E3 (Transcription factor
binding to IGHM enhancer 3)		 Xenopus tropicalis
TI:8364 None
   
A0A803KCB8_XENTR
Xenbase»
0.0
tfec Transcription factor EC Xenopus tropicalis
TI:8364 None
   
A0A803T982_ANOCA
Ensembl»
0.0
TFEC Transcription factor EC Anolis carolinensis
TI:28377 None
   
A0A803TPW1_ANOCA
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Anolis carolinensis
TI:28377 None
   
A0A8I3MZG5_CANLF
Ensembl»
0.0
TFEC Transcription factor EC Canis lupus
TI:9612 None
   
A0A8I3N265_CANLF
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Canis lupus
TI:9612 None
   
A0A8I3NYB7_CANLF
Ensembl»
0.0
TFEB Transcription factor EB Canis lupus
TI:9612 None
   
A0A8I3S522_CANLF
Ensembl»
0.0
MiT/TFE transcription factors
N-terminal domain-containing protein		 Canis lupus
TI:9612 None
   
A0A8I3S7X7_CANLF
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Canis lupus
TI:9612 None
   
A0A8I6ATP3_RAT
RGD»
10.0
Tfeb Transcription factor EB Rattus norvegicus
TI:10116 None
   
A0A8J0UR63_XENLA
Xenbase»
0.0
tfec.L Transcription factor EC Xenopus laevis
TI:8355 None
   
A0A8J0V374_XENLA
Xenbase»
0.0
mitf.S Melanocyte inducing transcription factor
S homeolog isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J1J5S8_XENTR
Xenbase»
0.0
tfeb Transcription factor EB isoform X1 Xenopus tropicalis
TI:8364 None
   
A0A8J1MDJ3_XENLA
CTD»
0.0
tfeb.S Transcription factor EB isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J1MRN3_XENLA
CTD»
0.0
LOC108713110 Transcription factor EC Xenopus laevis
TI:8355 None
   
A0A8V0X7F5_CHICK
Ensembl»
1.5
TFEC Transcription factor EC Gallus gallus
TI:9031 None
   
A0A8V1AD97_CHICK
Ensembl»
2.5
TFEB Transcription factor EB Gallus gallus
TI:9031 None
   
A0A9J7MPM9_BRAFL
neXtProt»
0.0
LOC118415416 Microphthalmia-associated transcription
factor-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
A0AAA9SVL5_BOVIN
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Bos taurus
TI:9913 None
   
A0AAA9TE54_BOVIN
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Bos taurus
TI:9913 None
   
A0ABI7W1E1_FELCA
Ensembl»
0.0
TFEC Transcription factor EC Felis catus
TI:9685 None
   
A0ABI7W2Z2_FELCA
Ensembl»
0.0
MITF BHLH domain-containing protein Felis catus
TI:9685 None
   
A0ABI7W470_FELCA
Ensembl»
0.0
TFE3 BHLH domain-containing protein Felis catus
TI:9685 None
   
A0ABI7ZFL3_FELCA
Ensembl»
0.0
TFEB BHLH domain-containing protein Felis catus
TI:9685 None
   
A0ACD6B819_DANRE
ZFIN»
0.0
tfeb Transcription factor EB isoform X1 Danio rerio
TI:7955 None 		     
A4IID0_XENTR
Xenbase»
0.0
mitf Microphthalmia-associated transcription
factor (Mitf protein)		 Xenopus tropicalis
TI:8364 None
 
A7RVM3_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g240998 BHLH domain-containing protein Nematostella vectensis
TI:45351 None
 
A7USK4_ANOGA
EnsemblMetazoa»
0.0
5666790 AGAP000807-PA Anopheles gambiae
TI:7165 None
 
A8WZP5_CAEBR
WormBase»
0.0
hlh-30 Protein CBR-HLH-30 Caenorhabditis briggsae
TI:6238 None
 
B3S741_TRIAD
CTD»
0.0
TRIADDRAFT_60032 BHLH domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B7Q780_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011795 Helix-loop-helix transcription factor, putative Ixodes scapularis
TI:6945 None
 
B7Q781_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011796 Microphthalmia-associated transcription
factor, putative		 Ixodes scapularis
TI:6945 None
 
C3KGP2_DROME
FlyBase»
10.3
Mitf MIP04163p (Mitf, isoform C) Drosophila melanogaster
TI:7227 None
 
D2JUK3_PIG
Ensembl»
0.0
MITF Melanocyte inducing transcription factor
(Microphtalmia-associated transcription factor isoform M)		 Sus scrofa
TI:9823 None
 
D3ZAW6_RAT
RGD»
9.0
Tfe3 Transcription factor binding to IGHM enhancer 3 Rattus norvegicus
TI:10116 None
   
E9FXN6_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_96359 MiT/TFE transcription factors
N-terminal domain-containing protein		 Daphnia pulex
TI:6669 None
 
E9FXN7_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_28469 BHLH domain-containing protein Daphnia pulex
TI:6669 None
 
F1MX26_BOVIN
Ensembl»
0.0
TFEB Transcription factor EB Bos taurus
TI:9913 None
   
F1Q885_DANRE
ZFIN»
4.4
mitfb Melanocyte-inducing transcription factor b
(Microphthalmia-associated transcription factor b)		 Danio rerio
TI:7955 None
 
F1R1N1_DANRE
ZFIN»
1.5
tfe3b Transcription factor E3b isoform X1
(Transcription factor-binding to IGHM enhancer 3b)		 Danio rerio
TI:7955 None
 
F1RUY2_PIG
Ensembl»
0.0
TFEB Transcription factor EB (Transcription
factor EB isoform X2)		 Sus scrofa
TI:9823 None
 
F1RW57_PIG
Ensembl»
0.0
TFE3 Transcription factor E3 isoform 1 (Transcription
factor binding to IGHM enhancer 3)		 Sus scrofa
TI:9823 None
 
F5HIY4_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP013107 AGAP013107-PA Anopheles gambiae
TI:7165 None
 
F6QNF1_CIOIN
Ensembl»
0.0
BHLH domain-containing protein Ciona intestinalis
TI:7719 None
 
F6T5E1_HORSE
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Equus caballus
TI:9796 None
   
F6TIG8_ORNAN
Ensembl»
0.0
TFEB Transcription factor EB Ornithorhynchus anatinus
TI:9258 None
   
F7BMF4_HORSE
Ensembl»
0.0
TFEC Transcription factor EC Equus caballus
TI:9796 None
   
F7DUA0_ORNAN
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Ornithorhynchus anatinus
TI:9258 None
   
F7DUX6_MONDO
Ensembl»
0.0
TFEC Transcription factor EC Monodelphis domestica
TI:13616 None
   
F7DV34_MONDO
Ensembl»
0.0
MITF Melanocyte inducing transcription factor Monodelphis domestica
TI:13616 None
   
F7E1U7_HORSE
Ensembl»
0.0
TFEB Transcription factor EB Equus caballus
TI:9796 None
   
F7FA62_MONDO
Ensembl»
0.0
BHLH domain-containing protein Monodelphis domestica
TI:13616 None
   
F7FXN6_MACMU
Ensembl»
0.0
TFEB Transcription factor EB Macaca mulatta
TI:9544 None
 
G1KB16_ANOCA
Ensembl»
0.0
TFEB Transcription factor EB Anolis carolinensis
TI:28377 None
   
G3QJP3_GORGO
Ensembl»
0.0
TFEB Transcription factor EB Gorilla gorilla
TI:9593 None
 
H2MGI4_ORYLA
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3b Oryzias latipes
TI:8090 None
   
H2MMD1_ORYLA
Ensembl»
0.0
tfeb Transcription factor EB Oryzias latipes
TI:8090 None
   
H2QSZ5_PANTR
Ensembl»
0.0
TFEB Transcription factor EB Pan troglodytes
TI:9598 None
 
H2QYK8_PANTR
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Pan troglodytes
TI:9598 None
 
H8WHA0_CAEBR
WormBase»
0.0
CBG24924 CBG_24924 Protein CBG24924 Caenorhabditis briggsae
TI:6238 None
 
H9ELZ8_MACMU
Ensembl»
0.0
MITF Melanocyte inducing transcription factor
(Microphthalmia-associated transcription factor isoform 1)		 Macaca mulatta
TI:9544 None
 
H9GTC2_ANOCA
Ensembl»
0.0
TFE3 Transcription factor binding to IGHM enhancer 3 Anolis carolinensis
TI:28377 None
   
HLH30_CAEEL
WormBase»
13.2
hlh-30 Helix-loop-helix protein 30 Caenorhabditis elegans
TI:6239 None
 
K9L437_ORYLA
Ensembl»
0.0
mitfa Melanocyte inducing transcription factor a (Microphthalmia-associated
transcription factor 2 isoform m) (Mitf2)		 Oryzias latipes
TI:8090 None
 
MITF_HUMAN
Ensembl»
16.9
MITF Microphthalmia-associated transcription factor (Class E
basic helix-loop-helix protein 32) (bHLHe32)		 Homo sapiens
TI:9606 None
 
MITF_MOUSE
Ensembl»
33.2
Mitf Microphthalmia-associated transcription factor Mus musculus
TI:10090 None
 
MITF_RAT
RGD»
23.0
Mitf Microphthalmia-associated transcription factor Rattus norvegicus
TI:10116 None
 
Q561Z2_DANRE
ZFIN»
3.1
tfe3a Tfe3a protein (Transcription factor E3a) (Transcription
factor binding to IGHM enhancer 3a)		 Danio rerio
TI:7955 None
 
Q5XHC0_XENLA
Xenbase»
0.0
tfe3.S LOC495043 protein (Transcription factor binding
to IGHM enhancer 3 S homeolog)		 Xenopus laevis
TI:8355 None
 
Q6C201_YARLI
TubercuList»
0.0
YALI0_F11979g YALI0F11979p Yarrowia lipolytica
TI:4952 None
 
Q757M6_EREGS
euHCVdb»
0.0
AGOS_AEL012C AEL012Cp Eremothecium gossypii
TI:33169 None
 
Q75A52_EREGS
euHCVdb»
0.0
AGOS_ADR067W ADR067Wp Eremothecium gossypii
TI:33169 None
 
Q76DN3_XENLA
euHCVdb»
0.0
Mitf-M Melanocyte inducing transcription factor S homeolog
isoform X8 (Microphthalmia-associated transcription factor type M)		 Xenopus laevis
TI:8355 None
 
Q76DN4_XENLA
Xenbase»
0.0
mitf.L Melanocyte inducing transcription factor L
homeolog (Micophthalmia-associated transcription factor type A)		 Xenopus laevis
TI:8355 None
 
Q9PWC2_DANRE
ZFIN»
10.0
mitfa Melanocyte inducing transcription factor a isoform 1 (Melanocyte-inducing
transcription factor a) (Microphthalmia-associated transcription factor a) (Microphthalmia-related protein)		 Danio rerio
TI:7955 None
 
RTG3_YEAST
SGD»
10.0
RTG3 Retrograde regulation protein 3 Saccharomyces cerevisiae
TI:4932 None
 
T1FGC6_HELRO
EnsemblMetazoa»
0.0
20207875 BHLH domain-containing protein Helobdella robusta
TI:6412 None
 
T1FZB3_HELRO
EnsemblMetazoa»
0.0
20214161 BHLH domain-containing protein Helobdella robusta
TI:6412 None
 
TFE3_BOVIN
CTD»
0.0
TFE3 Transcription factor E3 Bos taurus
TI:9913 None
 
TFE3_HUMAN
Ensembl»
11.7
TFE3 Transcription factor E3 (Class E
basic helix-loop-helix protein 33) (bHLHe33)		 Homo sapiens
TI:9606 None
 
TFE3_MOUSE
Ensembl»
16.1
Tfe3 Transcription factor E3 (mTFE3) Mus musculus
TI:10090 None
 
TFEB_HUMAN
Ensembl»
17.2
TFEB Transcription factor EB (Class E
basic helix-loop-helix protein 35) (bHLHe35)		 Homo sapiens
TI:9606 None
 
TFEB_MOUSE
Ensembl»
21.1
Tfeb Transcription factor EB Mus musculus
TI:10090 None
 
TFEC_BOVIN
CTD»
0.0
TFEC Transcription factor EC Bos taurus
TI:9913 None
 
TFEC_CHICK
CTD»
1.5
TFEC Transcription factor EC (TFE-C) Gallus gallus
TI:9031 None
 
TFEC_HUMAN
Ensembl»
6.1
TFEC Transcription factor EC (TFE-C) (Class E basic
helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L)		 Homo sapiens
TI:9606 None
 
TFEC_MOUSE
Ensembl»
4.8
Tfec Transcription factor EC (TFE-C) (mTFEC) Mus musculus
TI:10090 None
 
TFEC_PANTR
Ensembl»
0.0
TFEC Transcription factor EC (TFE-C) Pan troglodytes
TI:9598 None
 
TFEC_RAT
RGD»
7.2
Tfec Transcription factor EC (TFE-C) (rTFEC) Rattus norvegicus
TI:10116 None
 
W5MV93_LEPOC
Ensembl»
0.0
Melanocyte inducing transcription factor b Lepisosteus oculatus
TI:7918 None
 
W5N2T2_LEPOC
Ensembl»
0.0
Transcription factor EB Lepisosteus oculatus
TI:7918 None
 
W5NBS7_LEPOC
Ensembl»
0.0
Transcription factor binding to IGHM enhancer 3a Lepisosteus oculatus
TI:7918 None
 
W5NG68_LEPOC
Ensembl»
0.0
Transcription factor EC Lepisosteus oculatus
TI:7918 None