Cluster UKP06795
- MIP04163P
Standard knownness: 33.2; Custom knownness: None; Num. species: 37; Orthology database: Panther19.0; Protein members: 113
Collated Gene Ontology terms
DNA-binding transcription repressor activity, RNA polymerase II-specific2014, 2020, 2025 protein heterodimerization activity2009, 2025 enzyme binding2020, 2025 sequence-specific DNA binding2010, 2016, 2018 RNA polymerase II-specific DNA-binding transcription factor binding2021
Molecular function:
DNA-templated transcription2004, 2017, 2025
regulation of transcription by RNA polymerase II2011, 2017, 2019, 2024, 2025
regulation of DNA-templated transcription2001, 2005, 2006, 2017, 2025
positive regulation of transcription by RNA polymerase II2009, 2013, 2014, 2016, 2018, 2020, 2023, 2025
positive regulation of DNA-templated transcription2001, 2003, 2016, 2019, 2020, 2025
lysosome organization2013, 2016, 2021, 2023, 2025
humoral immune response2009, 2025
melanocyte differentiation2001, 2004, 2008, 2017, 2020, 2025
positive regulation of autophagy2013, 2020, 2025
negative regulation of transcription by RNA polymerase II2014, 2020, 2025
regulation of osteoclast differentiation2004, 2025
positive regulation of cell adhesion2013, 2025
positive regulation of gene expression2014, 2021, 2025
regulation of RNA biosynthetic process2011, 2025
protein-containing complex assembly2011, 2025
positive regulation of DNA-templated transcription initiation2014, 2025
negative regulation of cell migration2018, 2025
cellular response to starvation2016, 2020, 2025
cellular response to amino acid starvation2020, 2025
antibacterial innate immune response2022, 2023, 2025
regulation of lysosome organization2022, 2024, 2025
lysosome localization2019, 2025
defense response to Gram-negative bacterium2014, 2016, 2025
embryonic placenta development2009, 2025
pigmentation2006, 2008, 2015, 2017
immune system process2025
adaptive immune response2025
positive regulation of brown fat cell differentiation2020
negative regulation of cold-induced thermogenesis2018
defense response to Gram-positive bacterium2014, 2016, 2017, 2025
osteoclast differentiation2008, 2022
determination of adult lifespan2014, 2016, 2025
regulation of gene expression2008
regulation of cell population proliferation2003
regulation of autophagy2013, 2025
positive regulation of macroautophagy2021, 2025
positive regulation of cell size2025
negative regulation of apoptotic process2008
cellular response to toxic substance2021, 2025
cellular response to heat2009
cell fate commitment2005
cell differentiation2005
camera-type eye development2005
bone remodeling2008
autophagy2025
Wnt signaling pathway2003
response to ethanol2022
positive regulation of xenophagy2021
positive regulation of plasma membrane repair2021
positive regulation of melanocyte differentiation2021
positive regulation of autophagosome maturation2016
peroxisome fission2024
mitochondria-nucleus signaling pathway2024
lipid catabolic process2016
imaginal disc morphogenesis2025
compound eye morphogenesis2006
closure of optic fissure2021
circadian rhythm2016
cellular response to zinc ion starvation2022
cellular response to tumor cell2024
cellular response to oleic acid2013
autophagy of mitochondrion2013
Cellular component: nucleus2001, 2003, 2009, 2011, 2013, 2019, 2020, 2021, 2023, 2024, 2025 cytoplasm2009, 2013, 2019, 2020, 2022, 2023, 2025 lysosomal membrane2020, 2023, 2025 nucleoplasm2004, 2024, 2025 cytosol2020, 2023, 2024, 2025 protein-containing complex2011, 2025 transcription regulator complex2005, 2025 chromatin2019
Phylogenetic distribution
| Chordates: | 22/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 3/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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MITF_MOUSE Ensembl» |
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Mitf | Microphthalmia-associated transcription factor |
Mus musculus TI:10090 None |
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MITF_RAT RGD» |
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Mitf | Microphthalmia-associated transcription factor |
Rattus norvegicus TI:10116 None |
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TFEB_MOUSE Ensembl» |
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Tfeb | Transcription factor EB |
Mus musculus TI:10090 None |
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TFEB_HUMAN Ensembl» |
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TFEB | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) |
Homo sapiens TI:9606 None |
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MITF_HUMAN Ensembl» |
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MITF | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) |
Homo sapiens TI:9606 None |
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TFE3_MOUSE Ensembl» |
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Tfe3 | Transcription factor E3 (mTFE3) |
Mus musculus TI:10090 None |
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HLH30_CAEEL WormBase» |
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hlh-30 | Helix-loop-helix protein 30 |
Caenorhabditis elegans TI:6239 None |
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TFE3_HUMAN Ensembl» |
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TFE3 | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) |
Homo sapiens TI:9606 None |
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C3KGP2_DROME FlyBase» |
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Mitf | MIP04163p (Mitf, isoform C) |
Drosophila melanogaster TI:7227 None |
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A0A8I6ATP3_RAT RGD» |
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Tfeb | Transcription factor EB |
Rattus norvegicus TI:10116 None |
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Q9PWC2_DANRE ZFIN» |
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mitfa | Melanocyte inducing transcription factor a isoform 1 (Melanocyte-inducing transcription factor a) (Microphthalmia-associated transcription factor a) (Microphthalmia-related protein) |
Danio rerio TI:7955 None |
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RTG3_YEAST SGD» |
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RTG3 | Retrograde regulation protein 3 |
Saccharomyces cerevisiae TI:4932 None |
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D3ZAW6_RAT RGD» |
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Tfe3 | Transcription factor binding to IGHM enhancer 3 |
Rattus norvegicus TI:10116 None |
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TFEC_RAT RGD» |
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Tfec | Transcription factor EC (TFE-C) (rTFEC) |
Rattus norvegicus TI:10116 None |
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TFEC_HUMAN Ensembl» |
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TFEC | Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) |
Homo sapiens TI:9606 None |
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TFEC_MOUSE Ensembl» |
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Tfec | Transcription factor EC (TFE-C) (mTFEC) |
Mus musculus TI:10090 None |
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F1Q885_DANRE ZFIN» |
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mitfb | Melanocyte-inducing transcription factor b (Microphthalmia-associated transcription factor b) |
Danio rerio TI:7955 None |
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Q561Z2_DANRE ZFIN» |
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tfe3a | Tfe3a protein (Transcription factor E3a) (Transcription factor binding to IGHM enhancer 3a) |
Danio rerio TI:7955 None |
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A0A8V1AD97_CHICK Ensembl» |
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TFEB | Transcription factor EB |
Gallus gallus TI:9031 None |
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A0A3Q2U6P0_CHICK Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Gallus gallus TI:9031 None |
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A0A8V0X7F5_CHICK Ensembl» |
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TFEC | Transcription factor EC |
Gallus gallus TI:9031 None |
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F1R1N1_DANRE ZFIN» |
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tfe3b | Transcription factor E3b isoform X1 (Transcription factor-binding to IGHM enhancer 3b) |
Danio rerio TI:7955 None |
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TFEC_CHICK CTD» |
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TFEC | Transcription factor EC (TFE-C) |
Gallus gallus TI:9031 None |
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A0A139WP70_TRICA euHCVdb» |
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AUGUSTUS-3.0.2_14225 | Transcription factor E3-like Protein |
Tribolium castaneum TI:7070 None |
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A0A1D5QF51_MACMU Ensembl» |
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TFE3 | Transcription factor E3 (Transcription factor binding to IGHM enhancer 3) |
Macaca mulatta TI:9544 None |
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A0A1D5QUV2_MACMU Ensembl» |
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TFEC | Transcription factor EC |
Macaca mulatta TI:9544 None |
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A0A1L8F5F4_XENLA Xenbase» |
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tfe3.L | Transcription factor E3 |
Xenopus laevis TI:8355 None |
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A0A287BAS8_PIG Ensembl» |
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TFEC | Transcription factor EC |
Sus scrofa TI:9823 None |
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|
A0A2A6BYJ1_PRIPA EnsemblMetazoa» |
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WBGene00202776 | Hlh-30 |
Pristionchus pacificus TI:54126 None |
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A0A2I2Y530_GORGO Ensembl» |
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TFEC | Transcription factor EC |
Gorilla gorilla TI:9593 None |
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A0A2I2YS93_GORGO Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Gorilla gorilla TI:9593 None |
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A0A2I2YXN7_GORGO Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Gorilla gorilla TI:9593 None |
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A0A2I3RWW4_PANTR Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Pan troglodytes TI:9598 None |
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A0A3B3HNN5_ORYLA Ensembl» |
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MITF | Melanocyte inducing transcription factor b |
Oryzias latipes TI:8090 None |
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A0A3B3I0H0_ORYLA Ensembl» |
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TFEC | Transcription factor EC |
Oryzias latipes TI:8090 None |
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A0A3B3ILR6_ORYLA Ensembl» |
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tfe3a | BHLH domain-containing protein |
Oryzias latipes TI:8090 None |
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A0A3Q1LFW9_BOVIN Ensembl» |
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TFEC | Transcription factor EC |
Bos taurus TI:9913 None |
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A0A5F5PRV7_HORSE Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Equus caballus TI:9796 None |
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A0A5F8GMJ1_MONDO Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Monodelphis domestica TI:13616 None |
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A0A6I8MYD3_ORNAN Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Ornithorhynchus anatinus TI:9258 None |
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A0A6I8N1N4_ORNAN Ensembl» |
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TFEC | Transcription factor EC |
Ornithorhynchus anatinus TI:9258 None |
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A0A7M7RDY6_STRPU EnsemblMetazoa» |
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BHLH domain-containing protein |
Strongylocentrotus purpuratus TI:7668 None |
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A0A803J330_XENTR Xenbase» |
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tfe3 | Transcription factor E3 (Transcription factor binding to IGHM enhancer 3) |
Xenopus tropicalis TI:8364 None |
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A0A803KCB8_XENTR Xenbase» |
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tfec | Transcription factor EC |
Xenopus tropicalis TI:8364 None |
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A0A803T982_ANOCA Ensembl» |
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TFEC | Transcription factor EC |
Anolis carolinensis TI:28377 None |
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A0A803TPW1_ANOCA Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Anolis carolinensis TI:28377 None |
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A0A8I3MZG5_CANLF Ensembl» |
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TFEC | Transcription factor EC |
Canis lupus TI:9612 None |
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A0A8I3N265_CANLF Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Canis lupus TI:9612 None |
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A0A8I3NYB7_CANLF Ensembl» |
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TFEB | Transcription factor EB |
Canis lupus TI:9612 None |
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A0A8I3S522_CANLF Ensembl» |
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MiT/TFE transcription factors N-terminal domain-containing protein |
Canis lupus TI:9612 None |
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A0A8I3S7X7_CANLF Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Canis lupus TI:9612 None |
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A0A8J0UR63_XENLA Xenbase» |
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tfec.L | Transcription factor EC |
Xenopus laevis TI:8355 None |
|
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||||||
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A0A8J0V374_XENLA Xenbase» |
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mitf.S | Melanocyte inducing transcription factor S homeolog isoform X1 |
Xenopus laevis TI:8355 None |
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A0A8J1J5S8_XENTR Xenbase» |
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tfeb | Transcription factor EB isoform X1 |
Xenopus tropicalis TI:8364 None |
|
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||||||
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A0A8J1MDJ3_XENLA CTD» |
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tfeb.S | Transcription factor EB isoform X1 |
Xenopus laevis TI:8355 None |
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A0A8J1MRN3_XENLA CTD» |
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LOC108713110 | Transcription factor EC |
Xenopus laevis TI:8355 None |
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A0A9J7MPM9_BRAFL neXtProt» |
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LOC118415416 | Microphthalmia-associated transcription factor-like isoform X1 |
Branchiostoma floridae TI:7739 None |
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A0AAA9SVL5_BOVIN Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Bos taurus TI:9913 None |
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A0AAA9TE54_BOVIN Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Bos taurus TI:9913 None |
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A0ABI7W1E1_FELCA Ensembl» |
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TFEC | Transcription factor EC |
Felis catus TI:9685 None |
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A0ABI7W2Z2_FELCA Ensembl» |
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MITF | BHLH domain-containing protein |
Felis catus TI:9685 None |
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A0ABI7W470_FELCA Ensembl» |
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TFE3 | BHLH domain-containing protein |
Felis catus TI:9685 None |
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A0ABI7ZFL3_FELCA Ensembl» |
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TFEB | BHLH domain-containing protein |
Felis catus TI:9685 None |
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A0ACD6B819_DANRE ZFIN» |
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tfeb | Transcription factor EB isoform X1 |
Danio rerio TI:7955 None |
|
|||||||
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A4IID0_XENTR Xenbase» |
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mitf | Microphthalmia-associated transcription factor (Mitf protein) |
Xenopus tropicalis TI:8364 None |
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A7RVM3_NEMVE neXtProt» |
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NEMVEDRAFT_v1g240998 | BHLH domain-containing protein |
Nematostella vectensis TI:45351 None |
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A7USK4_ANOGA EnsemblMetazoa» |
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5666790 | AGAP000807-PA |
Anopheles gambiae TI:7165 None |
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A8WZP5_CAEBR WormBase» |
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hlh-30 | Protein CBR-HLH-30 |
Caenorhabditis briggsae TI:6238 None |
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B3S741_TRIAD CTD» |
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TRIADDRAFT_60032 | BHLH domain-containing protein |
Trichoplax adhaerens TI:10228 None |
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B7Q780_IXOSC EnsemblMetazoa» |
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IscW_ISCW011795 | Helix-loop-helix transcription factor, putative |
Ixodes scapularis TI:6945 None |
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B7Q781_IXOSC EnsemblMetazoa» |
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IscW_ISCW011796 | Microphthalmia-associated transcription factor, putative |
Ixodes scapularis TI:6945 None |
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D2JUK3_PIG Ensembl» |
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MITF | Melanocyte inducing transcription factor (Microphtalmia-associated transcription factor isoform M) |
Sus scrofa TI:9823 None |
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E9FXN6_DAPPU euHCVdb» |
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DAPPUDRAFT_96359 | MiT/TFE transcription factors N-terminal domain-containing protein |
Daphnia pulex TI:6669 None |
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E9FXN7_DAPPU euHCVdb» |
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DAPPUDRAFT_28469 | BHLH domain-containing protein |
Daphnia pulex TI:6669 None |
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F1MX26_BOVIN Ensembl» |
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TFEB | Transcription factor EB |
Bos taurus TI:9913 None |
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F1RUY2_PIG Ensembl» |
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TFEB | Transcription factor EB (Transcription factor EB isoform X2) |
Sus scrofa TI:9823 None |
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F1RW57_PIG Ensembl» |
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TFE3 | Transcription factor E3 isoform 1 (Transcription factor binding to IGHM enhancer 3) |
Sus scrofa TI:9823 None |
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F5HIY4_ANOGA EnsemblMetazoa» |
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AgaP_AGAP013107 | AGAP013107-PA |
Anopheles gambiae TI:7165 None |
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F6QNF1_CIOIN Ensembl» |
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BHLH domain-containing protein |
Ciona intestinalis TI:7719 None |
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F6T5E1_HORSE Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Equus caballus TI:9796 None |
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F6TIG8_ORNAN Ensembl» |
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TFEB | Transcription factor EB |
Ornithorhynchus anatinus TI:9258 None |
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F7BMF4_HORSE Ensembl» |
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TFEC | Transcription factor EC |
Equus caballus TI:9796 None |
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F7DUA0_ORNAN Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Ornithorhynchus anatinus TI:9258 None |
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F7DUX6_MONDO Ensembl» |
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TFEC | Transcription factor EC |
Monodelphis domestica TI:13616 None |
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F7DV34_MONDO Ensembl» |
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MITF | Melanocyte inducing transcription factor |
Monodelphis domestica TI:13616 None |
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F7E1U7_HORSE Ensembl» |
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TFEB | Transcription factor EB |
Equus caballus TI:9796 None |
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||||||
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F7FA62_MONDO Ensembl» |
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BHLH domain-containing protein |
Monodelphis domestica TI:13616 None |
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|||||||
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F7FXN6_MACMU Ensembl» |
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TFEB | Transcription factor EB |
Macaca mulatta TI:9544 None |
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G1KB16_ANOCA Ensembl» |
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TFEB | Transcription factor EB |
Anolis carolinensis TI:28377 None |
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G3QJP3_GORGO Ensembl» |
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TFEB | Transcription factor EB |
Gorilla gorilla TI:9593 None |
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H2MGI4_ORYLA Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3b |
Oryzias latipes TI:8090 None |
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H2MMD1_ORYLA Ensembl» |
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tfeb | Transcription factor EB |
Oryzias latipes TI:8090 None |
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||||||
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H2QSZ5_PANTR Ensembl» |
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TFEB | Transcription factor EB |
Pan troglodytes TI:9598 None |
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H2QYK8_PANTR Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Pan troglodytes TI:9598 None |
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H8WHA0_CAEBR WormBase» |
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CBG24924 CBG_24924 | Protein CBG24924 |
Caenorhabditis briggsae TI:6238 None |
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|||||
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H9ELZ8_MACMU Ensembl» |
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MITF | Melanocyte inducing transcription factor (Microphthalmia-associated transcription factor isoform 1) |
Macaca mulatta TI:9544 None |
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|||||
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H9GTC2_ANOCA Ensembl» |
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TFE3 | Transcription factor binding to IGHM enhancer 3 |
Anolis carolinensis TI:28377 None |
|
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||||||
|
K9L437_ORYLA Ensembl» |
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mitfa | Melanocyte inducing transcription factor a (Microphthalmia-associated transcription factor 2 isoform m) (Mitf2) |
Oryzias latipes TI:8090 None |
|
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|||||
|
Q5XHC0_XENLA Xenbase» |
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tfe3.S | LOC495043 protein (Transcription factor binding to IGHM enhancer 3 S homeolog) |
Xenopus laevis TI:8355 None |
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|||||
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Q6C201_YARLI TubercuList» |
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YALI0_F11979g | YALI0F11979p |
Yarrowia lipolytica TI:4952 None |
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Q757M6_EREGS euHCVdb» |
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AGOS_AEL012C | AEL012Cp |
Eremothecium gossypii TI:33169 None |
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Q75A52_EREGS euHCVdb» |
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AGOS_ADR067W | ADR067Wp |
Eremothecium gossypii TI:33169 None |
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Q76DN3_XENLA euHCVdb» |
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Mitf-M | Melanocyte inducing transcription factor S homeolog isoform X8 (Microphthalmia-associated transcription factor type M) |
Xenopus laevis TI:8355 None |
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Q76DN4_XENLA Xenbase» |
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mitf.L | Melanocyte inducing transcription factor L homeolog (Micophthalmia-associated transcription factor type A) |
Xenopus laevis TI:8355 None |
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T1FGC6_HELRO EnsemblMetazoa» |
|
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20207875 | BHLH domain-containing protein |
Helobdella robusta TI:6412 None |
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T1FZB3_HELRO EnsemblMetazoa» |
|
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20214161 | BHLH domain-containing protein |
Helobdella robusta TI:6412 None |
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TFE3_BOVIN CTD» |
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|
TFE3 | Transcription factor E3 |
Bos taurus TI:9913 None |
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TFEC_BOVIN CTD» |
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|
TFEC | Transcription factor EC |
Bos taurus TI:9913 None |
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TFEC_PANTR Ensembl» |
|
|
TFEC | Transcription factor EC (TFE-C) |
Pan troglodytes TI:9598 None |
|
|
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W5MV93_LEPOC Ensembl» |
|
|
Melanocyte inducing transcription factor b |
Lepisosteus oculatus TI:7918 None |
|
|
|
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|
W5N2T2_LEPOC Ensembl» |
|
|
Transcription factor EB |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
|
W5NBS7_LEPOC Ensembl» |
|
|
Transcription factor binding to IGHM enhancer 3a |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
|
W5NG68_LEPOC Ensembl» |
|
|
Transcription factor EC |
Lepisosteus oculatus TI:7918 None |
|
|
|
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