Collated Gene Ontology terms

Biological process: transcription cis-regulatory region binding(2009, 2025) histone binding(2022, 2025) histone H3K4 methyltransferase activity(2013, 2025) zinc ion binding(2025) metal ion binding(2025) DNA-binding transcription factor activity(2025) DNA binding(2025)

Molecular function: DNA-templated transcription2025 chromatin organization2025 transcription initiation-coupled chromatin remodeling2015, 2022, 2025 response to estrogen2009, 2025 subtelomeric heterochromatin formation2021, 2024, 2025 regulation of DNA-templated transcription2013, 2025 telomere maintenance2013, 2025 DNA damage response2012 transdifferentiation2014, 2025 programmed cell death2021, 2025
heterochromatin organization2023, 2025 germ cell development2014, 2025 gene expression2025 egg-laying behavior2014, 2025 vegetative to reproductive phase transition of meristem2011 positive regulation of transcription elongation by RNA polymerase II2024 positive regulation of transcription by RNA polymerase II2024 positive regulation of mitotic nuclear division2014 heart development2025 G2/M transition of mitotic cell cycle2014

Cellular component: Set1C/COMPASS complex2004, 2010, 2012, 2013, 2023, 2025 nucleus2005, 2006, 2009, 2011, 2012, 2014, 2018, 2024, 2025 nucleoplasm2011, 2014, 2024, 2025 MLL3/4 complex2012, 2016, 2017, 2025 MLL1 complex2009, 2025 nucleolus2024, 2025 histone methyltransferase complex2009, 2012, 2025 chromosome, telomeric region2025 MLL1/2 complex2012, 2025 protein-containing complex2020
cytosol2009 chromatin2004

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
SWD1_YEAST
SGD»
4.6
SWD1 COMPASS component SWD1 (Complex proteins associated
with SET1 protein SWD1) (Set1C component SWD1)		 Saccharomyces cerevisiae
TI:4932 None
 
RBBP5_CAEEL
WormBase»
4.0
rbbp-5 Retinoblastoma-binding protein homolog 5 Caenorhabditis elegans
TI:6239 None
 
RBBP5_HUMAN
Ensembl»
4.0
RBBP5 Retinoblastoma-binding protein 5
(RBBP-5) (Retinoblastoma-binding protein RBQ-3)		 Homo sapiens
TI:9606 None
 
RBBP5_MOUSE
Ensembl»
3.3
Rbbp5 Retinoblastoma-binding protein 5 (RBBP-5) Mus musculus
TI:10090 None
 
D3ZC01_RAT
RGD»
3.0
Rbbp5 Retinoblastoma-binding protein 5 Rattus norvegicus
TI:10116 None
   
RBBP5_DROME
FlyBase»
2.0
Rbbp5 Retinoblastoma-binding protein 5 homolog Drosophila melanogaster
TI:7227 None
 
SWD1_SCHPO
PomBase»
1.6
swd1 Set1 complex component swd1 (Set1C component swd1) (COMPASS
component swd1) (Complex proteins associated with set1 protein swd1)		 Schizosaccharomyces pombe
TI:4896 None
 
RBBP_ARATH
TAIR»
0.8
RBL Protein RBL (COMPASS-like H3K4 histone methylation complex
component RBL) (RBBP5-like protein) (AtRbBp5) (Retinoblastoma-binding protein-like)		 Arabidopsis thaliana
TI:3702 None
 
A0A022QHX6_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a004535mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
A0A061FX18_THECC
neXtProt»
0.0
TCM_044422 Transducin/WD40 repeat-like superfamily protein Theobroma cacao
TI:3641 None
 
A0A067EM26_CITSI
neXtProt»
0.0
CISIN_1g0088442mg Uncharacterized protein Citrus sinensis
TI:2711 None
 
A0A078GSI8_BRANA
euHCVdb»
0.0
BnaC01g32310D BnaC01g32310D protein Brassica napus
TI:3708 None
 
A0A078HJ06_BRANA
euHCVdb»
0.0
BnaA01g25390D BnaA01g25390D protein Brassica napus
TI:3708 None
 
A0A0A0KR99_CUCSA
euHCVdb»
0.0
Csa_5G612300 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0K9NXL8_ZOSMR
neXtProt»
0.0
ZOSMA_52G00830 Retinoblastoma-binding protein Zostera marina
TI:29655 None
 
A0A0Q3HJY6_BRADI
EnsemblPlants»
0.0
LOC100829872 Uncharacterized protein Brachypodium distachyon
TI:15368 None
 
A0A0Q3QWJ3_SETIT
EnsemblPlants»
0.0
Uncharacterized protein Setaria italica
TI:4555 None
 
A0A0R0GMD3_SOYBN
EnsemblPlants»
0.0
LOC100816297 Uncharacterized protein Glycine max
TI:3847 None
 
A0A0R0JNH9_SOYBN
EnsemblPlants»
0.0
GLYMA_06G315900 Uncharacterized protein Glycine max
TI:3847 None
 
A0A1D5QC74_MACMU
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Macaca mulatta
TI:9544 None
   
A0A1S3Z1G2_TOBAC
euHCVdb»
0.0
LOC107781895 Protein RBL isoform X1 Nicotiana tabacum
TI:4097 None
   
A0A1S4H5C8_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A1U8AXX6_NELNU
euHCVdb»
0.0
LOC104607600 Protein RBL Nelumbo nucifera
TI:4432 None
   
A0A1U8B7W5_NELNU
euHCVdb»
0.0
LOC104611675 Protein RBL-like Nelumbo nucifera
TI:4432 None
   
A0A1U8P5D7_GOSHI
euHCVdb»
0.0
LOC107954465 Protein RBL Gossypium hirsutum
TI:3635 None
   
A0A1Y1ISZ9_KLENI
euHCVdb»
0.0
KFL_007620040 WD40 repeat protein Klebsormidium nitens
TI:105231 None
 
A0A1Z5SAU0_SORBI
euHCVdb»
0.0
SORBI_3001G462600 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
A0A251SI50_HELAN
neXtProt»
0.0
HannXRQ_Chr14g0446551 HanXRQr2_Chr14g0648701 Putative zinc finger, BED-type, Zinc finger, C2H2,
WD40/YVTN repeat-like-containing domain protein (Transcription factor WD40-like family)		 Helianthus annuus
TI:4232 None
 
A0A251TW65_HELAN
neXtProt»
0.0
HannXRQ_Chr09g0259631 HanXRQr2_Chr09g0391551 Putative transducin/WD40 repeat-like superfamily
protein (Transcription factor WD40-like family)		 Helianthus annuus
TI:4232 None
 
A0A2A6CX09_PRIPA
EnsemblMetazoa»
0.0
WBGene00091516 Rbbp-5 Pristionchus pacificus
TI:54126 None
   
A0A2C9UQ04_MANES
euHCVdb»
0.0
MANES_13G078700v8 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2I2ZE71_GORGO
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Gorilla gorilla
TI:9593 None
 
A0A2I4HHE9_JUGRE
euHCVdb»
0.0
LOC109017847 Protein RBL isoform X1 Juglans regia
TI:51240 None
   
A0A2K1JQT2_PHYPA
EnsemblPlants»
0.0
LOC112289829 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Physcomitrium patens
TI:3218 None
 
A0A2K1KML8_PHYPA
EnsemblPlants»
0.0
PHYPA_005907 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A0A2K3DYL9_CHLRE
neXtProt»
0.0
CHLRE_03g195750v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6X9H5_MARPO
euHCVdb»
0.0
MARPO_0028s0049 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
A0A317YBL4_MAIZE
EnsemblPlants»
0.0
RBL Protein RBL Zea mays
TI:4577 None
 
A0A3B3I1P7_ORYLA
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Oryzias latipes
TI:8090 None
   
A0A3B6HNB1_WHEAT
EnsemblPlants»
0.0
LOC123085020 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B6ITZ7_WHEAT
EnsemblPlants»
0.0
LOC123093044 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B6JLE4_WHEAT
EnsemblPlants»
0.0
LOC123098325 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3Q7EN42_SOLLC
EnsemblPlants»
0.0
Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
A0A7M7SVB1_STRPU
EnsemblMetazoa»
0.0
Retinoblastoma-binding protein 5 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7U2FCQ1_PHANO
TubercuList»
0.0
JI435_115570 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None
 
A0A803T2J8_ANOCA
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Anolis carolinensis
TI:28377 None
   
A0A804IIF6_MUSAM
EnsemblPlants»
0.0
GSMUA_187310.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A8D0NW66_PIG
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Sus scrofa
TI:9823 None
   
A0A8I3PRI4_CANLF
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Canis lupus
TI:9612 None
   
A0A8J1MDE2_XENLA
CTD»
0.0
rbbp5.S Retinoblastoma-binding protein 5 Xenopus laevis
TI:8355 None
   
A0A8M2BFL1_DANRE
ZFIN»
0.0
rbbp5 Retinoblastoma-binding protein 5 Danio rerio
TI:7955 None
   
A0A9J7L9X1_BRAFL
neXtProt»
0.0
LOC118417448 Retinoblastoma-binding protein 5 homolog Branchiostoma floridae
TI:7739 None
   
A0A9L0SIU1_HORSE
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Equus caballus
TI:9796 None
   
A0A9R0HR54_SPIOL
euHCVdb»
0.0
LOC110774646 Protein RBL Spinacia oleracea
TI:3562 None
   
A0A9R1VXN4_LACSA
euHCVdb»
0.0
LSAT_V11C400210980 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Lactuca sativa
TI:4236 None
 
A0ABI7YHR0_FELCA
Ensembl»
0.0
RBBP5 RB binding protein 5,
histone lysine methyltransferase complex subunit		 Felis catus
TI:9685 None
   
A0ABM3BFB9_GOSHI
neXtProt»
0.0
LOC107935533 Protein RBL Gossypium hirsutum
TI:3635 None
   
A2DH64_TRIV3
TubercuList»
0.0
TVAG_193500 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Trichomonas vaginalis
TI:5722 None
 
A2DRS0_TRIV3
TubercuList»
0.0
TVAG_150180 Uncharacterized protein Trichomonas vaginalis
TI:5722 None
 
A7EKS9_SCLS1
TubercuList»
0.0
SS1G_05926 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A7RYD1_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g31888 Retinoblastoma-binding protein 5 Nematostella vectensis
TI:45351 None
 
A8WU06_CAEBR
WormBase»
0.0
rbbp-5 Protein CBG02573 Caenorhabditis briggsae
TI:6238 None
 
B3SCU4_TRIAD
CTD»
0.0
TRIADDRAFT_33540 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
B6K146_SCHJY
TubercuList»
0.0
swd1 Set1C complex subunit Swd1 Schizosaccharomyces japonicus
TI:4897 None
 
B7PWV2_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW019990 Retinoblastoma binding protein, putative Ixodes scapularis
TI:6945 None
 
B8C7G9_THAPS
euHCVdb»
0.0
THAPSDRAFT_17952 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
B9GHA4_POPTR
euHCVdb»
0.0
POPTR_001G305500 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
B9SA71_RICCO
euHCVdb»
0.0
RCOM_0862780 Nucleotide binding protein, putative Ricinus communis
TI:3988 None
 
D6WGH2_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_03004 Retinoblastoma-binding protein
5 homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
D8RR87_SELML
neXtProt»
0.0
SELMODRAFT_413979 Minichromosome loss protein Mcl1
middle region domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8RX51_SELML
neXtProt»
0.0
SELMODRAFT_103410 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
E3LBL6_PUCGT
TubercuList»
0.0
PGTG_20001 Chromatin binding protein Puccinia graminis
TI:5297 None
 
E9GS67_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_321168 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZVI4_DICPU
TubercuList»
0.0
DICPUDRAFT_82100 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F2DIB6_HORVV
EnsemblPlants»
0.0
LOC123449373 Predicted protein Hordeum vulgare
TI:4513 None
 
F4P1V1_BATDJ
neXtProt»
0.0
BATDEDRAFT_35007 BZIP domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6GVB5_VITVI
neXtProt»
0.0
RBL_1 Protein RBL Vitis vinifera
TI:29760 None
 
F6QNY3_BOVIN
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Bos taurus
TI:9913 None
   
F6QZB2_XENTR
Xenbase»
0.0
rbbp5 Retinoblastoma-binding protein 5 Xenopus tropicalis
TI:8364 None
   
F6RMK8_MONDO
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Monodelphis domestica
TI:13616 None
   
F6WY47_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
   
F7FAW9_ORNAN
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Ornithorhynchus anatinus
TI:9258 None
   
G7KE36_MEDTR
EnsemblPlants»
0.0
MTR_5g069620 Retinoblastoma-binding-like protein Medicago truncatula
TI:3880 None
 
G7L7T0_MEDTR
EnsemblPlants»
0.0
11409786 Putative transcription factor
WD40-like family (Retinoblastoma-binding-like protein)		 Medicago truncatula
TI:3880 None
 
G7L7T3_MEDTR
EnsemblPlants»
0.0
25501141 Retinoblastoma-binding-like protein Medicago truncatula
TI:3880 None
 
H2RCM9_PANTR
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Pan troglodytes
TI:9598 None
 
H3GGV1_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
K4A759_SETIT
EnsemblPlants»
0.0
Uncharacterized protein Setaria italica
TI:4555 None
 
K7KJV9_SOYBN
EnsemblPlants»
0.0
LOC100818581 Uncharacterized protein Glycine max
TI:3847 None
 
K7KNW8_SOYBN
EnsemblPlants»
0.0
LOC100811475 Uncharacterized protein Glycine max
TI:3847 None
 
K7L897_SOYBN
EnsemblPlants»
0.0
LOC100786748 Uncharacterized protein Glycine max
TI:3847 None
 
M1CMP6_SOLTU
EnsemblPlants»
0.0
LOC102602044 Nucleotide binding protein Solanum tuberosum
TI:4113 None
   
M4E554_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
M5WBL3_PRUPE
euHCVdb»
0.0
PRUPE_5G058900 Uncharacterized protein Prunus persica
TI:3760 None
 
Q1S5M0_MEDTR
EnsemblPlants»
0.0
11407712 Putative transcription factor
WD40-like family (Retinoblastoma-binding-like protein)		 Medicago truncatula
TI:3880 None
 
Q4WRY4_ASPFU
TubercuList»
0.0
AFUA_1G14670 WD repeat protein Aspergillus fumigatus
TI:746128 None
 
Q5A7S8_CANAL
CGD»
0.0
SWD1 COMPASS subunit protein Candida albicans
TI:5476 None
 
Q5BF72_EMENI
TubercuList»
0.0
ANIA_00808 WD repeat protein (AFU_orthologue AFUA_1G14670) Emericella nidulans
TI:162425 None
 
Q5KKF8_CRYD1
TubercuList»
0.0
CNC03150 Transcriptional activator, putative Cryptococcus deneoformans
TI:40410 None
 
Q5ZLX3_CHICK
Ensembl»
0.0
RBBP5 Retinoblastoma-binding protein 5 Gallus gallus
TI:9031 None
 
Q6CB07_YARLI
TubercuList»
0.0
YALI0_C22858g YALI0C22858p Yarrowia lipolytica
TI:4952 None
 
Q754S7_EREGS
euHCVdb»
0.0
AGOS_AFL006C AFL006Cp Eremothecium gossypii
TI:33169 None
 
Q7SDM9_NEUCR
TubercuList»
0.0
NCU02104 WD domain-containing protein Neurospora crassa
TI:5141 None
 
Q8H060_ORYSJ
euHCVdb»
0.0
LOC_Os03g10990 Os03g0207900 Os03g0207900 protein (Retinoblastoma-binding
protein, putative, expressed)		 Oryza sativa
TI:4530 None
 
Q8IC38_PLAF7
TubercuList»
0.0
PF3D7_0703200 Uncharacterized protein Plasmodium falciparum
TI:5833 None
 
RBBE_DICDI
dictyBase»
0.0
rbbE Retinoblastoma-binding-like protein E Dictyostelium discoideum
TI:44689 None
 
T1FN14_HELRO
EnsemblMetazoa»
0.0
20210213 Uncharacterized protein Helobdella robusta
TI:6412 None
 
U5FF12_POPTR
euHCVdb»
0.0
POPTR_019G000900 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
W1NLL9_AMBTC
euHCVdb»
0.0
AMTR_s00001p00273050 Uncharacterized protein Amborella trichopoda
TI:13333 None
 
W5N041_LEPOC
Ensembl»
0.0
Retinoblastoma-binding protein 5 Lepisosteus oculatus
TI:7918 None