Collated Gene Ontology terms

Biological process: dioxygenase activity(2025) oxidoreductase activity(2025) metal ion binding(2025) tRNA demethylase activity(2025) oxidative RNA demethylase activity(2025) 2-oxoglutarate-dependent dioxygenase activity(2022, 2025) transferase activity(2025) tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity(2023, 2025) methyltransferase activity(2025) histone binding(2011, 2025)
ferrous iron binding2011, 2025 tRNA binding2017 protein kinase activity2025 nucleotide binding2025 L-ascorbic acid binding2025 ATP binding2025

Molecular function: DNA damage response2013, 2025 fatty acid metabolic process2013, 2014, 2021, 2025 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death2014, 2024, 2025 programmed cell death2025 oxidative RNA demethylation2025 regulation of lipid storage2013, 2025 methylation2025 cellular response to hypoxia2009, 2025 tRNA wobble uridine modification2024 tRNA methylation2025

Cellular component: mitochondrial matrix2013, 2021, 2024, 2025 mitochondrion2009, 2014, 2024, 2025 nucleus2009, 2011, 2018, 2025 cytoplasm2017, 2025 nuclear lumen2017 ciliary plasm2017 chromatin2015, 2025 nucleolus2011 kinetoplast2025 cytosol2009

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 6/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A022S360_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a012176mg Fe2OG dioxygenase domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A061DRI2_THECC
euHCVdb»
0.0
TCM_004624 2-oxoglutarate and Fe(II)-dependent
oxygenase superfamily protein		 Theobroma cacao
TI:3641 None
 
A0A067HGW5_CITSI
euHCVdb»
0.0
CISIN_1g024968mg Fe2OG dioxygenase domain-containing protein Citrus sinensis
TI:2711 None
 
A0A078G9N5_BRANA
euHCVdb»
0.0
BnaA09g00830D BnaA09g00830D protein Brassica napus
TI:3708 None
 
A0A078IHE7_BRANA
euHCVdb»
0.0
BnaCnng19120D BnaCnng19120D protein Brassica napus
TI:3708 None
 
A0A0A0KV56_CUCSA
euHCVdb»
0.0
Csa_4G001660 Fe2OG dioxygenase domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0Q3L4A4_BRADI
EnsemblPlants»
0.0
LOC100835151 Fe2OG dioxygenase domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A0R0GIH9_SOYBN
EnsemblPlants»
0.0
GLYMA_14G026500 Protein kinase domain-containing protein Glycine max
TI:3847 None
 
A0A139WDN1_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_33955 Alpha-ketoglutarate-dependent dioxygenase alkB
homolog 7, mitochondrial-like Protein		 Tribolium castaneum
TI:7070 None
 
A0A1D5RAC5_MACMU
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Macaca mulatta
TI:9544 None
   
A0A1L8H331_XENLA
Xenbase»
0.0
alkbh7.L Alpha-ketoglutarate-dependent dioxygenase alkB homolog
7, mitochondrial isoform X1		 Xenopus laevis
TI:8355 None
   
A0A1S3Z8F0_TOBAC
neXtProt»
0.0
LOC107784116 Alkylated DNA repair protein alkB homolog
8 isoform X1 (Uncharacterized protein LOC107784116)		 Nicotiana tabacum
TI:4097 None
   
A0A1S4B1G8_TOBAC
euHCVdb»
0.0
LOC107803554 Alkylated DNA repair protein alkB homolog 8
isoform X1 (Uncharacterized protein P8A3.02c isoform X1)		 Nicotiana tabacum
TI:4097 None
   
A0A1U8ABW5_NELNU
euHCVdb»
0.0
LOC104598977 Alkylated DNA repair protein
alkB homolog 8 isoform X5		 Nelumbo nucifera
TI:4432 None
   
A0A1U8LQR0_GOSHI
euHCVdb»
0.0
LOC107929857 Alkylated DNA repair protein alkB homolog 8 Gossypium hirsutum
TI:3635 None
   
A0A1U8MSY5_GOSHI
neXtProt»
0.0
LOC107940991 Alkylated DNA repair protein alkB homolog 8 Gossypium hirsutum
TI:3635 None
   
A0A1Y1I2R0_KLENI
euHCVdb»
0.0
KFL_002240070 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Klebsormidium nitens
TI:105231 None
 
A0A251S4R7_HELAN
euHCVdb»
0.0
HannXRQ_Chr15g0465711 HanXRQr2_Chr15g0673401 Putative 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase
superfamily protein (tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase (EC 2.1.1.229))		 Helianthus annuus
TI:4232 None
 
A0A2C9VTV7_MANES
euHCVdb»
0.0
MANES_05G063800v8 Fe2OG dioxygenase domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2G2ZW56_CAPAN
neXtProt»
0.0
T459_08301 Fe2OG dioxygenase domain-containing protein Capsicum annuum
TI:4072 None
 
A0A2I2YF29_GORGO
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Gorilla gorilla
TI:9593 None
 
A0A2I4E758_JUGRE
euHCVdb»
0.0
LOC108986878 Alkylated DNA repair protein ALKBH8 homolog Juglans regia
TI:51240 None
   
A0A2K1IYQ8_PHYPA
EnsemblPlants»
0.0
LOC112295982 Fe2OG dioxygenase domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K1XUW5_POPTR
neXtProt»
0.0
POPTR_014G131200 Fe2OG dioxygenase domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2K3CS77_CHLRE
neXtProt»
0.0
CHLRE_16g695851v5 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6XSS9_MARPO
neXtProt»
0.0
MARPO_0003s0075 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Marchantia polymorpha
TI:3197 None
 
A0A3B6NVV8_WHEAT
EnsemblPlants»
0.0
LOC123131075 Fe2OG dioxygenase domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6PT00_WHEAT
EnsemblPlants»
0.0
LOC123134677 Fe2OG dioxygenase domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6QM43_WHEAT
EnsemblPlants»
0.0
LOC123145715 Fe2OG dioxygenase domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3Q7I5Q5_SOLLC
EnsemblPlants»
0.0
LOC101250926 Fe2OG dioxygenase domain-containing protein Solanum lycopersicum
TI:4081 None
   
A0A6I8PNL5_ORNAN
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7HKI6_STRPU
EnsemblMetazoa»
0.0
Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SXG8_ANOCA
Ensembl»
0.0
LOC100555519 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Anolis carolinensis
TI:28377 None
   
A0A804L8N8_MUSAM
EnsemblPlants»
0.0
Fe2OG dioxygenase domain-containing protein Musa acuminata
TI:4641 None
   
A0A804MVY1_MAIZE
EnsemblPlants»
0.0
LOC100217124 Fe2OG dioxygenase domain-containing protein Zea mays
TI:4577 None
   
A0A8I3NI00_CANLF
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Canis lupus
TI:9612 None
   
A0A9J7NCK1_BRAFL
neXtProt»
0.0
LOC118431761 Alpha-ketoglutarate-dependent dioxygenase alkB
homolog 7, mitochondrial-like		 Branchiostoma floridae
TI:7739 None
   
A0A9L0TPH0_HORSE
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Equus caballus
TI:9796 None
   
A0A9R1UIQ0_LACSA
euHCVdb»
0.0
LSAT_V11C900456300 Fe2OG dioxygenase domain-containing protein Lactuca sativa
TI:4236 None
 
A0AAF6ZCQ2_BOVIN
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Bos taurus
TI:9913 None
   
A0ABI8ASC7_FELCA
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Felis catus
TI:9685 None
   
A0ABM3R0B5_SPIOL
neXtProt»
0.0
LOC110788614 Uncharacterized protein isoform X1 Spinacia oleracea
TI:3562 None
   
A7SDG8_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g114209 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A8X5C5_CAEBR
WormBase»
0.0
alkb-7 Protein CBG07885 Caenorhabditis briggsae
TI:6238 None
 
A9UXP3_MONBE
euHCVdb»
0.0
MONBRDRAFT_24773 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
A9UXP9_MONBE
euHCVdb»
0.0
MONBRDRAFT_24779 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
ALKB7_BOVIN
CTD»
0.0
ALKBH7 RNA demethylase ALKBH7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair
protein alkB homolog 7) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial)		 Bos taurus
TI:9913 None
 
ALKB7_HUMAN
Ensembl»
5.5
ALKBH7 RNA demethylase ALKBH7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7,
mitochondrial) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11) (pre-tRNA N1-methyl adenine demethylase ALKBH7) (pre-tRNA N2-dimethyl guanosine demethylase ALKBH7)		 Homo sapiens
TI:9606 None
 
ALKB7_MOUSE
Ensembl»
7.1
Alkbh7 RNA demethylase ALKBH7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair
protein alkB homolog 7) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial)		 Mus musculus
TI:10090 None
 
B3S3R8_TRIAD
CTD»
0.0
TRIADDRAFT_28544 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
B6JV21_SCHJY
TubercuList»
0.0
ofd2 2 OG-Fe(II) oxygenase superfamily protein Ofd2 Schizosaccharomyces japonicus
TI:4897 None
 
B7PDP2_IXOSC
EnsemblMetazoa»
0.0
8028371 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Ixodes scapularis
TI:6945 None
 
B8BQR0_THAPS
neXtProt»
0.0
THAPSDRAFT_31380 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Thalassiosira pseudonana
TI:35128 None
 
B9T0W3_RICCO
euHCVdb»
0.0
RCOM_1439870 Fe2OG dioxygenase domain-containing protein Ricinus communis
TI:3988 None
 
C5Y7E7_SORBI
neXtProt»
0.0
SORBI_3005G204400 Fe2OG dioxygenase domain-containing protein Sorghum bicolor
TI:4558 None
 
D7U265_VITVI
euHCVdb»
0.0
VIT_07s0005g00160 Fe2OG dioxygenase domain-containing protein Vitis vinifera
TI:29760 None
 
D8QT65_SELML
neXtProt»
0.0
SELMODRAFT_165238 Fe2OG dioxygenase domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8R2E8_SELML
neXtProt»
0.0
SELMODRAFT_230539 Fe2OG dioxygenase domain-containing protein Selaginella moellendorffii
TI:88036 None
 
E3JUY1_PUCGT
TubercuList»
0.0
PGTG_01187 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Puccinia graminis
TI:5297 None
 
E3L532_PUCGT
TubercuList»
0.0
PGTG_17513 Fe2OG dioxygenase domain-containing protein Puccinia graminis
TI:5297 None
 
E9GBB5_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_100794 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Daphnia pulex
TI:6669 None
 
F1SBT3_PIG
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Sus scrofa
TI:9823 None
   
F4NSQ8_BATDJ
euHCVdb»
0.0
BATDEDRAFT_22164 Fe2OG dioxygenase domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F4NXK5_BATDJ
euHCVdb»
0.0
BATDEDRAFT_22790 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F4P2L5_BATDJ
euHCVdb»
0.0
BATDEDRAFT_88958 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F4PF23_BATDJ
euHCVdb»
0.0
BATDEDRAFT_15023 Fe2OG dioxygenase domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F4PF30_BATDJ
euHCVdb»
0.0
BATDEDRAFT_15031 Fe2OG dioxygenase domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F5HJY0_ANOGA
EnsemblMetazoa»
0.0
1272350 AGAP000760-PA (AGAP000760-PB) (AGAP000760-PC) Anopheles gambiae
TI:7165 None
 
F6WL76_XENTR
Xenbase»
0.0
alkbh7 AlkB homolog 7 Xenopus tropicalis
TI:8364 None
   
F7AW28_CIOIN
Ensembl»
0.0
Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Ciona intestinalis
TI:7719 None
 
G7K3F0_MEDTR
EnsemblPlants»
0.0
11436623 2OG-Fe(II) oxygenase family oxidoreductase
(Putative tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase (EC 2.1.1.229))		 Medicago truncatula
TI:3880 None
 
H2MX03_ORYLA
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Oryzias latipes
TI:8090 None
   
H2QF45_PANTR
Ensembl»
0.0
ALKBH7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Pan troglodytes
TI:9598 None
 
H3H396_PHYRM
EnsemblProtists»
0.0
Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
K3ZMH9_SETIT
EnsemblPlants»
0.0
LOC101759691 Fe2OG dioxygenase domain-containing protein Setaria italica
TI:4555 None
 
M0R7T2_RAT
RGD»
4.0
Alkbh7 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Rattus norvegicus
TI:10116 None
   
M0VAG3_HORVV
EnsemblPlants»
0.0
LOC123401543 Uncharacterized protein Hordeum vulgare
TI:4513 None
   
M1AT59_SOLTU
EnsemblPlants»
0.0
Fe2OG dioxygenase domain-containing protein Solanum tuberosum
TI:4113 None
   
M4F5A7_BRACM
EnsemblPlants»
0.0
Fe2OG dioxygenase domain-containing protein Brassica campestris
TI:3711 None
   
M5VJ71_PRUPE
euHCVdb»
0.0
PRUPE_8G258600 Uncharacterized protein Prunus persica
TI:3760 None
 
Q1ECQ5_ARATH
TAIR»
0.5
At4g02485 2-oxoglutarate (2OG) and Fe(II)-dependent
oxygenase superfamily protein (At4g02485)		 Arabidopsis thaliana
TI:3702 None
 
Q2R067_ORYSJ
euHCVdb»
0.0
LOC_Os11g43610 Os11g0657200 Os11g0657200 protein (Oxidoreductase, 2OG-Fe oxygenase family protein,
putative, expressed) (cDNA clone:006-211-E11, full insert sequence)		 Oryza sativa
TI:4530 None
 
Q383D9_TRYB2
TubercuList»
0.0
Tb11.01.3200 Uncharacterized protein Trypanosoma brucei
TI:5691 None
 
Q4Q7Z1_LEIMA
TubercuList»
0.0
LMJF_28_2710 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Leishmania major
TI:5664 None
 
Q566X4_DANRE
ZFIN»
0.5
alkbh7 Alpha-ketoglutarate-dependent dioxygenase alkB
homolog 7, mitochondrial (Zgc:112404)		 Danio rerio
TI:7955 None
 
Q57W43_TRYB2
TubercuList»
0.0
Tb05.28F8.370 Fe2OG dioxygenase domain-containing protein Trypanosoma brucei
TI:5691 None
 
Q5KJN7_CRYD1
TubercuList»
0.0
CNC05880 Fe2OG dioxygenase domain-containing protein Cryptococcus deneoformans
TI:40410 None
 
Q7YWP5_CAEEL
WormBase»
0.5
alkb-7 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
Q9GNH7_LEIMA
TubercuList»
0.0
L3377.4 Uncharacterized protein L3377.4 Leishmania major
TI:5664 None
 
Q9VTP1_DROME
FlyBase»
1.5
Dmel\CG14130 IP06473p Drosophila melanogaster
TI:7227 None
 
T1G2N9_HELRO
EnsemblMetazoa»
0.0
20215337 Alpha-ketoglutarate-dependent dioxygenase
AlkB-like domain-containing protein		 Helobdella robusta
TI:6412 None
 
W1P3J5_AMBTC
neXtProt»
0.0
AMTR_s00045p00203370 Fe2OG dioxygenase domain-containing protein Amborella trichopoda
TI:13333 None
 
W5MH42_LEPOC
Ensembl»
0.0
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
(Alkylated DNA repair protein alkB homolog 7)		 Lepisosteus oculatus
TI:7918 None
 
YLW2_SCHPO
PomBase»
4.2
SPAP8A3.02c Uncharacterized protein P8A3.02c Schizosaccharomyces pombe
TI:4896 None