Collated Gene Ontology terms

Biological process: membrane insertase activity(2020, 2022, 2025)

Molecular function: protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 tail-anchored membrane protein insertion into ER membrane2020, 2022, 2024, 2025

Cellular component: EMC complex2012, 2020, 2025 endoplasmic reticulum membrane2024, 2025 cytoplasm2012, 2025 endoplasmic reticulum2016, 2017, 2021, 2024, 2025 striated muscle dense body2012 plastid2019 peroxisome2017 nucleus2018 nuclear envelope2025 mitochondrion2007
membrane2014 endomembrane system2014 Golgi apparatus2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 4/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
EMC8_MOUSE
Ensembl»
4.5
Emc8 ER membrane protein complex
subunit 8 (Neighbor of COX4)		 Mus musculus
TI:10090 None
 
EMC8_RAT
RGD»
4.5
Emc8 ER membrane protein complex
subunit 8 (Neighbor of COX4)		 Rattus norvegicus
TI:10116 None
 
EMC9_MOUSE
Ensembl»
4.5
Emc9 ER membrane protein complex
subunit 9 (Protein FAM158A)		 Mus musculus
TI:10090 None
 
EMC9_RAT
RGD»
4.5
Emc9 ER membrane protein complex
subunit 9 (Protein FAM158A)		 Rattus norvegicus
TI:10116 None
 
EMC8_HUMAN
Ensembl»
4.7
EMC8 ER membrane protein complex subunit
8 (Neighbor of COX4) (Protein FAM158B)		 Homo sapiens
TI:9606 None
 
EMC89_DROME
FlyBase»
4.8
EMC8-9 ER membrane protein complex subunit 8/9 homolog Drosophila melanogaster
TI:7227 None
 
EMC9_HUMAN
Ensembl»
4.7
EMC9 ER membrane protein complex
subunit 9 (Protein FAM158A)		 Homo sapiens
TI:9606 None
 
A0A6I8PEL9_ORNAN
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Ornithorhynchus anatinus
TI:9258 None
   
EMC8_BOVIN
CTD»
0.0
EMC8 ER membrane protein complex
subunit 8 (Neighbor of COX4)		 Bos taurus
TI:9913 None
 
F1N5N2_BOVIN
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Bos taurus
TI:9913 None
   
G3RLC5_GORGO
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Gorilla gorilla
TI:9593 None
 
H2QBN4_PANTR
Ensembl»
0.0
EMC8 COX4 neighbor (ER membrane
protein complex subunit 8)		 Pan troglodytes
TI:9598 None
 
A0A3Q2HTF6_HORSE
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Equus caballus
TI:9796 None
   
A0A5F8HG77_MONDO
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Monodelphis domestica
TI:13616 None
   
A0A6I8NEX8_ORNAN
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Ornithorhynchus anatinus
TI:9258 None
   
E1BF12_BOVIN
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Bos taurus
TI:9913 None
   
F1N8E6_CHICK
Ensembl»
1.5
EMC8 ER membrane protein complex subunit 8 Gallus gallus
TI:9031 None
   
F1SGM2_PIG
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Sus scrofa
TI:9823 None
 
H2Q819_PANTR
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9
(Family with sequence similarity 158, member A)		 Pan troglodytes
TI:9598 None
 
H9GAA6_ANOCA
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Anolis carolinensis
TI:28377 None
   
Q580G6_TRYB2
TubercuList»
0.0
Tb08.29O9.280 MPN domain-containing protein Trypanosoma brucei
TI:5691 None
 
EMC89_ARATH
TAIR»
1.5
EMB2731 ER membrane protein complex subunit
8/9 homolog (Protein EMBRYO DEFECTIVE 2731)		 Arabidopsis thaliana
TI:3702 None
 
Q93568_CAEEL
WormBase»
1.5
CELE_F25H2.4 F25H2.4 MPN domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A1D5R636_MACMU
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Macaca mulatta
TI:9544 None
   
A0A8I3MPT8_CANLF
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Canis lupus
TI:9612 None
   
A0A8I3N960_CANLF
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Canis lupus
TI:9612 None
   
F6QIS0_MONDO
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Monodelphis domestica
TI:13616 None
   
F7FF56_MACMU
Ensembl»
0.0
EMC9 ER membrane protein complex
subunit 9 (UPF0172 protein FAM158A)		 Macaca mulatta
TI:9544 None
 
F7FT91_MONDO
Ensembl»
0.0
LOC103094817 MPN domain-containing protein Monodelphis domestica
TI:13616 None
   
Q4QIR5_LEIMA
TubercuList»
0.0
LMJF_07_0290 MPN domain-containing protein Leishmania major
TI:5664 None
 
A0A022R4F1_ERYGU
neXtProt»
0.0
MIMGU_mgv1a014067mg MPN domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A061F4Y0_THECC
neXtProt»
0.0
TCM_030596 UPF0172 protein Theobroma cacao
TI:3641 None
 
A0A067EVQ6_CITSI
neXtProt»
0.0
CISIN_1g028839mg MPN domain-containing protein Citrus sinensis
TI:2711 None
 
A0A078FIN8_BRANA
neXtProt»
0.0
BnaC03g13940D (rape) hypothetical
protein (BnaC03g13940D protein)		 Brassica napus
TI:3708 None
 
A0A078GU45_BRANA
euHCVdb»
0.0
BnaC09g32480D (rape) hypothetical protein
(BnaA10g10020D protein) (BnaC09g32480D protein)		 Brassica napus
TI:3708 None
 
A0A078HEI0_BRANA
euHCVdb»
0.0
BnaA03g11160D (rape) hypothetical
protein (BnaA03g11160D protein)		 Brassica napus
TI:3708 None
 
A0A078JEU1_BRANA
euHCVdb»
0.0
BnaA02g35420D (rape) hypothetical
protein (BnaA02g35420D protein)		 Brassica napus
TI:3708 None
 
A0A0A0KYR9_CUCSA
neXtProt»
0.0
Csa_4G419600 MPN domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0K9PMK0_ZOSMR
neXtProt»
0.0
ZOSMA_1G02770 Putative Neighbor of COX4 Zostera marina
TI:29655 None
 
A0A0S2M5R0_CRYD1
TubercuList»
0.0
CNG02035 MPN domain-containing protein Cryptococcus deneoformans
TI:40410 None
 
A0A1B6QID0_SORBI
euHCVdb»
0.0
SORBI_3001G105100 MPN domain-containing protein Sorghum bicolor
TI:4558 None
 
A0A1D5V0Z3_WHEAT
EnsemblPlants»
0.0
LOC123051333 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A1L8GKZ9_XENLA
Xenbase»
0.0
emc8.L ER membrane protein complex subunit 8 Xenopus laevis
TI:8355 None
   
A0A1S4BDS5_TOBAC
neXtProt»
0.0
LOC107807154 ER membrane protein complex subunit 8/9 homolog Nicotiana tabacum
TI:4097 None
   
A0A1U7ZD14_NELNU
euHCVdb»
0.0
LOC104588827 ER membrane protein complex subunit 8/9 homolog Nelumbo nucifera
TI:4432 None
   
A0A1U8BIH7_NELNU
euHCVdb»
0.0
LOC104611464 ER membrane protein complex subunit 8/9 homolog Nelumbo nucifera
TI:4432 None
   
A0A1U8HGZ8_CAPAN
euHCVdb»
0.0
T459_18844 ER membrane protein complex
subunit 8/9 -like protein		 Capsicum annuum
TI:4072 None
 
A0A1U8L0R2_GOSHI
euHCVdb»
0.0
LOC107922609 ER membrane protein complex subunit 8/9 homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8LYY8_GOSHI
euHCVdb»
0.0
LOC107931188 ER membrane protein complex subunit 8/9 homolog Gossypium hirsutum
TI:3635 None
   
A0A1Y1IGU9_KLENI
neXtProt»
0.0
KFL_003480120 MPN domain-containing protein Klebsormidium nitens
TI:105231 None
 
A0A251TA53_HELAN
euHCVdb»
0.0
EMC9 ER membrane protein complex subunit 8/9
(Putative ER membrane protein complex subunit 9)		 Helianthus annuus
TI:4232 None
 
A0A251V287_HELAN
euHCVdb»
0.0
HannXRQ_Chr04g0114541 HanXRQr2_Chr06g0270901 ER membrane protein complex subunit 8/9 Helianthus annuus
TI:4232 None
 
A0A2A6BGY9_PRIPA
EnsemblMetazoa»
0.0
WBGene00116297 MPN domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A2C9UED2_MANES
neXtProt»
0.0
MANES_15G058100v8 MPN domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2I4E202_JUGRE
euHCVdb»
0.0
LOC108985544 ER membrane protein complex subunit 8/9 homolog Juglans regia
TI:51240 None
   
A0A2I4F1U0_JUGRE
euHCVdb»
0.0
LOC108994741 ER membrane protein complex subunit 8/9 homolog Juglans regia
TI:51240 None
   
A0A2K1J4E0_PHYPA
EnsemblPlants»
0.0
LOC112294016 MPN domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K1JIJ2_PHYPA
EnsemblPlants»
0.0
PHYPA_018777 MPN domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K2C9P5_POPTR
euHCVdb»
0.0
POPTR_001G370000 MPN domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2R6WAL4_MARPO
euHCVdb»
0.0
MARPO_0118s0025 MPN domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A3B3IGA6_ORYLA
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Oryzias latipes
TI:8090 None
   
A0A3B6AQU5_WHEAT
EnsemblPlants»
0.0
LOC123187285 MPN domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6C1S1_WHEAT
EnsemblPlants»
0.0
LOC123043473 MPN domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3Q7H4R2_SOLLC
EnsemblPlants»
0.0
LOC101268196 MPN domain-containing protein Solanum lycopersicum
TI:4081 None
   
A0A5G2QJM6_PIG
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Sus scrofa
TI:9823 None
   
A0A7M7N6P8_STRPU
EnsemblMetazoa»
0.0
MPN domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A804HPV9_MUSAM
EnsemblPlants»
0.0
GSMUA_287370.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A8I6X1I3_HORVV
EnsemblPlants»
0.0
LOC123424568 MPN domain-containing protein Hordeum vulgare
TI:4513 None
   
A0A9R0JFQ5_SPIOL
euHCVdb»
0.0
LOC110805671 ER membrane protein complex subunit 8/9 homolog Spinacia oleracea
TI:3562 None
   
A0A9R1VGY2_LACSA
neXtProt»
0.0
LSAT_V11C500298300 MPN domain-containing protein Lactuca sativa
TI:4236 None
 
A0CVM0_PARTE
euHCVdb»
0.0
GSPATT00011005001 MPN domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0D917_PARTE
neXtProt»
0.0
GSPATT00014480001 MPN domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A7RMN9_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g160601 MPN domain-containing protein Nematostella vectensis
TI:45351 None
 
A8WS69_CAEBR
WormBase»
0.0
CBG02246 CBG_02246 Protein CBG02246 Caenorhabditis briggsae
TI:6238 None
 
A9UQH6_MONBE
euHCVdb»
0.0
MONBRDRAFT_22408 MPN domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3S6U6_TRIAD
CTD»
0.0
TRIADDRAFT_29978 MPN domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B6T5Q6_MAIZE
EnsemblPlants»
0.0
LOC100276147 ER membrane protein
complex subunit 8/9-like protein		 Zea mays
TI:4577 None
 
B7P0N7_IXOSC
EnsemblMetazoa»
0.0
8023129 COX4 neighbor protein, putative Ixodes scapularis
TI:6945 None
 
B8C265_THAPS
neXtProt»
0.0
THAPSDRAFT_5178 MPN domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B9GFZ6_POPTR
euHCVdb»
0.0
POPTR_001G370200 MPN domain-containing protein Populus trichocarpa
TI:3694 None
 
B9S9X3_RICCO
euHCVdb»
0.0
RCOM_0523270 Neighbor of COX4, putative Ricinus communis
TI:3988 None
 
C3ZBN0_BRAFL
neXtProt»
0.0
LOC118417765 ER membrane protein complex subunit 8-like Branchiostoma floridae
TI:7739 None
 
C5YDD7_SORBI
euHCVdb»
0.0
SORBI_3006G034800 MPN domain-containing protein Sorghum bicolor
TI:4558 None
 
C6SYG0_SOYBN
EnsemblPlants»
0.0
LOC100306212 MPN domain-containing protein Glycine max
TI:3847 None
 
C6T3E5_SOYBN
EnsemblPlants»
0.0
LOC100527135 MPN domain-containing protein Glycine max
TI:3847 None
 
D6WHD0_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_02922 ER membrane protein complex
subunit 8/9 homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
D7UAL1_VITVI
euHCVdb»
0.0
VIT_19s0015g00910 MPN domain-containing protein Vitis vinifera
TI:29760 None
 
D8QNN0_SELML
euHCVdb»
0.0
SELMODRAFT_73953 MPN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8RDW5_SELML
neXtProt»
0.0
SELMODRAFT_91476 MPN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
E3KPT4_PUCGT
TubercuList»
0.0
PGTG_12275 MPN domain-containing protein Puccinia graminis
TI:5297 None
 
E9H1Y4_DAPPU
neXtProt»
0.0
DAPPUDRAFT_307352 MPN domain-containing protein Daphnia pulex
TI:6669 None
 
EMC89_DICDI
dictyBase»
1.5
DDB_G0268048 ER membrane protein complex subunit 8/9 homolog Dictyostelium discoideum
TI:44689 None
 
F0ZM58_DICPU
TubercuList»
0.0
DICPUDRAFT_79295 MPN domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F4P6T5_BATDJ
euHCVdb»
0.0
BATDEDRAFT_90046 MPN domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6SMK1_XENTR
Xenbase»
0.0
emc9 ER membrane protein complex subunit 9 Xenopus tropicalis
TI:8364 None
   
G7KEJ5_MEDTR
EnsemblPlants»
0.0
11433699 ER membrane protein complex subunit-like protein
(Putative ER membrane protein complex subunit 8/9)		 Medicago truncatula
TI:3880 None
 
H2XJW9_CIOIN
Ensembl»
0.0
MPN domain-containing protein Ciona intestinalis
TI:7719 None
 
I1IWN9_BRADI
EnsemblPlants»
0.0
LOC100841998 MPN domain-containing protein Brachypodium distachyon
TI:15368 None
 
K3YA14_SETIT
EnsemblPlants»
0.0
LOC101764250 MPN domain-containing protein Setaria italica
TI:4555 None
 
M1AGM8_SOLTU
EnsemblPlants»
0.0
LOC102580872 Neighbor of COX4 Solanum tuberosum
TI:4113 None
   
M1C8P1_SOLTU
EnsemblPlants»
0.0
LOC102599477 Neighbor of COX4 Solanum tuberosum
TI:4113 None
   
M4CF84_BRACM
EnsemblPlants»
0.0
MPN domain-containing protein Brassica campestris
TI:3711 None
   
M4EJI7_BRACM
EnsemblPlants»
0.0
MPN domain-containing protein Brassica campestris
TI:3711 None
   
M5W166_PRUPE
euHCVdb»
0.0
PRUPE_6G026500 Uncharacterized protein Prunus persica
TI:3760 None
 
Q3B8G2_XENLA
Xenbase»
0.0
emc9.L MGC131176 protein
(Uncharacterized protein LOC734811)		 Xenopus laevis
TI:8355 None
 
Q5TPN5_ANOGA
EnsemblMetazoa»
0.0
3292446 AGAP010320-PA Anopheles gambiae
TI:7165 None
 
Q5XHD9_XENLA
Xenbase»
0.0
emc8.S ER membrane protein complex subunit
8 S homeolog (LOC495028 protein)		 Xenopus laevis
TI:8355 None
 
Q6P4M9_XENTR
Xenbase»
0.0
emc8 COX4 neighbor (ER membrane protein
complex subunit 8) (Novel protein)		 Xenopus tropicalis
TI:8364 None
 
Q7XWV6_ORYSJ
euHCVdb»
0.0
Os04g0270200 Os04g0270200 protein (cDNA clone:001-040-F11, full insert
sequence) (cDNA clone:J013110N19, full insert sequence)		 Oryza sativa
TI:4530 None
 
Q7ZUY2_DANRE
ZFIN»
1.5
emc8 Cox4 neighbor (ER membrane
protein complex subunit 8)		 Danio rerio
TI:7955 None
 
Q8AWD7_DANRE
ZFIN»
1.5
emc9 ER membrane protein
complex subunit 9 (Zgc:55317)		 Danio rerio
TI:7955 None
 
Q8IHW7_PLAF7
TubercuList»
0.0
PF3D7_1139900 ER membrane protein complex subunit 8, putative Plasmodium falciparum
TI:5833 None
 
Q8L439_CHLRE
euHCVdb»
0.0
TLA1 Chlorophyll antenna size regulatory protein Chlamydomonas reinhardtii
TI:3055 None
 
T1ELZ1_HELRO
EnsemblMetazoa»
0.0
20197591 MPN domain-containing protein Helobdella robusta
TI:6412 None
 
W1NI66_AMBTC
euHCVdb»
0.0
AMTR_s00009p00262730 MPN domain-containing protein Amborella trichopoda
TI:13333 None
 
W5LY47_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 8 Lepisosteus oculatus
TI:7918 None
 
A0A1P8BFG8_ARATH
TAIR»
0.0
At5g51620 Uncharacterized protein family (UPF0172) Arabidopsis thaliana
TI:3702 None
 
A0ABI7WGR1_FELCA
Ensembl»
0.0
EMC8 MPN domain-containing protein Felis catus
TI:9685 None
   
A0A2I2YZI0_GORGO
Ensembl»
0.0
EMC9 ER membrane protein complex subunit 9 Gorilla gorilla
TI:9593 None
   
A0A3B3IBB2_ORYLA
Ensembl»
0.0
ER membrane protein complex subunit 9 Oryzias latipes
TI:8090 None
   
A0A5F5PQN3_HORSE
Ensembl»
0.0
EMC8 ER membrane protein complex subunit 8 Equus caballus
TI:9796 None
   
H2MDQ3_ORYLA
Ensembl»
0.0
ER membrane protein complex subunit 9 Oryzias latipes
TI:8090 None
   
M4F3E7_BRACM
EnsemblPlants»
0.0
MPN domain-containing protein Brassica campestris
TI:3711 None
   
W5LYZ5_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 9 Lepisosteus oculatus
TI:7918 None