Collated Gene Ontology terms

Biological process: membrane insertase activity(2020, 2024) transferase activity(2024) calcium ion binding(2024)

Molecular function: protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2023, 2024 tail-anchored membrane protein insertion into ER membrane2020, 2024 protein folding in endoplasmic reticulum2022, 2024 phospholipid transport2016, 2024 phospholipid metabolic process2016, 2024 retrograde transport, endosome to Golgi2021 protein insertion into ER membrane2020 cytoplasm to vacuole transport by the Cvt pathway2021

Cellular component: EMC complex2012, 2016, 2017, 2020, 2022, 2023, 2024 endoplasmic reticulum membrane2020, 2024 endoplasmic reticulum2006, 2012, 2018, 2021, 2024 membrane2024 extrinsic component of endoplasmic reticulum membrane2020, 2024 cytoplasm2012, 2024 nucleus2009, 2018, 2024 cytosol2009, 2019, 2024 sarcoplasmic reticulum2012 mitochondrion2009
cell division site2009 Golgi apparatus2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
EMC2_HUMAN
Ensembl»
3.2
EMC2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Homo sapiens
TI:9606 None
 
EMC2_MOUSE
Ensembl»
2.5
Emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Mus musculus
TI:10090 None
 
EMC2_YEAST
SGD»
3.7
EMC2 ER membrane protein complex subunit 2 Saccharomyces cerevisiae
TI:4932 None
 
H2QWK7_PANTR
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Pan troglodytes
TI:9598 None
 
Q9CAU9_ARATH
TAIR»
0.0
At3g04830 ER membrane protein complex subunit 2 Arabidopsis thaliana
TI:3702 None
 
B6SJZ7_MAIZE
EnsemblPlants»
0.0
100381916 ER membrane protein complex subunit 2 Zea mays
TI:4577 None
 
B7PRG5_IXOSC
EnsemblMetazoa»
0.0
8030273 ER membrane protein complex subunit 2 Ixodes scapularis
TI:6945 None
 
EMC2_BOVIN
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Bos taurus
TI:9913 None
 
G3S2S4_GORGO
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Gorilla gorilla
TI:9593 None
 
Q9VEQ1_DROME
FlyBase»
0.0
EMC2A ER membrane protein complex subunit 2 Drosophila melanogaster
TI:7227 None
 
Q9VEQ2_DROME
FlyBase»
0.0
EMC2B ER membrane protein complex subunit 2 Drosophila melanogaster
TI:7227 None
 
A0A078HYV4_BRANA
EnsemblPlants»
0.0
BnaC05g47010D ER membrane protein complex subunit 2 Brassica napus
TI:3708 None
 
A0A078IMX0_BRANA
EnsemblPlants»
0.0
BnaAnng10660D ER membrane protein complex subunit 2 Brassica napus
TI:3708 None
 
A0A251TB48_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr11g0340961 HanXRQr2_Chr11g0501651 ER membrane protein complex subunit 2 Helianthus annuus
TI:4232 None
 
A0A251U6U6_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr08g0230031 HanXRQr2_Chr01g0024241 ER membrane protein complex subunit 2 Helianthus annuus
TI:4232 None
 
B7ZYT3_MAIZE
EnsemblPlants»
0.0
100279572 ER membrane protein complex subunit 2 Zea mays
TI:4577 None
 
E9HIT5_DAPPU
EnsemblMetazoa»
0.0
EOG090X0CGE ER membrane protein complex subunit 2 Daphnia pulex
TI:6669 None
 
EMC2_DANRE
ZFIN»
1.5
emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Danio rerio
TI:7955 None
 
EMC2_XENTR
Xenbase»
0.0
emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Xenopus tropicalis
TI:8364 None
 
F2D0K9_HORVV
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Hordeum vulgare
TI:4513 None
 
G7L1T5_MEDTR
EnsemblPlants»
0.0
11431330 ER membrane protein complex subunit 2 Medicago truncatula
TI:3880 None
 
I0FH38_MACMU
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Macaca mulatta
TI:9544 None
 
Q57VI5_TRYB2
VEuPathDB»
0.0
Tb07.2F2.580 ER membrane protein complex subunit 2 Trypanosoma brucei
TI:5691 None
 
T1G1B8_HELRO
EnsemblMetazoa»
0.0
20214866 ER membrane protein complex subunit 2 Helobdella robusta
TI:6412 None
 
A0A022QZ36_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a016856mg ER membrane protein complex subunit 2 Erythranthe guttata
TI:4155 None
 
A0A061F258_THECC
EnsemblPlants»
0.0
TCM_026387 ER membrane protein complex subunit 2 Theobroma cacao
TI:3641 None
 
A0A067DNW9_CITSI
Ensembl»
0.0
CISIN_1g022205mg ER membrane protein complex subunit 2 Citrus sinensis
TI:2711 None
 
A0A078HV87_BRANA
EnsemblPlants»
0.0
BnaC03g33940D ER membrane protein complex subunit 2 Brassica napus
TI:3708 None
 
A0A0A0LFJ7_CUCSA
EnsemblPlants»
0.0
Csa_2G011580 ER membrane protein complex subunit 2 Cucumis sativus
TI:3659 None
 
A0A0K9NP24_ZOSMR
EnsemblPlants»
0.0
ZOSMA_82G00320 ER membrane protein complex subunit 2 Zostera marina
TI:29655 None
 
A0A0P0VEC6_ORYSJ
EnsemblPlants»
0.0
Os02g0127000 ER membrane protein complex subunit 2 Oryza sativa
TI:4530 None
 
A0A0Q3J402_BRADI
EnsemblPlants»
0.0
100840337 ER membrane protein complex subunit 2 Brachypodium distachyon
TI:15368 None
 
A0A1D8PNZ8_CANAL
EnsemblFungi»
0.0
CAALFM_C504550WA orf19.11421 ER membrane protein complex subunit 2 Candida albicans
TI:5476 None
 
A0A1U8DTU5_CAPAN
EnsemblPlants»
0.0
T459_22217 ER membrane protein complex subunit 2 Capsicum annuum
TI:4072 None
 
A0A1Y1HWB0_KLENI
EnsemblPlants»
0.0
KFL_000810300 ER membrane protein complex subunit 2 Klebsormidium nitens
TI:105231 None
 
A0A2A6CZF7_PRIPA
EnsemblMetazoa»
0.0
WBGene00113426 ER membrane protein complex subunit 2 Pristionchus pacificus
TI:54126 None
 
A0A2C9VDD0_MANES
EnsemblPlants»
0.0
MANES_09G154700 ER membrane protein complex subunit 2 Manihot esculenta
TI:3983 None
 
A0A2C9VHX4_MANES
EnsemblPlants»
0.0
MANES_08G132100 ER membrane protein complex subunit 2 Manihot esculenta
TI:3983 None
 
A0A2I4G7Y9_JUGRE
EnsemblPlants»
0.0
LOC109005498 ER membrane protein complex subunit 2 Juglans regia
TI:51240 None
 
A0A2K1IN44_PHYPA
EnsemblPlants»
0.0
PHYPA_027018 ER membrane protein complex subunit 2 Physcomitrium patens
TI:3218 None
 
A0A2K1Y0M8_POPTR
EnsemblPlants»
0.0
POPTR_013G038700 ER membrane protein complex subunit 2 Populus trichocarpa
TI:3694 None
 
A0A2K2ABW3_POPTR
EnsemblPlants»
0.0
POPTR_005G051300 ER membrane protein complex subunit 2 Populus trichocarpa
TI:3694 None
 
A0A2K3D0B1_CHLRE
EnsemblPlants»
0.0
CHLRE_13g579950v5 ER membrane protein complex subunit 2 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6XL65_MARPO
EnsemblPlants»
0.0
MARPO_0010s0190 ER membrane protein complex subunit 2 Marchantia polymorpha
TI:3197 None
 
A0A3B6U9V2_WHEAT
EnsemblPlants»
0.0
CFC21_112245 ER membrane protein complex subunit 2 Triticum aestivum
TI:4565 None
 
A0A3N7FV85_POPTR
EnsemblPlants»
0.0
POPTR_013G038501 ER membrane protein complex subunit 2 Populus trichocarpa
TI:3694 None
 
A0A5F5XSS9_FELCA
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Felis catus
TI:9685 None
 
A0BJN8_PARTE
EnsemblProtists»
0.0
GSPATT00029383001 ER membrane protein complex subunit 2 Paramecium tetraurelia
TI:5888 None
 
A0C6W2_PARTE
EnsemblProtists»
0.0
GSPATT00035658001 ER membrane protein complex subunit 2 Paramecium tetraurelia
TI:5888 None
 
A2DQU8_TRIV3
VEuPathDB»
0.0
TVAG_291670 ER membrane protein complex subunit 2 Trichomonas vaginalis
TI:5722 None
 
A7F0Y6_SCLS1
EnsemblFungi»
0.0
SS1G_11255 ER membrane protein complex subunit 2 Sclerotinia sclerotiorum
TI:5180 None
 
A7S9U3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g110221 ER membrane protein complex subunit 2 Nematostella vectensis
TI:45351 None
 
A8X3N8_CAEBR
WormBase»
0.0
emc-2 ER membrane protein complex subunit 2 Caenorhabditis briggsae
TI:6238 None
 
A9UTJ4_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31493 ER membrane protein complex subunit 2 Monosiga brevicollis
TI:81824 None
 
B3S1Y5_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_28044 ER membrane protein complex subunit 2 Trichoplax adhaerens
TI:10228 None
 
B6JZM2_SCHJY
EnsemblFungi»
0.0
SJAG_02065 ER membrane protein complex subunit 2 Schizosaccharomyces japonicus
TI:4897 None
 
B8BY83_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_32843 ER membrane protein complex subunit 2 Thalassiosira pseudonana
TI:35128 None
 
B9RER2_RICCO
EnsemblBacteria»
0.0
RCOM_1427860 ER membrane protein complex subunit 2 Ricinus communis
TI:3988 None
 
C4LSE8_ENTH1
EnsemblProtists»
0.0
EHI_153660 ER membrane protein complex subunit 2 Entamoeba histolytica
TI:5759 None
 
C5WSY6_SORBI
EnsemblPlants»
0.0
SORBI_3001G014800 ER membrane protein complex subunit 2 Sorghum bicolor
TI:4558 None
 
D6WAQ9_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_01201 ER membrane protein complex subunit 2 Tribolium castaneum
TI:7070 None
 
D7TUM1_VITVI
EnsemblPlants»
0.0
VIT_14s0030g01820 ER membrane protein complex subunit 2 Vitis vinifera
TI:29760 None
 
D8R3A5_SELML
EnsemblPlants»
0.0
SELMODRAFT_167610 ER membrane protein complex subunit 2 Selaginella moellendorffii
TI:88036 None
 
D8SHZ2_SELML
EnsemblPlants»
0.0
SELMODRAFT_445359 ER membrane protein complex subunit 2 Selaginella moellendorffii
TI:88036 None
 
E3L8S4_PUCGT
EnsemblFungi»
0.0
PGTG_18962 ER membrane protein complex subunit 2 Puccinia graminis
TI:5297 None
 
E3NXA7_PUCGT
EnsemblFungi»
0.0
PGTG_20106 ER membrane protein complex subunit 2 Puccinia graminis
TI:5297 None
 
EMC2A_XENLA
Xenbase»
0.0
emc2-a ER membrane protein complex subunit 2-A (Tetratricopeptide
repeat protein 35-A) (TPR repeat protein 35-A)		 Xenopus laevis
TI:8355 None
 
EMC2B_XENLA
Xenbase»
0.0
emc2-b ER membrane protein complex subunit 2-B (Tetratricopeptide
repeat protein 35-B) (TPR repeat protein 35-B)		 Xenopus laevis
TI:8355 None
 
EMC2_DICDI
dictyBase»
1.5
emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Dictyostelium discoideum
TI:44689 None
 
EMC2_RAT
RGD»
3.0
Emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Rattus norvegicus
TI:10116 None
 
F0ZT11_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_37554 ER membrane protein complex subunit 2 Dictyostelium purpureum
TI:5786 None
 
F4K725_ARATH
TAIR»
0.0
At5g28220 ER membrane protein complex subunit 2 Arabidopsis thaliana
TI:3702 None
 
F4NVC4_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_34325 ER membrane protein complex subunit 2 Batrachochytrium dendrobatidis
TI:109871 None
 
F6UA18_CIOIN
Ensembl»
0.0
ER membrane protein complex subunit 2 Ciona intestinalis
TI:7719 None
 
H3HDU6_PHYRM
EnsemblProtists»
0.0
ER membrane protein complex subunit 2 Phytophthora ramorum
TI:164328 None
 
I1JRL7_SOYBN
EnsemblPlants»
0.0
100791078 ER membrane protein complex subunit 2 Glycine max
TI:3847 None
 
I1NC77_SOYBN
EnsemblPlants»
0.0
GLYMA_19G243300 ER membrane protein complex subunit 2 Glycine max
TI:3847 None
 
K4ABA2_SETIT
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Setaria italica
TI:4555 None
 
K7WVC7_SOLTU
EnsemblPlants»
0.0
102596649 ER membrane protein complex subunit 2 Solanum tuberosum
TI:4113 None
 
M5VZE2_PRUPE
EnsemblPlants»
0.0
PRUPE_6G340800 ER membrane protein complex subunit 2 Prunus persica
TI:3760 None
 
O76630_CAEEL
WormBase»
0.0
emc-2 ER membrane protein complex subunit 2 Caenorhabditis elegans
TI:6239 None
 
OCA3_SCHPO
PomBase»
2.0
oca3 TPR repeat protein oca3 (Overexpression-mediated
cell cycle arrest protein 3)		 Schizosaccharomyces pombe
TI:4896 None
 
Q1K6G4_NEUCR
EnsemblFungi»
0.0
NCU04651 ER membrane protein complex subunit 2 Neurospora crassa
TI:5141 None
 
Q4QEH6_LEIMA
EnsemblProtists»
0.0
LMJF_17_0120 ER membrane protein complex subunit 2 Leishmania major
TI:5664 None
 
Q4WG36_ASPFU
EnsemblFungi»
0.0
AFUA_7G03650 ER membrane protein complex subunit 2 Aspergillus fumigatus
TI:746128 None
 
Q5KNL8_CRYNJ
EnsemblFungi»
0.0
CNA06040 ER membrane protein complex subunit 2 Cryptococcus neoformans
TI:5207 None
 
Q6CAZ3_YARLI
EnsemblFungi»
0.0
YALI0_C23188g ER membrane protein complex subunit 2 Yarrowia lipolytica
TI:4952 None
 
Q75BU8_ASHGO
EnsemblFungi»
0.0
AGOS_ACR173W ER membrane protein complex subunit 2 Ashbya gossypii
TI:33169 None
 
Q7PWZ6_ANOGA
EnsemblMetazoa»
0.0
1282030 ER membrane protein complex subunit 2 Anopheles gambiae
TI:7165 None
 
Q8ILZ5_PLAF7
EnsemblProtists»
0.0
PF3D7_1410000 ER membrane protein complex subunit 2 Plasmodium falciparum
TI:5833 None
 
W1P0U3_AMBTC
EnsemblPlants»
0.0
AMTR_s00002p00271640 ER membrane protein complex subunit 2 Amborella trichopoda
TI:13333 None
 
W5M5I6_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 2 Lepisosteus oculatus
TI:7918 None
 
A0A1S3ZM95_TOBAC
EnsemblFungi»
0.0
LOC107788222 ER membrane protein complex subunit 2 Nicotiana tabacum
TI:4097 None
   
A0A1S4BXS4_TOBAC
EnsemblFungi»
0.0
LOC107813006 ER membrane protein complex subunit 2 Nicotiana tabacum
TI:4097 None
   
A0A1U7ZRP7_NELNU
EnsemblBacteria»
0.0
LOC104596596 ER membrane protein complex subunit 2 Nelumbo nucifera
TI:4432 None
   
A0A1U8IB79_GOSHI
Ensembl»
0.0
LOC107894762 ER membrane protein complex subunit 2 Gossypium hirsutum
TI:3635 None
   
A0A1U8IQ70_GOSHI
Ensembl»
0.0
LOC107899150 ER membrane protein complex subunit 2 Gossypium hirsutum
TI:3635 None
   
A0A1U8LF21_GOSHI
Ensembl»
0.0
LOC107926809 ER membrane protein complex subunit 2 Gossypium hirsutum
TI:3635 None
   
A0A3B3IMT6_ORYLA
Ensembl»
0.0
emc2 ER membrane protein complex subunit 2 Oryzias latipes
TI:8090 None
   
A0A3B6NL97_WHEAT
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Triticum aestivum
TI:4565 None
   
A0A3B6PJ30_WHEAT
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Triticum aestivum
TI:4565 None
   
A0A3Q2I2Z3_HORSE
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Equus caballus
TI:9796 None
   
A0A3Q2UDL9_CHICK
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Gallus gallus
TI:9031 None
   
A0A3Q7ENJ6_SOLLC
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Solanum lycopersicum
TI:4081 None
   
A0A5G2QW85_PIG
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Sus scrofa
TI:9823 None
   
A0A6I8NXT4_ORNAN
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7HMP5_STRPU
EnsemblMetazoa»
0.0
ER membrane protein complex subunit 2 Strongylocentrotus purpuratus
TI:7668 None
   
A0A804HP85_MUSAM
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Musa acuminata
TI:4641 None
   
A0A804L5A8_MUSAM
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Musa acuminata
TI:4641 None
   
A0A8I3NGK8_CANLF
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Canis lupus
TI:9612 None
   
A0A8I3PG22_CANLF
Ensembl»
0.0
LOC481017 ER membrane protein complex subunit 2 Canis lupus
TI:9612 None
   
A0A9J7HIV0_BRAFL
CTD»
0.0
LOC118405156 ER membrane protein complex subunit 2 Branchiostoma floridae
TI:7739 None
   
F7A6D8_MONDO
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Monodelphis domestica
TI:13616 None
   
G1KK22_ANOCA
Ensembl»
0.0
EMC2 ER membrane protein complex subunit 2 Anolis carolinensis
TI:28377 None
   
M4CA97_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Brassica campestris
TI:3711 None
   
M4FH30_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 2 Brassica campestris
TI:3711 None