Collated Gene Ontology terms

Biological process: membrane insertase activity(2020, 2025) transferase activity(2025) calcium ion binding(2025)

Molecular function: tail-anchored membrane protein insertion into ER membrane2020, 2024, 2025 protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 phospholipid transport2024, 2025 phospholipid metabolic process2024, 2025 protein folding in endoplasmic reticulum2022

Cellular component: EMC complex2012, 2017, 2022, 2023, 2024, 2025 endoplasmic reticulum membrane2020, 2024, 2025 endoplasmic reticulum2006, 2012, 2018, 2021, 2025 extrinsic component of endoplasmic reticulum membrane2020, 2025 cytoplasm2012, 2025 nucleus2009, 2018, 2025 cytosol2009, 2019 sarcoplasmic reticulum2012 nuclear envelope2025 mitochondrion2009
cell division site2009 Golgi apparatus2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A3Q2UDL9_CHICK
Ensembl»
1.0
EMC2 ER membrane protein complex subunit 2 Gallus gallus
TI:9031 None
   
EMC2_DANRE
ZFIN»
2.5
emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Danio rerio
TI:7955 None
 
EMC2_DICDI
dictyBase»
2.5
emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Dictyostelium discoideum
TI:44689 None
 
EMC2_HUMAN
Ensembl»
4.2
EMC2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Homo sapiens
TI:9606 None
 
EMC2_MOUSE
Ensembl»
4.0
Emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Mus musculus
TI:10090 None
 
EMC2_RAT
RGD»
4.0
Emc2 ER membrane protein complex subunit 2 (Tetratricopeptide
repeat protein 35) (TPR repeat protein 35)		 Rattus norvegicus
TI:10116 None
 
EMC2_YEAST
SGD»
4.7
EMC2 ER membrane protein complex subunit 2 Saccharomyces cerevisiae
TI:4932 None
 
F4K725_ARATH
TAIR»
1.0
At5g28220 ER membrane protein complex subunit 2 Arabidopsis thaliana
TI:3702 None
 
O76630_CAEEL
WormBase»
1.0
emc-2 ER membrane protein complex subunit 2 Caenorhabditis elegans
TI:6239 None
 
OCA3_SCHPO
PomBase»
1.8
oca3 TPR repeat protein oca3 (Overexpression-mediated
cell cycle arrest protein 3)		 Schizosaccharomyces pombe
TI:4896 None
 
Q9CAU9_ARATH
TAIR»
1.0
At3g04830 ER membrane protein complex subunit 2 Arabidopsis thaliana
TI:3702 None
 
Q9VEQ1_DROME
FlyBase»
2.2
EMC2A ER membrane protein complex subunit 2 Drosophila melanogaster
TI:7227 None
 
Q9VEQ2_DROME
FlyBase»
2.2
EMC2B ER membrane protein complex subunit 2 Drosophila melanogaster
TI:7227 None