Cluster UKP05518
- TETRATRICOPEPTIDE REPEAT PROTEIN
Standard knownness: 4.7; Custom knownness: None; Num. species: 97; Orthology database: Panther19.0; Protein members: 122
Collated Gene Ontology terms
Biological process:
membrane insertase activity(2020, 2025)
transferase activity(2025)
calcium ion binding(2025)
Molecular function: tail-anchored membrane protein insertion into ER membrane2020, 2024, 2025 protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 phospholipid transport2024, 2025 phospholipid metabolic process2024, 2025 protein folding in endoplasmic reticulum2022
Cellular component:
EMC complex2012, 2017, 2022, 2023, 2024, 2025
endoplasmic reticulum membrane2020, 2024, 2025
endoplasmic reticulum2006, 2012, 2018, 2021, 2025
extrinsic component of endoplasmic reticulum membrane2020, 2025
cytoplasm2012, 2025
nucleus2009, 2018, 2025
cytosol2009, 2019
sarcoplasmic reticulum2012
nuclear envelope2025
mitochondrion2009
cell division site2009
Golgi apparatus2021
Phylogenetic distribution
| Chordates: | 22/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 14/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 3/3 | |
| Excavates: | 3/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 39/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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EMC2_YEAST SGD» |
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EMC2 | ER membrane protein complex subunit 2 |
Saccharomyces cerevisiae TI:4932 None |
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EMC2_HUMAN Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Homo sapiens TI:9606 None |
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EMC2_MOUSE Ensembl» |
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Emc2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Mus musculus TI:10090 None |
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EMC2_RAT RGD» |
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Emc2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Rattus norvegicus TI:10116 None |
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EMC2_DANRE ZFIN» |
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emc2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Danio rerio TI:7955 None |
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EMC2_DICDI dictyBase» |
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emc2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Dictyostelium discoideum TI:44689 None |
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Q9VEQ1_DROME FlyBase» |
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EMC2A | ER membrane protein complex subunit 2 |
Drosophila melanogaster TI:7227 None |
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Q9VEQ2_DROME FlyBase» |
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EMC2B | ER membrane protein complex subunit 2 |
Drosophila melanogaster TI:7227 None |
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OCA3_SCHPO PomBase» |
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oca3 | TPR repeat protein oca3 (Overexpression-mediated cell cycle arrest protein 3) |
Schizosaccharomyces pombe TI:4896 None |
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A0A3Q2UDL9_CHICK Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Gallus gallus TI:9031 None |
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F4K725_ARATH TAIR» |
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At5g28220 | ER membrane protein complex subunit 2 |
Arabidopsis thaliana TI:3702 None |
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O76630_CAEEL WormBase» |
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emc-2 | ER membrane protein complex subunit 2 |
Caenorhabditis elegans TI:6239 None |
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Q9CAU9_ARATH TAIR» |
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At3g04830 | ER membrane protein complex subunit 2 |
Arabidopsis thaliana TI:3702 None |
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A0A022QZ36_ERYGU euHCVdb» |
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MIMGU_mgv1a016856mg | ER membrane protein complex subunit 2 |
Erythranthe guttata TI:4155 None |
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A0A061F258_THECC euHCVdb» |
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TCM_026387 | ER membrane protein complex subunit 2 |
Theobroma cacao TI:3641 None |
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A0A067DNW9_CITSI euHCVdb» |
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CISIN_1g022205mg | ER membrane protein complex subunit 2 |
Citrus sinensis TI:2711 None |
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A0A078HV87_BRANA euHCVdb» |
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BnaC03g33940D | ER membrane protein complex subunit 2 |
Brassica napus TI:3708 None |
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A0A078HYV4_BRANA euHCVdb» |
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BnaC05g47010D | ER membrane protein complex subunit 2 |
Brassica napus TI:3708 None |
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A0A078IMX0_BRANA euHCVdb» |
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BnaAnng10660D | ER membrane protein complex subunit 2 |
Brassica napus TI:3708 None |
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A0A0A0LFJ7_CUCSA euHCVdb» |
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Csa_2G011580 | ER membrane protein complex subunit 2 |
Cucumis sativus TI:3659 None |
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A0A0K9NP24_ZOSMR euHCVdb» |
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ZOSMA_82G00320 | ER membrane protein complex subunit 2 |
Zostera marina TI:29655 None |
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A0A0P0VEB0_ORYSJ euHCVdb» |
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Os02g0127000 | ER membrane protein complex subunit 2 |
Oryza sativa TI:4530 None |
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A0A0Q3J402_BRADI EnsemblPlants» |
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LOC100840337 | ER membrane protein complex subunit 2 |
Brachypodium distachyon TI:15368 None |
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A0A1D8PNZ8_CANAL CGD» |
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CAALFM_C504550WA orf19.11421 | ER membrane protein complex subunit 2 |
Candida albicans TI:5476 None |
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A0A1S3ZM95_TOBAC euHCVdb» |
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LOC107788222 | ER membrane protein complex subunit 2 |
Nicotiana tabacum TI:4097 None |
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A0A1S4BXS4_TOBAC euHCVdb» |
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LOC107813006 | ER membrane protein complex subunit 2 |
Nicotiana tabacum TI:4097 None |
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A0A1U7ZRP7_NELNU euHCVdb» |
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LOC104596596 | ER membrane protein complex subunit 2 |
Nelumbo nucifera TI:4432 None |
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A0A1U8DTU5_CAPAN euHCVdb» |
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T459_22217 | ER membrane protein complex subunit 2 |
Capsicum annuum TI:4072 None |
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A0A1U8IB79_GOSHI euHCVdb» |
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LOC107894762 | ER membrane protein complex subunit 2 |
Gossypium hirsutum TI:3635 None |
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A0A1U8IQ70_GOSHI euHCVdb» |
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LOC107899150 | ER membrane protein complex subunit 2 |
Gossypium hirsutum TI:3635 None |
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A0A1U8LF21_GOSHI euHCVdb» |
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LOC107926809 | ER membrane protein complex subunit 2 |
Gossypium hirsutum TI:3635 None |
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A0A1Y1HWB0_KLENI euHCVdb» |
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KFL_000810300 | ER membrane protein complex subunit 2 |
Klebsormidium nitens TI:105231 None |
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A0A251TB48_HELAN euHCVdb» |
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HannXRQ_Chr11g0340961 HanXRQr2_Chr11g0501651 | ER membrane protein complex subunit 2 |
Helianthus annuus TI:4232 None |
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A0A251U6U6_HELAN euHCVdb» |
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HannXRQ_Chr08g0230031 HanXRQr2_Chr01g0024241 | ER membrane protein complex subunit 2 |
Helianthus annuus TI:4232 None |
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A0A2A6CZF7_PRIPA EnsemblMetazoa» |
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WBGene00113426 | ER membrane protein complex subunit 2 |
Pristionchus pacificus TI:54126 None |
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A0A2C9VDD0_MANES euHCVdb» |
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MANES_09G154700v8 | ER membrane protein complex subunit 2 |
Manihot esculenta TI:3983 None |
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A0A2I4G7Y9_JUGRE euHCVdb» |
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LOC109005498 | ER membrane protein complex subunit 2 |
Juglans regia TI:51240 None |
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A0A2K1IN44_PHYPA EnsemblPlants» |
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LOC112274694 | ER membrane protein complex subunit 2 |
Physcomitrium patens TI:3218 None |
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A0A2K1Y0M8_POPTR euHCVdb» |
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POPTR_013G038700 | ER membrane protein complex subunit 2 |
Populus trichocarpa TI:3694 None |
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A0A2K2ABW3_POPTR euHCVdb» |
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POPTR_005G051300 | ER membrane protein complex subunit 2 |
Populus trichocarpa TI:3694 None |
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A0A2K3D0B1_CHLRE euHCVdb» |
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CHLRE_13g579950v5 | ER membrane protein complex subunit 2 |
Chlamydomonas reinhardtii TI:3055 None |
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A0A2R6XL65_MARPO euHCVdb» |
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MARPO_0010s0190 | ER membrane protein complex subunit 2 |
Marchantia polymorpha TI:3197 None |
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A0A3B3IMT6_ORYLA Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Oryzias latipes TI:8090 None |
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A0A3B6NL97_WHEAT EnsemblPlants» |
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ER membrane protein complex subunit 2 |
Triticum aestivum TI:4565 None |
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A0A3B6PJ30_WHEAT EnsemblPlants» |
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LOC123136002 | ER membrane protein complex subunit 2 |
Triticum aestivum TI:4565 None |
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A0A3B6U9V2_WHEAT EnsemblPlants» |
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LOC123143551 | ER membrane protein complex subunit 2 |
Triticum aestivum TI:4565 None |
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A0A3N7FV85_POPTR euHCVdb» |
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POPTR_013G038501 | ER membrane protein complex subunit 2 |
Populus trichocarpa TI:3694 None |
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A0A3Q2I2Z3_HORSE Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Equus caballus TI:9796 None |
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A0A3Q7ENJ6_SOLLC EnsemblPlants» |
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LOC101267847 | ER membrane protein complex subunit 2 |
Solanum lycopersicum TI:4081 None |
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A0A5G2QW85_PIG Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Sus scrofa TI:9823 None |
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A0A6I8NXT4_ORNAN Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Ornithorhynchus anatinus TI:9258 None |
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A0A7M7HMP5_STRPU EnsemblMetazoa» |
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ER membrane protein complex subunit 2 |
Strongylocentrotus purpuratus TI:7668 None |
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A0A7U2HX12_PHANO TubercuList» |
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JI435_037240 | ER membrane protein complex subunit 2 |
Phaeosphaeria nodorum TI:13684 None |
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A0A803SRQ1_ANOCA Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Anolis carolinensis TI:28377 None |
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A0A804HP85_MUSAM EnsemblPlants» |
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ER membrane protein complex subunit 2 |
Musa acuminata TI:4641 None |
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A0A804L5A8_MUSAM EnsemblPlants» |
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ER membrane protein complex subunit 2 |
Musa acuminata TI:4641 None |
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A0A8I3NGK8_CANLF Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Canis lupus TI:9612 None |
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A0A8I3PG22_CANLF Ensembl» |
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LOC481017 | ER membrane protein complex subunit 2 |
Canis lupus TI:9612 None |
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A0A9J7HIV0_BRAFL euHCVdb» |
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LOC118405156 | ER membrane protein complex subunit 2 |
Branchiostoma floridae TI:7739 None |
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A0A9R0JDV9_SPIOL euHCVdb» |
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LOC110803462 | ER membrane protein complex subunit 2 |
Spinacia oleracea TI:3562 None |
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A0A9R1UPI1_LACSA euHCVdb» |
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LSAT_V11C800421280 | ER membrane protein complex subunit 2 |
Lactuca sativa TI:4236 None |
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A0A9R1VZ57_LACSA euHCVdb» |
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LSAT_V11C400167800 | ER membrane protein complex subunit 2 |
Lactuca sativa TI:4236 None |
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A0A9R1WQT1_LACSA euHCVdb» |
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LSAT_V11C100038620 | ER membrane protein complex subunit 2 |
Lactuca sativa TI:4236 None |
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A0AAF6YUU2_BOVIN Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Bos taurus TI:9913 None |
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A0ABE4N8W8_XENLA euHCVdb» |
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emc2.L | ER membrane protein complex subunit 2 |
Xenopus laevis TI:8355 None |
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A0ABI7WE82_FELCA Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Felis catus TI:9685 None |
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A0BJN8_PARTE euHCVdb» |
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GSPATT00029383001 | ER membrane protein complex subunit 2 |
Paramecium tetraurelia TI:5888 None |
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A0C6W2_PARTE euHCVdb» |
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GSPATT00035658001 | ER membrane protein complex subunit 2 |
Paramecium tetraurelia TI:5888 None |
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A2DQU8_TRIV3 TubercuList» |
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TVAG_291670 | ER membrane protein complex subunit 2 |
Trichomonas vaginalis TI:5722 None |
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A7F0Y6_SCLS1 euHCVdb» |
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SS1G_11255 | ER membrane protein complex subunit 2 |
Sclerotinia sclerotiorum TI:5180 None |
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A7S9U3_NEMVE euHCVdb» |
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NEMVEDRAFT_v1g110221 | ER membrane protein complex subunit 2 |
Nematostella vectensis TI:45351 None |
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A8X3N8_CAEBR WormBase» |
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emc-2 | ER membrane protein complex subunit 2 |
Caenorhabditis briggsae TI:6238 None |
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A9UTJ4_MONBE euHCVdb» |
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MONBRDRAFT_31493 | EMC2 TPR-like domain-containing protein |
Monosiga brevicollis TI:81824 None |
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B3S1Y5_TRIAD CTD» |
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TRIADDRAFT_28044 | ER membrane protein complex subunit 2 |
Trichoplax adhaerens TI:10228 None |
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B6JZM2_SCHJY TubercuList» |
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oca3 | ER membrane protein complex subunit 2 |
Schizosaccharomyces japonicus TI:4897 None |
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B6SJZ7_MAIZE EnsemblPlants» |
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LOC100381916 | ER membrane protein complex subunit 2 |
Zea mays TI:4577 None |
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B7PRG5_IXOSC EnsemblMetazoa» |
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8030273 | ER membrane protein complex subunit 2 |
Ixodes scapularis TI:6945 None |
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B7ZYT3_MAIZE EnsemblPlants» |
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LOC100279572 | ER membrane protein complex subunit 2 |
Zea mays TI:4577 None |
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B8BY83_THAPS euHCVdb» |
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THAPSDRAFT_32843 | ER membrane protein complex subunit 2 |
Thalassiosira pseudonana TI:35128 None |
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B9RER2_RICCO euHCVdb» |
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RCOM_1427860 | ER membrane protein complex subunit 2 |
Ricinus communis TI:3988 None |
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C4LSE8_ENTH1 TubercuList» |
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EHI_153660 | ER membrane protein complex subunit 2 |
Entamoeba histolytica TI:5759 None |
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C5WSY6_SORBI euHCVdb» |
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SORBI_3001G014800 | ER membrane protein complex subunit 2 |
Sorghum bicolor TI:4558 None |
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D6WAQ9_TRICA euHCVdb» |
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AUGUSTUS-3.0.2_01201 | ER membrane protein complex subunit 2 |
Tribolium castaneum TI:7070 None |
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D7TUM1_VITVI euHCVdb» |
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VIT_14s0030g01820 | ER membrane protein complex subunit 2 |
Vitis vinifera TI:29760 None |
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D8R3A5_SELML euHCVdb» |
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SELMODRAFT_167610 | ER membrane protein complex subunit 2 |
Selaginella moellendorffii TI:88036 None |
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D8SHZ2_SELML euHCVdb» |
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SELMODRAFT_445359 | ER membrane protein complex subunit 2 |
Selaginella moellendorffii TI:88036 None |
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E3L8S4_PUCGT TubercuList» |
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PGTG_18962 | ER membrane protein complex subunit 2 |
Puccinia graminis TI:5297 None |
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E3NXA7_PUCGT TubercuList» |
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PGTG_20106 | ER membrane protein complex subunit 2 |
Puccinia graminis TI:5297 None |
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E9HIT5_DAPPU euHCVdb» |
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EOG090X0CGE | ER membrane protein complex subunit 2 |
Daphnia pulex TI:6669 None |
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EMC2A_XENLA Xenbase» |
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emc2-a | ER membrane protein complex subunit 2-A (Tetratricopeptide repeat protein 35-A) (TPR repeat protein 35-A) |
Xenopus laevis TI:8355 None |
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EMC2B_XENLA Xenbase» |
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emc2-b | ER membrane protein complex subunit 2-B (Tetratricopeptide repeat protein 35-B) (TPR repeat protein 35-B) |
Xenopus laevis TI:8355 None |
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EMC2_BOVIN CTD» |
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EMC2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Bos taurus TI:9913 None |
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EMC2_XENTR Xenbase» |
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emc2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) |
Xenopus tropicalis TI:8364 None |
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F0ZT11_DICPU TubercuList» |
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DICPUDRAFT_37554 | ER membrane protein complex subunit 2 |
Dictyostelium purpureum TI:5786 None |
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F2D0K9_HORVV EnsemblPlants» |
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LOC123402424 | ER membrane protein complex subunit 2 |
Hordeum vulgare TI:4513 None |
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F4NVC4_BATDJ euHCVdb» |
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BATDEDRAFT_34325 | ER membrane protein complex subunit 2 |
Batrachochytrium dendrobatidis TI:109871 None |
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F6UA18_CIOIN Ensembl» |
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ER membrane protein complex subunit 2 |
Ciona intestinalis TI:7719 None |
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F7A6D8_MONDO Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Monodelphis domestica TI:13616 None |
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G3S2S4_GORGO Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Gorilla gorilla TI:9593 None |
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G7L1T5_MEDTR EnsemblPlants» |
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11431330 | ER membrane protein complex subunit 2 |
Medicago truncatula TI:3880 None |
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H2QWK7_PANTR Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Pan troglodytes TI:9598 None |
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H3HDU6_PHYRM EnsemblProtists» |
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ER membrane protein complex subunit 2 |
Phytophthora ramorum TI:164328 None |
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I0FH38_MACMU Ensembl» |
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EMC2 | ER membrane protein complex subunit 2 |
Macaca mulatta TI:9544 None |
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I1JRL7_SOYBN EnsemblPlants» |
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LOC100791078 | ER membrane protein complex subunit 2 |
Glycine max TI:3847 None |
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I1NC77_SOYBN EnsemblPlants» |
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LOC100796542 | ER membrane protein complex subunit 2 |
Glycine max TI:3847 None |
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K4ABA2_SETIT EnsemblPlants» |
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LOC101757411 | ER membrane protein complex subunit 2 |
Setaria italica TI:4555 None |
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K7WVC7_SOLTU EnsemblPlants» |
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LOC102596649 | ER membrane protein complex subunit 2 |
Solanum tuberosum TI:4113 None |
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M4CA97_BRACM EnsemblPlants» |
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ER membrane protein complex subunit 2 |
Brassica campestris TI:3711 None |
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M4FH30_BRACM EnsemblPlants» |
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ER membrane protein complex subunit 2 |
Brassica campestris TI:3711 None |
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M5VZE2_PRUPE euHCVdb» |
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PRUPE_6G340800 | ER membrane protein complex subunit 2 |
Prunus persica TI:3760 None |
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Q1K6G4_NEUCR TubercuList» |
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NCU04651 | ER membrane protein complex subunit 2 |
Neurospora crassa TI:5141 None |
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Q4QEH6_LEIMA TubercuList» |
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LMJF_17_0120 | ER membrane protein complex subunit 2 |
Leishmania major TI:5664 None |
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Q4WG36_ASPFU euHCVdb» |
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AFUA_7G03650 | ER membrane protein complex subunit 2 |
Aspergillus fumigatus TI:746128 None |
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Q57VI5_TRYB2 TubercuList» |
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Tb07.2F2.580 | ER membrane protein complex subunit 2 |
Trypanosoma brucei TI:5691 None |
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Q5KNL8_CRYD1 TubercuList» |
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CNA06040 | ER membrane protein complex subunit 2 |
Cryptococcus deneoformans TI:40410 None |
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Q6CAZ3_YARLI TubercuList» |
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YALI0_C23188g | ER membrane protein complex subunit 2 |
Yarrowia lipolytica TI:4952 None |
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Q75BU8_EREGS euHCVdb» |
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AGOS_ACR173W | ER membrane protein complex subunit 2 |
Eremothecium gossypii TI:33169 None |
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Q7PWZ6_ANOGA EnsemblMetazoa» |
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1282030 | ER membrane protein complex subunit 2 |
Anopheles gambiae TI:7165 None |
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Q8ILZ5_PLAF7 TubercuList» |
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PF3D7_1410000 | ER membrane protein complex subunit 2 |
Plasmodium falciparum TI:5833 None |
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T1G1B8_HELRO EnsemblMetazoa» |
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20214866 | ER membrane protein complex subunit 2 |
Helobdella robusta TI:6412 None |
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W1P0U3_AMBTC euHCVdb» |
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AMTR_s00002p00271640 | ER membrane protein complex subunit 2 |
Amborella trichopoda TI:13333 None |
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W5M5I6_LEPOC Ensembl» |
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ER membrane protein complex subunit 2 |
Lepisosteus oculatus TI:7918 None |
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