Cluster UKP05365
- ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4
Standard knownness: 3.7; Custom knownness: None; Num. species: 89; Orthology database: Panther19.0; Protein members: 109
Collated Gene Ontology terms
Biological process:
membrane insertase activity(2020, 2022, 2024)
Molecular function: protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024 tail-anchored membrane protein insertion into ER membrane2020, 2022, 2024 phospholipid transport2016, 2024 phospholipid metabolic process2016, 2024 protein folding in endoplasmic reticulum2019, 2024 apoptotic process2024 protein insertion into ER membrane2020 proteasome-mediated ubiquitin-dependent protein catabolic process2021 cell redox homeostasis2021
Cellular component: EMC complex2012, 2016, 2020, 2024 endoplasmic reticulum membrane2020, 2024 membrane2012, 2024 endoplasmic reticulum2009, 2018, 2021, 2024 nucleus2017 endomembrane system2014
Phylogenetic distribution
| Chordates: | 19/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 2/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 14/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 2/3 | |
| Excavates: | 2/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 37/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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A0A3B3IEF0_ORYLA Ensembl» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Oryzias latipes TI:8090 None |
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A0A8J1M525_XENLA Xenbase» |
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LOC108705001 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus laevis TI:8355 None |
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A0A8M9PHX7_DANRE CTD» |
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LOC110438456 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Danio rerio TI:7955 None |
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B7PMF9_IXOSC EnsemblMetazoa» |
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IscW_ISCW006586 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Ixodes scapularis TI:6945 None |
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D6WMR9_TRICA EnsemblMetazoa» |
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AUGUSTUS-3.0.2_16317 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Tribolium castaneum TI:7070 None |
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EMC4_BOVIN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Bos taurus TI:9913 None |
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EMC4_DANRE ZFIN» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Danio rerio TI:7955 None |
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EMC4_MOUSE Ensembl» |
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Emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Mus musculus TI:10090 None |
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EMC4_XENLA Xenbase» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus laevis TI:8355 None |
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EMC4_XENTR Xenbase» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus tropicalis TI:8364 None |
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H9GEQ5_ANOCA Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Anolis carolinensis TI:28377 None |
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A0A022Q488_ERYGU EnsemblFungi» |
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MIMGU_mgv1a014714mg | ER membrane protein complex subunit 4 |
Erythranthe guttata TI:4155 None |
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A0A022QPH6_ERYGU EnsemblFungi» |
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MIMGU_mgv1a014736mg | ER membrane protein complex subunit 4 |
Erythranthe guttata TI:4155 None |
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A0A061GIQ5_THECC EnsemblPlants» |
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TCM_036875 | ER membrane protein complex subunit 4 |
Theobroma cacao TI:3641 None |
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A0A067FJ52_CITSI Ensembl» |
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CISIN_1g030270mg | ER membrane protein complex subunit 4 |
Citrus sinensis TI:2711 None |
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A0A078HTP4_BRANA EnsemblPlants» |
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BnaC02g00120D | ER membrane protein complex subunit 4 |
Brassica napus TI:3708 None |
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A0A0A0L0B6_CUCSA EnsemblPlants» |
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Csa_4G651820 | ER membrane protein complex subunit 4 |
Cucumis sativus TI:3659 None |
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A0A0K9P101_ZOSMR EnsemblPlants» |
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ZOSMA_44G01330 | ER membrane protein complex subunit 4 |
Zostera marina TI:29655 None |
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A0A0R0FGT9_SOYBN EnsemblPlants» |
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100806417 | ER membrane protein complex subunit 4 |
Glycine max TI:3847 None |
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A0A0U9HPB2_KLENI EnsemblPlants» |
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KFL_003350070 | ER membrane protein complex subunit 4 |
Klebsormidium nitens TI:105231 None |
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A0A1D5XTG1_WHEAT EnsemblPlants» |
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CFC21_052184 CFC21_057500 | ER membrane protein complex subunit 4 |
Triticum aestivum TI:4565 None |
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A0A1D8PRI7_CANAL EnsemblFungi» |
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CAALFM_C703980WA orf19.7183 | ER membrane protein complex subunit 4 |
Candida albicans TI:5476 None |
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A0A1S3ZKI5_TOBAC EnsemblFungi» |
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LOC107787939 | ER membrane protein complex subunit 4 |
Nicotiana tabacum TI:4097 None |
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A0A1S4C767_TOBAC EnsemblFungi» |
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LOC107815857 | ER membrane protein complex subunit 4 |
Nicotiana tabacum TI:4097 None |
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A0A1U7Z4I3_NELNU EnsemblBacteria» |
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LOC104589159 | ER membrane protein complex subunit 4 |
Nelumbo nucifera TI:4432 None |
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A0A1U8A9F3_NELNU EnsemblBacteria» |
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LOC104602144 | ER membrane protein complex subunit 4 |
Nelumbo nucifera TI:4432 None |
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A0A1U8ER87_CAPAN EnsemblPlants» |
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T459_31620 | ER membrane protein complex subunit 4 |
Capsicum annuum TI:4072 None |
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A0A1U8IYR9_GOSHI Ensembl» |
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LOC107901650 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A1U8JGJ2_GOSHI Ensembl» |
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LOC107906804 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A1U8PGU3_GOSHI Ensembl» |
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LOC107958964 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A1W2W8Q4_CIOIN Ensembl» |
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LOC100179818 | ER membrane protein complex subunit 4 |
Ciona intestinalis TI:7719 None |
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A0A251T3R6_HELAN EnsemblPlants» |
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EMC4 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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A0A251UCU0_HELAN EnsemblPlants» |
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HannXRQ_Chr07g0201211 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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A0A286ZIA2_PIG Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Sus scrofa TI:9823 None |
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A0A2C9UCE2_MANES EnsemblPlants» |
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MANES_16G131700 | ER membrane protein complex subunit 4 |
Manihot esculenta TI:3983 None |
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A0A2C9W4V3_MANES EnsemblPlants» |
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MANES_03G007300 | ER membrane protein complex subunit 4 |
Manihot esculenta TI:3983 None |
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A0A2I2ZU21_GORGO Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Gorilla gorilla TI:9593 None |
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A0A2I4FPT6_JUGRE EnsemblPlants» |
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LOC109000999 | ER membrane protein complex subunit 4 |
Juglans regia TI:51240 None |
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A0A2I4G6N1_JUGRE EnsemblPlants» |
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LOC109005208 | ER membrane protein complex subunit 4 |
Juglans regia TI:51240 None |
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A0A2K3DLB9_CHLRE EnsemblPlants» |
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CHLRE_07g351700v5 | ER membrane protein complex subunit 4 |
Chlamydomonas reinhardtii TI:3055 None |
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A0A2R6X315_MARPO EnsemblPlants» |
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MARPO_0039s0015 | ER membrane protein complex subunit 4 |
Marchantia polymorpha TI:3197 None |
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A0A3B6JHL6_WHEAT EnsemblPlants» |
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ER membrane protein complex subunit 4 |
Triticum aestivum TI:4565 None |
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A0A3Q7HK72_SOLLC EnsemblPlants» |
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101246647 | ER membrane protein complex subunit 4 |
Solanum lycopersicum TI:4081 None |
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A0A5F8AS46_MACMU Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Macaca mulatta TI:9544 None |
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A0A7M7N6K0_STRPU EnsemblMetazoa» |
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ER membrane protein complex subunit 4 |
Strongylocentrotus purpuratus TI:7668 None |
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A0A804IBJ2_MUSAM EnsemblPlants» |
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103973869 | ER membrane protein complex subunit 4 |
Musa acuminata TI:4641 None |
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A0A804JSG8_MUSAM EnsemblPlants» |
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103990559 | ER membrane protein complex subunit 4 |
Musa acuminata TI:4641 None |
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A0A8I3PBW5_CANLF Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Canis lupus TI:9612 None |
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A0A8I7B760_HORVV EnsemblPlants» |
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ER membrane protein complex subunit 4 |
Hordeum vulgare TI:4513 None |
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A0A9K3INY4_HELAN EnsemblPlants» |
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HanXRQr2_Chr07g0310381 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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A0CDS1_PARTE EnsemblProtists» |
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GSPATT00007150001 | ER membrane protein complex subunit 4 |
Paramecium tetraurelia TI:5888 None |
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A0DF93_PARTE EnsemblProtists» |
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GSPATT00016523001 | ER membrane protein complex subunit 4 |
Paramecium tetraurelia TI:5888 None |
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A5BA14_VITVI EnsemblPlants» |
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VIT_04s0008g06880 | ER membrane protein complex subunit 4 |
Vitis vinifera TI:29760 None |
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A7ET08_SCLS1 EnsemblFungi» |
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SS1G_08463 | ER membrane protein complex subunit 4 |
Sclerotinia sclerotiorum TI:5180 None |
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A7RQ29_NEMVE EnsemblMetazoa» |
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NEMVEDRAFT_v1g200413 | ER membrane protein complex subunit 4 |
Nematostella vectensis TI:45351 None |
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A8MQD8_ARATH TAIR» |
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At5g10780 | ER membrane protein complex subunit 4 |
Arabidopsis thaliana TI:3702 None |
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A8XWS9_CAEBR WormBase» |
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perm-3 | ER membrane protein complex subunit 4 |
Caenorhabditis briggsae TI:6238 None |
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A9PHF1_POPTR EnsemblPlants» |
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POPTR_018G016800 | ER membrane protein complex subunit 4 |
Populus trichocarpa TI:3694 None |
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A9RDI8_PHYPA EnsemblPlants» |
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PHYPA_023206 | ER membrane protein complex subunit 4 |
Physcomitrium patens TI:3218 None |
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A9UUF5_MONBE EnsemblProtists» |
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MONBRDRAFT_18332 | ER membrane protein complex subunit 4 |
Monosiga brevicollis TI:81824 None |
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B1N2I5_ENTH1 EnsemblProtists» |
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EHI_012430 | ER membrane protein complex subunit 4 |
Entamoeba histolytica TI:5759 None |
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B3RM27_TRIAD EnsemblMetazoa» |
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TRIADDRAFT_63524 | ER membrane protein complex subunit 4 |
Trichoplax adhaerens TI:10228 None |
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B6K1I4_SCHJY EnsemblFungi» |
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SJAG_02914 | ER membrane protein complex subunit 4 |
Schizosaccharomyces japonicus TI:4897 None |
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B8C1D2_THAPS EnsemblProtists» |
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THAPSDRAFT_33995 | ER membrane protein complex subunit 4 |
Thalassiosira pseudonana TI:35128 None |
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B9HB78_POPTR EnsemblPlants» |
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POPTR_006G266300 | ER membrane protein complex subunit 4 |
Populus trichocarpa TI:3694 None |
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B9RNT0_RICCO EnsemblBacteria» |
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RCOM_0920530 | ER membrane protein complex subunit 4 |
Ricinus communis TI:3988 None |
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C0HHQ5_MAIZE EnsemblPlants» |
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100381640 | ER membrane protein complex subunit 4 |
Zea mays TI:4577 None |
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C3YFL5_BRAFL CTD» |
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LOC118417826 | ER membrane protein complex subunit 4 |
Branchiostoma floridae TI:7739 None |
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C4MBJ2_ENTH1 EnsemblProtists» |
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EHI_063570 | ER membrane protein complex subunit 4 |
Entamoeba histolytica TI:5759 None |
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C5WZL2_SORBI EnsemblPlants» |
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SORBI_3001G364600 | ER membrane protein complex subunit 4 |
Sorghum bicolor TI:4558 None |
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C7FZZ9_DICDI dictyBase» |
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DDB_G0295773 | ER membrane protein complex subunit 4 |
Dictyostelium discoideum TI:44689 None |
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D4A0W1_RAT RGD» |
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Emc4 | ER membrane protein complex subunit 4 |
Rattus norvegicus TI:10116 None |
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D8QQY7_SELML EnsemblPlants» |
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SELMODRAFT_402529 | ER membrane protein complex subunit 4 |
Selaginella moellendorffii TI:88036 None |
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D8R7Z7_SELML EnsemblPlants» |
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SELMODRAFT_168891 | ER membrane protein complex subunit 4 |
Selaginella moellendorffii TI:88036 None |
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E3K5M8_PUCGT EnsemblFungi» |
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PGTG_06102 | ER membrane protein complex subunit 4 |
Puccinia graminis TI:5297 None |
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E3KN39_PUCGT EnsemblFungi» |
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PGTG_11004 | ER membrane protein complex subunit 4 |
Puccinia graminis TI:5297 None |
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E9GKX4_DAPPU EnsemblMetazoa» |
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EOG090X0GNX | ER membrane protein complex subunit 4 |
Daphnia pulex TI:6669 None |
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EMC4_YEAST SGD» |
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EMC4 | ER membrane protein complex subunit 4 |
Saccharomyces cerevisiae TI:4932 None |
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F4P654_BATDJ EnsemblBacteria» |
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BATDEDRAFT_89618 | ER membrane protein complex subunit 4 |
Batrachochytrium dendrobatidis TI:109871 None |
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F6SR81_MONDO Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Monodelphis domestica TI:13616 None |
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F7EP23_ORNAN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Ornithorhynchus anatinus TI:9258 None |
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G7I7L8_MEDTR EnsemblPlants» |
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11432390 | ER membrane protein complex subunit 4 |
Medicago truncatula TI:3880 None |
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H2Q938_PANTR Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Pan troglodytes TI:9598 None |
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H3GTT9_PHYRM EnsemblProtists» |
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ER membrane protein complex subunit 4 |
Phytophthora ramorum TI:164328 None |
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I1H591_BRADI EnsemblPlants» |
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100824221 | ER membrane protein complex subunit 4 |
Brachypodium distachyon TI:15368 None |
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I1M9A1_SOYBN EnsemblPlants» |
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GLYMA_14G103800 | ER membrane protein complex subunit 4 |
Glycine max TI:3847 None |
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K4AFT2_SETIT EnsemblPlants» |
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101767452 | ER membrane protein complex subunit 4 |
Setaria italica TI:4555 None |
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M1CHJ9_SOLTU EnsemblPlants» |
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102588607 | ER membrane protein complex subunit 4 |
Solanum tuberosum TI:4113 None |
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M3VX67_FELCA Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Felis catus TI:9685 None |
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M4CPE0_BRACM EnsemblPlants» |
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BRARA_C00441 | ER membrane protein complex subunit 4 |
Brassica campestris TI:3711 None |
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M4EIF2_BRACM EnsemblPlants» |
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BRARA_B00376 | ER membrane protein complex subunit 4 |
Brassica campestris TI:3711 None |
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M5XM02_PRUPE EnsemblPlants» |
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PRUPE_1G396200 | ER membrane protein complex subunit 4 |
Prunus persica TI:3760 None |
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Q10L35_ORYSJ EnsemblPlants» |
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LOC_Os03g24580 Os03g0360500 | ER membrane protein complex subunit 4 |
Oryza sativa TI:4530 None |
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Q4Q7D8_LEIMA EnsemblProtists» |
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LMJF_30_1625 LMJF_30_1630 LMJF_30_1635 LMJF_30_1640 LMJF_30_1645 LMJF_30_1650 LMJF_30_1660 | ER membrane protein complex subunit 4 |
Leishmania major TI:5664 None |
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Q4X1D5_ASPFU EnsemblFungi» |
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AFUA_2G10350 | ER membrane protein complex subunit 4 |
Aspergillus fumigatus TI:746128 None |
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Q584P6_TRYB2 VEuPathDB» |
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Tb06.4M18.1350 | ER membrane protein complex subunit 4 |
Trypanosoma brucei TI:5691 None |
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Q5B0H9_EMENI EnsemblFungi» |
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ANIA_05951 | ER membrane protein complex subunit 4 |
Emericella nidulans TI:162425 None |
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Q5KPR9_CRYNJ EnsemblFungi» |
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CNA01770 | ER membrane protein complex subunit 4 |
Cryptococcus neoformans TI:5207 None |
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Q6CHC4_YARLI EnsemblFungi» |
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YALI0_A10274g | ER membrane protein complex subunit 4 |
Yarrowia lipolytica TI:4952 None |
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Q753S7_ASHGO EnsemblFungi» |
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AGOS_AFR249W | ER membrane protein complex subunit 4 |
Ashbya gossypii TI:33169 None |
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Q7Q8U0_ANOGA EnsemblMetazoa» |
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1275294 | ER membrane protein complex subunit 4 |
Anopheles gambiae TI:7165 None |
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Q7S8H7_NEUCR EnsemblFungi» |
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NCU05231 | ER membrane protein complex subunit 4 |
Neurospora crassa TI:5141 None |
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Q8ILB0_PLAF7 EnsemblProtists» |
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PF3D7_1435400 | ER membrane protein complex subunit 4 |
Plasmodium falciparum TI:5833 None |
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Q9N4N3_CAEEL WormBase» |
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perm-3 | ER membrane protein complex subunit 4 |
Caenorhabditis elegans TI:6239 None |
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Q9VNQ3_DROME FlyBase» |
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EMC4 | ER membrane protein complex subunit 4 |
Drosophila melanogaster TI:7227 None |
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T1FM17_HELRO EnsemblMetazoa» |
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20209866 | ER membrane protein complex subunit 4 |
Helobdella robusta TI:6412 None |
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W1PHA9_AMBTC EnsemblPlants» |
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AMTR_s00019p00068750 | ER membrane protein complex subunit 4 |
Amborella trichopoda TI:13333 None |
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YQ13_SCHPO PomBase» |
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SPCC1281.03c | ER membrane protein complex subunit 4 |
Schizosaccharomyces pombe TI:4896 None |
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EMC4_HUMAN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) |
Homo sapiens TI:9606 None |
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