Cluster UKP05365
- ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4
Standard knownness: 3.7; Custom knownness: None; Num. species: 93; Orthology database: Panther19.0; Protein members: 112
Collated Gene Ontology terms
Biological process:
membrane insertase activity(2020, 2022, 2025)
Molecular function: protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 tail-anchored membrane protein insertion into ER membrane2020, 2022, 2024, 2025 phospholipid transport2024, 2025 phospholipid metabolic process2024, 2025 apoptotic process2025 protein insertion into ER membrane2020 protein folding in endoplasmic reticulum2019
Cellular component: EMC complex2012, 2020, 2025 endoplasmic reticulum membrane2020, 2024, 2025 membrane2012, 2025 endoplasmic reticulum2009, 2018, 2021, 2025 nucleus2017, 2018 endomembrane system2014
Phylogenetic distribution
| Chordates: | 20/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 2/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 15/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 2/3 | |
| Excavates: | 2/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 39/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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A0A3B6JHL6_WHEAT EnsemblPlants» |
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ER membrane protein complex subunit 4 |
Triticum aestivum TI:4565 None |
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A0A7M7N6K0_STRPU EnsemblMetazoa» |
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ER membrane protein complex subunit 4 |
Strongylocentrotus purpuratus TI:7668 None |
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H3GTT9_PHYRM EnsemblProtists» |
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ER membrane protein complex subunit 4 |
Phytophthora ramorum TI:164328 None |
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G7I7L8_MEDTR EnsemblPlants» |
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11432390 | ER membrane protein complex subunit 4 |
Medicago truncatula TI:3880 None |
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Q7Q8U0_ANOGA EnsemblMetazoa» |
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1275294 | ER membrane protein complex subunit 4 |
Anopheles gambiae TI:7165 None |
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T1FM17_HELRO EnsemblMetazoa» |
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20209866 | ER membrane protein complex subunit 4 |
Helobdella robusta TI:6412 None |
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Q4X1D5_ASPFU TubercuList» |
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AFUA_2G10350 | ER membrane protein complex subunit 4 |
Aspergillus fumigatus TI:746128 None |
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Q753S7_EREGS euHCVdb» |
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AGOS_AFR249W | ER membrane protein complex subunit 4 |
Eremothecium gossypii TI:33169 None |
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W1PHA9_AMBTC neXtProt» |
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AMTR_s00019p00068750 | ER membrane protein complex subunit 4 |
Amborella trichopoda TI:13333 None |
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Q5B0H9_EMENI TubercuList» |
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ANIA_05951 | ER membrane protein complex subunit 4 |
Emericella nidulans TI:162425 None |
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D6WMR9_TRICA neXtProt» |
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AUGUSTUS-3.0.2_16317 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Tribolium castaneum TI:7070 None |
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A8MQD8_ARATH TAIR» |
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At5g10780 | ER membrane protein complex subunit 4 |
Arabidopsis thaliana TI:3702 None |
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F4P654_BATDJ euHCVdb» |
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BATDEDRAFT_89618 | ER membrane protein complex subunit 4 |
Batrachochytrium dendrobatidis TI:109871 None |
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M4EIF2_BRACM EnsemblPlants» |
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BRARA_B00376 | ER membrane protein complex subunit 4 |
Brassica campestris TI:3711 None |
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M4CPE0_BRACM EnsemblPlants» |
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BRARA_C00441 | ER membrane protein complex subunit 4 |
Brassica campestris TI:3711 None |
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A0A078HTP4_BRANA euHCVdb» |
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BnaC02g00120D | ER membrane protein complex subunit 4 |
Brassica napus TI:3708 None |
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A0A1D8PRI7_CANAL CGD» |
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CAALFM_C703980WA orf19.7183 | ER membrane protein complex subunit 4 |
Candida albicans TI:5476 None |
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A0A2K3DLB9_CHLRE euHCVdb» |
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CHLRE_07g351700v5 | ER membrane protein complex subunit 4 |
Chlamydomonas reinhardtii TI:3055 None |
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A0A067FJ52_CITSI neXtProt» |
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CISIN_1g030270mg | ER membrane protein complex subunit 4 |
Citrus sinensis TI:2711 None |
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Q5KPR9_CRYD1 TubercuList» |
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CNA01770 | ER membrane protein complex subunit 4 |
Cryptococcus deneoformans TI:40410 None |
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A0A0A0L0B6_CUCSA euHCVdb» |
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Csa_4G651820 | ER membrane protein complex subunit 4 |
Cucumis sativus TI:3659 None |
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C7FZZ9_DICDI dictyBase» |
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DDB_G0295773 | ER membrane protein complex subunit 4 |
Dictyostelium discoideum TI:44689 None |
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B1N2I5_ENTH1 TubercuList» |
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EHI_012430 | ER membrane protein complex subunit 4 |
Entamoeba histolytica TI:5759 None |
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C4MBJ2_ENTH1 TubercuList» |
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EHI_063570 | ER membrane protein complex subunit 4 |
Entamoeba histolytica TI:5759 None |
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A0A251T3R6_HELAN euHCVdb» |
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EMC4 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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A0A286ZIA2_PIG Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Sus scrofa TI:9823 None |
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A0A2I2ZU21_GORGO Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Gorilla gorilla TI:9593 None |
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A0A3B3IEF0_ORYLA Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Oryzias latipes TI:8090 None |
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A0A5F8AS46_MACMU Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Macaca mulatta TI:9544 None |
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A0A8I3PBW5_CANLF Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Canis lupus TI:9612 None |
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A0A9L0SAD5_HORSE Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Equus caballus TI:9796 None |
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A0ABI7Z673_FELCA Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Felis catus TI:9685 None |
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EMC4_BOVIN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Bos taurus TI:9913 None |
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EMC4_HUMAN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) |
Homo sapiens TI:9606 None |
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EMC4_YEAST SGD» |
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EMC4 | ER membrane protein complex subunit 4 |
Saccharomyces cerevisiae TI:4932 None |
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F6SR81_MONDO Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Monodelphis domestica TI:13616 None |
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F7EP23_ORNAN Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Ornithorhynchus anatinus TI:9258 None |
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H2Q938_PANTR Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 |
Pan troglodytes TI:9598 None |
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H9GEQ5_ANOCA Ensembl» |
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EMC4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Anolis carolinensis TI:28377 None |
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Q9VNQ3_DROME FlyBase» |
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EMC4 | ER membrane protein complex subunit 4 |
Drosophila melanogaster TI:7227 None |
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E9GKX4_DAPPU neXtProt» |
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EOG090X0GNX | ER membrane protein complex subunit 4 |
Daphnia pulex TI:6669 None |
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D4A0W1_RAT RGD» |
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Emc4 | ER membrane protein complex subunit 4 |
Rattus norvegicus TI:10116 None |
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EMC4_MOUSE Ensembl» |
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Emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Mus musculus TI:10090 None |
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A0A804IBJ2_MUSAM EnsemblPlants» |
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GSMUA_216070.1 | ER membrane protein complex subunit 4 |
Musa acuminata TI:4641 None |
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A0A804JSG8_MUSAM EnsemblPlants» |
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GSMUA_49380.1 | ER membrane protein complex subunit 4 |
Musa acuminata TI:4641 None |
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A0CDS1_PARTE euHCVdb» |
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GSPATT00007150001 | ER membrane protein complex subunit 4 |
Paramecium tetraurelia TI:5888 None |
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A0DF93_PARTE euHCVdb» |
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GSPATT00016523001 | ER membrane protein complex subunit 4 |
Paramecium tetraurelia TI:5888 None |
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A0A9K3INY4_HELAN euHCVdb» |
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HanXRQr2_Chr07g0310381 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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A0A251UCU0_HELAN neXtProt» |
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HannXRQ_Chr07g0201211 | ER membrane protein complex subunit 4 |
Helianthus annuus TI:4232 None |
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B7PMF9_IXOSC EnsemblMetazoa» |
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IscW_ISCW006586 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Ixodes scapularis TI:6945 None |
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A0A7U2IBA3_PHANO TubercuList» |
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JI435_135370 | ER membrane protein complex subunit 4 |
Phaeosphaeria nodorum TI:13684 None |
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A0A0U9HPB2_KLENI euHCVdb» |
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KFL_003350070 | ER membrane protein complex subunit 4 |
Klebsormidium nitens TI:105231 None |
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Q4Q7D8_LEIMA TubercuList» |
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LMJF_30_1625 LMJF_30_1630 LMJF_30_1635 LMJF_30_1640 LMJF_30_1645 LMJF_30_1650 LMJF_30_1660 | ER membrane protein complex subunit 4 |
Leishmania major TI:5664 None |
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A0A1W2W8Q4_CIOIN Ensembl» |
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LOC100179818 | ER membrane protein complex subunit 4 |
Ciona intestinalis TI:7719 None |
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I1M9A1_SOYBN EnsemblPlants» |
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LOC100305631 | ER membrane protein complex subunit 4 |
Glycine max TI:3847 None |
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C0HHQ5_MAIZE EnsemblPlants» |
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LOC100381640 | ER membrane protein complex subunit 4 |
Zea mays TI:4577 None |
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A0A0R0FGT9_SOYBN EnsemblPlants» |
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LOC100806417 | ER membrane protein complex subunit 4 |
Glycine max TI:3847 None |
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I1H591_BRADI EnsemblPlants» |
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LOC100824221 | ER membrane protein complex subunit 4 |
Brachypodium distachyon TI:15368 None |
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A0A3Q7HK72_SOLLC EnsemblPlants» |
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LOC101246647 | ER membrane protein complex subunit 4 |
Solanum lycopersicum TI:4081 None |
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K4AFT2_SETIT EnsemblPlants» |
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LOC101767452 | ER membrane protein complex subunit 4 |
Setaria italica TI:4555 None |
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M1CHJ9_SOLTU EnsemblPlants» |
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LOC102588607 | ER membrane protein complex subunit 4 |
Solanum tuberosum TI:4113 None |
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A0A1U7Z4I3_NELNU euHCVdb» |
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LOC104589159 | ER membrane protein complex subunit 4 |
Nelumbo nucifera TI:4432 None |
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A0A1U8A9F3_NELNU euHCVdb» |
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LOC104602144 | ER membrane protein complex subunit 4 |
Nelumbo nucifera TI:4432 None |
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A0A1S3ZKI5_TOBAC neXtProt» |
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LOC107787939 | ER membrane protein complex subunit 4 |
Nicotiana tabacum TI:4097 None |
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A0A1S4C767_TOBAC euHCVdb» |
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LOC107815857 | ER membrane protein complex subunit 4 |
Nicotiana tabacum TI:4097 None |
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A0A1U8IYR9_GOSHI euHCVdb» |
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LOC107901650 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A1U8JGJ2_GOSHI neXtProt» |
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LOC107906804 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A1U8PGU3_GOSHI euHCVdb» |
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LOC107958964 | ER membrane protein complex subunit 4 |
Gossypium hirsutum TI:3635 None |
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A0A8J1M525_XENLA CTD» |
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LOC108705001 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus laevis TI:8355 None |
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A0A2I4FPT6_JUGRE euHCVdb» |
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LOC109000999 | ER membrane protein complex subunit 4 |
Juglans regia TI:51240 None |
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A0A2I4G6N1_JUGRE euHCVdb» |
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LOC109005208 | ER membrane protein complex subunit 4 |
Juglans regia TI:51240 None |
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A0A9R0KAP4_SPIOL euHCVdb» |
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LOC110802730 | ER membrane protein complex subunit 4 |
Spinacia oleracea TI:3562 None |
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A9RDI8_PHYPA EnsemblPlants» |
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LOC112295353 | ER membrane protein complex subunit 4 |
Physcomitrium patens TI:3218 None |
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C3YFL5_BRAFL euHCVdb» |
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LOC118417826 | ER membrane protein complex subunit 4 |
Branchiostoma floridae TI:7739 None |
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A0A1D5XTG1_WHEAT EnsemblPlants» |
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LOC123091993 | ER membrane protein complex subunit 4 |
Triticum aestivum TI:4565 None |
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A0A8I7B760_HORVV EnsemblPlants» |
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LOC123448560 | ER membrane protein complex subunit 4 |
Hordeum vulgare TI:4513 None |
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Q10L35_ORYSJ neXtProt» |
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LOC_Os03g24580 Os03g0360500 | ER membrane protein complex subunit 4 |
Oryza sativa TI:4530 None |
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A0A9R1WZY8_LACSA neXtProt» |
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LSAT_V11C800395610 | ER membrane protein complex subunit 4 |
Lactuca sativa TI:4236 None |
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A0A2C9W4V3_MANES neXtProt» |
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MANES_03G007300v8 | ER membrane protein complex subunit 4 |
Manihot esculenta TI:3983 None |
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A0A2C9UCE2_MANES euHCVdb» |
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MANES_16G131700v8 | ER membrane protein complex subunit 4 |
Manihot esculenta TI:3983 None |
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A0A2R6X315_MARPO euHCVdb» |
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MARPO_0039s0015 | ER membrane protein complex subunit 4 |
Marchantia polymorpha TI:3197 None |
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A0A022Q488_ERYGU neXtProt» |
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MIMGU_mgv1a014714mg | ER membrane protein complex subunit 4 |
Erythranthe guttata TI:4155 None |
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A0A022QPH6_ERYGU euHCVdb» |
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MIMGU_mgv1a014736mg | ER membrane protein complex subunit 4 |
Erythranthe guttata TI:4155 None |
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A9UUF5_MONBE euHCVdb» |
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MONBRDRAFT_18332 | ER membrane protein complex subunit 4 |
Monosiga brevicollis TI:81824 None |
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Q7S8H7_NEUCR TubercuList» |
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NCU05231 | ER membrane protein complex subunit 4 |
Neurospora crassa TI:5141 None |
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A7RQ29_NEMVE euHCVdb» |
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NEMVEDRAFT_v1g200413 | ER membrane protein complex subunit 4 |
Nematostella vectensis TI:45351 None |
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Q8ILB0_PLAF7 TubercuList» |
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PF3D7_1435400 | ER membrane protein complex subunit 4 |
Plasmodium falciparum TI:5833 None |
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E3K5M8_PUCGT TubercuList» |
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PGTG_06102 | ER membrane protein complex subunit 4 |
Puccinia graminis TI:5297 None |
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E3KN39_PUCGT TubercuList» |
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PGTG_11004 | ER membrane protein complex subunit 4 |
Puccinia graminis TI:5297 None |
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B9HB78_POPTR euHCVdb» |
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POPTR_006G266300 | ER membrane protein complex subunit 4 |
Populus trichocarpa TI:3694 None |
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A9PHF1_POPTR euHCVdb» |
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POPTR_018G016800 | ER membrane protein complex subunit 4 |
Populus trichocarpa TI:3694 None |
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M5XM02_PRUPE euHCVdb» |
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PRUPE_1G396200 | ER membrane protein complex subunit 4 |
Prunus persica TI:3760 None |
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B9RNT0_RICCO euHCVdb» |
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RCOM_0920530 | ER membrane protein complex subunit 4 |
Ricinus communis TI:3988 None |
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D8R7Z7_SELML euHCVdb» |
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SELMODRAFT_168891 | ER membrane protein complex subunit 4 |
Selaginella moellendorffii TI:88036 None |
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D8QQY7_SELML neXtProt» |
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SELMODRAFT_402529 | ER membrane protein complex subunit 4 |
Selaginella moellendorffii TI:88036 None |
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C5WZL2_SORBI euHCVdb» |
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SORBI_3001G364600 | ER membrane protein complex subunit 4 |
Sorghum bicolor TI:4558 None |
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YQ13_SCHPO PomBase» |
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SPCC1281.03c | ER membrane protein complex subunit 4 |
Schizosaccharomyces pombe TI:4896 None |
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A7ET08_SCLS1 TubercuList» |
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SS1G_08463 | ER membrane protein complex subunit 4 |
Sclerotinia sclerotiorum TI:5180 None |
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A0A1U8ER87_CAPAN euHCVdb» |
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T459_31620 | ER membrane protein complex subunit 4 |
Capsicum annuum TI:4072 None |
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A0A061GIQ5_THECC euHCVdb» |
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TCM_036875 | ER membrane protein complex subunit 4 |
Theobroma cacao TI:3641 None |
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B8C1D2_THAPS euHCVdb» |
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THAPSDRAFT_33995 | ER membrane protein complex subunit 4 |
Thalassiosira pseudonana TI:35128 None |
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B3RM27_TRIAD CTD» |
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TRIADDRAFT_63524 | ER membrane protein complex subunit 4 |
Trichoplax adhaerens TI:10228 None |
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Q584P6_TRYB2 TubercuList» |
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Tb06.4M18.1350 | ER membrane protein complex subunit 4 |
Trypanosoma brucei TI:5691 None |
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A5BA14_VITVI neXtProt» |
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VIT_04s0008g06880 | ER membrane protein complex subunit 4 |
Vitis vinifera TI:29760 None |
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Q6CHC4_YARLI TubercuList» |
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YALI0_A10274g | ER membrane protein complex subunit 4 |
Yarrowia lipolytica TI:4952 None |
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A0A0K9P101_ZOSMR neXtProt» |
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ZOSMA_44G01330 | ER membrane protein complex subunit 4 |
Zostera marina TI:29655 None |
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B6K1I4_SCHJY TubercuList» |
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emc4 | ER membrane protein complex subunit 4 |
Schizosaccharomyces japonicus TI:4897 None |
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EMC4_DANRE ZFIN» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Danio rerio TI:7955 None |
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EMC4_XENLA Xenbase» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus laevis TI:8355 None |
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EMC4_XENTR Xenbase» |
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emc4 | ER membrane protein complex subunit 4 (Transmembrane protein 85) |
Xenopus tropicalis TI:8364 None |
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A8XWS9_CAEBR WormBase» |
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perm-3 | ER membrane protein complex subunit 4 |
Caenorhabditis briggsae TI:6238 None |
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Q9N4N3_CAEEL WormBase» |
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perm-3 | ER membrane protein complex subunit 4 |
Caenorhabditis elegans TI:6239 None |
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