Collated Gene Ontology terms

Biological process: peptidase activity(2025) hydrolase activity(2025) deubiquitinase activity(2014, 2020, 2025) palmitoyl-(protein) hydrolase activity(2025) long-chain fatty acyl-CoA hydrolase activity(2023, 2025) cysteine-type deubiquitinase activity(2020, 2025) K63-linked deubiquitinase activity(2018, 2025) K48-linked deubiquitinase activity(2018, 2025) importin-alpha family protein binding(2020, 2025) identical protein binding(2025)
deSUMOylase activity2020, 2025 metal ion binding2025

Molecular function: proteolysis2025 regulation of proteasomal ubiquitin-dependent protein catabolic process2020, 2024, 2025 protein export from nucleus2020, 2024, 2025 protein modification by small protein removal2025 protein deubiquitination2025 protein desumoylation2020, 2025 convergent extension involved in gastrulation2008 meiotic cell cycle2025

Cellular component: cytoplasm2011, 2014, 2018, 2025 nucleus2011, 2025 cytosol2009, 2020, 2025 protein-containing complex2020, 2025 nuclear lumen2025 mitochondrial outer membrane2025 chloroplast2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 10/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
DESI1_MOUSE
Ensembl»
5.9
Desi1 Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing
protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (S-depalmitoylase DESI1)		 Mus musculus
TI:10090 None
 
DESI2_HUMAN
Ensembl»
3.7
DESI2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing
protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)		 Homo sapiens
TI:9606 None
 
DESI1_HUMAN
Ensembl»
4.2
DESI1 Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2)
(Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1)		 Homo sapiens
TI:9606 None
 
PPDEX_ARATH
TAIR»
0.5
At4g17486 DeSI-like protein At4g17486 (EC 3.4.-.-) Arabidopsis thaliana
TI:3702 None
 
Q8RXP3_ARATH
TAIR»
0.5
At1g47740 PPPDE putative thiol peptidase family protein Arabidopsis thaliana
TI:3702 None
 
Q9SZZ6_ARATH
TAIR»
0.5
At4g25680 At4g25680 (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
DESI2_MOUSE
Ensembl»
4.0
Desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing
protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)		 Mus musculus
TI:10090 None
 
O81728_ARATH
TAIR»
0.5
At2g25190 At2g25190/T22F11.22 Expressed protein (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9SFT9_ARATH
TAIR»
1.0
T1B9.26 PPPDE putative thiol peptidase
family protein (T1B9.26 protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9SZZ4_ARATH
TAIR»
0.5
At4g25660 At4g25660 (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q6NQ19_ARATH
TAIR»
0.5
At5g25170 At5g25170 (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9LVS8_ARATH
TAIR»
0.5
MQL5.17 At5g47310 (PPPDE putative thiol peptidase
family protein) (Similarity to EREBP-4)		 Arabidopsis thaliana
TI:3702 None
 
DESI2_DANRE
ZFIN»
2.6
desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing
protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)		 Danio rerio
TI:7955 None
 
Q6PC81_DANRE
ZFIN»
1.0
desi1a palmitoyl-protein hydrolase (EC 3.1.2.22) Danio rerio
TI:7955 None
 
Q7K2B1_DROME
FlyBase»
1.0
Dmel\CG7222 LD11371p Drosophila melanogaster
TI:7227 None
 
DESI1_CAEEL
WormBase»
0.5
F36D4.5 Desumoylating isopeptidase 1 homolog (DeSI-1)
(EC 3.4.-.-) (Polyubiquitinated substrate transporter) (POST)		 Caenorhabditis elegans
TI:6239 None
 
Q9SAI9_ARATH
TAIR»
0.5
At1g80690 F23A5.4 protein (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q9VWH2_DROME
FlyBase»
1.0
Dmel\CG12231 IP06716p Drosophila melanogaster
TI:7227 None
 
SDU1_SCHPO
PomBase»
1.3
sdu1 DeSI-like protein sdu1 (EC 3.4.-.-)
(Meiotically up-regulated gene 67 protein)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A2R8QHD8_DANRE
Ensembl»
0.0
LOC794838 Deubiquitinase DESI2 (EC 3.1.2.22) (EC 3.4.19.12) (Desumoylating isopeptidase 2) (PPPDE peptidase
domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (Protein FAM152A) (S-depalmitoylase DESI2)		 Danio rerio
TI:7955 None
 
DESI1_RAT
RGD»
5.0
Desi1 Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing
protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (S-depalmitoylase DESI1)		 Rattus norvegicus
TI:10116 None
 
DESI2_CHICK
Ensembl»
1.0
DESI2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing
protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)		 Gallus gallus
TI:9031 None
 
DESI2_RAT
RGD»
4.0
Desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing
protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)		 Rattus norvegicus
TI:10116 None
 
Q54CK2_DICDI
dictyBase»
1.0
DDB_G0292886 PPPDE domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54T20_DICDI
dictyBase»
0.5
DDB_G0282041 PPPDE domain-containing protein Dictyostelium discoideum
TI:44689 None
 
A0A3Q3B0Z9_CHICK
Ensembl»
0.0
DESI1 palmitoyl-protein hydrolase (EC 3.1.2.22) Gallus gallus
TI:9031 None
   
F1P042_CHICK
Ensembl»
0.5
SYNJ2BP palmitoyl-protein hydrolase (EC 3.1.2.22) Gallus gallus
TI:9031 None