Collated Gene Ontology terms

Biological process: peptidase activity(2024) hydrolase activity(2024) deubiquitinase activity(2014, 2020, 2024) long-chain fatty acyl-CoA hydrolase activity(2023, 2024) cysteine-type deubiquitinase activity(2020, 2024) K63-linked deubiquitinase activity(2018, 2024) K48-linked deubiquitinase activity(2018, 2024) palmitoyl-(protein) hydrolase activity(2024) importin-alpha family protein binding(2020, 2024) identical protein binding(2024)
deSUMOylase activity2020, 2024

Molecular function: protein deubiquitination2020, 2024 protein modification by small protein removal2020, 2024 proteolysis2024 regulation of proteasomal ubiquitin-dependent protein catabolic process2020, 2024 protein export from nucleus2020, 2024 macromolecule depalmitoylation2024 protein desumoylation2020, 2024 convergent extension involved in gastrulation2008 meiotic cell cycle2024

Cellular component: cytoplasm2011, 2018, 2024 nucleus2011, 2024 cytosol2009, 2020, 2024 protein-containing complex2020, 2024 membrane2024 mitochondrial membrane2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 9/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
DESI1_RAT
RGD»
4.5
Desi1 Desumoylating isopeptidase 1 (DeSI-1) (EC
3.4.-.-) (PPPDE peptidase domain-containing protein 2)		 Rattus norvegicus
TI:10116 None
 
DESI2_RAT
RGD»
4.5
Desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2)
(DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)		 Rattus norvegicus
TI:10116 None
 
DESI2_HUMAN
Ensembl»
4.2
DESI2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2)
(DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)		 Homo sapiens
TI:9606 None
 
DESI1_HUMAN
Ensembl»
3.7
DESI1 Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE
peptidase domain-containing protein 2) (Polyubiquitinated substrate transporter) (POST)		 Homo sapiens
TI:9606 None
 
DESI2_DANRE
ZFIN»
3.1
desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2)
(DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)		 Danio rerio
TI:7955 None
 
DESI1_MOUSE
Ensembl»
2.9
Desi1 Desumoylating isopeptidase 1 (DeSI-1) (EC
3.4.-.-) (PPPDE peptidase domain-containing protein 2)		 Mus musculus
TI:10090 None
 
SDU1_SCHPO
PomBase»
1.8
sdu1 DeSI-like protein sdu1 (EC 3.4.-.-)
(Meiotically up-regulated gene 67 protein)		 Schizosaccharomyces pombe
TI:4896 None
 
DESI2_CHICK
Ensembl»
1.5
DESI2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2)
(DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)		 Gallus gallus
TI:9031 None
 
DESI2_MOUSE
Ensembl»
1.5
Desi2 Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2)
(DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)		 Mus musculus
TI:10090 None
 
Q7K2B1_DROME
FlyBase»
1.5
Dmel\CG7222 LD11371p (Uncharacterized protein, isoform
A) (Uncharacterized protein, isoform B)		 Drosophila melanogaster
TI:7227 None
 
Q9VWH2_DROME
FlyBase»
1.5
Dmel\CG12231 IP06716p Drosophila melanogaster
TI:7227 None
 
DESI1_CAEEL
WormBase»
1.0
F36D4.5 Desumoylating isopeptidase 1 homolog (DeSI-1)
(EC 3.4.-.-) (Polyubiquitinated substrate transporter) (POST)		 Caenorhabditis elegans
TI:6239 None
 
F1P042_CHICK
Ensembl»
1.0
SYNJ2BP Uncharacterized protein Gallus gallus
TI:9031 None
   
Q54T20_DICDI
dictyBase»
1.0
DDB_G0282041 PPPDE domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q9SAI9_ARATH
TAIR»
1.0
At1g80690 F23A5.4 protein (PPPDE putative
thiol peptidase family protein)		 Arabidopsis thaliana
TI:3702 None
 
Q54CK2_DICDI
dictyBase»
0.5
DDB_G0292886 PPPDE domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q6PC81_DANRE
ZFIN»
0.5
pppde2a Desumoylating isopeptidase 1a (PPPDE peptidase domain
containing 2a) (PPPDE peptidase domain-containing protein 2)		 Danio rerio
TI:7955 None
 
Q7ZTH7_DANRE
ZFIN»
0.5
pppde2b Desumoylating isopeptidase 1b (PPPDE
peptidase domain containing 2b)		 Danio rerio
TI:7955 None
 
A0A8M2B3Z2_DANRE
CTD»
0.0
LOC794838 Desumoylating isopeptidase 2-like isoform X1 Danio rerio
TI:7955 None
   
A0A8V0Y1Y5_CHICK
Ensembl»
0.0
DESI1 Desumoylating isopeptidase 1 Gallus gallus
TI:9031 None
   
O81728_ARATH
TAIR»
0.0
At2g25190 At2g25190/T22F11.22 Expressed protein (PPPDE putative thiol peptidase family
protein) (Uncharacterized protein At2g25190) (Uncharacterized protein At2g25190; T22F11.22)		 Arabidopsis thaliana
TI:3702 None
 
PPDEX_ARATH
TAIR»
0.0
At4g17486 DeSI-like protein At4g17486 (EC 3.4.-.-) Arabidopsis thaliana
TI:3702 None
 
Q6NQ19_ARATH
TAIR»
0.0
At5g25170 At5g25170 (PPPDE putative thiol peptidase
family protein) (Uncharacterized protein At5g25170)		 Arabidopsis thaliana
TI:3702 None
 
Q8RXP3_ARATH
TAIR»
0.0
At1g47740 PPPDE putative thiol peptidase
family protein (Uncharacterized protein At1g47740)		 Arabidopsis thaliana
TI:3702 None
 
Q9LVS8_ARATH
TAIR»
0.0
MQL5.17 At5g47310 (PPPDE putative thiol peptidase family
protein) (Similarity to EREBP-4) (Uncharacterized protein At5g47310)		 Arabidopsis thaliana
TI:3702 None
 
Q9SFT9_ARATH
TAIR»
0.0
T1B9.26 PPPDE putative thiol peptidase family
protein (T1B9.26 protein) (Uncharacterized protein At3g07090)		 Arabidopsis thaliana
TI:3702 None
 
Q9SZZ4_ARATH
TAIR»
0.0
At4g25660 At4g25660 (PPPDE putative thiol peptidase family
protein) (Uncharacterized protein At4g25660) (Uncharacterized protein L73G19.40)		 Arabidopsis thaliana
TI:3702 None
 
Q9SZZ6_ARATH
TAIR»
0.0
At4g25680 At4g25680 (PPPDE putative thiol peptidase family
protein) (Uncharacterized protein At4g25680) (Uncharacterized protein L73G19.60)		 Arabidopsis thaliana
TI:3702 None