Biological process: 1-phosphatidylinositol-4-phosphate 5-kinase activity^{(2005, 2006, 2007, 2008, 2009, 2010, 2011, 2013, 2014, 2015, 2016, 2018, 2019, 2020, 2022, 2023, 2024)} kinase activity⁽²⁰²⁴⁾ ATP binding^{(2019, 2020, 2024)} phosphatidylinositol kinase activity^{(2006, 2023, 2024)} 1-phosphatidylinositol-5-phosphate 4-kinase activity^{(2020, 2022, 2023, 2024)} protein homodimerization activity^{(2016, 2020, 2024)} GTP binding^{(2020, 2024)} identical protein binding⁽²⁰²⁴⁾ kinase binding^{(2010, 2024)} calcium ion binding⁽²⁰²⁴⁾
± 19 transmembrane signaling receptor activity²⁰²⁴ phospholipid binding^{2020, 2024} phosphatidylinositol-4-phosphate binding^{2012, 2017, 2024} phosphatidylinositol-3-phosphate binding^{2012, 2017, 2024} metal ion binding²⁰²⁴ 1-phosphatidylinositol-3-phosphate 4-kinase activity^{2018, 2024} G protein-coupled receptor activity²⁰²⁴ 1-phosphatidylinositol-3-phosphate 5-kinase activity²⁰²⁴ protein kinase regulator activity^{2022, 2024} 1-phosphatidylinositol-5-kinase activity²⁰²⁴ talin binding²⁰¹³ phosphatidylserine binding²⁰¹² phosphatidylinositol-5-phosphate binding²⁰¹² mRNA 3'-UTR binding²⁰²¹ lipid kinase activity²⁰¹⁷ diacylglycerol binding²⁰⁰⁶ calmodulin binding²⁰¹⁰ actin monomer binding²⁰⁰⁷ actin filament binding²⁰⁰⁷

Molecular function: phosphatidylinositol metabolic process^{2004, 2009, 2011, 2012, 2015, 2024} phosphorylation²⁰²⁴ phosphatidylinositol phosphate biosynthetic process^{2013, 2019, 2023, 2024} 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process^{2020, 2022, 2024} regulation of autophagy^{2015, 2020, 2024} negative regulation of insulin receptor signaling pathway^{2019, 2020, 2024} positive regulation of autophagosome assembly^{2017, 2024} autophagosome-lysosome fusion^{2020, 2024} lipid metabolic process²⁰²⁴ phosphatidylinositol biosynthetic process^{2005, 2016, 2024}
± 81 vesicle-mediated cholesterol transport^{2020, 2024} megakaryocyte development^{2011, 2024} positive regulation of apoptotic process^{2019, 2024} negative regulation of mitochondrial membrane potential^{2019, 2024} actin cytoskeleton organization^{2011, 2012, 2014, 2024} negative regulation of cell migration^{2018, 2024} cell surface receptor signaling pathway^{2003, 2024} ruffle assembly^{2011, 2024} protein localization to plasma membrane^{2012, 2024} negative regulation of protein phosphorylation^{2018, 2024} focal adhesion assembly^{2011, 2024} cell chemotaxis^{2011, 2024} phospholipid biosynthetic process^{2010, 2024} fibroblast migration^{2011, 2024} activation of GTPase activity^{2011, 2024} phagocytosis^{2012, 2024} regulation of postsynaptic neurotransmitter receptor internalization²⁰²⁴ regulation of mitotic cytokinesis²⁰²⁴ cortical actin cytoskeleton organization^{2009, 2014, 2024} clathrin-dependent endocytosis^{2011, 2012, 2024} G protein-coupled receptor signaling pathway^{2007, 2024} signal transduction^{2006, 2007, 2014} regulation of synaptic vesicle endocytosis²⁰²⁴ regulation of protein kinase B signaling²⁰²⁴ pollen tube growth²⁰⁰⁹ exocytosis²⁰²⁴ endocytosis^{2009, 2015} chemotaxis²⁰²⁴ cell adhesion²⁰²⁴ carbohydrate metabolic process^{2007, 2024} ascospore-type prospore assembly^{2013, 2024} amino acid metabolic process^{2007, 2024} regulation of muscle organ development^{2017, 2024} regulation of Ras protein signal transduction^{2015, 2024} protein localization^{2014, 2015} pollen germination²⁰⁰⁹ platelet aggregation²⁰¹³ plant-type cell wall modification²⁰⁰⁹ chemotaxis to cAMP^{2015, 2024} axonogenesis²⁰⁰⁸ synaptic vesicle exocytosis²⁰¹² synaptic vesicle endocytosis²⁰¹² stomatal movement²⁰⁰⁷ spermatid development²⁰¹⁰ sorocarp development²⁰⁰⁷ root hair initiation²⁰¹⁶ root hair elongation²⁰⁰⁸ root hair cell tip growth²⁰⁰⁸ regulation of mitotic spindle elongation²⁰¹⁵ regulation of establishment of cell polarity²⁰¹⁶ regulation of TOR signaling²⁰¹³ positive regulation of phagocytosis²⁰¹² positive regulation of multicellular organism growth²⁰¹³ positive regulation of defense response to bacterium²⁰¹² positive regulation of cell growth²⁰¹³ positive gravitropism²⁰¹¹ piecemeal microautophagy of the nucleus²⁰²¹ oocyte microtubule cytoskeleton polarization²⁰⁰⁹ oocyte dorsal/ventral axis specification²⁰¹⁷ neutrophil chemotaxis²⁰¹² negative regulation of protein kinase B signaling²⁰²³ negative regulation of clathrin-dependent endocytosis²⁰¹⁷ membrane organization²⁰²⁴ lateral root formation²⁰¹¹ keratinocyte differentiation²⁰¹² invasive filamentous growth²⁰¹⁴ glycerophospholipid metabolic process²⁰⁰⁶ flower development²⁰²⁴ establishment of tissue polarity²⁰⁰⁹ endosome organization²⁰²¹ dynein-driven meiotic oscillatory nuclear movement²⁰¹⁹ developmental process involved in reproduction²⁰¹⁰ defense response²⁰²⁴ cell-cell adhesion²⁰¹² cell migration²⁰¹⁰ cell division²⁰²⁴ cell differentiation²⁰²⁴ basement membrane organization²⁰¹⁴ autophagy of mitochondrion²⁰²¹ aggregation involved in sorocarp development²⁰⁰⁶ adherens junction assembly²⁰¹²

Cellular component: plasma membrane^{2007, 2010, 2011, 2014, 2016, 2017, 2020, 2021, 2022, 2023, 2024} membrane^{2007, 2014, 2024} cytosol^{2007, 2011, 2013, 2016, 2020, 2023, 2024} cytoplasm^{2008, 2024} nucleus^{2006, 2007, 2010, 2011, 2013, 2020, 2024} autophagosome^{2015, 2024} nucleoplasm^{2016, 2023, 2024} lysosome^{2020, 2024} endoplasmic reticulum²⁰²⁴ cell projection^{2005, 2024}
± 34 uropod^{2011, 2012, 2024} ruffle membrane^{2011, 2024} nuclear speck^{2010, 2012, 2024} lamellipodium^{2010, 2024} intracellular membrane-bounded organelle²⁰²⁴ mRNA cleavage and polyadenylation specificity factor complex^{2010, 2024} apical plasma membrane^{2008, 2009, 2011, 2014, 2024} endomembrane system²⁰²⁴ pollen tube^{2011, 2024} focal adhesion^{2012, 2014, 2024} endosome membrane^{2017, 2024} postsynaptic density²⁰²⁴ photoreceptor outer segment²⁰²⁴ photoreceptor inner segment²⁰²⁴ glutamatergic synapse²⁰²⁴ cell division site^{2022, 2024} ruffle²⁰²⁴ phagocytic cup²⁰²⁴ endoplasmic reticulum membrane²⁰²⁴ ciliary pocket^{2015, 2018} anchoring junction²⁰²⁴ adherens junction²⁰²⁴ cell cortex^{2009, 2024} site of polarized growth²⁰¹⁴ presynaptic endocytic zone membrane²⁰²⁴ presynapse²⁰²⁴ phagolysosome membrane²⁰¹² motile cilium²⁰²⁴ male germline ring canal²⁰¹⁰ late endosome membrane²⁰¹² extracellular exosome²⁰¹⁴ endosome²⁰⁰⁷ early endosome²⁰¹⁷ chromosome²⁰²⁴