Collated Gene Ontology terms

Biological process: oxidoreductase activity(2014, 2024) estradiol 17-beta-dehydrogenase [NAD(P)] activity(2017, 2018, 2024) 3-keto sterol reductase activity(2017, 2018, 2024) 17-beta-ketosteroid reductase activity(2017, 2018, 2024) 17-beta-hydroxysteroid dehydrogenase (NADP+) activity(2017, 2018, 2024) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(2023, 2024) nucleotide binding(2024) NAD-retinol dehydrogenase activity(2014, 2024)

Molecular function: steroid biosynthetic process2017, 2024 steroid metabolic process2024 estrogen biosynthetic process2024 rhodopsin biosynthetic process2014

Cellular component: membrane2021, 2024 extracellular region2024 cytoplasm2014

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 2/8 
Bacteria: 9/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
DHR11_HUMAN
Ensembl»
4.0
DHRS11 Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC
1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)		 Homo sapiens
TI:9606 None
 
G3V978_RAT
RGD»
2.5
Dhrs11 Dehydrogenase/reductase 11 Rattus norvegicus
TI:10116 None
   
Q9VZ19_DROME
FlyBase»
2.5
Antdh Antdh (EC 1.-.-.-, EC 1.1.1.270, EC 1.1.1.62) Drosophila melanogaster
TI:7227 None
 
Q5LJT3_DROME
FlyBase»
2.0
CG12466 MIP01391p (Uncharacterized protein, isoform B (EC
1.1.1.270, EC 1.1.1.62)) (Uncharacterized protein, isoform C)		 Drosophila melanogaster
TI:7227 None
 
Q6NNV7_DROME
FlyBase»
2.0
Dmel\CG40485 RH03309p (Uncharacterized protein, isoform B) (Uncharacterized
protein, isoform C (EC 1.1.1.270, EC 1.1.1.62))		 Drosophila melanogaster
TI:7227 None
 
Q8IRN0_DROME
FlyBase»
2.0
CG7090 FI06485p Drosophila melanogaster
TI:7227 None
 
Q9VDC0_DROME
FlyBase»
2.0
FOHSDR GH01837p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform
B (EC 1.1.1.270, EC 1.1.1.62)) (Uncharacterized protein, isoform C)		 Drosophila melanogaster
TI:7227 None
 
Q9VMH9_DROME
FlyBase»
2.0
Dmel\CG9150 Uncharacterized protein Drosophila melanogaster
TI:7227 None
 
Q9VU92_DROME
FlyBase»
2.0
FOHSDR Uncharacterized protein Drosophila melanogaster
TI:7227 None
 
Q9VYU9_DROME
FlyBase»
2.0
Dmel\CG9360 RH17287p Drosophila melanogaster
TI:7227 None
 
Q9VD30_DROME
FlyBase»
1.6
rdhB GH05294p (Retinol dehydrogenase B, isoform A
(EC 1.1.1.105)) (Retinol dehydrogenase B, isoform B)		 Drosophila melanogaster
TI:7227 None
 
A0A139WGG2_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_33405 Dehydrogenase/reductase SDR family
member 11-like Protein		 Tribolium castaneum
TI:7070 None
 
A0A1L8H723_XENLA
Xenbase»
0.0
dhrs11.S Dehydrogenase/reductase (SDR family) member
11 S homeolog isoform X1		 Xenopus laevis
TI:8355 None 		     
A0A1S4H3L9_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None 		 
 
A0A3B3IBU1_ORYLA
Ensembl»
0.0
LOC101160498 Dehydrogenase/reductase SDR family member 11 Oryzias latipes
TI:8090 None 		     
A0A452DID6_BOVIN
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Bos taurus
TI:9913 None
   
A0A5F8H7E0_MONDO
Ensembl»
0.0
Dehydrogenase/reductase 11 Monodelphis domestica
TI:13616 None 		     
A0A6I8T1Q5_XENTR
Xenbase»
0.0
dhrs11 Dehydrogenase/reductase (SDR family) member 11 (Dehydrogenase/reductase
SDR family member 11 isoform X2)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7P939_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7R952_STRPU
EnsemblMetazoa»
0.0
Dehydrogenase/reductase SDR family member 11 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7RB07_STRPU
EnsemblMetazoa»
0.0
Dehydrogenase/reductase SDR family member 11 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7TG71_STRPU
EnsemblMetazoa»
0.0
Dehydrogenase/reductase SDR family member 11 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A8I3Q1V9_CANLF
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Canis lupus
TI:9612 None
   
A0A8J0U7P7_XENLA
Xenbase»
0.0
dhrs11.L Dehydrogenase/reductase SDR family member 11 Xenopus laevis
TI:8355 None
   
A0A9J7HTP0_BRAFL
CTD»
0.0
LOC118408418 Dehydrogenase/reductase SDR
family member 11-like		 Branchiostoma floridae
TI:7739 None
   
A0A9J7KL18_BRAFL
CTD»
0.0
LOC118408333 Dehydrogenase/reductase SDR
family member 11-like		 Branchiostoma floridae
TI:7739 None
   
A0A9J7KLH6_BRAFL
CTD»
0.0
LOC118408332 Dehydrogenase/reductase SDR
family member 11-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MZT3_BRAFL
CTD»
0.0
LOC118421586 Dehydrogenase/reductase SDR
family member 11-like		 Branchiostoma floridae
TI:7739 None 		     
A0NEE1_ANOGA
EnsemblMetazoa»
0.0
4576326 AGAP005500-PA Anopheles gambiae
TI:7165 None 		 
 
A0NEE2_ANOGA
EnsemblMetazoa»
0.0
4576324 AGAP005502-PA Anopheles gambiae
TI:7165 None
 
A5WUM7_DANRE
ZFIN»
0.0
zgc:153028 Dehydrogenase/reductase 11a (Dehydrogenase/reductase
SDR family member 11)		 Danio rerio
TI:7955 None 		 
 
A7ESK9_SCLS1
EnsemblFungi»
0.0
SS1G_08314 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None 		 
 
A8XWJ3_CAEBR
WormBase»
0.0
CBG19827 CBG_19827 Protein CBG19827 Caenorhabditis briggsae
TI:6238 None 		 
 
A9A3Y2_NITMS
EnsemblBacteria»
0.0
Nmar_1786 Short-chain dehydrogenase/reductase SDR Nitrosopumilus maritimus
TI:338192 None
 
B5YFM1_THEYD
EnsemblBacteria»
0.0
THEYE_A1253 Clavaldehyde dehydrogenase Thermodesulfovibrio yellowstonii
TI:28262 None
 
C3XS58_BRAFL
CTD»
0.0
LOC118421569 Dehydrogenase/reductase SDR family
member 11-like isoform X2		 Branchiostoma floridae
TI:7739 None
 
D2A464_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_14887 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None
 
D2A4S0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15414 Dehydrogenase/reductase SDR family
member 11-like Protein		 Tribolium castaneum
TI:7070 None
 
D2A5J6_TRICA
EnsemblMetazoa»
0.0
GLEAN_15161 Farnesol dehydrogenase-like Tribolium castaneum
TI:7070 None
 
D2A5K0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15159 Dehydrogenase/reductase SDR family
member 11-like Protein		 Tribolium castaneum
TI:7070 None 		 
 
D2A5K2_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15158 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None 		 
 
D2A5K3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15554 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None 		 
 
D2A5V5_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15599 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None 		 
 
D2A5V7_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15101 Peroxisomal multifunctional enzyme
type 2-like Protein		 Tribolium castaneum
TI:7070 None 		 
 
D2A5V8_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15100 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None
 
D2A5V9_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15601 Dehydrogenase/reductase SDR family
member 11-like Protein		 Tribolium castaneum
TI:7070 None 		 
 
D6WF36_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_03807 3-hydroxyacyl-CoA dehydrogenase
type-2-like Protein		 Tribolium castaneum
TI:7070 None
 
D7EJA1_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_10240 Dehydrogenase/reductase SDR family
member 11-like Protein		 Tribolium castaneum
TI:7070 None
 
D7ELE5_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_05026 Dehydrogenase/reductase SDR
family protein 7-like		 Tribolium castaneum
TI:7070 None
 
DHR11_BOVIN
CTD»
0.0
DHRS11 Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC
1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)		 Bos taurus
TI:9913 None
 
DHR11_CHICK
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC
1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)		 Gallus gallus
TI:9031 None
 
DHR11_MOUSE
Ensembl»
0.0
Dhrs11 Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC
1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)		 Mus musculus
TI:10090 None
 
E9FY40_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_306348 Dehydrogenase/reductase SDR family member 11 Daphnia pulex
TI:6669 None 		 
 
F0ZLT7_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_92084 Oxidoreductase Dictyostelium purpureum
TI:5786 None
 
F1QDB3_DANRE
ZFIN»
0.0
zgc:92630 Dehydrogenase/reductase SDR family member
11-like isoform X1 (Zgc:92630)		 Danio rerio
TI:7955 None 		 
 
F1R5X7_DANRE
ZFIN»
0.0
dhrs11b Dehydrogenase/reductase (SDR family) member 11b Danio rerio
TI:7955 None
 
F1S1B9_PIG
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Sus scrofa
TI:9823 None
   
F6PTH0_CIOIN
Ensembl»
0.0
Dehydrogenase/reductase SDR family member 11 Ciona intestinalis
TI:7719 None
 
F6PTW3_CIOIN
Ensembl»
0.0
Dehydrogenase/reductase SDR family member 11 Ciona intestinalis
TI:7719 None
 
F6PUC9_CIOIN
Ensembl»
0.0
LOC100183772 Dehydrogenase/reductase SDR
family member 11-like		 Ciona intestinalis
TI:7719 None
 
F6RPI4_CIOIN
Ensembl»
0.0
LOC100175937 Dehydrogenase/reductase SDR
family member 11-like		 Ciona intestinalis
TI:7719 None
 
F6RPK0_CIOIN
Ensembl»
0.0
Dehydrogenase/reductase SDR family member 11 Ciona intestinalis
TI:7719 None
 
F6RSS5_CIOIN
Ensembl»
0.0
Dehydrogenase/reductase SDR family member 11 Ciona intestinalis
TI:7719 None 		 
 
F6T446_ORNAN
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Ornithorhynchus anatinus
TI:9258 None
   
G3QY64_GORGO
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Gorilla gorilla
TI:9593 None
 
H2M6Z5_ORYLA
Ensembl»
0.0
dhrs11 Dehydrogenase/reductase 11 Oryzias latipes
TI:8090 None 		     
H2R0C6_PANTR
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase (SDR family)
member 11 (Dehydrogenase/reductase 11)		 Pan troglodytes
TI:9598 None
 
M3W6Y9_FELCA
Ensembl»
0.0
DHRS11 Dehydrogenase/reductase 11 Felis catus
TI:9685 None
 
Q54PT0_DICDI
dictyBase»
0.0
DDB_G0284351 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q55922_SYNY3
EnsemblBacteria»
0.0
slr0315 Slr0315 protein Synechocystis sp.
TI:1148 None
 
Q5TRM2_ANOGA
EnsemblMetazoa»
0.0
3289985 AGAP005501-PA Anopheles gambiae
TI:7165 None
 
Q7Q6V7_ANOGA
EnsemblMetazoa»
0.0
1276330 AGAP005645-PA Anopheles gambiae
TI:7165 None
 
Q7Q752_ANOGA
EnsemblMetazoa»
0.0
1276185 AGAP005503-PA Anopheles gambiae
TI:7165 None
 
Q7Q754_ANOGA
EnsemblMetazoa»
0.0
1276182 AGAP005499-PA Anopheles gambiae
TI:7165 None
 
Q7QBB1_ANOGA
EnsemblMetazoa»
0.0
1273927 AGAP004103-PA Anopheles gambiae
TI:7165 None
 
Q815Q8_BACCR
EnsemblBacteria»
0.0
BC_5076 Short chain dehydrogenase Bacillus cereus
TI:1396 None
 
Q89KW0_BRADU
EnsemblBacteria»
0.0
blr4790 Blr4790 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q8E9X1_SHEON
EnsemblPlants»
0.0
SO_4141 Oxidoreductase short-chain
dehydrogenase/reductase family		 Shewanella oneidensis
TI:70863 None
 
Q9HSR4_HALSA
EnsemblBacteria»
0.0
yusZ1 Oxidoreductase (Probable oxidoreductase
(Short-chaindehydrogenase family) (EC 1.1.1.-))		 Halobacterium salinarum
TI:2242 None
 
Q9KKP5_VIBCH
EnsemblBacteria»
0.0
VC_A1057 Oxidoreductase, short-chain
dehydrogenase/reductase family		 Vibrio cholerae
TI:666 None
 
Q9RJL6_STRCO
EnsemblBacteria»
0.0
SCO0519 Oxidoreductase Streptomyces coelicolor
TI:1902 None
 
Q9RK87_STRCO
EnsemblBacteria»
0.0
SCO0522 Oxidoreductase Streptomyces coelicolor
TI:1902 None
 
Q9TYR0_CAEEL
WormBase»
0.0
CELE_H04M03.3 H04M03.3 DeHydrogenases, Short chain Caenorhabditis elegans
TI:6239 None
 
T1G2M7_HELRO
EnsemblMetazoa»
0.0
20215325 Dehydrogenase/reductase SDR family member 11 Helobdella robusta
TI:6412 None 		 
 
W5M606_LEPOC
Ensembl»
0.0
Dehydrogenase/reductase 11 Lepisosteus oculatus
TI:7918 None
 
Y2778_STAA8
EnsemblBacteria»
0.0
SAOUHSC_02778 Uncharacterized oxidoreductase
SAOUHSC_02778 (EC 1.-.-.-)		 Staphylococcus aureus
TI:1280 None
 
Y432_LISMO
EnsemblBacteria»
0.0
lmo0432 Uncharacterized oxidoreductase Lmo0432
(EC 1.-.-.-) (ORFA)		 Listeria monocytogenes
TI:1639 None