Collated Gene Ontology terms

Biological process: transcription cis-regulatory region binding(2011, 2021, 2024) Y-form DNA binding(2008, 2017, 2024) chromatin binding(2008, 2014, 2017, 2024) protein-macromolecule adaptor activity(2011, 2024) phosphoprotein binding(2021, 2024) four-way junction DNA binding(2008, 2024) double-stranded DNA binding(2008, 2024) R-SMAD binding(2009, 2024) DNA binding(2015, 2024) sequence-specific DNA binding(2011)
DNA-binding transcription activator activity2021

Molecular function: negative regulation of cell population proliferation2008, 2022, 2024 negative regulation of cell cycle2008, 2021, 2024 regulation of transcription by RNA polymerase II2021, 2024 positive regulation of transcription by RNA polymerase II2008, 2011, 2014, 2021, 2024 negative regulation of transcription by RNA polymerase II2008, 2014, 2016, 2023, 2024 negative regulation of osteoblast differentiation2008, 2024 osteoblast development2008, 2024 transcription initiation-coupled chromatin remodeling2023, 2024 negative regulation of JNK cascade2008, 2024 negative regulation of DNA-templated transcription2004, 2008, 2024
DNA damage response2007, 2008, 2024 response to gamma radiation2008, 2024 response to UV2008, 2024 positive regulation of transforming growth factor beta receptor signaling pathway2008, 2024 T-helper 2 cell differentiation2022, 2024 MAPK cascade2008, 2024 negative regulation of protein phosphorylation2008, 2024 negative regulation of cyclin-dependent protein serine/threonine kinase activity2008, 2024 negative regulation of DNA-binding transcription factor activity2008, 2024 chromatin organization2024 cell population proliferation2008 type B pancreatic cell proliferation2008 stem cell proliferation2008 positive regulation of gene expression2015, 2023 positive regulation of fibroblast apoptotic process2008 negative regulation of type B pancreatic cell proliferation2008 negative regulation of stem cell proliferation2008 fibroblast apoptotic process2008 chromatin remodeling2008 stem cell differentiation2008 roof of mouth development2008 regulation of gene expression2015 regulation of G1/S transition of mitotic cell cycle2021 positive regulation of stem cell differentiation2008 positive regulation of osteoblast differentiation2008 positive regulation of cell division2008 positive regulation of DNA-templated transcription2005 osteoblast fate commitment2008 ossification2008 organ growth2008 negative regulation of organ growth2008 negative regulation of fibroblast proliferation2008 maternal process involved in female pregnancy2008 leukocyte homeostasis2008 hemopoiesis2008 fibroblast proliferation2008 embryonic skeletal system morphogenesis2008 cell division2008 type B pancreatic cell differentiation2014 response to transforming growth factor beta2014 response to salt stress2007 response to oxidative stress2007 response to ionizing radiation2007 response to hypoxia2007 response to heat2007 regulation of type B pancreatic cell proliferation2014 regulation of activin receptor signaling pathway2008 proboscis development2007 positive regulation of JNK cascade2008 nucleotide-excision repair2008 negative regulation of epithelial cell proliferation2014 negative regulation of cell-substrate adhesion2014 negative regulation of cell cycle G1/S phase transition2014 mitotic G1 DNA damage checkpoint signaling2010 interstrand cross-link repair2013 imaginal disc fusion, thorax closure2007 determination of adult lifespan2007 decidualization2014 cellular response to peptide hormone stimulus2014 cellular response to glucose stimulus2014 DNA repair2008

Cellular component: nucleus2005, 2007, 2008, 2009, 2024 histone methyltransferase complex2009, 2021, 2024 chromatin2020, 2021, 2024 transcription repressor complex2016, 2023, 2024 cytosol2006, 2015, 2023, 2024 cytoplasm2008, 2024 MLL1/2 complex2012, 2023, 2024 protein-containing complex2008, 2024 nucleoplasm2012, 2023, 2024 nuclear matrix2008, 2024
cleavage furrow2006, 2024 MLL1 complex2023, 2024 chromosome, telomeric region2016 endoplasmic reticulum lumen2017

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 10.0 20.0 30.0 40.0 Knownness

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Proteins

UniProt ID
Organism DB»
Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
MEN1_HUMAN
Ensembl»
23.6
MEN1 Menin Homo sapiens
TI:9606 None
 
MEN1_MOUSE
Ensembl»
43.9
Men1 Menin Mus musculus
TI:10090 None
 
MEN1_RAT
RGD»
40.4
Men1 Menin Rattus norvegicus
TI:10116 None
 
Q9VM47_DROME
FlyBase»
14.2
Mnn1 Menin Drosophila melanogaster
TI:7227 None
 
Q9IAA9_DANRE
ZFIN»
3.8
zgc:110510 Menin Danio rerio
TI:7955 None