Collated Gene Ontology terms

Biological process: phosphoprotein phosphatase activity(2025) hydrolase activity(2025) protein serine/threonine phosphatase activity(2025) MAP kinase tyrosine/serine/threonine phosphatase activity(2022, 2025) protein tyrosine phosphatase activity(2025) phosphatase activity(2016, 2025) protein tyrosine/threonine phosphatase activity(2020) MAP kinase tyrosine phosphatase activity(2024) protein tyrosine/serine/threonine phosphatase activity(2024) RNA binding(2014)

Molecular function: dephosphorylation2016, 2025 neuromast hair cell development2023 auditory receptor cell development2023

Cellular component: cytoplasm2008, 2012, 2025 striated muscle myosin thick filament2012 striated muscle dense body2012 nucleus2008 cytosol2023

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
DUS28_MOUSE
Ensembl»
2.0
Dusp28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Mus musculus
TI:10090 None
 
A0AB32T8A1_DANRE
ZFIN»
1.6
dusp14 Dual specificity protein
phosphatase 14 isoform X1		 Danio rerio
TI:7955 None
   
DUS28_HUMAN
Ensembl»
1.6
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Homo sapiens
TI:9606 None
 
A0ABK0LCV3_RAT
Ensembl»
1.0
Dusp28 Dual specificity phosphatase 28 Rattus norvegicus
TI:10116 None
   
DUS14_HUMAN
Ensembl»
0.5
DUSP14 Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine
phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)		 Homo sapiens
TI:9606 None
 
Q9VAB0_DROME
FlyBase»
0.5
Dmel\CG15528 IP21249p Drosophila melanogaster
TI:7227 None
 
A0A1D5R0Y9_MACMU
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Macaca mulatta
TI:9544 None
   
A0A1L8GAW0_XENLA
Xenbase»
0.0
dusp28.L Dual specificity phosphatase 28 Xenopus laevis
TI:8355 None
   
A0A2A6BKC3_PRIPA
EnsemblMetazoa»
0.0
WBGene00093477 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6BQK6_PRIPA
EnsemblMetazoa»
0.0
WBGene00092163 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6C529_PRIPA
EnsemblMetazoa»
0.0
WBGene00096089 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2A6C6J2_PRIPA
EnsemblMetazoa»
0.0
WBGene00273212 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2I2YD41_GORGO
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Gorilla gorilla
TI:9593 None
 
A0A2I2ZFS7_GORGO
Ensembl»
0.0
Dual specificity phosphatase 14 Gorilla gorilla
TI:9593 None
 
A0A3B3I2G0_ORYLA
Ensembl»
0.0
LOC101159168 Protein-tyrosine-phosphatase Oryzias latipes
TI:8090 None
   
A0A3Q1MH98_BOVIN
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Bos taurus
TI:9913 None
   
A0A3Q2HCE2_HORSE
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Equus caballus
TI:9796 None
   
A0A6I8NE24_ORNAN
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7GG29_STRPU
EnsemblMetazoa»
0.0
protein-serine/threonine phosphatase
(EC 3.1.3.16)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3NI61_CANLF
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Canis lupus
TI:9612 None
   
A0A8J0SXC1_XENTR
Xenbase»
0.0
dusp28 Dual specificity phosphatase 28 isoform X1 Xenopus tropicalis
TI:8364 None
   
A0A8M2BIT0_DANRE
ZFIN»
0.0
LOC100150565 Dual specificity protein phosphatase 14 Danio rerio
TI:7955 None
   
A0A8V0ZXB3_CHICK
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Gallus gallus
TI:9031 None
   
A0A9J7KLD4_BRAFL
neXtProt»
0.0
LOC118408152 Dual specificity protein phosphatase 19-like Branchiostoma floridae
TI:7739 None
   
A0A9J7LSD5_BRAFL
neXtProt»
0.0
LOC118423481 protein-serine/threonine phosphatase
(EC 3.1.3.16)		 Branchiostoma floridae
TI:7739 None
   
A0ABI7XB06_FELCA
Ensembl»
0.0
PHETA2 Dual specificity phosphatase 28 Felis catus
TI:9685 None
   
A0ABI8AAM8_FELCA
Ensembl»
0.0
DUSP14 Protein-tyrosine-phosphatase Felis catus
TI:9685 None
   
A0ABK0LD64_RAT
Ensembl»
0.0
Dusp14l1 Dual specificity phosphatase 14-like 1 Rattus norvegicus
TI:10116 None
   
A0C390_PARTE
euHCVdb»
0.0
GSPATT00034735001 Protein-tyrosine-phosphatase Paramecium tetraurelia
TI:5888 None
 
A0CEA7_PARTE
neXtProt»
0.0
GSPATT00037560001 Protein-tyrosine-phosphatase Paramecium tetraurelia
TI:5888 None
 
A0DP38_PARTE
neXtProt»
0.0
GSPATT00018986001 Tyrosine specific protein
phosphatases domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A0E8V2_PARTE
neXtProt»
0.0
GSPATT00024450001 Tyrosine-protein phosphatase
domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A1EC97_RAT
RGD»
0.0
Dusp14 Dual specificity phosphatase 14
(Dual specificity phosphate 14)		 Rattus norvegicus
TI:10116 None
 
A7RMT6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g234224 protein-serine/threonine phosphatase
(EC 3.1.3.16)		 Nematostella vectensis
TI:45351 None
 
A8WML9_CAEBR
WormBase»
0.0
CBG00285 CBG_00285 Protein CBG00285 Caenorhabditis briggsae
TI:6238 None
 
A8WWP5_CAEBR
WormBase»
0.0
CBG03773 CBG_03773 Protein CBG03773 Caenorhabditis briggsae
TI:6238 None
 
A8XA12_CAEBR
WormBase»
0.0
CBG09952 CBG_09952 Protein CBG09952 Caenorhabditis briggsae
TI:6238 None
 
A8XKL4_CAEBR
WormBase»
0.0
CBG14753 CBG_14753 Protein CBG14753 Caenorhabditis briggsae
TI:6238 None
 
B7P362_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW016177 Dual specificity phosphatase, catalytic
domain, putative (EC 3.1.3.16)		 Ixodes scapularis
TI:6945 None
 
C3YFH4_BRAFL
euHCVdb»
0.0
LOC118417768 protein-serine/threonine phosphatase
(EC 3.1.3.16)		 Branchiostoma floridae
TI:7739 None
 
D6WN84_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_10951 Dual specificity protein
phosphatase Mpk3-like Protein		 Tribolium castaneum
TI:7070 None
 
DUS14_BOVIN
Ensembl»
0.0
DUSP14 Dual specificity protein phosphatase
14 (EC 3.1.3.16) (EC 3.1.3.48)		 Bos taurus
TI:9913 None
 
DUS14_MOUSE
Ensembl»
0.0
Dusp14 Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48)
(Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)		 Mus musculus
TI:10090 None
 
F0ZU34_DICPU
TubercuList»
0.0
DICPUDRAFT_10471 Protein-tyrosine-phosphatase Dictyostelium purpureum
TI:5786 None
 
F1QE47_DANRE
ZFIN»
0.0
dusp28 Dual specificity phosphatase 28 Danio rerio
TI:7955 None
 
F6PUA3_ORNAN
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Ornithorhynchus anatinus
TI:9258 None
   
F6YY21_HORSE
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Equus caballus
TI:9796 None
   
F7DK42_MONDO
Ensembl»
0.0
Uncharacterized protein Monodelphis domestica
TI:13616 None
   
F7FYZ5_MONDO
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Monodelphis domestica
TI:13616 None
   
F7GXT5_MACMU
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14
(Dual specificity protein phosphatase 14)		 Macaca mulatta
TI:9544 None
 
H2LI35_ORYLA
Ensembl»
0.0
Dual specificity phosphatase 14 Oryzias latipes
TI:8090 None
   
H2LQW9_ORYLA
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28 Oryzias latipes
TI:8090 None
   
H2LSC0_ORYLA
Ensembl»
0.0
Si:ch1073-184j22.2 Oryzias latipes
TI:8090 None
   
H2QCS1_PANTR
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Pan troglodytes
TI:9598 None
 
H2QJQ7_PANTR
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Pan troglodytes
TI:9598 None
 
H9GKZ7_ANOCA
Ensembl»
0.0
dusp14 Uncharacterized protein Anolis carolinensis
TI:28377 None
   
I3L5M7_PIG
Ensembl»
0.0
DUSP28 Dual specificity phosphatase 28
(EC 3.1.3.16) (EC 3.1.3.48)		 Sus scrofa
TI:9823 None
 
I3LNI4_PIG
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Sus scrofa
TI:9823 None
   
Q19388_CAEEL
WormBase»
0.0
CELE_F13D11.3 F13D11.3 Protein-tyrosine-phosphatase Caenorhabditis elegans
TI:6239 None
 
Q7Q581_ANOGA
EnsemblMetazoa»
0.0
1277176 AGAP006593-PA Anopheles gambiae
TI:7165 None
 
Q93592_CAEEL
WormBase»
0.0
CELE_F26A3.4 F26A3.4 Protein-tyrosine-phosphatase Caenorhabditis elegans
TI:6239 None
 
Q9XVE7_CAEEL
WormBase»
0.0
C04F12.8 CELE_C04F12.8 Protein-tyrosine-phosphatase Caenorhabditis elegans
TI:6239 None
 
R4GIQ5_CHICK
Ensembl»
0.0
DUSP14 Dual specificity phosphatase 14 Gallus gallus
TI:9031 None
   
T1EP36_HELRO
EnsemblMetazoa»
0.0
20198336 Protein-tyrosine-phosphatase Helobdella robusta
TI:6412 None
 
T1EY97_HELRO
EnsemblMetazoa»
0.0
20201547 Protein-tyrosine-phosphatase Helobdella robusta
TI:6412 None
 
T1FWZ5_HELRO
EnsemblMetazoa»
0.0
20213343 Protein-tyrosine-phosphatase Helobdella robusta
TI:6412 None
 
T1G8V3_HELRO
EnsemblMetazoa»
0.0
20217500 Protein-tyrosine-phosphatase Helobdella robusta
TI:6412 None
 
W5MRY7_LEPOC
Ensembl»
0.0
Dual specificity phosphatase 28 Lepisosteus oculatus
TI:7918 None
 
W5NLN5_LEPOC
Ensembl»
0.0
Dual specificity phosphatase 14 Lepisosteus oculatus
TI:7918 None
 
YO42_CAEEL
WormBase»
0.0
ZK757.2 Uncharacterized protein ZK757.2 Caenorhabditis elegans
TI:6239 None