Collated Gene Ontology terms

Biological process: 6,7-dihydropteridine reductase activity(2003, 2008, 2010, 2011, 2019, 2020, 2022, 2024) oxidoreductase activity(2024) NADPH binding(2011, 2017, 2024) NADH binding(2011, 2017, 2024) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(2024) identical protein binding(2011, 2019, 2024) NAD binding(2019, 2024) electron transfer activity(2006)

Molecular function: tetrahydrobiopterin biosynthetic process2005, 2008, 2010, 2011, 2013, 2017, 2024 L-phenylalanine catabolic process2011, 2017, 2024 response to oxidative stress2013, 2024 melanin biosynthetic process2020, 2024 L-phenylalanine metabolic process2020, 2024 response to lead ion2011 response to glucagon2011 response to aluminum ion2011 liver development2011 glutamine metabolic process2020
gliogenesis2020 dihydrobiopterin metabolic process2004 cellular response to xenobiotic stimulus2011 brain development2020 amino acid metabolic process2003

Cellular component: cytoplasm2010, 2023, 2024 mitochondrion2009, 2024 phagocytic vesicle2009 extracellular exosome2014 cytosol2013

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 5 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A2A6BHS8_PRIPA
EnsemblMetazoa»
0.0
WBGene00281248 Dehydrogenase Pristionchus pacificus
TI:54126 None
 
A0A8I6G9Y8_RAT
RGD»
0.0
AABR07068905.1 Uncharacterized protein Rattus norvegicus
TI:10116 None
   
A0A8V0Y9C4_CHICK
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Gallus gallus
TI:9031 None
   
A0A9J7KWR9_BRAFL
CTD»
0.0
LOC118412990 Dihydropteridine reductase-like Branchiostoma floridae
TI:7739 None
   
H3GJ45_PHYRM
EnsemblProtists»
0.0
NAD-dependent epimerase/dehydratase
domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
A0A2A6BZ98_PRIPA
EnsemblMetazoa»
0.0
WBGene00101428 Qdpr-1 Pristionchus pacificus
TI:54126 None
 
F6TQR0_MACMU
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Macaca mulatta
TI:9544 None
   
Q5HZU9_XENTR
Xenbase»
0.0
qdpr Dihydropteridine reductase (EC
1.5.1.34) (Quinoid dihydropteridine reductase)		 Xenopus tropicalis
TI:8364 None
 
A0A5G2QZN1_PIG
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Sus scrofa
TI:9823 None
   
A0A8I3MGQ6_CANLF
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Canis lupus
TI:9612 None
   
A0A5F8H6H4_MONDO
Ensembl»
0.0
Quinoid dihydropteridine reductase Monodelphis domestica
TI:13616 None
   
A0A6I8PJE6_ORNAN
Ensembl»
0.0
Quinoid dihydropteridine reductase Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7NUM3_STRPU
EnsemblMetazoa»
0.0
Dihydropteridine reductase Strongylocentrotus purpuratus
TI:7668 None
   
A0A8M3B0J5_DANRE
CTD»
2.5
qdprb2 Quinoid dihydropteridine reductase b2 isoform X2 Danio rerio
TI:7955 None
   
A0BZW3_PARTE
EnsemblProtists»
0.0
GSPATT00005932001 Chromosome undetermined scaffold_14,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
   
A0DJ73_PARTE
EnsemblProtists»
0.0
GSPATT00017447001 Chromosome undetermined scaffold_52,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A7S0R5_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g242045 Dihydropteridine reductase Nematostella vectensis
TI:45351 None
 
A8KB38_DANRE
ZFIN»
2.5
qdprb.4 Uncharacterized protein LOC563255
precursor (Zgc:171517 protein)		 Danio rerio
TI:7955 None
 
B3S318_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_28401 Dihydropteridine reductase Trichoplax adhaerens
TI:10228 None
 
B8CBV4_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_269710 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
DHPR_MOUSE
Ensembl»
1.0
Qdpr Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Mus musculus
TI:10090 None
 
E9HX37_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_66856 NAD-dependent epimerase/dehydratase
domain-containing protein		 Daphnia pulex
TI:6669 None
 
F4P0I7_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_87544 Dihydropteridine reductase Batrachochytrium dendrobatidis
TI:109871 None
 
F6WTU8_CIOIN
Ensembl»
0.0
LOC100175137 Dihydropteridine reductase Ciona intestinalis
TI:7719 None
 
Q3KPR4_XENLA
Xenbase»
0.0
qdpr.S Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Xenopus laevis
TI:8355 None
 
Q52KN0_XENLA
Xenbase»
0.0
qdpr.L Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Xenopus laevis
TI:8355 None
 
T1FYA4_HELRO
EnsemblMetazoa»
0.0
20213802 NAD-dependent epimerase/dehydratase
domain-containing protein		 Helobdella robusta
TI:6412 None
 
A8X3U9_CAEBR
WormBase»
0.0
qdpr-1 Protein CBR-QDPR-1 Caenorhabditis briggsae
TI:6238 None
 
B7QAP3_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW022552 Dihydropteridine reductase,
putative (EC 1.5.1.34)		 Ixodes scapularis
TI:6945 None
 
D6W812_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_04773 Dihydropteridine reductase-like Protein Tribolium castaneum
TI:7070 None
 
E9G3B9_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_127519 Dihydropteridine reductase Daphnia pulex
TI:6669 None
 
F7AUQ4_MONDO
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Monodelphis domestica
TI:13616 None
   
F7G0H0_ORNAN
Ensembl»
0.0
LOC100074628 Quinoid dihydropteridine reductase Ornithorhynchus anatinus
TI:9258 None
   
Q7PRC0_ANOGA
EnsemblMetazoa»
0.0
1273428 AGAP002534-PA Anopheles gambiae
TI:7165 None
 
Q9XVJ3_CAEEL
WormBase»
2.5
qdpr-1 Dihydropteridine reductase dhpr/qdpr Caenorhabditis elegans
TI:6239 None
 
W5M5V3_LEPOC
Ensembl»
0.0
Quinoid dihydropteridine reductase Lepisosteus oculatus
TI:7918 None
 
A0A3B3I9E6_ORYLA
Ensembl»
0.0
qdpr Quinoid dihydropteridine reductase Oryzias latipes
TI:8090 None
   
Q4Q290_LEIMA
EnsemblProtists»
0.0
QDPR-7 Quinonoid dihydropteridine reductase
(EC 1.5.1.34, EC 1.6.99.7)		 Leishmania major
TI:5664 None
 
Q4Q2A8_LEIMA
EnsemblProtists»
0.0
QDPR-1 Quinonoid dihydropteridine
reductase (EC 1.5.1.34)		 Leishmania major
TI:5664 None
 
Q9VSU6_DROME
FlyBase»
2.5
Dhpr Dihydropteridine reductase (Dihydropteridine reductase, isoform A (EC 1.5.1.34))
(Dihydropteridine reductase, isoform B) (Dihydropteridine reductase, isoform C) (RE58329p)		 Drosophila melanogaster
TI:7227 None
 
A7YT77_DANRE
ZFIN»
4.1
si:ch211-89f22.2 Qdpra protein (Quinoid
dihydropteridine reductase a)		 Danio rerio
TI:7955 None
 
G1KL09_ANOCA
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Anolis carolinensis
TI:28377 None
   
G3QNB9_GORGO
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Gorilla gorilla
TI:9593 None
 
H2QP94_PANTR
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Pan troglodytes
TI:9598 None
 
A0A337SDH4_FELCA
Ensembl»
0.0
QDPR Quinoid dihydropteridine reductase Felis catus
TI:9685 None
 
Q66IB5_DANRE
ZFIN»
5.7
qdprb1 Dihydropteridine reductase (EC 1.5.1.34) (Qdprb1
protein) (Quinoid dihydropteridine reductase b1)		 Danio rerio
TI:7955 None
 
DHPR_BOVIN
Ensembl»
0.0
QDPR Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Bos taurus
TI:9913 None
 
DHPR_PIG
CTD»
0.0
QDPR Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Sus scrofa
TI:9823 None
 
F0ZBZ1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_28422 Dihydropteridine reductase Dictyostelium purpureum
TI:5786 None
 
DHPR_DICDI
dictyBase»
7.5
qdpr Dihydropteridine reductase (EC
1.5.1.34) (Quinoid dihydropteridine reductase)		 Dictyostelium discoideum
TI:44689 None
 
DHPR_HUMAN
Ensembl»
6.9
QDPR Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine
reductase) (Short chain dehydrogenase/reductase family 33C member 1)		 Homo sapiens
TI:9606 None
 
DHPR_RAT
RGD»
14.3
Qdpr Dihydropteridine reductase (EC 1.5.1.34)
(HDHPR) (Quinoid dihydropteridine reductase)		 Rattus norvegicus
TI:10116 None