Collated Gene Ontology terms

Biological process: transferase activity(2025) methyltransferase activity(2025) histone deacetylase binding(2011, 2022, 2025) zinc ion binding(2025) metal ion binding(2025) protein-lysine N-methyltransferase activity(2025) protein methyltransferase activity(2025) S-adenosylmethionine-dependent methyltransferase activity(2025) N-methyltransferase activity(2025) histone H3K4 methyltransferase activity(2023, 2025)
histone methyltransferase activity2025 histone deacetylase activity2023, 2025

Molecular function: methylation2025 heart development2021, 2022, 2025 compound eye photoreceptor development2015, 2023 chromatin remodeling2025 negative regulation of gene expression2011 heart morphogenesis2020 heart looping2020 eclosion2011 determination of heart left/right asymmetry2020

Cellular component: nucleus2009, 2011, 2021, 2025 cytoplasm2009, 2011, 2021, 2022, 2025 plasma membrane2010 nucleoplasm2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 3/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A139WK24_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_32600 SET and MYND
domain-containing protein 4-like Protein		 Tribolium castaneum
TI:7070 None
 
A0A139WPI6_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_31547 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Tribolium castaneum
TI:7070 None
 
A0A1L8HD90_XENLA
Xenbase»
0.0
smyd4.L Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Xenopus laevis
TI:8355 None
   
A0A1S4GGT5_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A1S4GZE1_ANOGA
EnsemblMetazoa»
0.0
SET domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A1S4H0J5_ANOGA
EnsemblMetazoa»
0.0
Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Anopheles gambiae
TI:7165 None
 
A0A2A6BJ65_PRIPA
EnsemblMetazoa»
0.0
WBGene00103908 Set-3 Pristionchus pacificus
TI:54126 None
   
A0A2K3E418_CHLRE
neXtProt»
0.0
CHLRE_02g142900v5 SET domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A5K1VBK2_PIG
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Sus scrofa
TI:9823 None
 
A0A7M7P8K9_STRPU
EnsemblMetazoa»
0.0
Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803K8P7_XENTR
Xenbase»
0.0
smyd4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Xenopus tropicalis
TI:8364 None
   
A0A8I3NFG5_CANLF
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Canis lupus
TI:9612 None
   
A0A8V1AM05_CHICK
Ensembl»
1.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Gallus gallus
TI:9031 None
   
A0A903XXM7_ANOGA
EnsemblMetazoa»
0.0
MYND-type domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A9J7HFQ9_BRAFL
euHCVdb»
0.0
LOC118404013 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Branchiostoma floridae
TI:7739 None
   
A0A9J7L050_BRAFL
euHCVdb»
0.0
LOC118414036 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Branchiostoma floridae
TI:7739 None
   
A0ABI8AJD3_FELCA
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Felis catus
TI:9685 None
   
A0E7K5_PARTE
neXtProt»
0.0
GSPATT00024000001 SET domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A1Z7W1_DROME
FlyBase»
2.8
Smyd4-1 SET and MYND domain containing, class 4, member 1, isoform B
(SET and MYND domain containing, class 4, member 1, isoform C)		 Drosophila melanogaster
TI:7227 None
 
A1Z8L3_DROME
FlyBase»
3.3
Smyd4-3 SET and MYND domain
containing, class 4, member 3		 Drosophila melanogaster
TI:7227 None
 
A7SLY0_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g246103 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A7SM79_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g214433 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Nematostella vectensis
TI:45351 None
 
A7SWX2_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g135947 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Nematostella vectensis
TI:45351 None
 
A8XA69_CAEBR
WormBase»
0.0
set-3 Protein CBR-SET-3 Caenorhabditis briggsae
TI:6238 None
 
A9UXH1_MONBE
euHCVdb»
0.0
MONBRDRAFT_36878 SET domain-containing protein Monosiga brevicollis
TI:81824 None
 
B7P356_IXOSC
EnsemblMetazoa»
0.0
8023918 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Ixodes scapularis
TI:6945 None
 
D4AEC7_RAT
RGD»
2.0
Smyd4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Rattus norvegicus
TI:10116 None
   
D6WFW8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_03856 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Tribolium castaneum
TI:7070 None
 
D6WV80_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_05322 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Tribolium castaneum
TI:7070 None
 
D6WV82_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_05321 SET domain-containing protein Tribolium castaneum
TI:7070 None
 
D6WW76_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_30778 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Tribolium castaneum
TI:7070 None
 
E1BEP0_BOVIN
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Bos taurus
TI:9913 None
   
E9FR23_DAPPU
neXtProt»
0.0
DAPPUDRAFT_309882 MYND-type domain-containing protein Daphnia pulex
TI:6669 None
 
E9FWI9_DAPPU
euHCVdb»
0.0
SMYD4A Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Daphnia pulex
TI:6669 None
 
E9FXH0_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_305694 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Daphnia pulex
TI:6669 None
 
E9G026_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_312722 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Daphnia pulex
TI:6669 None
 
E9I266_DAPPU
neXtProt»
0.0
DAPPUDRAFT_68494 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0Z8I3_DICPU
TubercuList»
0.0
DICPUDRAFT_147450 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Dictyostelium purpureum
TI:5786 None
 
F0ZMP1_DICPU
TubercuList»
0.0
DICPUDRAFT_34471 SET domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F0ZZL6_DICPU
TubercuList»
0.0
DICPUDRAFT_89992 SET domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F4P1H2_BATDJ
euHCVdb»
0.0
BATDEDRAFT_88247 SET domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
F4P1H3_BATDJ
euHCVdb»
0.0
BATDEDRAFT_88246 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6YNP6_HORSE
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Equus caballus
TI:9796 None
   
F6ZBQ9_CIOIN
Ensembl»
0.0
MYND-type domain-containing protein Ciona intestinalis
TI:7719 None
 
F6ZBS2_CIOIN
Ensembl»
0.0
SET domain-containing protein Ciona intestinalis
TI:7719 None
 
F6ZF19_MONDO
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Monodelphis domestica
TI:13616 None
   
F6ZGQ5_MACMU
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Macaca mulatta
TI:9544 None
   
F7AEN2_ORNAN
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Ornithorhynchus anatinus
TI:9258 None
   
G3QDC8_GORGO
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Gorilla gorilla
TI:9593 None
 
H2LE37_ORYLA
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Oryzias latipes
TI:8090 None
   
H9GLB6_ANOCA
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Anolis carolinensis
TI:28377 None
   
K7CB81_PANTR
Ensembl»
0.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Pan troglodytes
TI:9598 None
 
Q4Q3A0_LEIMA
TubercuList»
0.0
LMJF_34_1050 SET domain-containing protein Leishmania major
TI:5664 None
 
Q584A8_TRYB2
TubercuList»
0.0
Tb04.2H8.220 SET domain-containing protein Trypanosoma brucei
TI:5691 None
 
Q7PWV2_ANOGA
EnsemblMetazoa»
0.0
1279815 AGAP008839-PA Anopheles gambiae
TI:7165 None
 
Q7SFG1_NEUCR
TubercuList»
0.0
NCU00870 SET domain-containing protein Neurospora crassa
TI:5141 None
 
Q9V3J9_DROME
FlyBase»
0.0
dao Down and out, isoform A
(Down and out, isoform B) (FI18831p1)		 Drosophila melanogaster
TI:7227 None
 
Q9VEP2_DROME
FlyBase»
0.5
Dmel\CG18213 Uncharacterized protein, isoform B Drosophila melanogaster
TI:7227 None
 
Q9VTX2_DROME
FlyBase»
4.7
Smyd4-2 RE32936p (SET and MYND domain
containing, class 4, member 2)		 Drosophila melanogaster
TI:7227 None
 
SET3_CAEEL
WormBase»
0.0
set-3 SET domain-containing protein 3 (EC 2.1.1.-) Caenorhabditis elegans
TI:6239 None
 
SMYD4_CHICK
CTD»
2.0
SMYD4 Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-)
(SET and MYND domain-containing protein 4)		 Gallus gallus
TI:9031 None
 
SMYD4_DANRE
ZFIN»
5.5
smyd4 Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-)
(SET and MYND domain-containing protein 4)		 Danio rerio
TI:7955 None
 
SMYD4_HUMAN
Ensembl»
2.6
SMYD4 Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-)
(SET and MYND domain-containing protein 4)		 Homo sapiens
TI:9606 None
 
SMYD4_MOUSE
Ensembl»
3.0
Smyd4 Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-)
(SET and MYND domain-containing protein 4)		 Mus musculus
TI:10090 None
 
T1EGV2_HELRO
EnsemblMetazoa»
0.0
20195802 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Helobdella robusta
TI:6412 None
 
T1F298_HELRO
EnsemblMetazoa»
0.0
20202948 SET domain-containing protein Helobdella robusta
TI:6412 None
 
T1FSV6_HELRO
EnsemblMetazoa»
0.0
20211903 Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Helobdella robusta
TI:6412 None
 
T1FTG2_HELRO
EnsemblMetazoa»
0.0
20212109 MYND-type domain-containing protein Helobdella robusta
TI:6412 None
 
W5MH53_LEPOC
Ensembl»
0.0
Protein-lysine N-methyltransferase SMYD4 (SET
and MYND domain-containing protein 4)		 Lepisosteus oculatus
TI:7918 None
 
Y4059_DICDI
dictyBase»
0.5
DDB_G0284059 SET and MYND domain-containing
protein DDB_G0284059 (EC 2.1.1.-)		 Dictyostelium discoideum
TI:44689 None