Collated Gene Ontology terms

Biological process: ATP hydrolysis activity(2025) DNA-binding transcription factor activity(2025) phosphatidylinositol binding(2025) GTPase activator activity(2025) ATP binding(2025)

Molecular function: response to alkaloid2016, 2025 regulation of DNA-templated transcription2025 cell projection organization2025

Cellular component: synapse2024, 2025 nucleus2009, 2025 dendrite2009, 2025 axon2009, 2025 neuronal cell body2009, 2025 perikaryon2025 paraflagellar rod2025 membrane2025 cytosol2025 centriolar satellite2025
axoneme2016

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
QUI1_CAEEL
WormBase»
0.8
qui-1 Protein qui-1 (Quinine non-avoider protein 1) Caenorhabditis elegans
TI:6239 None
 
A0A2A6BGC7_PRIPA
EnsemblMetazoa»
0.0
WBGene00089822 TBC1 domain family member 13
(TBC1 domain family member 31)		 Pristionchus pacificus
TI:54126 None
   
A0A8R1Z1F2_PRIPA
EnsemblMetazoa»
0.0
WBGene00276986 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Pristionchus pacificus
TI:54126 None
   
A8WQX5_CAEBR
WormBase»
0.0
qui-1 Protein CBR-QUI-1 Caenorhabditis briggsae
TI:6238 None
 
NWD2_MOUSE
Ensembl»
0.0
Nwd2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Mus musculus
TI:10090 None
 
A0A0G2JZT1_RAT
RGD»
0.0
Nwd2 NACHT and WD repeat domain containing 2 Rattus norvegicus
TI:10116 None
   
A9V4P8_MONBE
euHCVdb»
0.0
MONBRDRAFT_9939 SAP domain-containing protein Monosiga brevicollis
TI:81824 None
 
Q38D82_TRYB2
TubercuList»
0.0
Tb09.211.4280 Flagellar Member 5 Trypanosoma brucei
TI:5691 None
 
A0A287AVZ9_PIG
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Sus scrofa
TI:9823 None
   
A0A5F8HAF2_MONDO
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Monodelphis domestica
TI:13616 None
   
A0A8I3RU04_CANLF
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Canis lupus
TI:9612 None
   
A0A8J1J516_XENTR
Xenbase»
0.0
LOC100489685 NACHT and WD repeat domain-containing protein 2 Xenopus tropicalis
TI:8364 None
   
A0A8V0YHX1_CHICK
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Gallus gallus
TI:9031 None
   
A9VAB9_MONBE
neXtProt»
0.0
MONBRDRAFT_29174 PH domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3RI54_TRIAD
CTD»
0.0
TRIADDRAFT_18708 AAA+ ATPase domain-containing protein Trichoplax adhaerens
TI:10228 None
 
F1MNF4_BOVIN
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Bos taurus
TI:9913 None
   
F6SIG6_ORNAN
Ensembl»
0.0
NWD2 NACHT and WD repeat domain containing 2 Ornithorhynchus anatinus
TI:9258 None
   
F6SP30_MACMU
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Macaca mulatta
TI:9544 None
   
F6Z731_HORSE
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Equus caballus
TI:9796 None
   
G3RJ79_GORGO
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Gorilla gorilla
TI:9593 None
 
H2QPB7_PANTR
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Pan troglodytes
TI:9598 None
 
H3HBI7_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
H9GC65_ANOCA
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Anolis carolinensis
TI:28377 None
   
NWD2_HUMAN
Ensembl»
0.0
NWD2 NACHT and WD repeat domain-containing protein 2
(Leucine-rich repeat and WD repeat-containing protein KIAA1239)		 Homo sapiens
TI:9606 None
 
T1G1V5_HELRO
EnsemblMetazoa»
0.0
20215053 Uncharacterized protein Helobdella robusta
TI:6412 None
 
A0A1L8HL05_XENLA
Xenbase»
0.0
nwd2.S NACHT and WD repeat domain-containing protein 2 Xenopus laevis
TI:8355 None 		     
A0A1S4GMA2_ANOGA
EnsemblMetazoa»
0.0
WD_REPEATS_REGION domain-containing protein Anopheles gambiae
TI:7165 None 		 
 
A0A1S4GW40_ANOGA
EnsemblMetazoa»
0.0
AAA domain-containing protein Anopheles gambiae
TI:7165 None 		 
 
A0A3B3IL25_ORYLA
Ensembl»
0.0
NWD2 NACHT and WD repeat domain containing 2 Oryzias latipes
TI:8090 None 		     
A0A6I8R7V6_XENTR
Xenbase»
0.0
LOC101730828 Uncharacterized LOC101730828
(Uncharacterized protein LOC101730828)		 Xenopus tropicalis
TI:8364 None 		     
A0A7M7GHT5_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7HBU8_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7HNP9_STRPU
EnsemblMetazoa»
0.0
NWD1/2-like winged
helix-turn-helix domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7MYF6_STRPU
EnsemblMetazoa»
0.0
NACHT and WD repeat domain-containing protein 1 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7N235_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7N246_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7NHU9_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7PC92_STRPU
EnsemblMetazoa»
0.0
NWD1/2-like winged
helix-turn-helix domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7RAB5_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
A0A7M7T4E2_STRPU
EnsemblMetazoa»
0.0
NACHT and WD repeat domain-containing protein 1 Strongylocentrotus purpuratus
TI:7668 None 		     
A0A8J0TKV0_XENLA
Xenbase»
0.0
LOC108698788 Uncharacterized protein LOC108698788 isoform X1 Xenopus laevis
TI:8355 None 		     
A0A8J0UBM3_XENLA
Xenbase»
0.0
LOC108707615 NACHT and WD repeat domain-containing protein 2 Xenopus laevis
TI:8355 None 		     
A0A8J1MAN1_XENLA
CTD»
0.0
LOC121400091 NACHT and WD
repeat domain-containing protein 2-like		 Xenopus laevis
TI:8355 None 		     
A0A8J1MR95_XENLA
CTD»
0.0
nwd2.L NACHT and WD repeat domain-containing protein 2 Xenopus laevis
TI:8355 None 		     
A0A8M6Z2R4_DANRE
ZFIN»
0.0
LOC108179119 NACHT and WD
repeat domain-containing protein 2-like		 Danio rerio
TI:7955 None 		     
A0A9J7KML0_BRAFL
neXtProt»
0.0
LOC118409668 Uncharacterized protein LOC118409668 Branchiostoma floridae
TI:7739 None 		     
A0A9J7KSF1_BRAFL
neXtProt»
0.0
LOC118411296 Uncharacterized protein LOC118411296 isoform X1 Branchiostoma floridae
TI:7739 None 		     
A0A9J7L4V0_BRAFL
euHCVdb»
0.0
LOC118415725 NACHT domain- and WD
repeat-containing protein 1-like isoform X1		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7LNR9_BRAFL
neXtProt»
0.0
LOC118422711 Uncharacterized protein LOC118422711 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MJT1_BRAFL
euHCVdb»
0.0
LOC118411808 NACHT domain- and
WD repeat-containing protein 1-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MQK9_BRAFL
euHCVdb»
0.0
LOC118416119 LOW QUALITY PROTEIN: NACHT domain-
and WD repeat-containing protein 1-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MU53_BRAFL
euHCVdb»
0.0
LOC118417410 NACHT domain- and
WD repeat-containing protein 1-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9L0SV10_HORSE
Ensembl»
0.0
NACHT and WD repeat domain containing 2 Equus caballus
TI:9796 None 		     
A0ABI7ZFE0_FELCA
Ensembl»
0.0
NWD2 NACHT and WD repeat domain containing 2 Felis catus
TI:9685 None 		     
A0C6A3_PARTE
euHCVdb»
0.0
GSPATT00035449001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0C8Q5_PARTE
euHCVdb»
0.0
GSPATT00036307001 NACHT domain-containing protein Paramecium tetraurelia
TI:5888 None 		 
 
A0CGD7_PARTE
euHCVdb»
0.0
GSPATT00007294001 NACHT domain-containing protein Paramecium tetraurelia
TI:5888 None 		 
 
A0E1W2_PARTE
euHCVdb»
0.0
GSPATT00022450001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0EG85_PARTE
euHCVdb»
0.0
GSPATT00026650001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A1ZB93_DROME
FlyBase»
0.0
BcDNA:GH04922 Uncharacterized protein, isoform A Drosophila melanogaster
TI:7227 None 		 
 
A7RNA8_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g60625 NACHT domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7RNA9_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g87696 AAA+ ATPase domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7RUS0_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g94204 NACHT domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7S3R7_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g50704 NACHT domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7S6Z9_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g106828 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A7SG70_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g40337 NACHT domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7SMT6_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g40239 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A7SYV4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g138346 NACHT domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A8X980_CAEBR
WormBase»
0.0
CBG09382 CBG_09382 Protein CBG09382 Caenorhabditis briggsae
TI:6238 None 		 
 
A9UQB6_MONBE
euHCVdb»
0.0
MONBRDRAFT_30943 PH domain-containing protein Monosiga brevicollis
TI:81824 None 		 
 
A9UXU9_MONBE
euHCVdb»
0.0
MONBRDRAFT_32133 NACHT domain-containing protein Monosiga brevicollis
TI:81824 None 		 
 
A9UY01_MONBE
euHCVdb»
0.0
MONBRDRAFT_32156 Uncharacterized protein Monosiga brevicollis
TI:81824 None 		 
 
A9V4S0_MONBE
neXtProt»
0.0
MONBRDRAFT_27255 Guanine nucleotide-binding protein
subunit beta-like protein		 Monosiga brevicollis
TI:81824 None 		 
 
A9V746_MONBE
euHCVdb»
0.0
MONBRDRAFT_33730 Uncharacterized protein Monosiga brevicollis
TI:81824 None 		 
 
B3RI55_TRIAD
CTD»
0.0
TRIADDRAFT_18392 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B3RLF5_TRIAD
CTD»
0.0
TRIADDRAFT_8888 Orc1-like AAA ATPase domain-containing protein Trichoplax adhaerens
TI:10228 None 		 
 
B3RLF6_TRIAD
CTD»
0.0
TRIADDRAFT_18313 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B3RLF8_TRIAD
CTD»
0.0
TRIADDRAFT_19804 NACHT domain-containing protein Trichoplax adhaerens
TI:10228 None 		 
 
B3RLF9_TRIAD
CTD»
0.0
TRIADDRAFT_19084 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B3RLG1_TRIAD
CTD»
0.0
TRIADDRAFT_20045 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None 		 
 
B3RLG2_TRIAD
CTD»
0.0
TRIADDRAFT_19428 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B3RYQ2_TRIAD
CTD»
0.0
TRIADDRAFT_24789 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B3SCJ3_TRIAD
CTD»
0.0
TRIADDRAFT_6104 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Trichoplax adhaerens
TI:10228 None 		 
 
B7P394_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW000698 Orc1-like AAA ATPase domain-containing protein Ixodes scapularis
TI:6945 None 		 
 
B7QBU6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW022709 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
D2A4Y1_TRICA
euHCVdb»
0.0
GLEAN_15281 DUF4062 domain-containing protein Tribolium castaneum
TI:7070 None 		 
 
D6W857_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_04796 AAA+ ATPase domain-containing protein Tribolium castaneum
TI:7070 None 		 
 
D6WR21_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_09369 NACHT domain-containing protein Tribolium castaneum
TI:7070 None 		 
 
D7GYE1_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_06899 NACHT and WD repeat
domain-containing protein 2-like Protein		 Tribolium castaneum
TI:7070 None 		 
 
D7GYI9_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_01487 NACHT and WD repeat
domain-containing protein 2-like Protein		 Tribolium castaneum
TI:7070 None 		 
 
E7EZX4_DANRE
ZFIN»
0.0
nwd2 NACHT and WD repeat domain-containing 2 (NACHT
and WD repeat domain-containing protein 2 isoform X2)		 Danio rerio
TI:7955 None 		 
 
E9HFF2_DAPPU
neXtProt»
0.0
DAPPUDRAFT_202786 Uncharacterized protein Daphnia pulex
TI:6669 None 		 
 
F6SZX5_XENTR
Xenbase»
0.0
nwd2 NACHT and WD repeat domain containing 2
(NACHT and WD repeat domain-containing protein 2)		 Xenopus tropicalis
TI:8364 None 		     
F7BI17_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
H2M335_ORYLA
Ensembl»
0.0
LOC101161570 Nephrocystin 3-like
N-terminal domain-containing protein		 Oryzias latipes
TI:8090 None 		     
H2XKB9_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
H2XQA3_CIOIN
Ensembl»
0.0
DUF4062 domain-containing protein Ciona intestinalis
TI:7719 None 		     
O16302_CAEEL
WormBase»
0.0
CELE_T05C3.2 T05C3.2 NACHT domain-containing protein Caenorhabditis elegans
TI:6239 None 		 
 
Q7QHF1_ANOGA
EnsemblMetazoa»
0.0
1270766 AGAP011163-PA (WD_REPEATS_REGION
domain-containing protein)		 Anopheles gambiae
TI:7165 None 		 
 
Q9VEZ2_DROME
FlyBase»
0.0
Dmel\CG10185 Uncharacterized protein Drosophila melanogaster
TI:7227 None 		 
 
Q9VIU8_DROME
FlyBase»
0.0
Dmel\CG10132 GH25853p Drosophila melanogaster
TI:7227 None 		 
 
T1EH28_HELRO
EnsemblMetazoa»
0.0
20195878 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Helobdella robusta
TI:6412 None 		 
 
T1EVQ9_HELRO
EnsemblMetazoa»
0.0
20200659 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
T1EY50_HELRO
EnsemblMetazoa»
0.0
20201500 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Helobdella robusta
TI:6412 None 		 
 
T1FXE9_HELRO
EnsemblMetazoa»
0.0
20213497 DUF4062 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1G5K2_HELRO
EnsemblMetazoa»
0.0
20216349 DUF4062 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1G5K3_HELRO
EnsemblMetazoa»
0.0
20216350 NWD1/2-like winged
helix-turn-helix domain-containing protein		 Helobdella robusta
TI:6412 None 		 
 
W5MH38_LEPOC
Ensembl»
0.0
NACHT and WD
repeat domain-containing protein 2-like		 Lepisosteus oculatus
TI:7918 None 		 
 
W5MTT7_LEPOC
Ensembl»
0.0
NACHT and WD repeat domain containing 2 Lepisosteus oculatus
TI:7918 None 		 
 
W5N8C7_LEPOC
Ensembl»
0.0
Si:ch211-212k18.6 Lepisosteus oculatus
TI:7918 None