Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2007, 2013, 2021, 2024) fatty-acyl-CoA binding(2021)

Molecular function: Rho protein signal transduction2020, 2024 endothelial cell migration2007, 2020, 2024 intracellular signal transduction2024 blood vessel endothelial cell migration2009, 2024 angiogenesis2009, 2024 endothelial cell chemotaxis2013 regulation protein catabolic process at presynapse2024 signal transduction2024 regulation of small GTPase mediated signal transduction2024 positive regulation of Rho protein signal transduction2013
positive regulation of I-kappaB kinase/NF-kappaB signaling2004 imaginal disc-derived leg morphogenesis2012 gastrulation2010

Cellular component: plasma membrane2007, 2020, 2024 endocytic vesicle2013, 2020, 2024 axon2020, 2024 lamellipodium2013, 2024 cytoplasm2013, 2024 cell-cell junction2013 perinuclear region of cytoplasm2024 cell projection2024 anchoring junction2024 presynapse2022, 2024
synapse2022 membrane2024 cytosol2023

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
PKHG5_MOUSE
Ensembl»
4.0
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Synectin-binding RhoA exchange factor) (SYX)		 Mus musculus
TI:10090 None
 
PKHG5_HUMAN
Ensembl»
3.8
PLEKHG5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)		 Homo sapiens
TI:9606 None
 
A0A0G2L933_DANRE
ZFIN»
4.2
plekhg5b Pleckstrin homology domain-containing family G member 5-like isoform X1
(Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5b)		 Danio rerio
TI:7955 None
 
PKHG7_HUMAN
Ensembl»
0.5
PLEKHG7 Pleckstrin homology domain-containing family G member
7 (PH domain-containing family G member 7)		 Homo sapiens
TI:9606 None
 
F1R1Q2_DANRE
ZFIN»
5.0
plekhg5a Pleckstrin homology domain-containing family G member 5 isoform X1
(Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5a)		 Danio rerio
TI:7955 None
 
A8HAL3_DANRE
ZFIN»
0.5
si:ch211-276p10.1 Pleckstrin homology domain-containing family G member 7 (Pleckstrin
homology domain-containing, family G (with RhoGef domain) member 7)		 Danio rerio
TI:7955 None
 
H2L0P5_CAEEL
WormBase»
0.0
prhg-1 Pleckstrin homology domain-containing
family G member 7		 Caenorhabditis elegans
TI:6239 None
 
PKHG5_RAT
RGD»
3.5
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member
5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus)		 Rattus norvegicus
TI:10116 None
 
Q9VW85_DROME
FlyBase»
2.8
CG13812 Uncharacterized protein, isoform C Drosophila melanogaster
TI:7227 None
 
S6EZU2_CAEEL
WormBase»
1.0
rhgf-2 DH domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Y6504_DICDI
dictyBase»
0.5
DDB_G0289917 Uncharacterized protein DDB_G0289917 Dictyostelium discoideum
TI:44689 None
 
A0A8M3ATA9_DANRE
CTD»
1.0
plekhg6 Pleckstrin homology domain-containing family
G member 6 isoform X1		 Danio rerio
TI:7955 None
   
A0A8M9P7M0_DANRE
CTD»
0.0
LOC110438497 Pleckstrin homology domain-containing
family G member 6-like		 Danio rerio
TI:7955 None 		     
A0A8V0Z9W1_CHICK
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Gallus gallus
TI:9031 None
   
F1P129_CHICK
Ensembl»
0.5
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Gallus gallus
TI:9031 None