Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2007, 2013, 2021, 2025) fatty-acyl-CoA binding(2024)

Molecular function: endothelial cell migration2007, 2020, 2025 intracellular signal transduction2025 angiogenesis2025 endothelial cell chemotaxis2013 Rho protein signal transduction2025 regulation protein catabolic process at presynapse2024 signal transduction2025 regulation of small GTPase mediated signal transduction2025 positive regulation of canonical NF-kappaB signal transduction2004 positive regulation of Rho protein signal transduction2013
imaginal disc-derived leg morphogenesis2012

Cellular component: plasma membrane2007, 2020, 2025 endocytic vesicle2013, 2020, 2025 cytoplasm2007, 2013, 2025 cell projection2025 lamellipodium2013, 2025 cell-cell junction2013 perinuclear region of cytoplasm2025 anchoring junction2025 presynapse2025 axon2025
cytosol2023

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
PKHG5_MOUSE
Ensembl»
5.5
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Synectin-binding RhoA exchange factor) (SYX)		 Mus musculus
TI:10090 None
 
PKHG5_HUMAN
Ensembl»
4.3
PLEKHG5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)		 Homo sapiens
TI:9606 None
 
PKHG7_HUMAN
Ensembl»
0.5
PLEKHG7 Pleckstrin homology domain-containing family G member
7 (PH domain-containing family G member 7)		 Homo sapiens
TI:9606 None
 
A8HAL3_DANRE
ZFIN»
0.5
plekhg7 Pleckstrin homology domain-containing family G member 7 (Pleckstrin
homology domain-containing, family G (with RhoGef domain) member 7)		 Danio rerio
TI:7955 None
 
H2L0P5_CAEEL
WormBase»
0.5
prhg-1 Pleckstrin homology domain-containing
family G member 7		 Caenorhabditis elegans
TI:6239 None
 
PKHG5_RAT
RGD»
4.0
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member
5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus)		 Rattus norvegicus
TI:10116 None
 
Q9VW85_DROME
FlyBase»
2.8
CG13812 Uncharacterized protein, isoform C Drosophila melanogaster
TI:7227 None
 
S6EZU2_CAEEL
WormBase»
1.0
rhgf-2 DH domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Y6504_DICDI
dictyBase»
0.5
DDB_G0289917 Uncharacterized protein DDB_G0289917 Dictyostelium discoideum
TI:44689 None
 
A0A8M3ATA9_DANRE
ZFIN»
1.5
plekhg6 Uncharacterized protein plekhg6 isoform X1 Danio rerio
TI:7955 None
   
A0A8V0Z9W1_CHICK
Ensembl»
1.5
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Gallus gallus
TI:9031 None
   
A0AB32TGG0_DANRE
ZFIN»
0.0
plekhg5b Pleckstrin homology domain-containing family
G member 5 isoform X1		 Danio rerio
TI:7955 None 		     
A0ACD6B6G0_DANRE
ZFIN»
0.0
plekhg5a Pleckstrin homology domain-containing family
G member 5 isoform X1		 Danio rerio
TI:7955 None 		     
F1P129_CHICK
Ensembl»
0.5
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Gallus gallus
TI:9031 None