Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2007, 2013, 2021, 2025) fatty-acyl-CoA binding(2024)

Molecular function: endothelial cell migration2007, 2020, 2025 intracellular signal transduction2025 angiogenesis2025 endothelial cell chemotaxis2013 Rho protein signal transduction2025 regulation protein catabolic process at presynapse2024 signal transduction2025 regulation of small GTPase mediated signal transduction2025 positive regulation of canonical NF-kappaB signal transduction2004 positive regulation of Rho protein signal transduction2013
imaginal disc-derived leg morphogenesis2012

Cellular component: plasma membrane2007, 2020, 2025 endocytic vesicle2013, 2020, 2025 cytoplasm2007, 2013, 2025 cell projection2025 lamellipodium2013, 2025 cell-cell junction2013 perinuclear region of cytoplasm2025 anchoring junction2025 presynapse2025 axon2025
cytosol2023

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1D5Q4S3_MACMU
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Macaca mulatta
TI:9544 None
   
A0A1L8GUP4_XENLA
Xenbase»
0.0
plekhg7.S Uncharacterized protein plekhg7.S isoform X1 Xenopus laevis
TI:8355 None
   
A0A1L8GYC9_XENLA
Xenbase»
0.0
plekhg7.L Pleckstrin homology domain-containing
family G member 5		 Xenopus laevis
TI:8355 None
   
A0A2A6BM49_PRIPA
EnsemblMetazoa»
0.0
WBGene00096248 Pleckstrin homology domain containing protein Pristionchus pacificus
TI:54126 None
   
A0A2I3RX28_PANTR
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Pan troglodytes
TI:9598 None
 
A0A3Q1NL77_BOVIN
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Bos taurus
TI:9913 None
   
A0A5F8HAX0_MONDO
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Monodelphis domestica
TI:13616 None
   
A0A6I8PLU1_ORNAN
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8QW21_XENTR
Xenbase»
0.0
plekhg7 Pleckstrin homology and RhoGEF domain-containing G7
(Pleckstrin homology domain-containing family G member 7)		 Xenopus tropicalis
TI:8364 None
   
A0A6I8SU90_XENTR
Xenbase»
0.0
plekhg5 Pleckstrin homology and RhoGEF domain containing G5 (Pleckstrin
homology domain-containing family G member 5 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7N0Z3_STRPU
EnsemblMetazoa»
0.0
DH domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PP29_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PWB4_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SZH1_STRPU
EnsemblMetazoa»
0.0
DH domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3PU67_CANLF
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Canis lupus
TI:9612 None
   
A0A8J0TGE2_XENLA
CTD»
0.0
plekhg5.S Pleckstrin homology domain-containing family
G member 5 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J1L723_XENLA
CTD»
0.0
plekhg5.L Pleckstrin homology domain-containing family
G member 5 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8M3ATA9_DANRE
ZFIN»
1.5
plekhg6 Uncharacterized protein plekhg6 isoform X1 Danio rerio
TI:7955 None
   
A0A8V0Z9W1_CHICK
Ensembl»
1.5
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Gallus gallus
TI:9031 None
   
A0A9J7MFD0_BRAFL
neXtProt»
0.0
LOC118431175 Pleckstrin homology domain-containing
family G member 5-like		 Branchiostoma floridae
TI:7739 None
   
A0A9J7MQF3_BRAFL
neXtProt»
0.0
LOC118415203 Uncharacterized protein LOC118415203 isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A9L0SGC7_HORSE
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Equus caballus
TI:9796 None
   
A0AAA9TPM2_BOVIN
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Bos taurus
TI:9913 None
   
A0AB32TGG0_DANRE
ZFIN»
0.0
plekhg5b Pleckstrin homology domain-containing family
G member 5 isoform X1		 Danio rerio
TI:7955 None 		     
A0ABI7ZDR2_FELCA
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Felis catus
TI:9685 None
   
A0ABK8FVG7_ANOGA
EnsemblMetazoa»
0.0
DH domain-containing protein Anopheles gambiae
TI:7165 None
 
A0ACD6B6G0_DANRE
ZFIN»
0.0
plekhg5a Pleckstrin homology domain-containing family
G member 5 isoform X1		 Danio rerio
TI:7955 None 		     
A7RG07_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g237981 Pleckstrin homology domain-containing
family G member 7		 Nematostella vectensis
TI:45351 None
 
A7S9N2_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g243788 Pleckstrin homology domain-containing
family G member 5		 Nematostella vectensis
TI:45351 None
 
A8HAL3_DANRE
ZFIN»
0.5
plekhg7 Pleckstrin homology domain-containing family G member 7 (Pleckstrin
homology domain-containing, family G (with RhoGef domain) member 7)		 Danio rerio
TI:7955 None
 
A8WZ74_CAEBR
WormBase»
0.0
prhg-1 Protein CBG05122 Caenorhabditis briggsae
TI:6238 None
 
A8XTC0_CAEBR
WormBase»
0.0
rhgf-2 Protein CBR-RHGF-2 Caenorhabditis briggsae
TI:6238 None
 
B3RZI4_TRIAD
CTD»
0.0
TRIADDRAFT_64013 DH domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3S744_TRIAD
CTD»
0.0
TRIADDRAFT_60035 DH domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B7Q3L1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW008875 Rho guanine exchange factor, putative Ixodes scapularis
TI:6945 None
 
B7Q8E5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW010836 DH domain-containing protein Ixodes scapularis
TI:6945 None
 
C4LYA1_ENTH1
TubercuList»
0.0
EHI_166990 DH domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4M177_ENTH1
TubercuList»
0.0
EHI_188030 DH domain-containing protein Entamoeba histolytica
TI:5759 None
 
D6WMV8_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_14600 DH domain-containing protein Tribolium castaneum
TI:7070 None
 
E9FTQ3_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_95014 DH domain-containing protein Daphnia pulex
TI:6669 None
 
F1A476_DICPU
TubercuList»
0.0
DICPUDRAFT_84941 Uncharacterized protein Dictyostelium purpureum
TI:5786 None 		 
 
F1P129_CHICK
Ensembl»
0.5
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Gallus gallus
TI:9031 None
   
F1RIK4_PIG
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Sus scrofa
TI:9823 None
   
F6TBV6_CIOIN
Ensembl»
0.0
DH domain-containing protein Ciona intestinalis
TI:7719 None
 
F6U0H1_MACMU
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Macaca mulatta
TI:9544 None
   
F7C6M3_ORNAN
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Ornithorhynchus anatinus
TI:9258 None
   
F7DNX0_HORSE
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Equus caballus
TI:9796 None
   
F7F9Z4_MONDO
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Monodelphis domestica
TI:13616 None
   
G1KMA5_ANOCA
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Anolis carolinensis
TI:28377 None
   
G3RDZ2_GORGO
Ensembl»
0.0
PLEKHG7 Pleckstrin homology and
RhoGEF domain containing G7		 Gorilla gorilla
TI:9593 None
 
G3SF04_GORGO
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Gorilla gorilla
TI:9593 None
 
H2L0P5_CAEEL
WormBase»
0.5
prhg-1 Pleckstrin homology domain-containing
family G member 7		 Caenorhabditis elegans
TI:6239 None
 
H2M6T9_ORYLA
Ensembl»
0.0
plekhg7 Pleckstrin homology domain containing, family
G (with RhoGef domain) member 7		 Oryzias latipes
TI:8090 None
   
H2MA02_ORYLA
Ensembl»
0.0
plekhg6 Pleckstrin homology domain containing, family
G (with RhoGef domain) member 6		 Oryzias latipes
TI:8090 None
   
H2MYE3_ORYLA
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Oryzias latipes
TI:8090 None
   
H2R042_PANTR
Ensembl»
0.0
PLEKHG5 Pleckstrin homology and
RhoGEF domain containing G5		 Pan troglodytes
TI:9598 None
 
PKHG5_HUMAN
Ensembl»
4.3
PLEKHG5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)		 Homo sapiens
TI:9606 None
 
PKHG5_MOUSE
Ensembl»
5.5
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing
family G member 5) (Synectin-binding RhoA exchange factor) (SYX)		 Mus musculus
TI:10090 None
 
PKHG5_RAT
RGD»
4.0
Plekhg5 Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member
5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus)		 Rattus norvegicus
TI:10116 None
 
PKHG7_HUMAN
Ensembl»
0.5
PLEKHG7 Pleckstrin homology domain-containing family G member
7 (PH domain-containing family G member 7)		 Homo sapiens
TI:9606 None
 
Q9VW85_DROME
FlyBase»
2.8
CG13812 Uncharacterized protein, isoform C Drosophila melanogaster
TI:7227 None
 
S6EZU2_CAEEL
WormBase»
1.0
rhgf-2 DH domain-containing protein Caenorhabditis elegans
TI:6239 None
 
T1EP78_HELRO
EnsemblMetazoa»
0.0
20198378 DH domain-containing protein Helobdella robusta
TI:6412 None
 
T1EP79_HELRO
EnsemblMetazoa»
0.0
20198379 Uncharacterized protein Helobdella robusta
TI:6412 None
 
T1EQC9_HELRO
EnsemblMetazoa»
0.0
20198779 PH domain-containing protein Helobdella robusta
TI:6412 None
 
T1EQD0_HELRO
EnsemblMetazoa»
0.0
20198780 DH domain-containing protein Helobdella robusta
TI:6412 None
 
T1EQU7_HELRO
EnsemblMetazoa»
0.0
20198947 Uncharacterized protein Helobdella robusta
TI:6412 None
 
T1F8Y3_HELRO
EnsemblMetazoa»
0.0
20205282 DH domain-containing protein Helobdella robusta
TI:6412 None
 
T1FGL0_HELRO
EnsemblMetazoa»
0.0
20207959 DH domain-containing protein Helobdella robusta
TI:6412 None
 
T1FU70_HELRO
EnsemblMetazoa»
0.0
20212366 DH domain-containing protein Helobdella robusta
TI:6412 None
 
W5M4N7_LEPOC
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G5		 Lepisosteus oculatus
TI:7918 None
 
W5MIT9_LEPOC
Ensembl»
0.0
DH domain-containing protein Lepisosteus oculatus
TI:7918 None
 
W5NDV9_LEPOC
Ensembl»
0.0
Pleckstrin homology domain containing, family
G (with RhoGef domain) member 7		 Lepisosteus oculatus
TI:7918 None
 
Y6504_DICDI
dictyBase»
0.5
DDB_G0289917 Uncharacterized protein DDB_G0289917 Dictyostelium discoideum
TI:44689 None