Collated Gene Ontology terms

Biological process: MHC class II protein binding(2002, 2015, 2016, 2018, 2019, 2024) protein tyrosine kinase binding(2015, 2017, 2018, 2024) coreceptor activity(2002, 2003, 2024) MHC class II protein complex binding(2020, 2024) protein kinase binding(2006, 2010, 2024) zinc ion binding(2005, 2024) protein homodimerization activity(2015, 2024) interleukin-16 receptor activity(2016, 2024) interleukin-16 binding(2016, 2024) identical protein binding(2024)
enzyme binding2011, 2024 transmembrane signaling receptor activity2003, 2019 lipid binding2022 virus receptor activity2024 signaling receptor binding2018 signaling receptor activity2003 immunoglobulin binding2015 extracellular matrix structural constituent2006

Molecular function: positive regulation of ERK1 and ERK2 cascade2016, 2018, 2024 interleukin-15-mediated signaling pathway2016, 2018, 2024 T cell activation2006, 2023, 2024 immune response2002, 2024 T cell selection2006, 2024 T cell differentiation2006, 2024 cell adhesion2024 maintenance of protein location in cell2009, 2024 adaptive immune response2024 regulation of calcium ion transport2016, 2024
regulation of T cell activation2006, 2024 positive regulation of viral entry into host cell2016, 2024 positive regulation of monocyte differentiation2016, 2024 positive regulation of MAPK cascade2016, 2024 positive regulation of I-kappaB kinase/NF-kappaB signaling2016, 2024 positive regulation of DNA-templated transcription2016, 2024 macrophage differentiation2019, 2024 cellular response to granulocyte macrophage colony-stimulating factor stimulus2016, 2024 positive regulation of protein phosphorylation2016, 2024 positive regulation of protein kinase activity2006, 2024 positive regulation of kinase activity2016, 2024 cell surface receptor signaling pathway2003, 2015, 2024 positive regulation of peptidyl-tyrosine phosphorylation2005, 2024 positive regulation of calcium-mediated signaling2005, 2024 positive regulation of T cell activation2006, 2024 helper T cell enhancement of adaptive immune response2015, 2024 defense response to Gram-negative bacterium2012, 2024 calcium-mediated signaling2005, 2024 viral entry into host cell2024 transmembrane receptor protein tyrosine kinase signaling pathway2002 signal transduction2003 response to vitamin D2015 response to estradiol2015 positive regulation of interleukin-2 production2002 positive regulation of calcium ion transport into cytosol2015 positive regulation of T cell proliferation2015 enzyme-linked receptor protein signaling pathway2003 blood coagulation2013

Cellular component: plasma membrane2007, 2010, 2015, 2016, 2024 membrane2024 external side of plasma membrane2011, 2015, 2017, 2018, 2024 membrane raft2009, 2015, 2018, 2024 cell surface2009, 2015, 2022, 2024 endoplasmic reticulum membrane2009, 2013, 2024 endoplasmic reticulum lumen2009, 2024 extracellular region2013 early endosome2013 clathrin-coated endocytic vesicle membrane2019
T cell receptor complex2002

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 10.0 20.0 30.0 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
CD4_HUMAN
Ensembl»
34.7
CD4 T-cell surface glycoprotein CD4 (T-cell
surface antigen T4/Leu-3) (CD antigen CD4)		 Homo sapiens
TI:9606 None
 
MFAP3_HUMAN
Ensembl»
2.5
MFAP3 Microfibril-associated glycoprotein 3 Homo sapiens
TI:9606 None
 
CD4_MOUSE
Ensembl»
8.4
Cd4 T-cell surface glycoprotein CD4 (T-cell differentiation antigen
L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)		 Mus musculus
TI:10090 None
 
H2QRU9_PANTR
Ensembl»
0.0
MFAP3 Microfibril associated protein
3 (Microfibrillar-associated protein 3)		 Pan troglodytes
TI:9598 None
 
H9ERG6_MACMU
Ensembl»
0.0
MFAP3 Microfibril associated protein 3
(Microfibril-associated glycoprotein 3 isoform 1)		 Macaca mulatta
TI:9544 None
 
CD4_MACMU
CTD»
0.0
CD4 T-cell surface glycoprotein CD4 (T-cell
surface antigen T4/Leu-3) (CD antigen CD4)		 Macaca mulatta
TI:9544 None
 
CD4_CANLF
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4 (T-cell
surface antigen T4/Leu-3) (CD antigen CD4)		 Canis lupus
TI:9612 None
 
CD4_PANTR
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4 (T-cell
surface antigen T4/Leu-3) (CD antigen CD4)		 Pan troglodytes
TI:9598 None
 
G3QL31_GORGO
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Gorilla gorilla
TI:9593 None
 
T1EVS1_HELRO
EnsemblMetazoa»
0.0
20200671 Ig-like domain-containing protein Helobdella robusta
TI:6412 None
 
W5MB57_LEPOC
Ensembl»
0.0
Uncharacterized LOC107080075 Lepisosteus oculatus
TI:7918 None
 
W5MJY9_LEPOC
Ensembl»
0.0
Uncharacterized LOC102685166 Lepisosteus oculatus
TI:7918 None
 
A0A287BM27_PIG
Ensembl»
0.0
MFAP3 Microfibril associated protein 3
(Microfibril-associated glycoprotein 3 isoform 1)		 Sus scrofa
TI:9823 None
 
A6MAP0_MONDO
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Monodelphis domestica
TI:13616 None
 
B5KH12_DANRE
ZFIN»
2.5
CD4-4 CD4-1 molecule precursor (CD4-4 protein) Danio rerio
TI:7955 None
 
CD4_RAT
RGD»
26.9
Cd4 T-cell surface glycoprotein CD4 (T-cell surface
antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)		 Rattus norvegicus
TI:10116 None
 
E0XMD0_ORYLA
Ensembl»
0.0
G6F-like G6F-like protein Oryzias latipes
TI:8090 None
 
E0XMD3_DANRE
ZFIN»
3.3
G6F-like G6F-like protein (G6f-like) Danio rerio
TI:7955 None
 
G3R643_GORGO
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Gorilla gorilla
TI:9593 None
 
M3W1W4_FELCA
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Felis catus
TI:9685 None
 
M3X646_FELCA
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Felis catus
TI:9685 None
 
W5LXH0_LEPOC
Ensembl»
0.0
Ig-like domain-containing protein Lepisosteus oculatus
TI:7918 None
 
W5MJR6_LEPOC
Ensembl»
0.0
Lymphocyte activation gene 3 protein-like Lepisosteus oculatus
TI:7918 None
 
W5MK07_LEPOC
Ensembl»
0.0
Ig-like domain-containing protein Lepisosteus oculatus
TI:7918 None
 
W5MK28_LEPOC
Ensembl»
0.0
Ig-like domain-containing protein Lepisosteus oculatus
TI:7918 None
 
A0A3B3HSU0_ORYLA
Ensembl»
0.0
lag3 Lymphocyte activating 3 Oryzias latipes
TI:8090 None
   
A0A3B3IE64_ORYLA
Ensembl»
0.0
Ig-like domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3B3IEL0_ORYLA
Ensembl»
0.0
Ig-like domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3B3IF68_ORYLA
Ensembl»
0.0
LOC105355351 Uncharacterized LOC105355351 Oryzias latipes
TI:8090 None
   
A0A3B3IJR0_ORYLA
Ensembl»
0.0
Ig-like domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3B3IM06_ORYLA
Ensembl»
0.0
Ig-like domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3B3IMG5_ORYLA
Ensembl»
0.0
Ig-like domain-containing protein Oryzias latipes
TI:8090 None
   
A0A5F5PMB0_HORSE
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Equus caballus
TI:9796 None
   
A0A5F8HFG9_MONDO
Ensembl»
0.0
Ig-like domain-containing protein Monodelphis domestica
TI:13616 None
   
A0A803K8J4_XENTR
Ensembl»
0.0
cd4 Cd4 receptor (T-cell surface glycoprotein CD4) Xenopus tropicalis
TI:8364 None
   
A0A803SY68_ANOCA
Ensembl»
0.0
LOC100567219 Ig-like domain-containing protein Anolis carolinensis
TI:28377 None
   
A0A8I3MU20_CANLF
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Canis lupus
TI:9612 None
   
A0A8J0T736_XENLA
Xenbase»
0.0
lag3.L Lymphocyte activation gene 3 protein Xenopus laevis
TI:8355 None
   
A0A8J1JUR7_XENTR
Xenbase»
0.0
LOC116412136 Lymphocyte activation gene 3 protein-like Xenopus tropicalis
TI:8364 None
   
A0A8J1JV84_XENTR
Xenbase»
0.0
LOC101731673 Lymphocyte activation gene 3 protein Xenopus tropicalis
TI:8364 None
   
A0A8J1L998_XENLA
Xenbase»
0.0
cd4.L T-cell surface glycoprotein CD4 Xenopus laevis
TI:8355 None
   
A0A8J1LB71_XENLA
Xenbase»
0.0
lag3.S Lymphocyte activation gene 3 protein-like Xenopus laevis
TI:8355 None
   
A0A8J1LBB3_XENLA
Xenbase»
0.0
cd4.S Cd4 receptor S homeolog isoform X1 Xenopus laevis
TI:8355 None
   
A0A8M1RN94_DANRE
CTD»
0.0
LOC100334508 Uncharacterized protein LOC100334508 Danio rerio
TI:7955 None
   
A0A8M2B4B3_DANRE
CTD»
0.0
zmp:0000000608 Uncharacterized protein zmp:0000000608 Danio rerio
TI:7955 None
   
A0A8M2BHI7_DANRE
CTD»
0.0
LOC101885506 Uncharacterized protein LOC101885506 isoform X1 Danio rerio
TI:7955 None
   
A0A8M3B0M1_DANRE
CTD»
0.0
LOC103910163 Uncharacterized protein LOC103910163 isoform X1 Danio rerio
TI:7955 None
   
A0A8M3B815_DANRE
CTD»
0.0
dicp1.5-6 Uncharacterized protein DDB_G0271670 isoform X1 Danio rerio
TI:7955 None
   
A0A8M6YWW9_DANRE
CTD»
0.0
dicp1.19 Uncharacterized protein DDB_G0271670 Danio rerio
TI:7955 None
   
A0A8M6YZD0_DANRE
CTD»
0.0
LOC100535743 Uncharacterized protein LOC100535743 Danio rerio
TI:7955 None
   
A0A8M9PAG1_DANRE
CTD»
0.0
LOC110438862 Uncharacterized protein LOC110438862 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PAH7_DANRE
CTD»
0.0
LOC110438870 Uncharacterized protein LOC110438870 Danio rerio
TI:7955 None
   
A0A8M9PC54_DANRE
CTD»
0.0
LOC101884583 Uncharacterized protein LOC101884583 Danio rerio
TI:7955 None
   
A0A8M9PHW4_DANRE
ZFIN»
0.0
im:7142016 Uncharacterized protein im:7142016 Danio rerio
TI:7955 None
   
A0A8M9PLS0_DANRE
CTD»
0.0
LOC110437750 Uncharacterized protein DDB_G0271670-like Danio rerio
TI:7955 None
   
A0A8M9PLX2_DANRE
CTD»
0.0
LOC103910162 Uncharacterized protein LOC103910162 Danio rerio
TI:7955 None
   
A0A8M9PMZ7_DANRE
CTD»
0.0
LOC100536667 Uncharacterized protein LOC100536667 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PNG6_DANRE
CTD»
2.5
LOC100334281 Hemicentin-1 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PNQ4_DANRE
CTD»
0.0
LOC110439012 Uncharacterized protein LOC110439012 Danio rerio
TI:7955 None
   
A0A8M9Q084_DANRE
CTD»
0.0
LOC103910169 Uncharacterized protein LOC103910169 Danio rerio
TI:7955 None
   
A0A8M9Q0A8_DANRE
CTD»
0.0
LOC108182761 Uncharacterized protein LOC108182761 Danio rerio
TI:7955 None
   
A0A8M9Q3F0_DANRE
CTD»
0.0
LOC108182910 Uncharacterized protein LOC108182910 Danio rerio
TI:7955 None
   
A0A8V0ZMF0_CHICK
Ensembl»
0.0
LAG3 Lymphocyte activating 3 Gallus gallus
TI:9031 None
   
A0A8V0ZMH6_CHICK
Ensembl»
0.0
CD4 CD4 molecule Gallus gallus
TI:9031 None
   
A0A9J7N089_BRAFL
CTD»
0.0
LOC118421974 Uncharacterized protein LOC118421974 Branchiostoma floridae
TI:7739 None
   
F1MGZ1_BOVIN
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Bos taurus
TI:9913 None
   
F6XGD3_MACMU
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Macaca mulatta
TI:9544 None
   
F6Y6X8_HORSE
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Equus caballus
TI:9796 None
   
F7DUW7_ORNAN
Ensembl»
0.0
MFAP3 Microfibril associated protein 3 Ornithorhynchus anatinus
TI:9258 None
   
H2MBR5_ORYLA
Ensembl»
0.0
LOC101172105 Uncharacterized LOC101172105 Oryzias latipes
TI:8090 None
   
H2MBS3_ORYLA
Ensembl»
0.0
LOC100125525 Carcinoembryonic antigen-related cell
adhesion molecule 5		 Oryzias latipes
TI:8090 None
   
H9GAP6_ANOCA
Ensembl»
0.0
Ig-like domain-containing protein Anolis carolinensis
TI:28377 None
   
I3L556_PIG
Ensembl»
0.0
CD4 T-cell surface glycoprotein CD4
(T-cell surface antigen T4/Leu-3)		 Sus scrofa
TI:9823 None
   
W5LXR7_LEPOC
Ensembl»
0.0
Uncharacterized LOC107076047 Lepisosteus oculatus
TI:7918 None