Collated Gene Ontology terms

Biological process: MHC class II protein binding(2002, 2015, 2016, 2018, 2019, 2024) protein tyrosine kinase binding(2015, 2017, 2018, 2024) coreceptor activity(2002, 2003, 2024) MHC class II protein complex binding(2020, 2024) protein kinase binding(2006, 2010, 2024) zinc ion binding(2005, 2024) protein homodimerization activity(2015, 2024) interleukin-16 receptor activity(2016, 2024) interleukin-16 binding(2016, 2024) identical protein binding(2024)
enzyme binding2011, 2024 transmembrane signaling receptor activity2003, 2019 lipid binding2022 virus receptor activity2024 signaling receptor binding2018 signaling receptor activity2003 immunoglobulin binding2015 extracellular matrix structural constituent2006

Molecular function: positive regulation of ERK1 and ERK2 cascade2016, 2018, 2024 interleukin-15-mediated signaling pathway2016, 2018, 2024 T cell activation2006, 2023, 2024 immune response2002, 2024 T cell selection2006, 2024 T cell differentiation2006, 2024 cell adhesion2024 maintenance of protein location in cell2009, 2024 adaptive immune response2024 regulation of calcium ion transport2016, 2024
regulation of T cell activation2006, 2024 positive regulation of viral entry into host cell2016, 2024 positive regulation of monocyte differentiation2016, 2024 positive regulation of MAPK cascade2016, 2024 positive regulation of I-kappaB kinase/NF-kappaB signaling2016, 2024 positive regulation of DNA-templated transcription2016, 2024 macrophage differentiation2019, 2024 cellular response to granulocyte macrophage colony-stimulating factor stimulus2016, 2024 positive regulation of protein phosphorylation2016, 2024 positive regulation of protein kinase activity2006, 2024 positive regulation of kinase activity2016, 2024 cell surface receptor signaling pathway2003, 2015, 2024 positive regulation of peptidyl-tyrosine phosphorylation2005, 2024 positive regulation of calcium-mediated signaling2005, 2024 positive regulation of T cell activation2006, 2024 helper T cell enhancement of adaptive immune response2015, 2024 defense response to Gram-negative bacterium2012, 2024 calcium-mediated signaling2005, 2024 viral entry into host cell2024 transmembrane receptor protein tyrosine kinase signaling pathway2002 signal transduction2003 response to vitamin D2015 response to estradiol2015 positive regulation of interleukin-2 production2002 positive regulation of calcium ion transport into cytosol2015 positive regulation of T cell proliferation2015 enzyme-linked receptor protein signaling pathway2003 blood coagulation2013

Cellular component: plasma membrane2007, 2010, 2015, 2016, 2024 membrane2024 external side of plasma membrane2011, 2015, 2017, 2018, 2024 membrane raft2009, 2015, 2018, 2024 cell surface2009, 2015, 2022, 2024 endoplasmic reticulum membrane2009, 2013, 2024 endoplasmic reticulum lumen2009, 2024 extracellular region2013 early endosome2013 clathrin-coated endocytic vesicle membrane2019
T cell receptor complex2002

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 10.0 20.0 30.0 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A8M1RN94_DANRE
CTD»
0.0
LOC100334508 Uncharacterized protein LOC100334508 Danio rerio
TI:7955 None
   
A0A8M2B4B3_DANRE
CTD»
0.0
zmp:0000000608 Uncharacterized protein zmp:0000000608 Danio rerio
TI:7955 None
   
A0A8M2BHI7_DANRE
CTD»
0.0
LOC101885506 Uncharacterized protein LOC101885506 isoform X1 Danio rerio
TI:7955 None
   
A0A8M3B0M1_DANRE
CTD»
0.0
LOC103910163 Uncharacterized protein LOC103910163 isoform X1 Danio rerio
TI:7955 None
   
A0A8M3B815_DANRE
CTD»
0.0
dicp1.5-6 Uncharacterized protein DDB_G0271670 isoform X1 Danio rerio
TI:7955 None
   
A0A8M6YWW9_DANRE
CTD»
0.0
dicp1.19 Uncharacterized protein DDB_G0271670 Danio rerio
TI:7955 None
   
A0A8M6YZD0_DANRE
CTD»
0.0
LOC100535743 Uncharacterized protein LOC100535743 Danio rerio
TI:7955 None
   
A0A8M9PAG1_DANRE
CTD»
0.0
LOC110438862 Uncharacterized protein LOC110438862 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PAH7_DANRE
CTD»
0.0
LOC110438870 Uncharacterized protein LOC110438870 Danio rerio
TI:7955 None
   
A0A8M9PC54_DANRE
CTD»
0.0
LOC101884583 Uncharacterized protein LOC101884583 Danio rerio
TI:7955 None
   
A0A8M9PHW4_DANRE
ZFIN»
0.0
im:7142016 Uncharacterized protein im:7142016 Danio rerio
TI:7955 None
   
A0A8M9PLS0_DANRE
CTD»
0.0
LOC110437750 Uncharacterized protein DDB_G0271670-like Danio rerio
TI:7955 None
   
A0A8M9PLX2_DANRE
CTD»
0.0
LOC103910162 Uncharacterized protein LOC103910162 Danio rerio
TI:7955 None
   
A0A8M9PMZ7_DANRE
CTD»
0.0
LOC100536667 Uncharacterized protein LOC100536667 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PNG6_DANRE
CTD»
2.5
LOC100334281 Hemicentin-1 isoform X1 Danio rerio
TI:7955 None
   
A0A8M9PNQ4_DANRE
CTD»
0.0
LOC110439012 Uncharacterized protein LOC110439012 Danio rerio
TI:7955 None
   
A0A8M9Q084_DANRE
CTD»
0.0
LOC103910169 Uncharacterized protein LOC103910169 Danio rerio
TI:7955 None
   
A0A8M9Q0A8_DANRE
CTD»
0.0
LOC108182761 Uncharacterized protein LOC108182761 Danio rerio
TI:7955 None
   
A0A8M9Q3F0_DANRE
CTD»
0.0
LOC108182910 Uncharacterized protein LOC108182910 Danio rerio
TI:7955 None
   
A0A8V0ZMF0_CHICK
Ensembl»
0.0
LAG3 Lymphocyte activating 3 Gallus gallus
TI:9031 None
   
A0A8V0ZMH6_CHICK
Ensembl»
0.0
CD4 CD4 molecule Gallus gallus
TI:9031 None
   
B5KH12_DANRE
ZFIN»
2.5
CD4-4 CD4-1 molecule precursor (CD4-4 protein) Danio rerio
TI:7955 None
 
CD4_HUMAN
Ensembl»
34.7
CD4 T-cell surface glycoprotein CD4 (T-cell
surface antigen T4/Leu-3) (CD antigen CD4)		 Homo sapiens
TI:9606 None
 
CD4_MOUSE
Ensembl»
8.4
Cd4 T-cell surface glycoprotein CD4 (T-cell differentiation antigen
L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)		 Mus musculus
TI:10090 None
 
CD4_RAT
RGD»
26.9
Cd4 T-cell surface glycoprotein CD4 (T-cell surface
antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)		 Rattus norvegicus
TI:10116 None
 
E0XMD3_DANRE
ZFIN»
3.3
G6F-like G6F-like protein (G6f-like) Danio rerio
TI:7955 None
 
MFAP3_HUMAN
Ensembl»
2.5
MFAP3 Microfibril-associated glycoprotein 3 Homo sapiens
TI:9606 None