Collated Gene Ontology terms

Biological process: ubiquitin-protein transferase activity(2013, 2025) actin filament binding(2020, 2025) ubiquitin-like ligase-substrate adaptor activity(2024)

Molecular function: proteasome-mediated ubiquitin-dependent protein catabolic process2013, 2022, 2025 regulation of microtubule-based process2013, 2022, 2025 protein polyubiquitination2013, 2022, 2025 relaxation of skeletal muscle2020, 2022 regulation of the force of skeletal muscle contraction2020, 2022 cell division2025 protein ubiquitination2024 pancreas regeneration2017 glucose homeostasis2017 endocrine pancreas development2017
actin filament organization2020

Cellular component: Cul3-RING ubiquitin ligase complex2013, 2022, 2024, 2025 spindle2025 cytoplasm2024, 2025 myofibril2025 cytosol2016 Z disc2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 2/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A5F8H0Q1_MONDO
Ensembl»
0.0
Kelch like family member 17 Monodelphis domestica
TI:13616 None
   
F6QD65_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
F7BAZ1_CIOIN
Ensembl»
0.0
Attractin/MKLN-like beta-propeller
domain-containing protein		 Ciona intestinalis
TI:7719 None 		     
H9GHZ0_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None 		     
W5M653_LEPOC
Ensembl»
0.0
Kelch repeat protein Lepisosteus oculatus
TI:7918 None 		 
 
W5NK94_LEPOC
Ensembl»
0.0
Kelch-like family, member 42 Lepisosteus oculatus
TI:7918 None 		 
 
W5NN41_LEPOC
Ensembl»
0.0
Kelch repeat and BTB domain containing 13 Lepisosteus oculatus
TI:7918 None 		 
 
O17702_CAEEL
WormBase»
1.0
C53A5.11 CELE_C53A5.11 Kelch-like protein 10 Caenorhabditis elegans
TI:6239 None
 
E9GJ05_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_243517 Uncharacterized protein Daphnia pulex
TI:6669 None 		 
 
B7PKF0_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW019108 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
B7QE29_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW024786 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
A0A287AJW4_PIG
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Sus scrofa
TI:9823 None
   
A0A6I8P157_ORNAN
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3S4U2_CANLF
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Canis lupus
TI:9612 None
   
A0A8V0Z2K6_CHICK
Ensembl»
1.0
KBTBD13 Kelch repeat and BTB domain containing 13 Gallus gallus
TI:9031 None
   
A0ABI7YHN3_FELCA
Ensembl»
0.0
KBTBD13 BTB domain-containing protein Felis catus
TI:9685 None 		     
F1MXY6_BOVIN
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Bos taurus
TI:9913 None
   
F6XG13_MACMU
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Macaca mulatta
TI:9544 None
   
F6XYH4_HORSE
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Equus caballus
TI:9796 None
   
H2L4U0_ORYLA
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Oryzias latipes
TI:8090 None 		     
H2LJG7_ORYLA
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Oryzias latipes
TI:8090 None 		     
H2RH57_PANTR
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Pan troglodytes
TI:9598 None
 
H9G966_ANOCA
Ensembl»
0.0
KBTBD13 Kelch repeat and BTB domain containing 13 Anolis carolinensis
TI:28377 None
   
KBTBD_HUMAN
Ensembl»
3.2
KBTBD13 Kelch repeat and
BTB domain-containing protein 13		 Homo sapiens
TI:9606 None
 
A0A2I2YF66_GORGO
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Gorilla gorilla
TI:9593 None
 
A0A3Q2KNZ3_HORSE
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Equus caballus
TI:9796 None
   
A0A803SMY8_ANOCA
Ensembl»
0.0
KLHL42 Kelch like family member 42 Anolis carolinensis
TI:28377 None
   
A0A8I3PR99_CANLF
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Canis lupus
TI:9612 None
   
A0ABI7XJR6_FELCA
Ensembl»
0.0
KLHL42 BTB domain-containing protein Felis catus
TI:9685 None 		     
F1MFH5_BOVIN
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Bos taurus
TI:9913 None
   
F1P5X6_CHICK
Ensembl»
1.5
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Gallus gallus
TI:9031 None
   
F1SG97_PIG
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Sus scrofa
TI:9823 None
 
F7BH48_MONDO
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Monodelphis domestica
TI:13616 None
   
F7DXU8_MACMU
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Macaca mulatta
TI:9544 None
 
H2MPP3_ORYLA
Ensembl»
0.0
KLHL42 Kelch-like family, member 42 Oryzias latipes
TI:8090 None
   
H2R7A4_PANTR
Ensembl»
0.0
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Pan troglodytes
TI:9598 None
 
KLH42_HUMAN
Ensembl»
5.3
KLHL42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Ctb9) (Kelch domain-containing protein 5)		 Homo sapiens
TI:9606 None
 
KBTBD_MOUSE
Ensembl»
5.2
Kbtbd13 Kelch repeat and
BTB domain-containing protein 13		 Mus musculus
TI:10090 None
 
D4A9Z3_RAT
RGD»
2.0
Klhl42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Kelch domain-containing protein 5)		 Rattus norvegicus
TI:10116 None
   
KLH42_MOUSE
Ensembl»
5.0
Klhl42 Kelch-like protein 42 (Cullin-3-binding protein
9) (Ctb9) (Kelch domain-containing protein 5)		 Mus musculus
TI:10090 None
 
A0A2R8QC39_DANRE
Ensembl»
1.5
LOC101886608 Kelch repeat and BTB domain-containing protein 13 isoform
X1 (Kelch repeat and BTB domain-containing protein 13-like)		 Danio rerio
TI:7955 None
 
C3YKP1_BRAFL
neXtProt»
0.0
LOC118404039 Kelch-like protein 22 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7KHK9_BRAFL
euHCVdb»
0.0
LOC118404347 Kelch-like protein 42 Branchiostoma floridae
TI:7739 None 		     
A0A9J7HNW8_BRAFL
euHCVdb»
0.0
LOC118406008 Kelch-like protein 42 Branchiostoma floridae
TI:7739 None 		     
A0A9J7HP56_BRAFL
euHCVdb»
0.0
LOC118406136 Kelch-like protein 9 Branchiostoma floridae
TI:7739 None 		     
A0A9J7KNJ8_BRAFL
euHCVdb»
0.0
LOC118409932 Kelch repeat and
BTB domain-containing protein 11-like		 Branchiostoma floridae
TI:7739 None 		     
C3YKX7_BRAFL
euHCVdb»
0.0
LOC118410970 Kelch repeat and
BTB domain-containing protein 13-like		 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7KY35_BRAFL
neXtProt»
0.0
LOC118413203 Kelch repeat and
BTB domain-containing protein 11-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7KXM9_BRAFL
neXtProt»
0.0
LOC118413269 Uncharacterized protein LOC118413269 Branchiostoma floridae
TI:7739 None 		     
A0A9J7KYB3_BRAFL
euHCVdb»
0.0
LOC118413461 Kelch repeat and
BTB domain-containing protein 13-like		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7L2Z5_BRAFL
neXtProt»
0.0
LOC118414887 Kelch-like protein 17 isoform X1 Branchiostoma floridae
TI:7739 None 		     
A0A9J7L860_BRAFL
euHCVdb»
0.0
LOC118415908 Kelch-like protein 26 Branchiostoma floridae
TI:7739 None 		     
C4A0X9_BRAFL
euHCVdb»
0.0
LOC118417037 Kelch-like protein 26 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7L9Z9_BRAFL
euHCVdb»
0.0
LOC118417479 Kelch-like protein 42 Branchiostoma floridae
TI:7739 None 		     
A0A9J7LB34_BRAFL
euHCVdb»
0.0
LOC118417783 Kelch-like protein 42 Branchiostoma floridae
TI:7739 None 		     
C4A0X7_BRAFL
euHCVdb»
0.0
LOC118418217 Kelch-like protein 26 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7LED3_BRAFL
euHCVdb»
0.0
LOC118418644 Kelch-like protein 26 Branchiostoma floridae
TI:7739 None 		     
A0A9J7N1Y5_BRAFL
euHCVdb»
0.0
LOC118424321 Kelch domain-containing protein 8B-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7N173_BRAFL
neXtProt»
0.0
LOC118424475 Kelch repeat and
BTB domain-containing protein 13-like		 Branchiostoma floridae
TI:7739 None 		     
C3ZHJ6_BRAFL
euHCVdb»
0.0
LOC118424870 Kelch repeat and
BTB domain-containing protein 11-like		 Branchiostoma floridae
TI:7739 None 		 
 
C3ZHJ5_BRAFL
euHCVdb»
0.0
LOC118424871 Uncharacterized protein LOC118424871 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7LW35_BRAFL
euHCVdb»
0.0
LOC118424875 Kelch domain-containing protein 7B-like Branchiostoma floridae
TI:7739 None 		     
C3ZHT5_BRAFL
euHCVdb»
0.0
LOC118426653 Kelch-like protein 17 Branchiostoma floridae
TI:7739 None 		 
 
A0A9J7M7X9_BRAFL
neXtProt»
0.0
LOC118428941 Kelch-like protein 42 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MAF8_BRAFL
euHCVdb»
0.0
LOC118429885 Kelch-like protein 21 Branchiostoma floridae
TI:7739 None 		     
A0A9J7NBJ3_BRAFL
neXtProt»
0.0
LOC118431318 Kelch domain-containing protein 7B-like Branchiostoma floridae
TI:7739 None 		     
A0A2R6XDR5_MARPO
neXtProt»
0.0
MARPO_0021s0098 Attractin/MKLN-like beta-propeller
domain-containing protein		 Marchantia polymorpha
TI:3197 None 		 
 
A7SES4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g115638 Attractin/MKLN-like beta-propeller
domain-containing protein		 Nematostella vectensis
TI:45351 None 		 
 
A8DVZ8_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g156941 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A7T963_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g7669 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
Q7UKK5_RHOBA
EnsemblBacteria»
0.0
RB10103 Kelch repeat-containing protein Rhodopirellula baltica
TI:265606 None 		 
 
D8STR3_SELML
euHCVdb»
0.0
SELMODRAFT_3894 Uncharacterized protein Selaginella moellendorffii
TI:88036 None 		 
 
F6U0R1_XENTR
Xenbase»
0.0
kbtbd13 Kelch repeat and BTB (POZ) domain-containing 13
(Kelch repeat and BTB domain-containing protein 13)		 Xenopus tropicalis
TI:8364 None 		     
A0A8J0UNC4_XENLA
Xenbase»
0.0
kbtbd13.L Kelch repeat and
BTB domain-containing protein 13		 Xenopus laevis
TI:8355 None 		     
A0A1L8GSJ7_XENLA
Xenbase»
0.0
kbtbd13.S Kelch repeat and
BTB domain-containing protein 13		 Xenopus laevis
TI:8355 None 		     
A0A8M1PS76_DANRE
ZFIN»
0.0
kbtbd13a Kelch repeat and
BTB domain-containing protein 13		 Danio rerio
TI:7955 None
   
X1WCK8_DANRE
ZFIN»
0.0
kbtbd13b Kelch repeat and BTB
domain-containing protein 13 (Si:ch211-253p14.2)		 Danio rerio
TI:7955 None 		 
 
A0A6I8PLU3_XENTR
Xenbase»
0.0
klhl42 Kelch like family member
42 (Kelch-like protein 42)		 Xenopus tropicalis
TI:8364 None 		     
A0AB32TSL1_DANRE
ZFIN»
2.4
klhl42 Kelch-like protein 42 isoform X1 Danio rerio
TI:7955 None
   
A0A1L8GQW2_XENLA
Xenbase»
0.0
klhl42.S Kelch-like protein 42 Xenopus laevis
TI:8355 None