Collated Gene Ontology terms

Biological process: translation release factor activity(2025) tRNA binding(2021, 2025) ribosomal large subunit binding(2021, 2025) peptidyl-tRNA hydrolase activity(2004, 2022, 2025) hydrolase activity(2025) translation release factor activity, codon specific(2025) RNA binding(2025)

Molecular function: translational termination2025 translation2025 mitochondrial translation2022, 2025 rescue of stalled ribosome2025 mitochondrial translational termination2016, 2025

Cellular component: mitochondrion2010, 2021, 2022, 2024, 2025 mitochondrial matrix2025 mitochondrial inner membrane2014 cytoplasm2025 apicoplast2015

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 3/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 3/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A7M7HFK3_STRPU
EnsemblMetazoa»
0.0
Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7T1P5_STRPU
EnsemblMetazoa»
0.0
Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
H3GR69_PHYRM
EnsemblProtists»
0.0
Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
W5MES2_LEPOC
Ensembl»
0.0
Mitochondrial translation release
factor in rescue		 Lepisosteus oculatus
TI:7918 None
 
Q7PV44_ANOGA
EnsemblMetazoa»
0.0
1280491 AGAP012195-PA Anopheles gambiae
TI:7165 None
 
T1ED32_HELRO
EnsemblMetazoa»
0.0
20194484 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Helobdella robusta
TI:6412 None
 
Q4WDA1_ASPFU
TubercuList»
0.0
AFUA_6G04020 Peptidyl-tRNA hydrolase domain protein Aspergillus fumigatus
TI:746128 None
 
Q74ZB8_EREGS
euHCVdb»
0.0
AGOS_AGR281C AGR281Cp Eremothecium gossypii
TI:33169 None
 
A0A139WBI1_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_34877 Putative peptide chain release
factor C12orf65 homolog, mitochondrial-like protein		 Tribolium castaneum
TI:7070 None
 
F4P930_BATDJ
neXtProt»
0.0
BATDEDRAFT_90766 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
A0A1D5PY53_CHICK
Ensembl»
0.0
C12orf65 Mitochondrial translation release
factor in rescue		 Gallus gallus
TI:9031 None
   
Q59P48_CANAL
CGD»
0.0
CAALFM_C206260WA orf19.12943 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Candida albicans
TI:5476 None
 
A8WV66_CAEBR
WormBase»
0.0
CBG03485 CBG_03485 Protein CBG03485 Caenorhabditis briggsae
TI:6238 None
 
E5QCJ3_CAEEL
WormBase»
0.0
CELE_T23B5.4 T23B5.4 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
A0A0S2M642_CRYD1
TubercuList»
0.0
CNL05155 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Cryptococcus deneoformans
TI:40410 None
 
A1ZAD7_DROME
FlyBase»
0.5
Dmel\CG30100 AT22563p2 Drosophila melanogaster
TI:7227 None
 
A0E3R4_PARTE
euHCVdb»
0.0
GSPATT00023104001 DBF4-type domain-containing protein Paramecium tetraurelia
TI:5888 None 		 
 
A0EDX8_PARTE
euHCVdb»
0.0
GSPATT00025839001 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A0EFT1_PARTE
euHCVdb»
0.0
GSPATT00026495001 DBF4-type domain-containing protein Paramecium tetraurelia
TI:5888 None 		 
 
Q74FR0_GEOSL
EnsemblBacteria»
0.0
GSU0546 Peptidyl-tRNA hydrolase-related protein Geobacter sulfurreducens
TI:35554 None
 
A0A7U2HZZ0_PHANO
TubercuList»
0.0
JI435_015490 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None
 
Q4Q6T4_LEIMA
TubercuList»
0.0
LMJF_30_3540 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Leishmania major
TI:5664 None
 
C3ZV34_BRAFL
euHCVdb»
0.0
LOC118426177 Probable peptide chain release
factor C12orf65 homolog, mitochondrial		 Branchiostoma floridae
TI:7739 None
 
A0A1D5Q6T6_MACMU
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Macaca mulatta
TI:9544 None
   
A0A5F8HDX0_MONDO
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Monodelphis domestica
TI:13616 None
   
A0A6I8NU09_ORNAN
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3P696_CANLF
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Canis lupus
TI:9612 None
   
A0A9L0T3M7_HORSE
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Equus caballus
TI:9796 None
   
A0ABI7ZZX7_FELCA
Ensembl»
0.0
MTRFR Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Felis catus
TI:9685 None
   
F1MLX1_BOVIN
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Bos taurus
TI:9913 None
   
F1RFL3_PIG
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Sus scrofa
TI:9823 None
   
G3RAQ6_GORGO
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Gorilla gorilla
TI:9593 None
 
H2LNV7_ORYLA
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Oryzias latipes
TI:8090 None
   
H2Q756_PANTR
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Pan troglodytes
TI:9598 None
 
H9GMG4_ANOCA
Ensembl»
0.0
MTRFR Mitochondrial translation release
factor in rescue		 Anolis carolinensis
TI:28377 None
   
MTRFR_HUMAN
Ensembl»
3.4
MTRFR Mitochondrial translation release
factor in rescue		 Homo sapiens
TI:9606 None
 
F1LWN5_RAT
RGD»
1.0
Mtrfr Mitochondrial translation release
factor in rescue		 Rattus norvegicus
TI:10116 None
 
MTRFR_MOUSE
Ensembl»
3.0
Mtrfr Mitochondrial translation release
factor in rescue		 Mus musculus
TI:10090 None
 
Q1K7F1_NEUCR
TubercuList»
0.0
NCU04174 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Neurospora crassa
TI:5141 None
 
A7SF22_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g115976 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Nematostella vectensis
TI:45351 None
 
A7T533_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g7994 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Nematostella vectensis
TI:45351 None
 
Q8I1W0_PLAF7
TubercuList»
0.0
PF3D7_0409700 Peptide chain release factor 2 (EC 3.1.1.29) Plasmodium falciparum
TI:5833 None
 
E3KTV9_PUCGT
TubercuList»
0.0
PGTG_13448 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Puccinia graminis
TI:5297 None
 
YONI_SCHPO
PomBase»
1.5
SPBC1105.18c Uncharacterized peptide chain release
factor-like protein C1105.18c, mitochondrial		 Schizosaccharomyces pombe
TI:4896 None
 
A7E3Y8_SCLS1
TubercuList»
0.0
SS1G_00010 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Sclerotinia sclerotiorum
TI:5180 None
 
B5YGC7_THEYD
EnsemblBacteria»
0.0
THEYE_A1528 Peptide chain release factor Thermodesulfovibrio yellowstonii
TI:28262 None
 
B3S4M4_TRIAD
CTD»
0.0
TRIADDRAFT_28629 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
Q586G6_TRYB2
TubercuList»
0.0
Tb06.30P15.550 Prokaryotic-type class I peptide
chain release factors domain-containing protein		 Trypanosoma brucei
TI:5691 None
 
Q6CG38_YARLI
TubercuList»
0.0
YALI0_B01144g YALI0B01144p Yarrowia lipolytica
TI:4952 None
 
YL281_YEAST
SGD»
1.6
YLR281C Uncharacterized peptide chain release
factor-like protein YLR281C, mitochondrial		 Saccharomyces cerevisiae
TI:4932 None
 
A0A6I8QB58_XENTR
Xenbase»
0.0
mtrfr Mitochondrial translation release
factor in rescue		 Xenopus tropicalis
TI:8364 None
   
MTRFR_DANRE
ZFIN»
1.0
mtrfr Mitochondrial translation release
factor in rescue		 Danio rerio
TI:7955 None
 
A0A1L8I0X6_XENLA
Xenbase»
0.0
mtrfr.L Probable Peptide chain
release factor C12orf65, mitochondrial		 Xenopus laevis
TI:8355 None
   
Q8F480_LEPIN
EnsemblBacteria»
0.0
prfB Peptidyl-tRNA hydrolase involved
in peptide chain release		 Leptospira interrogans
TI:173 None
 
B6JVA1_SCHJY
TubercuList»
0.0
pth3 Peptide release factor Schizosaccharomyces japonicus
TI:4897 None