Collated Gene Ontology terms

Biological process: protein disulfide isomerase activity(2014, 2022, 2023, 2024) isomerase activity(2024) protein-disulfide reductase activity(2021, 2022, 2024)

Molecular function: protein folding2021, 2023 response to endoplasmic reticulum stress2020, 2022 peptidyl-cysteine oxidation2024 protein folding in endoplasmic reticulum2012 peptide cross-linking2024 eye development2010

Cellular component: membrane2006, 2024 endoplasmic reticulum2014, 2021, 2022, 2023, 2024 endoplasmic reticulum membrane2015, 2024 cell surface2012, 2022, 2024 endoplasmic reticulum lumen2022 platelet alpha granule membrane2015 plasma membrane2015 Golgi apparatus2009

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803STJ6_ANOCA
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Anolis carolinensis
TI:28377 None
   
Q7Q792_ANOGA
EnsemblMetazoa»
0.0
1276128 AGAP005431-PA Anopheles gambiae
TI:7165 None
 
Q4X1B1_ASPFU
EnsemblFungi»
0.0
AFUA_2G10590 Disulfide isomerase, putative (EC 5.3.4.1) Aspergillus fumigatus
TI:746128 None
 
F4P6P0_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_26166 Thioredoxin domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
A0A9J7L950_BRAFL
CTD»
0.0
LOC118417183 Protein disulfide-isomerase TMX3-like Branchiostoma floridae
TI:7739 None
   
A8WJL5_CAEBR
WormBase»
0.0
CBG23928 CBG_23928 Protein CBG23928 Caenorhabditis briggsae
TI:6238 None
 
Q9N4L6_CAEEL
WormBase»
0.5
CELE_ZK973.11 ZK973.11 Thioredoxin domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3RQ90_CANLF
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Canis lupus
TI:9612 None
   
F6UUF9_CIOIN
Ensembl»
0.0
LOC100185726 Protein disulfide-isomerase TMX3-like Ciona intestinalis
TI:7719 None
 
Q5KCK8_CRYNJ
EnsemblFungi»
0.0
CNH01370 Thioredoxin domain-containing protein Cryptococcus neoformans
TI:5207 None
 
A0A8M1N5Y4_DANRE
CTD»
0.8
tmx3a Protein disulfide-isomerase TMX3
precursor (EC 5.3.4.1)		 Danio rerio
TI:7955 None
   
A0A8M9Q068_DANRE
ZFIN»
0.0
LOC110438517 Protein disulfide-isomerase TMX3-like Danio rerio
TI:7955 None
     
Q0IIP9_DANRE
ZFIN»
0.0
tmx3b Protein disulfide-isomerase TMX3
precursor (EC 5.3.4.1) (Zgc:152808)		 Danio rerio
TI:7955 None
 
E9H808_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_326524 Thioredoxin domain-containing protein Daphnia pulex
TI:6669 None
 
F0Z7Y2_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_93483 Thioredoxin domain-containing protein Dictyostelium purpureum
TI:5786 None
 
Q54BW3_DICDI
dictyBase»
1.5
DDB_G0293378 Thioredoxin domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q961B9_DROME
FlyBase»
0.5
Tmx3 LD24073p (Thioredoxin-related transmembrane
protein 3 (EC 5.3.4.1))		 Drosophila melanogaster
TI:7227 None
 
C8V3C6_EMENI
EnsemblFungi»
0.0
ANIA_05970 Disulfide isomerase,
putative (AFU_orthologue AFUA_2G10590)		 Emericella nidulans
TI:162425 None
 
A0A2I2U7B8_FELCA
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Felis catus
TI:9685 None
 
A0A8V0X9Y3_CHICK
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Gallus gallus
TI:9031 None
   
A8B3I4_GIAIC
EnsemblProtists»
0.0
GL50803_00103713 GL50803_103713 Protein disulfide isomerase PDI4 Giardia intestinalis
TI:5741 None
 
G3QRV9_GORGO
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Gorilla gorilla
TI:9593 None
 
T1G0H0_HELRO
EnsemblMetazoa»
0.0
20214568 Thioredoxin domain-containing protein Helobdella robusta
TI:6412 None 		 
 
TMX3_HUMAN
Ensembl»
0.8
TMX3 Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin
domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)		 Homo sapiens
TI:9606 None
 
B7P6M6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW001453 Uncharacterized protein Ixodes scapularis
TI:6945 None
   
W5N2V5_LEPOC
Ensembl»
0.0
Thioredoxin related transmembrane protein 3 Lepisosteus oculatus
TI:7918 None
 
A0A1D5R485_MACMU
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Macaca mulatta
TI:9544 None
   
F7CVH0_MONDO
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Monodelphis domestica
TI:13616 None
   
A9UX07_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_36711 Thioredoxin domain-containing protein Monosiga brevicollis
TI:81824 None
 
TMX3_MOUSE
Ensembl»
0.0
Tmx3 Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin
domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)		 Mus musculus
TI:10090 None
 
A7S406_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g242699 Thioredoxin domain-containing protein Nematostella vectensis
TI:45351 None
 
Q7S9W2_NEUCR
EnsemblFungi»
0.0
NCU06344 Disulfide isomerase Neurospora crassa
TI:5141 None
 
A0A6I8NQT1_ORNAN
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Ornithorhynchus anatinus
TI:9258 None
   
H2LU59_ORYLA
Ensembl»
0.0
LOC101157158 Protein disulfide-isomerase TMX3-like Oryzias latipes
TI:8090 None
   
H2MB11_ORYLA
Ensembl»
0.0
TMX3 Thioredoxin related transmembrane protein 3 Oryzias latipes
TI:8090 None
   
H2QEN9_PANTR
Ensembl»
0.0
TMX3 Thioredoxin-related transmembrane protein 3 Pan troglodytes
TI:9598 None
 
Q8II88_PLAF7
EnsemblProtists»
0.0
PF3D7_1127500 Protein disulfide-isomerase,
putative (EC 5.3.4.1)		 Plasmodium falciparum
TI:5833 None
 
A0A8R1V853_PRIPA
EnsemblMetazoa»
0.0
WBGene00305982 Thioredoxin domain-containing protein Pristionchus pacificus
TI:54126 None
   
E3L916_PUCGT
EnsemblFungi»
0.0
PGTG_18663 Uncharacterized protein Puccinia graminis
TI:5297 None
   
M0R402_RAT
RGD»
0.5
Tmx3 Thioredoxin-related transmembrane protein 3 Rattus norvegicus
TI:10116 None
   
B6JXI9_SCHJY
EnsemblFungi»
0.0
SJAG_00131 Protein disulfide isomerase Schizosaccharomyces japonicus
TI:4897 None
 
B6K237_SCHJY
EnsemblFungi»
0.0
SJAG_02301 ER associated protein disulfide isomerase Pdi2 Schizosaccharomyces japonicus
TI:4897 None
 
B6K828_SCHJY
EnsemblFungi»
0.0
SJAG_04904 Protein disulfide isomerase Schizosaccharomyces japonicus
TI:4897 None
 
YB1D_SCHPO
PomBase»
1.7
SPBC3D6.13c Uncharacterized protein C3D6.13c Schizosaccharomyces pombe
TI:4896 None
 
A7F6S0_SCLS1
VEuPathDB»
0.0
SS1G_13300 Thioredoxin domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A0A7M7N5B1_STRPU
EnsemblMetazoa»
0.0
Thioredoxin domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A4X1TWN6_PIG
Ensembl»
0.0
TMX3 Protein disulfide-isomerase TMX3 isoform 1
(Thioredoxin related transmembrane protein 3)		 Sus scrofa
TI:9823 None
 
D6WGR3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_02136 Protein disulfide-isomerase TMX3-like Protein Tribolium castaneum
TI:7070 None
 
A2DQ93_TRIV3
VEuPathDB»
0.0
TVAG_319450 Thioredoxin domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2EYD5_TRIV3
VEuPathDB»
0.0
TVAG_054600 Thioredoxin family protein Trichomonas vaginalis
TI:5722 None
 
A2F3V0_TRIV3
VEuPathDB»
0.0
TVAG_114230 Thioredoxin domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2G758_TRIV3
VEuPathDB»
0.0
TVAG_231810 Thioredoxin family protein Trichomonas vaginalis
TI:5722 None
 
B3RIS1_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_63562 Thioredoxin domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A8J0QWD3_XENTR
Xenbase»
0.0
tmx3 Protein disulfide-isomerase TMX3 Xenopus tropicalis
TI:8364 None
   
Q58E96_XENLA
Xenbase»
0.0
tmx3.L protein disulfide-isomerase (EC 5.3.4.1) Xenopus laevis
TI:8355 None
 
TMX3_XENLA
Xenbase»
0.0
tmx3 Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin
domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)		 Xenopus laevis
TI:8355 None
 
Q6C7A3_YARLI
EnsemblFungi»
0.0
YALI0_E02420g YALI0E02420p Yarrowia lipolytica
TI:4952 None