Collated Gene Ontology terms

Biological process: actin binding(2018, 2025) small GTPase binding(2025) microtubule binding(2018, 2025) protein kinase activity(2024) profilin binding(2025)

Molecular function: actin cytoskeleton organization2025 actin filament polymerization2024, 2025 stress fiber assembly2018, 2025 cilium assembly2018, 2025 Golgi ribbon formation2018, 2025 cell projection organization2025 regulation of mitochondrial fission2013 actin nucleation2023, 2025 regulation of tube size2015, 2025 regulation of microtubule polymerization2015, 2025
regulation of cellular component size2013 gene expression2023 epithelial tube morphogenesis2015, 2025 epithelial cell development2015, 2025 positive regulation of actin filament binding2015 branch fusion, open tracheal system2006 'de novo' actin filament nucleation2025

Cellular component: actin filament2023 microtubule2018, 2025 perinuclear region of cytoplasm2010, 2025 cilium2018, 2025 Golgi apparatus2018, 2025 cytoplasmic microtubule2018, 2025 filamentous actin2015, 2025 pseudopodium2025 membrane2025 cytoskeleton2025
actin cytoskeleton2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A9J7MXX3_BRAFL
euHCVdb»
0.0
LOC118420166 Caldesmon-like Branchiostoma floridae
TI:7739 None 		       
A9WHI6_CHLAA
EnsemblBacteria»
0.0
Caur_3113 DUF5667 domain-containing protein Chloroflexus aurantiacus
TI:1108 None 		 
 
A0A2A6CHH5_PRIPA
EnsemblMetazoa»
0.0
WBGene00104090 Exc-6 Pristionchus pacificus
TI:54126 None
   
EXC6_CAEEL
WormBase»
4.5
exc-6 Excretory canal abnormal protein 6 Caenorhabditis elegans
TI:6239 None
 
A0A287B6A0_PIG
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Sus scrofa
TI:9823 None
   
A0A3B3I1T5_ORYLA
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Oryzias latipes
TI:8090 None 		     
A0A8V0XYB8_CHICK
Ensembl»
0.5
FHDC1 FH2 domain containing 1 Gallus gallus
TI:9031 None
   
F1MQ88_BOVIN
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Bos taurus
TI:9913 None
   
F6Q350_ORNAN
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Ornithorhynchus anatinus
TI:9258 None
   
F7DPE4_MONDO
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Monodelphis domestica
TI:13616 None
   
G1KX09_ANOCA
Ensembl»
0.0
FHDC1 FH2 domain containing 1 Anolis carolinensis
TI:28377 None
   
W5MPP8_LEPOC
Ensembl»
0.0
FH2 domain containing 1 Lepisosteus oculatus
TI:7918 None
 
A0A3B3HEX6_ORYLA
Ensembl»
0.0
fhdc3 FH2 domain containing 3 Oryzias latipes
TI:8090 None 		     
A0A8M1NAL0_DANRE
ZFIN»
0.0
fhdc3 FH2 domain containing 3 Danio rerio
TI:7955 None 		     
A0A3B3HB89_ORYLA
Ensembl»
0.0
fhdc4 FH2 domain containing 4 Oryzias latipes
TI:8090 None 		     
W5MQ58_LEPOC
Ensembl»
0.0
FH2 domain containing 4 Lepisosteus oculatus
TI:7918 None
 
E7FGI9_DANRE
ZFIN»
0.5
fhdc2 FH2 domain-containing 2 (Formin-J) Danio rerio
TI:7955 None
 
E7F7A1_DANRE
ZFIN»
0.0
fhdc4 FH2 domain-containing 4
(FH2 domain-containing protein 1)		 Danio rerio
TI:7955 None 		 
 
A0A139WAN0_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_11477 FH2 domain-containing protein Tribolium castaneum
TI:7070 None
 
A0A139WDE5_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_33344 FH2 domain-containing protein Tribolium castaneum
TI:7070 None
 
A0A1S4GDG6_ANOGA
EnsemblMetazoa»
0.0
FH2 domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A3B3IFM3_ORYLA
Ensembl»
0.0
LOC101157847 FH2 domain-containing protein Oryzias latipes
TI:8090 None 		     
A0A7M7NII3_STRPU
EnsemblMetazoa»
0.0
FH2 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3NJG9_CANLF
Ensembl»
0.0
FHDC1 FH2 domain-containing protein
1 (Inverted formin-1)		 Canis lupus
TI:9612 None
   
A7T9E0_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g151209 FH2 domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A9V1R7_MONBE
neXtProt»
0.0
MONBRDRAFT_26231 FH2 domain-containing protein Monosiga brevicollis
TI:81824 None
 
B7PJI6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005175 FH2 domain-containing protein Ixodes scapularis
TI:6945 None 		 
 
B7PJI7_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005176 FH2 domain-containing protein Ixodes scapularis
TI:6945 None
 
B7PJJ2_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005181 FH2 domain-containing protein Ixodes scapularis
TI:6945 None 		 
 
D3ZL83_RAT
RGD»
3.0
Fhdc1 FH2 domain-containing protein
1 (Inverted formin-1)		 Rattus norvegicus
TI:10116 None
   
E9GMN5_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_34615 FH2 domain-containing protein Daphnia pulex
TI:6669 None 		 
 
F0ZAI9_DICPU
TubercuList»
0.0
DICPUDRAFT_148204 FH2 domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F6QE00_CIOIN
Ensembl»
0.0
FH2 domain-containing protein Ciona intestinalis
TI:7719 None 		 
 
F6Z5J0_HORSE
Ensembl»
0.0
FHDC1 FH2 domain-containing protein
1 (Inverted formin-1)		 Equus caballus
TI:9796 None
   
FHDC1_MOUSE
Ensembl»
5.7
Fhdc1 FH2 domain-containing protein
1 (Inverted formin-1)		 Mus musculus
TI:10090 None
 
H2LP90_ORYLA
Ensembl»
0.0
fhdc2 FH2 domain-containing protein Oryzias latipes
TI:8090 None 		     
H2XVP3_CIOIN
Ensembl»
0.0
FH2 domain-containing protein Ciona intestinalis
TI:7719 None 		     
T1F2W5_HELRO
EnsemblMetazoa»
0.0
20203164 FH2 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1F9D7_HELRO
EnsemblMetazoa»
0.0
20205436 FH2 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1F9D8_HELRO
EnsemblMetazoa»
0.0
20205437 FH2 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1FA98_HELRO
EnsemblMetazoa»
0.0
20205747 FH2 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1FPF9_HELRO
EnsemblMetazoa»
0.0
20210706 FH2 domain-containing protein Helobdella robusta
TI:6412 None
 
W5NCC0_LEPOC
Ensembl»
0.0
FH2 domain-containing protein Lepisosteus oculatus
TI:7918 None
 
A0A1L8F6Z7_XENLA
Xenbase»
0.0
LOC108698325 FH2 domain-containing protein 1 Xenopus laevis
TI:8355 None 		     
A0A1L8HBM5_XENLA
Xenbase»
0.0
LOC108710103 FH2 domain-containing protein 1 Xenopus laevis
TI:8355 None 		     
A0A1L8HLN4_XENLA
Xenbase»
0.0
fhdc1.S FH2 domain-containing protein 1 Xenopus laevis
TI:8355 None 		     
A0A6I8Q3B5_XENTR
Xenbase»
0.0
LOC100489883 FH2 domain-containing protein 1 Xenopus tropicalis
TI:8364 None 		     
A0A6I8R5X9_XENTR
Xenbase»
0.0
fhdc1 FH2 domain-containing protein 1 Xenopus tropicalis
TI:8364 None 		     
A0A6I8RXM1_XENTR
Xenbase»
0.0
LOC100496216 FH2 domain-containing protein 1 Xenopus tropicalis
TI:8364 None 		     
A0A8J0UHI1_XENLA
Xenbase»
0.0
LOC108708788 FH2 domain-containing protein 1 Xenopus laevis
TI:8355 None 		     
A0ACD6B5E5_DANRE
ZFIN»
0.0
fhdc1 FH2 domain-containing protein 1 Danio rerio
TI:7955 None 		     
A0A1L8HUD2_XENLA
Xenbase»
0.0
fhdc1.L FH2 domain-containing protein 1 isoform X1 Xenopus laevis
TI:8355 None 		     
A8JNM1_DROME
FlyBase»
0.8
form3 Formin 3, isoform B Drosophila melanogaster
TI:7227 None
 
A0A7M7NJ52_STRPU
EnsemblMetazoa»
0.0
Formin GTPase-binding domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NKR1_STRPU
EnsemblMetazoa»
0.0
Formin GTPase-binding domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A7SLR3_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g214243 Formin GTPase-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SLR4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g214244 Formin GTPase-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SLR5_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g122948 Formin GTPase-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SLR6_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g214246 Formin GTPase-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
H2Y113_CIOIN
Ensembl»
0.0
Formin GTPase-binding domain-containing protein Ciona intestinalis
TI:7719 None
 
B7PR18_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006839 Formin domain-containing protein, putative Ixodes scapularis
TI:6945 None
 
A0A9J7LD51_BRAFL
neXtProt»
0.0
LOC118418763 Formin-J-like isoform X1 Branchiostoma floridae
TI:7739 None
   
A9VAM4_MONBE
euHCVdb»
0.0
MONBRDRAFT_29277 Formin-like protein Monosiga brevicollis
TI:81824 None 		 
 
A0A5F5PK75_HORSE
Ensembl»
0.0
GBD/FH3 domain-containing protein Equus caballus
TI:9796 None
   
A0A8W4FEZ7_PIG
Ensembl»
0.0
GBD/FH3 domain-containing protein Sus scrofa
TI:9823 None
   
A7SLR7_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g122997 GBD/FH3 domain-containing protein Nematostella vectensis
TI:45351 None
 
B3RYM2_TRIAD
CTD»
0.0
TRIADDRAFT_25061 GBD/FH3 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3RYM3_TRIAD
CTD»
0.0
TRIADDRAFT_25420 GBD/FH3 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
E9GMN6_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_52627 GBD/FH3 domain-containing protein Daphnia pulex
TI:6669 None
 
H2MV43_ORYLA
Ensembl»
0.0
GBD/FH3 domain-containing protein Oryzias latipes
TI:8090 None
   
T1G547_HELRO
EnsemblMetazoa»
0.0
20216195 GBD/FH3 domain-containing protein Helobdella robusta
TI:6412 None
 
A0A286ZUJ0_PIG
Ensembl»
0.0
INF2 Inverted formin 2 Sus scrofa
TI:9823 None
   
A0A6I8NFG2_ORNAN
Ensembl»
0.0
INF2 Inverted formin 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A803TAN6_ANOCA
Ensembl»
0.0
INF2 Inverted formin 2 Anolis carolinensis
TI:28377 None
   
A0A8V0Z7F3_CHICK
Ensembl»
0.0
INF2 Inverted formin 2 Gallus gallus
TI:9031 None
   
A0ABK0LVR6_RAT
RGD»
2.0
Inf2 Inverted formin 2 Rattus norvegicus
TI:10116 None
   
F6TXY8_MONDO
Ensembl»
0.0
INF2 Inverted formin 2 Monodelphis domestica
TI:13616 None
   
F6UX87_HORSE
Ensembl»
0.0
INF2 Inverted formin 2 Equus caballus
TI:9796 None
   
H2MR56_ORYLA
Ensembl»
0.0
INF2 Inverted formin 2 Oryzias latipes
TI:8090 None
   
W5N4V5_LEPOC
Ensembl»
0.0
Inverted formin 2 Lepisosteus oculatus
TI:7918 None
 
A0A3B3IFX9_ORYLA
Ensembl»
0.0
LOC101164771 Inverted formin, FH2 and WH2 domain containing Oryzias latipes
TI:8090 None
   
A0A5S6L9Z4_XENTR
Xenbase»
0.0
inf2 Inverted formin-2 Xenopus tropicalis
TI:8364 None
   
A0A7M7SWK0_STRPU
EnsemblMetazoa»
0.0
Inverted formin-2 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SWT7_STRPU
EnsemblMetazoa»
0.0
Inverted formin-2 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8M9P0A2_DANRE
CTD»
0.0
inf2 Inverted formin-2 Danio rerio
TI:7955 None
   
A0AAA9SIE1_BOVIN
Ensembl»
0.0
INF2 Inverted formin-2 Bos taurus
TI:9913 None
   
E9GRX2_DAPPU
neXtProt»
0.0
DAPPUDRAFT_105824 Inverted formin-2 Daphnia pulex
TI:6669 None
 
F6W4E9_MACMU
Ensembl»
0.0
INF2 Inverted formin-2 Macaca mulatta
TI:9544 None
   
G3RE45_GORGO
Ensembl»
0.0
INF2 Inverted formin-2 Gorilla gorilla
TI:9593 None
 
H2RC71_PANTR
Ensembl»
0.0
INF2 Inverted formin-2 Pan troglodytes
TI:9598 None
 
INF2_MOUSE
AG»
2.9
Inf2 Inverted formin-2 Mus musculus
TI:10090 None
 
INF2_XENLA
Xenbase»
0.0
inf2 Inverted formin-2 Xenopus laevis
TI:8355 None
 
INF2_XENTR
Xenbase»
0.0
inf2 Inverted formin-2 Xenopus tropicalis
TI:8364 None
 
INF2_HUMAN
Ensembl»
1.3
INF2 Inverted formin-2 (HBEBP2-binding protein C) Homo sapiens
TI:9606 None
 
A0A8J0TK53_XENLA
CTD»
0.0
inf2.L Inverted formin-2-like isoform X1 Xenopus laevis
TI:8355 None
   
A0A9J7MVA3_BRAFL
neXtProt»
0.0
LOC118419076 Inverted formin-2-like isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A2K3E1Q2_CHLRE
euHCVdb»
0.0
CHLRE_02g095095v5 Pherophorin domain-containing protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
SLOB2_DICDI
dictyBase»
0.5
slob2 Probable inactive serine/threonine-protein kinase
slob2 (Slowpoke-binding protein 2)		 Dictyostelium discoideum
TI:44689 None
 
A8XLT4_CAEBR
WormBase»
0.0
exc-6 Protein CBR-INFT-1 Caenorhabditis briggsae
TI:6238 None
 
A0A2K3DXH6_CHLRE
euHCVdb»
0.0
CHLRE_03g177650v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
   
B3RW95_TRIAD
CTD»
0.0
TRIADDRAFT_56670 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
A0ABI7XFK7_FELCA
Ensembl»
0.0
WH2 domain-containing protein Felis catus
TI:9685 None