Collated Gene Ontology terms

Biological process: GTPase activator activity(2001, 2003, 2025) guanyl-nucleotide exchange factor activity(2012, 2025) GTPase activity(2024, 2025) calcium-dependent phospholipid binding(2013)

Molecular function: negative regulation of signal transduction2025 G protein-coupled receptor signaling pathway2001, 2025 somite development2011 regulation of actin filament polymerization2012 regulation of Wnt signaling pathway, calcium modulating pathway2011 regulation of G protein-coupled receptor signaling pathway2003 positive regulation of ruffle assembly2012 positive regulation of Rac protein signal transduction2013 negative regulation of Wnt signaling pathway, calcium modulating pathway2011 mushroom body development2012

Cellular component: plasma membrane2001, 2015, 2020, 2024, 2025 nucleus2001, 2020, 2025 cytoplasm2001, 2018, 2025 membrane2025 cytosol2003

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A3B3HLW7_ORYLA
Ensembl»
0.0
Regulator of G protein signaling 3a Oryzias latipes
TI:8090 None
   
A0A7M7T4H3_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803TDC3_ANOCA
Ensembl»
0.0
Regulator of G protein signaling 3 Anolis carolinensis
TI:28377 None 		     
A0ABK8G6R8_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
F6TZQ9_CIOIN
Ensembl»
0.0
C2 domain-containing protein Ciona intestinalis
TI:7719 None 		 
 
F6UMD2_CIOIN
Ensembl»
0.0
C2 domain-containing protein Ciona intestinalis
TI:7719 None 		 
 
W5MBF9_LEPOC
Ensembl»
0.0
Regulator of G protein signaling 3 Lepisosteus oculatus
TI:7918 None
 
T1FW19_HELRO
EnsemblMetazoa»
0.0
20213015 Uncharacterized protein Helobdella robusta
TI:6412 None
 
A0A139WMZ8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_30997 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
E9GYF8_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_323288 PDZ domain-containing protein Daphnia pulex
TI:6669 None 		 
 
H2MT99_ORYLA
Ensembl»
0.0
LOC101174109 Regulator of G-protein signaling 3-like Oryzias latipes
TI:8090 None
   
A0A9J7LK09_BRAFL
euHCVdb»
0.0
LOC118420735 Uncharacterized protein LOC118420735 Branchiostoma floridae
TI:7739 None
   
A0A9J7MXL5_BRAFL
neXtProt»
0.0
LOC118421866 Regulator of G-protein signaling 3-like Branchiostoma floridae
TI:7739 None 		     
Q7KVY9_DROME
FlyBase»
4.2
PsGEF Protostome-specific GEF, isoform E Drosophila melanogaster
TI:7227 None
 
A0A1D5P7S3_CHICK
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Gallus gallus
TI:9031 None
   
A0A287A820_PIG
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Sus scrofa
TI:9823 None
   
A0A2I3T705_PANTR
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Pan troglodytes
TI:9598 None
 
A0A3Q2KWB2_HORSE
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Equus caballus
TI:9796 None
   
A0A6I8NNE0_ORNAN
Ensembl»
0.0
RGS3 Regulator of G protein signaling 3 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3NBC6_CANLF
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Canis lupus
TI:9612 None
   
A0A8V1AG72_CHICK
Ensembl»
0.0
RGS3 Regulator of G protein signaling 3 Gallus gallus
TI:9031 None 		     
A0AAA9SCT2_BOVIN
Ensembl»
0.0
RGS3 Regulator of G protein signaling 3 Bos taurus
TI:9913 None 		     
A0ABI7XVX0_FELCA
Ensembl»
0.0
RGS3 Regulator of G protein signaling 3 Felis catus
TI:9685 None
   
F1MM15_BOVIN
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Bos taurus
TI:9913 None
   
F1SN86_PIG
Ensembl»
0.0
RGS3 Regulator of G protein signaling 3
(Regulator of G-protein signaling 3 isoform 3)		 Sus scrofa
TI:9823 None 		 
 
F6X2A9_MONDO
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Monodelphis domestica
TI:13616 None
   
F7EVQ4_MACMU
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Macaca mulatta
TI:9544 None
   
G3S4X9_GORGO
Ensembl»
0.0
RGS3 Regulator of G-protein signaling 3 Gorilla gorilla
TI:9593 None
 
RGS3_HUMAN
Ensembl»
3.6
RGS3 Regulator of G-protein signaling 3 (RGP3) (RGS3) Homo sapiens
TI:9606 None
 
RGS3_MOUSE
Ensembl»
1.8
Rgs3 Regulator of G-protein signaling 3 (RGS3) (C2PA) Mus musculus
TI:10090 None
 
RGS3_RAT
RGD»
0.0
Rgs3 Regulator of G-protein
signaling 3 (RGS3) (SRB-RGS)		 Rattus norvegicus
TI:10116 None
 
A0AB13A9N8_DANRE
ZFIN»
3.2
rgs3a Regulator of G-protein signaling 3a isoform 2
(Regulator of G-protein signaling 3a isoform X1)		 Danio rerio
TI:7955 None
   
A0AB32TW72_DANRE
ZFIN»
0.0
rgs3b Regulator of G-protein signaling 3 isoform X1 Danio rerio
TI:7955 None