Biological process: carbohydrate binding⁽²⁰²⁵⁾ Notch binding⁽²⁰²⁴⁾ signaling receptor activity^{(2003, 2018, 2025)} small GTPase binding^{(2019, 2025)} ubiquitin-like ligase-substrate adaptor activity⁽²⁰²⁵⁾ chromatin binding⁽²⁰¹⁸⁾ protein-membrane adaptor activity⁽²⁰²⁵⁾ calcium ion binding⁽²⁰²⁵⁾ ubiquitin protein ligase binding⁽²⁰²¹⁾

Molecular function: negative regulation of Ras protein signal transduction^{2019, 2025} signal transduction²⁰²⁵ protein ubiquitination^{2019, 2024, 2025} inflammatory response²⁰²⁵ proteasome-mediated ubiquitin-dependent protein catabolic process²⁰²⁵ system development²⁰²⁵ pigmentation^{2011, 2012, 2025} animal organ development²⁰²⁵ tissue development²⁰²⁵ animal organ morphogenesis²⁰²⁴
± 17 regulation of cell shape²⁰²⁵ establishment or maintenance of bipolar cell polarity²⁰²³ response to oxidative stress^{2007, 2025} regulation of multicellular organism growth²⁰⁰² regulation of actomyosin structure organization²⁰¹⁹ myelination²⁰¹² left/right pattern formation²⁰²⁵ cerebellum development²⁰¹² G protein-coupled receptor signaling pathway²⁰⁰⁴ triglyceride homeostasis²⁰²¹ synaptic target recognition²⁰¹² sleep²⁰²¹ positive regulation of glycogen metabolic process²⁰²¹ heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules²⁰²⁰ gamma-aminobutyric acid signaling pathway²⁰²¹ establishment or maintenance of epithelial cell apical/basal polarity²⁰¹⁷ endocytosis²⁰²⁵

Cellular component: membrane²⁰²⁵ Golgi apparatus^{2015, 2025} recycling endosome membrane^{2019, 2025} Cul3-RING ubiquitin ligase complex^{2019, 2025} extracellular space^{2003, 2010, 2014, 2025} plasma membrane^{2003, 2004, 2021, 2025} endomembrane system^{2019, 2025} recycling endosome²⁰²⁵ cytoplasm^{2017, 2018, 2024} extracellular region²⁰²⁵
± 4 cell cortex of cell tip²⁰¹⁷ protein-containing complex²⁰²¹ extracellular exosome²⁰¹⁴ basement membrane²⁰²⁵