Collated Gene Ontology terms

Biological process: oxidoreductase activity(2025) very-long-chain 3-oxoacyl-CoA reductase activity(2025) steroid dehydrogenase activity(2019) estradiol 17-beta-dehydrogenase [NAD(P)+] activity(2025)

Molecular function: steroid biosynthetic process2025 lipid metabolic process2025 fatty acid elongation2018

Cellular component: mitochondrion2009, 2018, 2019, 2024, 2025 endoplasmic reticulum2011, 2020, 2024 endoplasmic reticulum membrane2025 intermediate filament cytoskeleton2025 cytoplasm2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1L8GKK5_XENLA
Xenbase»
0.0
hsdl1.L 3-ketoacyl-CoA reductase (EC
1.1.1.330) (EC 1.1.1.62)		 Xenopus laevis
TI:8355 None
   
A0A803JKS5_XENTR
Xenbase»
0.0
hsdl1 3-ketoacyl-CoA reductase (EC
1.1.1.330) (EC 1.1.1.62)		 Xenopus tropicalis
TI:8364 None
   
HSDL1_CHICK
CTD»
0.5
HSDL1 Hydroxysteroid dehydrogenase-like protein
1 (EC 1.1.1.-)		 Gallus gallus
TI:9031 None
 
HSDL1_MOUSE
Ensembl»
0.5
Hsdl1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Mus musculus
TI:10090 None
 
HSDL1_RAT
RGD»
1.0
Hsdl1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Rattus norvegicus
TI:10116 None
 
Q8IGQ3_DROME
FlyBase»
1.0
Dmel\CG13284 RE48687p Drosophila melanogaster
TI:7227 None
 
Q8SX47_DROME
FlyBase»
1.0
Dmel\CG31810 RE06583p Drosophila melanogaster
TI:7227 None
 
B7PGB1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW004704 17 beta-hydroxysteroid dehydrogenase,
putative (EC 1.1.1.62)		 Ixodes scapularis
TI:6945 None
 
HSDL1_HUMAN
Ensembl»
0.8
HSDL1 Inactive hydroxysteroid dehydrogenase-like protein 1 (Short
chain dehydrogenase/reductase family 12C member 3)		 Homo sapiens
TI:9606 None
 
Q8INZ8_DROME
FlyBase»
1.0
Dmel\CG31809 Uncharacterized protein, isoform B (Uncharacterized
protein, isoform C (EC 1.-.-.-))		 Drosophila melanogaster
TI:7227 None
 
A0A1S4GYN2_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
D6WN07_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_14627 Hydroxysteroid dehydrogenase-like protein 1 Tribolium castaneum
TI:7070 None
 
E9G5E4_DAPPU
neXtProt»
0.0
DAPPUDRAFT_98658 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Daphnia pulex
TI:6669 None
 
HSDL1_BOVIN
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Bos taurus
TI:9913 None
 
HSDL1_DANRE
ZFIN»
0.0
hsdl1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Danio rerio
TI:7955 None
 
A0A5F8GB95_MONDO
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Monodelphis domestica
TI:13616 None
   
A0A7M7RFW9_STRPU
EnsemblMetazoa»
0.0
Inactive hydroxysteroid
dehydrogenase-like protein 1		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3NYZ5_CANLF
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Canis lupus
TI:9612 None
   
F6SBK8_ORNAN
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Ornithorhynchus anatinus
TI:9258 None
   
A0A286ZT08_PIG
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Sus scrofa
TI:9823 None
 
A0A9J7LSC1_BRAFL
neXtProt»
0.0
LOC118423320 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Branchiostoma floridae
TI:7739 None
   
A0A9L0QXV4_HORSE
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Equus caballus
TI:9796 None
   
G3RIW2_GORGO
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Gorilla gorilla
TI:9593 None
 
G7NPE7_MACMU
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Macaca mulatta
TI:9544 None
 
H2MTE2_ORYLA
Ensembl»
0.0
HSDL1 Hydroxysteroid dehydrogenase like 1 Oryzias latipes
TI:8090 None
   
H2QBM0_PANTR
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Pan troglodytes
TI:9598 None
 
A0A803SVI5_ANOCA
Ensembl»
0.0
HSDL1 Hydroxysteroid dehydrogenase like 1 Anolis carolinensis
TI:28377 None
   
A0ABI7WKU6_FELCA
Ensembl»
0.0
HSDL1 Inactive hydroxysteroid
dehydrogenase-like protein 1		 Felis catus
TI:9685 None
   
F1NLF1_CHICK
Ensembl»
0.0
HSDL1 Hydroxysteroid dehydrogenase like 1 Gallus gallus
TI:9031 None
   
W5NL31_LEPOC
Ensembl»
0.0
Hydroxysteroid dehydrogenase like 1 Lepisosteus oculatus
TI:7918 None