Collated Gene Ontology terms

Biological process: ubiquitin ligase-substrate adaptor activity(2021, 2022, 2024) ATP hydrolysis activity(2024) RNA binding(2024)

Molecular function: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway2021, 2022, 2024 regulation of autophagy2021, 2024 T cell activation2022, 2024 protein ubiquitination2024 protein polyubiquitination2024 proteasome-mediated ubiquitin-dependent protein catabolic process2024 positive regulation of hippo signaling2024 evoked neurotransmitter secretion2021 autophagic cell death2024

Cellular component: Cul4-RING E3 ubiquitin ligase complex2017, 2021, 2024 cytoplasm2021, 2022, 2024 centrosome2009, 2024 nucleus2021, 2024 cytosol2022, 2024 cytoskeleton2024 presynapse2021, 2024 synapse2024 membrane2024 cell projection2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
DCA12_HUMAN
Ensembl»
3.2
DCAF12 DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52)
(Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)		 Homo sapiens
TI:9606 None
 
DCA12_MOUSE
Ensembl»
1.5
Dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Mus musculus
TI:10090 None
 
DC121_MOUSE
Ensembl»
0.0
Dcaf12l1 DDB1- and CUL4-associated factor 12-like
protein 1 (WD repeat-containing protein 40B)		 Mus musculus
TI:10090 None 		 
 
TTC41_RAT
RGD»
0.0
Ttc41 Tetratricopeptide repeat protein 41 (TPR
repeat protein 41) (Grp94-neighboring nucleotidase)		 Rattus norvegicus
TI:10116 None
 
K7DN02_PANTR
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Pan troglodytes
TI:9598 None
 
TTC41_MOUSE
AG»
0.0
Ttc41 Tetratricopeptide repeat protein 41 (TPR
repeat protein 41) (Grp94-neighboring nucleotidase)		 Mus musculus
TI:10090 None
 
DC122_HUMAN
Ensembl»
0.0
DCAF12L2 DDB1- and CUL4-associated factor 12-like
protein 2 (WD repeat-containing protein 40C)		 Homo sapiens
TI:9606 None
 
A0A2I2YB32_GORGO
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Gorilla gorilla
TI:9593 None
 
DC121_HUMAN
Ensembl»
0.0
DCAF12L1 DDB1- and CUL4-associated factor 12-like
protein 1 (WD repeat-containing protein 40B)		 Homo sapiens
TI:9606 None
 
DC122_MOUSE
Ensembl»
0.0
Dcaf12l2 DDB1- and CUL4-associated factor 12-like
protein 2 (WD repeat-containing protein 40C)		 Mus musculus
TI:10090 None 		 
 
DCA12_DROME
FlyBase»
4.8
DCAF12 DDB1- and CUL4-associated factor 12 homolog Drosophila melanogaster
TI:7227 None
 
B7PVS6_IXOSC
EnsemblMetazoa»
0.0
8032079 WD-repeat protein, putative Ixodes scapularis
TI:6945 None
 
DCA12_BOVIN
Ensembl»
0.0
DCAF12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Bos taurus
TI:9913 None
 
Q57VS9_TRYB2
VEuPathDB»
0.0
Tb07.29K4.430 Telomerase-associated protein, putative Trypanosoma brucei
TI:5691 None
 
T1F3R5_HELRO
EnsemblMetazoa»
0.0
20203464 DUF4062 domain-containing protein Helobdella robusta
TI:6412 None 		 
 
T1F3R6_HELRO
EnsemblMetazoa»
0.0
20203465 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
   
T1FVE5_HELRO
EnsemblMetazoa»
0.0
20212791 DUF4062 domain-containing protein Helobdella robusta
TI:6412 None
 
A0A2A6C3Y4_PRIPA
EnsemblMetazoa»
0.0
WBGene00091788 AAA protein Pristionchus pacificus
TI:54126 None 		 
 
A0A337S7Q1_FELCA
Ensembl»
0.0
DCAF12L1 DDB1 and CUL4 associated factor 12 like 1 Felis catus
TI:9685 None
 
A0A337SRR5_FELCA
Ensembl»
0.0
DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 Felis catus
TI:9685 None
 
A0A4X1USW9_PIG
Ensembl»
0.0
DCAF12 DDB1-and CUL4-associated factor 12 Sus scrofa
TI:9823 None
 
A0DKP5_PARTE
EnsemblProtists»
0.0
GSPATT00017942001 Chromosome undetermined scaffold_54,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None 		 
   
A0E162_PARTE
EnsemblProtists»
0.0
GSPATT00022198001 Chromosome undetermined scaffold_72,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None 		 
   
A7RT98_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g240522 DUF4062 domain-containing protein Nematostella vectensis
TI:45351 None
 
A7S9R8_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g110220 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A7SA50_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g110663 Telomerase protein component 1 Nematostella vectensis
TI:45351 None
 
A7STP2_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g131326 NACHT domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SVC1_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g133949 DUF4062 domain-containing protein Nematostella vectensis
TI:45351 None
 
A7TAD9_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g224466 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A8WR71_CAEBR
WormBase»
0.0
CBG01633 CBG_01633 Protein CBG01633 Caenorhabditis briggsae
TI:6238 None
 
A9UUY9_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_36329 AAA+ ATPase domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9UXU8_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_24824 DUF4062 domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9V021_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_25662 DUF4062 domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9V2I3_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_32916 NACHT domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9V606_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_27684 DUF4062 domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3RL59_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_51888 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3RS36_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_54460 NACHT domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3RWW5_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_25733 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3RWW6_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_25073 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3S494_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_59003 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3S9T1_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_61017 DUF4062 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3SDX0_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_62474 Uncharacterized protein Trichoplax adhaerens
TI:10228 None 		 
   
D6WCT6_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_04935 DDB1-and CUL4-associated factor 12-like Protein Tribolium castaneum
TI:7070 None
 
DC12A_XENLA
Xenbase»
0.0
dcaf12-a DDB1- and CUL4-associated factor
12-A (WD repeat-containing protein 40A-A)		 Xenopus laevis
TI:8355 None
 
DC12B_XENLA
Xenbase»
0.0
dcaf12-b DDB1- and CUL4-associated factor
12-B (WD repeat-containing protein 40A-B)		 Xenopus laevis
TI:8355 None
 
DCA12_CHICK
Ensembl»
1.5
DCAF12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Gallus gallus
TI:9031 None
 
DCA12_DANRE
ZFIN»
1.5
dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Danio rerio
TI:7955 None
 
DCA12_XENTR
Xenbase»
0.0
dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Xenopus tropicalis
TI:8364 None
 
E9GSR8_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_305773 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0Z8S8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_96494 BRCT domain-containing protein Dictyostelium purpureum
TI:5786 None 		 
 
F0ZYQ8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_58027 IPT/TIG domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F4NWA4_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_34435 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
G3RJB4_GORGO
Ensembl»
0.0
DCAF12L1 DDB1 and CUL4 associated factor 12 like 1 Gorilla gorilla
TI:9593 None
 
G3SFP8_GORGO
Ensembl»
0.0
DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 Gorilla gorilla
TI:9593 None
 
H2QZ35_PANTR
Ensembl»
0.0
DCAF12L2 Uncharacterized protein Pan troglodytes
TI:9598 None
 
H2QZE9_PANTR
Ensembl»
0.0
DCAF12L1 DDB1 and CUL4 associated factor 12 like 1 Pan troglodytes
TI:9598 None
 
H2Y3R0_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
   
H3HDI0_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None 		 
   
M3WRK6_FELCA
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Felis catus
TI:9685 None
 
Q4Q983_LEIMA
EnsemblProtists»
0.0
LMJF_26_1110 TROVE domain-containing protein Leishmania major
TI:5664 None
 
Q54CE3_DICDI
dictyBase»
0.0
DDB_G0293032 NACHT domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54D26_DICDI
dictyBase»
0.0
DDB_G0292714 BRCT domain-containing protein Dictyostelium discoideum
TI:44689 None 		 
 
Q7QKC2_ANOGA
EnsemblMetazoa»
0.0
1269299 AGAP002260-PA Anopheles gambiae
TI:7165 None
 
Q7UEI0_RHOBA
EnsemblBacteria»
0.0
RB11319 Probable telomerase protein-1 Rhodopirellula baltica
TI:265606 None 		 
 
U4PAR2_CAEEL
WormBase»
0.0
CELE_F15E6.9 F15E6.9 RING-type domain-containing protein Caenorhabditis elegans
TI:6239 None
 
W5MC03_LEPOC
Ensembl»
0.0
DDB1 and CUL4 associated factor 12 Lepisosteus oculatus
TI:7918 None
 
W5NCX0_LEPOC
Ensembl»
0.0
Tetratricopeptide repeat domain 41 Lepisosteus oculatus
TI:7918 None
 
Y7407_DICDI
dictyBase»
0.0
DDB_G0287407 TPR repeat-containing protein DDB_G0287407 Dictyostelium discoideum
TI:44689 None
 
A0A1D5Q4Z3_MACMU
Ensembl»
0.0
DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 Macaca mulatta
TI:9544 None
   
A0A1L8GY37_XENLA
Xenbase»
0.0
LOC108711023 Tetratricopeptide repeat protein 41 Xenopus laevis
TI:8355 None
   
A0A1L8I017_XENLA
Xenbase»
0.0
LOC108715302 Telomerase protein component 1 isoform X1 Xenopus laevis
TI:8355 None
   
A0A3B3IHL4_ORYLA
Ensembl»
0.0
dcaf12 DDB1 and CUL4 associated factor 12 Oryzias latipes
TI:8090 None
   
A0A3Q1M0D2_BOVIN
Ensembl»
0.0
DCAF12L2 Uncharacterized protein Bos taurus
TI:9913 None
   
A0A3Q1NCX2_BOVIN
Ensembl»
0.0
Uncharacterized protein Bos taurus
TI:9913 None
   
A0A3Q2GTG3_HORSE
Ensembl»
0.0
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 Equus caballus
TI:9796 None
   
A0A3Q2H1Z6_HORSE
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Equus caballus
TI:9796 None
   
A0A3Q2HCG8_HORSE
Ensembl»
0.0
LOC100060012 Uncharacterized protein Equus caballus
TI:9796 None 		     
A0A6I8N9A9_ORNAN
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7HKL1_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7HMG9_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7HPJ9_STRPU
EnsemblMetazoa»
0.0
DUF4062 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7MX73_STRPU
EnsemblMetazoa»
0.0
DUF4062 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N4F8_STRPU
EnsemblMetazoa»
0.0
FBA domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N6E0_STRPU
EnsemblMetazoa»
0.0
FBA domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N7M7_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N8U8_STRPU
EnsemblMetazoa»
0.0
NACHT domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NBA0_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NX70_STRPU
EnsemblMetazoa»
0.0
Telomerase protein component 1 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NXZ9_STRPU
EnsemblMetazoa»
0.0
Telomerase protein component 1 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PIT2_STRPU
EnsemblMetazoa»
0.0
Telomerase protein component 1 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PK11_STRPU
EnsemblMetazoa»
0.0
NACHT domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RG86_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SVN3_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803JUR6_XENTR
Ensembl»
0.0
dcaf12 DDB1- and CUL4-associated factor 12 (DDB1-
and CUL4-associated factor 12 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
A0A803TTP5_ANOCA
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Anolis carolinensis
TI:28377 None
   
A0A8I3PHB0_CANLF
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Canis lupus
TI:9612 None
   
A0A8I3Q873_CANLF
Ensembl»
0.0
LOC609540 Uncharacterized protein Canis lupus
TI:9612 None 		     
A0A8I3QDD1_CANLF
Ensembl»
0.0
LOC492114 DDB1 and CUL4 associated factor 12 like 2 Canis lupus
TI:9612 None 		     
A0A8J0QV18_XENTR
Ensembl»
0.0
LOC101730219 Telomerase protein component 1 Xenopus tropicalis
TI:8364 None 		     
A0A8M2BBQ7_DANRE
CTD»
0.0
ttc41 Tetratricopeptide repeat protein 41 Danio rerio
TI:7955 None 		     
A0A9J7HJI4_BRAFL
CTD»
0.0
LOC118404194 DDB1- and CUL4-associated factor 12-like isoform X1
(DDB1- and CUL4-associated factor 12-like isoform X2)		 Branchiostoma floridae
TI:7739 None
   
A0A9J7HL48_BRAFL
CTD»
0.0
LOC118404859 Nephrocystin-3-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7KQZ6_BRAFL
CTD»
0.0
LOC118410916 Telomerase protein component 1-like isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A9J7KTC2_BRAFL
CTD»
0.0
LOC118411586 TPR repeat-containing protein DDB_G0287407-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7L6B4_BRAFL
CTD»
0.0
LOC118415518 TPR repeat-containing protein DDB_G0287407-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7LXS2_BRAFL
CTD»
0.0
LOC118425504 Telomerase protein component 1-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7MG80_BRAFL
CTD»
0.0
LOC118432595 Telomerase protein component 1-like Branchiostoma floridae
TI:7739 None 		     
A0A9J7MGM4_BRAFL
CTD»
0.0
LOC118409597 Uncharacterized protein LOC118409597 isoform X1 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MJZ5_BRAFL
CTD»
0.0
LOC118411587 TPR repeat-containing protein DDB_G0287407-like Branchiostoma floridae
TI:7739 None 		     
D3ZKN9_RAT
RGD»
0.0
Dcaf12l2 DDB1 and CUL4 associated factor 12-like 2 Rattus norvegicus
TI:10116 None
   
D4ABX0_RAT
RGD»
0.0
Dcaf12l1 DDB1 and CUL4 associated factor 12-like 1 Rattus norvegicus
TI:10116 None
   
F1MRZ1_BOVIN
Ensembl»
0.0
TTC41 Tetratricopeptide repeat domain 41 Bos taurus
TI:9913 None 		     
F1RTJ3_PIG
Ensembl»
0.0
DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 Sus scrofa
TI:9823 None
   
F6QEX1_XENTR
Ensembl»
0.0
LOC100496167 Putative tetratricopeptide repeat protein 41
(Tetratricopeptide repeat protein 41 isoform X1)		 Xenopus tropicalis
TI:8364 None 		     
F6SM10_MACMU
Ensembl»
0.0
DCAF12L1 DDB1 and CUL4 associated factor 12 like 1 Macaca mulatta
TI:9544 None
   
F7DFF6_MONDO
Ensembl»
0.0
LOC100021696 Putative tetratricopeptide repeat protein 41 Monodelphis domestica
TI:13616 None 		     
F7FPY6_MONDO
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Monodelphis domestica
TI:13616 None
   
F7HKC2_MACMU
Ensembl»
0.0
DCAF12 DDB1 and CUL4 associated factor 12 Macaca mulatta
TI:9544 None
   
M0RC41_RAT
RGD»
2.0
Dcaf12 DDB1 and CUL4 associated factor 12 Rattus norvegicus
TI:10116 None